Page last updated: 2024-09-03

ro 19-4603 and flumazenil

ro 19-4603 has been researched along with flumazenil in 8 studies

Compound Research Comparison

Studies
(ro 19-4603)
Trials
(ro 19-4603)
Recent Studies (post-2010)
(ro 19-4603)
Studies
(flumazenil)
Trials
(flumazenil)
Recent Studies (post-2010) (flumazenil)
24034,673426981

Protein Interaction Comparison

ProteinTaxonomyro 19-4603 (IC50)flumazenil (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.0005
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0038
GABA theta subunitRattus norvegicus (Norway rat)0.0038
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0038

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's7 (87.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cook, JM; Harris, B; Liu, R; Skolnick, P; Zhang, P; Zhang, W1
de Costa, BR; Dominguez, C; Gu, ZQ; Rice, KC; Skolnick, P; Wong, G1
Ananthan, S; Cook, JM; Gu, ZQ; Hunkeler, W; Koehler, KF; Schönholzer, P; Skolnick, P; Wong, G; Zhang, W1
Jackson, HC; Nutt, DJ1
Moreau, JL; Pieri, L1
Chen, SH; Devaraju, SL; Duemler, SE; Greene, TL; June, HL; Lewis, MJ; Lin, M; Murphy, JM; Williams, JA1
Gardner, CR; Pringle, AK; Walker, RJ1
Cason, CR; Cox, R; Duemler, SE; Greene, TL; Hite, ML; June, HL; Li, TK; Lumeng, L; Mellon-Burke, J; Murphy, JM; Torres, L; Williams, JA1

Other Studies

8 other study(ies) available for ro 19-4603 and flumazenil

ArticleYear
Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.
    Journal of medicinal chemistry, 1995, May-12, Volume: 38, Issue:10

    Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Diazepam; Male; Molecular Probes; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship

1995
Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.
    Journal of medicinal chemistry, 1993, Apr-16, Volume: 36, Issue:8

    Topics: Animals; Benzodiazepines; Binding Sites; Brain; Esters; Imidazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

1993
Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors.
    Journal of medicinal chemistry, 1993, Jun-25, Volume: 36, Issue:13

    Topics: Animals; Azepines; Benzodiazepines; Cerebellum; Computer Simulation; Diazepam; In Vitro Techniques; Ligands; Male; Models, Molecular; Molecular Conformation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; X-Ray Diffraction

1993
Effects of benzodiazepine receptor inverse agonists on locomotor activity and exploration in mice.
    European journal of pharmacology, 1992, Oct-20, Volume: 221, Issue:2-3

    Topics: Animals; Azepines; Azides; Benzodiazepines; Benzodiazepinones; Exploratory Behavior; Flumazenil; Male; Mice; Motor Activity; Receptors, GABA-A

1992
Effects of an intrathecally administered benzodiazepine receptor agonist, antagonist and inverse agonist on morphine-induced inhibition of a spinal nociceptive reflex.
    British journal of pharmacology, 1988, Volume: 93, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Azepines; Flumazenil; Injections, Spinal; Male; Midazolam; Morphine; Nociceptors; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A

1988
Effects of the benzodiazepine inverse agonist RO19-4603 on the maintenance of tolerance to a single dose of ethanol.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:3

    Topics: Animals; Azepines; Behavior, Animal; Benzodiazepines; Drug Tolerance; Ethanol; Flumazenil; GABA Modulators; Locomotion; Male; Rats; Rats, Sprague-Dawley

1995
Different functional effect of Ro 15-4513 and Ro 19-4603 on synaptic responses of Purkinje cells in the rat cerebellar slice.
    Brain research, 1994, Dec-05, Volume: 665, Issue:2

    Topics: Animals; Azepines; Azides; Benzodiazepines; Cerebellum; Diazepam; Electrophysiology; Flumazenil; In Vitro Techniques; Male; Neural Inhibition; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA-A; Synapses

1994
Effects of the benzodiazepine inverse agonist RO19-4603 alone and in combination with the benzodiazepine receptor antagonists flumazenil, ZK 93426 and CGS 8216, on ethanol intake in alcohol-preferring (P) rats.
    Brain research, 1996, Sep-23, Volume: 734, Issue:1-2

    Topics: Alcohol Drinking; Animals; Azepines; Benzodiazepines; Dose-Response Relationship, Drug; Drinking; Drug Combinations; Eating; Ethanol; Female; Flumazenil; GABA-A Receptor Antagonists; Pyrazoles; Rats; Saccharin; Solutions; Time Factors

1996