Compounds > ro 15-4513
Page last updated: 2024-08-16

ro 15-4513 and histidine

ro 15-4513 has been researched along with histidine in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Maksay, G1
Lüddens, H; Seeburg, PH; Wieland, HA1
Binkley, P; Ticku, MK1
Kettenmann, H; Kleingoor, C; Korpi, ER; Seeburg, PH1
Atack, J; Banks, G; Kelly, MD; Maubach, KA; Seabrook, GR; Smith, A; Whiting, PW; Wingrove, P1

Other Studies

5 other study(ies) available for ro 15-4513 and histidine

ArticleYear
Modification of benzodiazepine receptors supports the distinctive role of histidine residues.
    European journal of pharmacology, 1992, Sep-01, Volume: 227, Issue:1

    Topics: Animals; Azides; Benzodiazepines; Brain; Diethyl Pyrocarbonate; Epoxy Compounds; Histidine; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, GABA-A; Structure-Activity Relationship; Tetranitromethane; Tritium

1992
A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.
    The Journal of biological chemistry, 1992, Jan-25, Volume: 267, Issue:3

    Topics: Affinity Labels; Amino Acid Sequence; Anti-Anxiety Agents; Azides; Base Sequence; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Chimera; Histidine; Humans; Kinetics; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Protein Conformation; Receptors, GABA-A; Transfection

1992
Histidine residue is crucial for the binding of ligands to the benzodiazepine site except Ro15-4513.
    European journal of pharmacology, 1991, Nov-13, Volume: 208, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Binding Sites; Cerebellum; Cerebral Cortex; Diethyl Pyrocarbonate; Flunitrazepam; Histidine; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A

1991
Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor.
    Nature, 1993, Jan-28, Volume: 361, Issue:6410

    Topics: Affinity Labels; Amino Acid Sequence; Animals; Arginine; Autoradiography; Azides; Base Sequence; Benzodiazepines; Binding, Competitive; Cerebellum; Diazepam; Drug Tolerance; Ethanol; gamma-Aminobutyric Acid; Histidine; In Situ Hybridization; Kinetics; Macromolecular Substances; Models, Structural; Molecular Sequence Data; Motor Activity; Oligodeoxyribonucleotides; Point Mutation; Poly A; Protein Structure, Secondary; Rats; Rats, Mutant Strains; Receptors, GABA-A; RNA; RNA, Messenger; Tritium

1993
Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands.
    British journal of pharmacology, 2002, Volume: 135, Issue:1

    Topics: Anticonvulsants; Arginine; Azides; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Cell Line; Cells, Cultured; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Histidine; Humans; Ligands; Mutation; Protein Subunits; Receptors, GABA-A

2002