Compounds > ro 31-4639
Page last updated: 2024-09-03

ro 31-4639 and quinacrine

ro 31-4639 has been researched along with quinacrine in 2 studies

*Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. [MeSH]

*Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. [MeSH]

Compound Research Comparison

Studies
(ro 31-4639)		Trials
(ro 31-4639)		Recent Studies (post-2010)
(ro 31-4639)		Studies
(quinacrine)		Trials
(quinacrine)		Recent Studies (post-2010) (quinacrine)
5004,05165289

Protein Interaction Comparison

ProteinTaxonomyro 31-4639 (IC50)quinacrine (IC50)
cystic fibrosis transmembrane conductance regulatorHomo sapiens (human)19.88
Major prion proteinMus musculus (house mouse)0.0951
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.896
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.964
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.983
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M5Homo sapiens (human)3.736
Alpha-2A adrenergic receptorHomo sapiens (human)2.28
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M1Homo sapiens (human)1.489
Alpha-2B adrenergic receptorHomo sapiens (human)1.825
Alpha-2C adrenergic receptorHomo sapiens (human)3.857
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.255
AcetylcholinesteraseHomo sapiens (human)2.667
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.896
Histamine H2 receptorHomo sapiens (human)3.535
Alpha-1D adrenergic receptorHomo sapiens (human)2.065
5-hydroxytryptamine receptor 2AHomo sapiens (human)2.663
D(3) dopamine receptorHomo sapiens (human)1.318
Aldehyde oxidase 1Oryctolagus cuniculus (rabbit)10
CholinesteraseEquus caballus (horse)4.5
Aldehyde oxidaseHomo sapiens (human)3.3
Cyclic GMP-AMP synthaseHomo sapiens (human)7

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mollinedo, F; Roldan, ER1
Chappell, JB; Henderson, LM; Jones, OT1

Other Studies

2 other study(ies) available for ro 31-4639 and quinacrine

ArticleYear
Diacylglycerol stimulates the Ca2(+)-dependent phospholipase A2 of ram spermatozoa.
    Biochemical and biophysical research communications, 1991, Apr-15, Volume: 176, Issue:1

    Topics: Amino Alcohols; Animals; Calcium; Dexamethasone; Diglycerides; Kinetics; Male; Phenothiazines; Phospholipases A; Phospholipases A2; Quinacrine; Sheep; Spermatozoa

1991
Superoxide generation is inhibited by phospholipase A2 inhibitors. Role for phospholipase A2 in the activation of the NADPH oxidase.
    The Biochemical journal, 1989, Nov-15, Volume: 264, Issue:1

    Topics: Acetophenones; Amino Alcohols; Arachidonic Acid; Arachidonic Acids; Cell-Free System; Enzyme Activation; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Quinacrine; Sodium Dodecyl Sulfate; Superoxides; Tetradecanoylphorbol Acetate

1989