Compounds > ro 15-5458
Page last updated: 2024-09-04

ro 15-5458 and acridines

ro 15-5458 has been researched along with acridines in 10 studies

Compound Research Comparison

Studies
(ro 15-5458)		Trials
(ro 15-5458)		Recent Studies (post-2010)
(ro 15-5458)		Studies
(acridines)		Trials
(acridines)		Recent Studies (post-2010) (acridines)
11016,987169856

Protein Interaction Comparison

ProteinTaxonomyro 15-5458 (IC50)acridines (IC50)
AcetylcholinesteraseHomo sapiens (human)6.84

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's6 (60.00)18.2507
2000's2 (20.00)29.6817
2010's0 (0.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Bennett, JL; Eshete, F3
Bickle, QD; Sacko, M; Vignali, DA1
Ali, HM; Bennett, JL; Homeida, MM; Sulaiman, SM1
Abdel Hadi, A; Aboú Shadi, O; el-Nahal, H; Metwally, A; Mikhail, EG; Sabry, H1
Mohamed, SH1
Guirguis, F; Kamel, G; Metwally, A; Nessim, NG; Noseir, M1
Guirguis, FR1
Caffrey, CR; Charman, SA; Dong, Y; El-Sakkary, N; Gangoiti, J; Häberli, C; Huang, J; Keiser, J; Momper, JD; Probst, A; Siegel, D; Skinner, DE; Ta, AP; Vennerstrom, JL; Vigneron, S1

Other Studies

10 other study(ies) available for ro 15-5458 and acridines

ArticleYear
The schistosomicidal compound Ro 15-5458 causes a reduction in the RNA content of Schistosoma mansoni.
    Molecular and biochemical parasitology, 1991, Volume: 45, Issue:1

    Topics: Acridines; Actins; Animals; Densitometry; Female; Mice; Mice, Inbred Strains; RNA, Messenger; RNA, Ribosomal, 18S; RNA, Ribosomal, 28S; Schistosoma mansoni; Schistosomicides

1991
Schistosoma mansoni: biochemical characteristics of the antischistosomal effects of Ro 15-5458.
    Experimental parasitology, 1990, Volume: 71, Issue:1

    Topics: Acridines; Adenosine Triphosphate; Animals; Carbohydrate Metabolism; Cricetinae; Culture Media; Female; Helminth Proteins; Lactates; Male; Mesocricetus; Mice; Microscopy, Electron, Scanning; Molecular Structure; Pigments, Biological; RNA, Messenger; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides

1990
Induction of immunity against Schistosoma mansoni by drug (Ro11-3128)-terminated infections: analysis of surface antigen recognition.
    Parasite immunology, 1990, Volume: 12, Issue:6

    Topics: Acridines; Animals; Antibodies, Helminth; Antibodies, Monoclonal; Antigens, Helminth; Antigens, Surface; Benzodiazepinones; Blister; Blotting, Western; Female; Immunity; Lung; Mice; Mice, Inbred CBA; Precipitin Tests; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Skin; Species Specificity

1990
The apparent absorption kinetics of Ro 15-5458, a schistosomicidal drug.
    The Journal of antimicrobial chemotherapy, 1990, Volume: 25, Issue:2

    Topics: Acridines; Animals; Female; Half-Life; Intestinal Absorption; Rabbits; Schistosomicides

1990
Efficacy of a new Hoffmann-La Roche compound (Ro 15-5458) against Schistosoma mansoni (Gezira strain, Sudan) in vervet monkeys (Cercopithecus aethiops).
    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1989, Volume: 40, Issue:3

    Topics: Acridines; Animals; Chlorocebus aethiops; Parasite Egg Count; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides

1989
Study of the efficacy of the new antischistosomal drug 10-[2-(diethylamino)ethyl]-9-acridanone-(thiazolidin-2-ylidene) hydrazone against an Egyptian strain of S. mansoni in mice.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:8

    Topics: Acridines; Animals; Granuloma; Intestines; Liver; Male; Mice; Mice, Inbred Strains; Portal Vein; Schistosomiasis mansoni; Schistosomicides

1997
Schistosoma mansoni: testis alterations induced by antischistosomal drug Ro15-5458.
    Journal of the Egyptian Society of Parasitology, 1999, Volume: 29, Issue:2

    Topics: Acridines; Animals; Male; Mice; Microscopy, Electron; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Testis

1999
Effect of a combination of the new antischistosomal drug Ro 15-5458 and praziquantel on different strains of Schistosoma mansoni infected mice.
    Arzneimittel-Forschung, 2000, Volume: 50, Issue:4

    Topics: Acridines; Animals; Antiplatyhelmintic Agents; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance; Female; Intestines; Liver; Male; Mice; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Sulfates

2000
Efficacy of praziquantel and Ro 15-5458, a 9-acridanone-hydrazone derivative, against Schistosoma haematobium.
    Arzneimittel-Forschung, 2003, Volume: 53, Issue:1

    Topics: Acridines; Animals; Cricetinae; Egypt; Female; Male; Mesocricetus; Parasite Egg Count; Praziquantel; Schistosoma haematobium; Schistosomiasis haematobia; Schistosomicides

2003
Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.
    The Journal of antimicrobial chemotherapy, 2020, 10-01, Volume: 75, Issue:10

    Topics: Acridines; Animals; Cricetinae; Hydrazones; Mice; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides

2020