ro 15-4513 has been researched along with flunitrazepam in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (19.05) | 18.7374 |
| 1990's | 27 (64.29) | 18.2507 |
| 2000's | 4 (9.52) | 29.6817 |
| 2010's | 2 (4.76) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S | 1 |
| Clayton, T; Cook, J; DeLorey, TM; Furtmüller, R; Halliwell, RF; Harris, D; Huck, S; Sahbaie, P; Sieghart, W | 1 |
| Uusi-Oukari, M | 2 |
| Gibert-Rahola, J; Maldonado, R; Micó, JA; Valverde, O | 1 |
| Sei, Y; Skolnick, P; Wong, G | 1 |
| Chen, JP; Lal, H; Martin, MW; Prather, PL; Rezazadeh, SM | 1 |
| Binkley, P; Ticku, MK | 1 |
| Ewert, M; Kettenmann, H; Kleingoor, C; Seeburg, PH; von Blankenfeld, G | 1 |
| Buck, KJ; Harris, RA | 1 |
| Borden, LA; Gibbs, TT | 1 |
| Kulkarni, SK; Ticku, MK | 1 |
| McIntyre, TD; Skolnick, P; Trullas, R | 1 |
| Mhatre, M; Ticku, MK | 1 |
| Chiu, TH; Rosenberg, HC; Yu, OF | 1 |
| Sieghart, W | 1 |
| Hellevuo, K; Korpi, ER | 1 |
| Eichinger, A; Sieghart, W | 1 |
| Eichinger, A; Möhler, H; Richards, JG; Sieghart, W | 1 |
| Eichinger, A; Sieghart, W; Zezula, J | 1 |
| Clark, M; Massenburg, GS; Post, RM; Weiss, SR | 1 |
| Hu, XJ; Ticku, MK | 1 |
| Ferenci, P; Herneth, A; Püspök, A; Steindl, P | 1 |
| Duggan, MJ; Pollard, S; Stephenson, FA | 1 |
| Korpi, ER; Taira, T; Uusi-Oukari, M | 1 |
| Hiramatsu, M; Ishihara, S; Kameyama, T; Nabeshima, T | 1 |
| Anderson, SM; Cross, AJ; De Souza, RJ | 1 |
| Duncalfe, LL; Dunn, SM | 2 |
| File, SE; Hogg, S; Mills, AD | 1 |
| Mehta, AK; Shank, RP | 1 |
| Bateson, AN; Davies, M; Dunn, SM; Hadingham, KL; Martin, IL; Whiting, PJ | 1 |
| Berning, B; Gerner, FM; Hauser, CA; Rupprecht, R; Wetzel, CH | 1 |
| Davies, M; Dunn, SM; Thuynsma, RP | 1 |
| Bateson, AN; Davies, M; Dunn, SM | 1 |
| Asuni, A; Broughton, H; Collins, I; Emms, F; Farrar, S; McKernan, RM; Quirk, K | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Boileau, AJ; Czajkowski, C; Kucken, AM; Teissére, JA; Wagner, DA; Ward, PR | 1 |
| Bromidge, FA; Casula, MA; Hadingham, KL; Martin, K; Maubach, K; Pillai, GV; Seabrook, GR; Whiting, PJ; Wingrove, PB | 1 |
| Abe, K; Hosoi, R; Inoue, O; Momosaki, S | 1 |
| Contó, MB; de Carvalho, JG; Hipólide, DC; Venditti, MA | 1 |
| Benkherouf, AY; Kortesniemi, M; Laaksonen, O; Logrén, N; Salo-Ahen, OMH; Soini, SL; Somborac, T; Uusi-Oukari, M; Yang, B | 1 |
42 other study(ies) available for ro 15-4513 and flunitrazepam
| Article | Year |
|---|---|
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship | 2000 |
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Databases, Factual; Electrophysiology; Female; Ligands; Male; Memory; Mice; Models, Molecular; Molecular Structure; Oocytes; Protein Isoforms; Protein Subunits; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2008 |
Effect of diethyl pyrocarbonate modification of benzodiazepine receptors on [3H]Ro 15-4513 binding.
Topics: Animals; Appetite Depressants; Azides; Benzodiazepines; Carbolines; Cerebellum; Cerebral Cortex; Diazepam; Diethyl Pyrocarbonate; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium | 1992 |
Characterization of two cerebellar binding sites of [3H]Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Cell Membrane; Cerebellum; Chromatography, Affinity; Diazepam; Flunitrazepam; Receptors, GABA-A; Swine; Tritium | 1992 |
Changes in benzodiazepine-receptor activity modify morphine withdrawal syndrome in mice.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Flumazenil; Flunitrazepam; Male; Mice; Morphine; Receptors, GABA-A; Substance Withdrawal Syndrome | 1992 |
Stable expression of type I gamma-aminobutyric acidA/benzodiazepine receptors in a transfected cell line.
Topics: Animals; Azides; Benzodiazepines; Blotting, Northern; Blotting, Southern; Cell Line; Flunitrazepam; Humans; Male; Plasmids; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Transfection | 1992 |
Modulation of benzodiazepine agonist and inverse-agonist receptor binding by GABA during ethanol withdrawal.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Synaptic Transmission | 1991 |
Histidine residue is crucial for the binding of ligands to the benzodiazepine site except Ro15-4513.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Cerebellum; Cerebral Cortex; Diethyl Pyrocarbonate; Flunitrazepam; Histidine; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Inverse but not full benzodiazepine agonists modulate recombinant alpha 6 beta 2 gamma 2 GABAA receptors in transfected human embryonic kidney cells.
Topics: Action Potentials; Azides; Benzodiazepines; Carbolines; Cells, Cultured; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kidney; Receptors, GABA-A; Recombinant Proteins; Transfection | 1991 |
Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels. II. Chronic effects of ethanol.
Topics: Animals; Azides; Benzodiazepines; Brain; Carbolines; Chloride Channels; Chlorides; Convulsants; Ethanol; Flunitrazepam; GABA Antagonists; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Pyridazines; Receptors, GABA-A; Substance Withdrawal Syndrome; Tritium | 1990 |
Flunitrazepam photoaffinity labeling of the GABA(A) receptor reduces inhibition of [3H]Ro15-4513 binding by GABA.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain; Chick Embryo; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Membranes; Photochemistry; Receptors, GABA-A | 1990 |
Chronic benzodiazepine antagonist treatment and its withdrawal upregulates components of GABA-benzodiazepine receptor ionophore complex in cerebral cortex of rat.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Up-Regulation | 1990 |
Differences in the biophysical properties of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex in the long-sleep and short-sleep mouse lines.
Topics: Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Heart; Ion Channels; Male; Mice; Mice, Mutant Strains; Receptors, GABA-A; Sleep | 1988 |
Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cells, Cultured; Female; Flumazenil; Flunitrazepam; Male; Mice; Mice, Inbred C57BL; Neurons; Receptors, GABA-A; Spinal Cord | 1989 |
Photoaffinity labeling of [3H]flunitrazepam- and [3H]Ro15-4513-bound pellets in rat cerebral cortex and cerebellum.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Cerebellum; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Suspensions; Synaptic Membranes; Time Factors | 1989 |
Comparison of two different benzodiazepine binding proteins by peptide mapping after limited proteolysis.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Brain Chemistry; Cerebellum; Clonazepam; Flunitrazepam; Hippocampus; Molecular Weight; Peptide Mapping; Rats; Receptors, GABA-A | 1988 |
Failure of Ro 15-4513 to antagonize ethanol in rat lines selected for differential sensitivity to ethanol and in Wistar rats.
Topics: Animals; Azides; Benzodiazepines; Brain; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Lorazepam; Male; Motor Skills; Rats; Rats, Inbred Strains; Receptors, GABA-A; Species Specificity | 1988 |
Postnatal development of proteins associated with different benzodiazepine receptors.
Topics: Age Factors; Animals; Azides; Benzodiazepines; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Membrane Proteins; Molecular Weight; Pyridazines; Rats; Receptors, GABA-A | 1986 |
Photoaffinity labeling of benzodiazepine receptor proteins with the partial inverse agonist [3H]Ro 15-4513: a biochemical and autoradiographic study.
Topics: Affinity Labels; Animals; Autoradiography; Azides; Benzodiazepines; Brain; Carbolines; Cell Membrane; Cerebellum; Flunitrazepam; Hippocampus; Molecular Weight; Photochemistry; Pyridazines; Rats; Receptors, GABA-A | 1987 |
Comparison of tryptic peptides of benzodiazepine binding proteins photolabeled with [3H]flunitrazepam or [3H]Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Brain; Cell Membrane; Cerebellum; Flunitrazepam; Hippocampus; Molecular Weight; Peptide Fragments; Photochemistry; Rats; Receptors, GABA-A; Trypsin | 1987 |
Analysis of the hippocampal GABAA receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine.
Topics: Affinity Labels; Amygdala; Animals; Autoradiography; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbamazepine; Convulsants; Drug Tolerance; Electric Stimulation; Electroencephalography; Flunitrazepam; Functional Laterality; Gene Expression; Hippocampus; In Situ Hybridization; Kindling, Neurologic; Macromolecular Substances; Muscimol; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Seizures; Tritium | 1994 |
Development pattern of the GABAA-benzodiazepine receptor ionophore complex in primary cultures of cortical neurons.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; Mice; Mice, Inbred C57BL; Muscimol; Neurons; Receptors, GABA-A | 1994 |
Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Convulsants; Flunitrazepam; Hepatic Encephalopathy; Liver Failure, Acute; Male; Rats; Rats, Sprague-Dawley; Thioacetamide | 1993 |
Further evidence for the existence of alpha subunit heterogeneity within discrete gamma-aminobutyric acidA receptor subpopulations.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding Sites; Cattle; Cerebellum; Cerebral Cortex; Chromatography, Affinity; Cysteine; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Immunoblotting; Macromolecular Substances; Molecular Weight; Receptors, GABA-A | 1993 |
Early postnatal treatment with muscimol transiently alters brain GABAA receptors and open-field behavior in rat.
Topics: Aging; Animals; Animals, Newborn; Azides; Behavior, Animal; Benzodiazepines; Brain Chemistry; Ethanol; Flunitrazepam; Male; Muscimol; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Weight Gain | 1993 |
Development of tolerance to anxiolytic effects of chlordiazepoxide in elevated plus-maze test and decrease of GABAA receptors.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Brain Chemistry; Chlordiazepoxide; Down-Regulation; Drug Tolerance; Exploratory Behavior; Flunitrazepam; Male; Mice; Receptors, GABA-A | 1993 |
The human neuroblastoma cell line, IMR-32 possesses a GABAA receptor lacking the benzodiazepine modulatory site.
Topics: Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chloride Channels; Flunitrazepam; Humans; Kinetics; Membrane Proteins; Neuroblastoma; Radioligand Assay; Rats; Receptors, GABA-A; Tumor Cells, Cultured | 1993 |
Benzodiazepine binding to GABAA receptors: differential effects of sulfhydryl modification.
Topics: Animals; Azides; Benzodiazepines; Cattle; Cerebral Cortex; Disulfides; Dithiothreitol; Ethylmaleimide; Flunitrazepam; In Vitro Techniques; Kinetics; Membranes; Muscimol; Radioligand Assay; Receptors, GABA-A; Sulfhydryl Compounds | 1993 |
Differences in benzodiazepine binding in quail selectively bred for differences in tonic immobility.
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Brain; Chlorine; Coturnix; Diazepam; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Motor Activity; Radioisotopes; Receptors, GABA-A | 1996 |
Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNS.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Central Nervous System; Cerebellum; Chlorides; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; Hippocampus; Imidazoles; Male; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Tritium | 1995 |
Mapping of GABAA receptor sites that are photoaffinity-labelled by [3H]flunitrazepam and [3H]Ro 15-4513.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain Chemistry; Brain Mapping; Cattle; Cerebellum; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Hydrogen-Ion Concentration; Hydroxylamines; In Vitro Techniques; Molecular Weight; Radioligand Assay; Receptors, GABA-A | 1996 |
Identification of domains in human recombinant GABAA receptors that are photoaffinity labelled by [3H]flunitrazepam and [3H]Ro15-4513.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; GABA Agonists; GABA Modulators; Humans; Hydroxylamines; Membranes; Mice; Radioligand Assay; Receptors, GABA-A; Recombinant Proteins | 1996 |
Flunitrazepam has an inverse agonistic effect on recombinant alpha6beta2gamma2-GABAA receptors via a flunitrazepam-binding site.
Topics: Affinity Labels; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Chloride Channels; Flunitrazepam; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Kidney; Kinetics; Macromolecular Substances; Membrane Potentials; Receptors, GABA-A; Recombinant Proteins; Transfection | 1997 |
Effects of propofol and pentobarbital on ligand binding to GABAA receptors suggest a similar mechanism of action.
Topics: Allosteric Site; Anesthetics, Intravenous; Animals; Azides; Benzodiazepines; Brain; Cattle; Flunitrazepam; GABA Agonists; In Vitro Techniques; Ligands; Membranes; Muscimol; Pentobarbital; Propofol; Receptors, GABA-A | 1998 |
Structural requirements for ligand interactions at the benzodiazepine recognition site of the GABA(A) receptor.
Topics: Allosteric Site; Animals; Azides; Benzodiazepines; Carbolines; Cell Line; Flunitrazepam; GABA Modulators; Ligands; Mutation; Rats; Receptors, GABA-A | 1998 |
Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of these w
Topics: Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Flunitrazepam; GABA Modulators; Humans; Ligands; Models, Molecular; Photoaffinity Labels; Receptors, GABA-A; Structure-Activity Relationship; Ultraviolet Rays | 1998 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous System Depressants; Cerebellum; Cerebral Cortex; Chronic Disease; Ethanol; Flunitrazepam; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Male; Muscimol; Precipitin Tests; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium; Zolpidem | 1999 |
Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor.
Topics: Amino Acid Sequence; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Cloning, Molecular; Flumazenil; Flunitrazepam; Humans; Molecular Sequence Data; Point Mutation; Receptors, GABA-A; Recombinant Fusion Proteins; Sequence Homology, Amino Acid | 2000 |
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Carbolines; DNA, Complementary; Female; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Imidazoles; Isoleucine; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Fusion Proteins; Sequence Alignment; Structure-Activity Relationship; Threonine; Transfection; Xenopus laevis; Zolpidem | 2001 |
Remarkable selectivity of the in vivo binding of [3H]Ro15-4513 to α5 subtype of benzodiazepine receptor in the living mouse brain.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Carbolines; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Male; Mice; Protein Subunits; Receptors, GABA-A; Tritium | 2010 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepam; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Flunitrazepam; GABA Modulators; Male; Pentobarbital; Rats; Rats, Wistar; Reaction Time; Seizures; Sleep; Statistics, Nonparametric; Tritium | 2012 |
Hops compounds modulatory effects and 6-prenylnaringenin dual mode of action on GABA
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Cyclohexenes; Dose-Response Relationship, Drug; Flavonoids; Flumazenil; Flunitrazepam; GABA Modulators; Humulus; Male; Molecular Docking Simulation; Plant Extracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Terpenes | 2020 |