ro 24-5098 has been researched along with dideoxyadenosine in 6 studies
*Dideoxyadenosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite. [MeSH]
*Dideoxyadenosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite. [MeSH]
| Studies (ro 24-5098) | Trials (ro 24-5098) | Recent Studies (post-2010) (ro 24-5098) | Studies (dideoxyadenosine) | Trials (dideoxyadenosine) | Recent Studies (post-2010) (dideoxyadenosine) |
|---|---|---|---|---|---|
| 8 | 0 | 0 | 422 | 1 | 38 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, BD; Broder, S; Huryn, DM; Mitsuya, H; Sim, I; Sluboski, BC; Tam, SY; Weigele, M | 1 |
| Connell, EV; Frank, KB; Holman, MJ; Huryn, DM; Mitsuya, H; Richman, DD; Sluboski, BC; Tam, SY; Todaro, LJ; Weigele, M | 1 |
| abu Sheikha, G; Cappellacci, L; de Montis, A; Franchetti, P; Grifantini, M; La Colla, P; Loi, AG; Messini, L; Spiga, MG; Tramontano, E | 1 |
| Boone, LR; Dornsife, RE; Hazen, RJ; Krasny, HC; Nair, V; Najera, I; Paff, MT; Reardon, JE; St Clair, MH; Tisdale, M | 1 |
| Cappellacci, L; Franchetti, P; Girardet, JL; Gosselin, G; Grifantini, M; Imbach, JL; La Colla, P; Loi, AG; Périgaud, C; Pompon, A; Valette, G | 1 |
| Nair, V; Pal, S | 1 |
1 review(s) available for ro 24-5098 and dideoxyadenosine
| Article | Year |
|---|---|
Anabolism and mechanism of action of Ro24-5098, an isomer of 2',3'-dideoxyadenosine (ddA) with anti-HIV activity.
Topics: Antiviral Agents; Dideoxyadenosine; HIV; Humans; Isomerism; Reverse Transcriptase Inhibitors | 1990 |
5 other study(ies) available for ro 24-5098 and dideoxyadenosine
| Article | Year |
|---|---|
Synthesis and anti-HIV activity of isonucleosides.
Topics: Antiviral Agents; Cells, Cultured; Chromatography, Liquid; Dideoxynucleosides; Drug Stability; Gene Products, gag; HIV-1; Humans; Isomerism; Monocytes; Spectrum Analysis; Virus Replication | 1992 |
Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs.
Topics: Adenosine Triphosphate; Antiviral Agents; Aza Compounds; Dideoxyadenosine; Dideoxynucleotides; HIV Reverse Transcriptase; HIV-1; HIV-2; Molecular Structure; Phosphates; Recombinant Proteins; Reverse Transcriptase Inhibitors | 1994 |
Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol.
Topics: Adenosine Deaminase; Animals; Antibody-Dependent Cell Cytotoxicity; Antiviral Agents; Cells, Cultured; Dideoxyadenosine; DNA, Viral; Drug Resistance, Microbial; Erythroid Precursor Cells; Hepatitis B virus; HIV-1; HIV-2; Humans; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Polymerase Chain Reaction; Rats; Viral Plaque Assay | 1995 |
Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates.
Topics: Cell Line; Dideoxyadenosine; HIV-1; HIV-2; Humans; Kinetics; Magnetic Resonance Spectroscopy; Nucleotides; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Phosphorylation of the anti-HIV compound (S,S)-isodideoxyadenosine by human recombinant deoxycytidine kinase.
Topics: Animals; Anti-HIV Agents; Cattle; Deoxycytidine Kinase; Dideoxyadenosine; Humans; Liver; Phosphorylation; Recombinant Proteins | 2000 |