Page last updated: 2024-09-04

ro 12-5637 and moclobemide

ro 12-5637 has been researched along with moclobemide in 5 studies

*Moclobemide: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties. [MeSH]

*Moclobemide: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties. [MeSH]

Compound Research Comparison

Studies
(ro 12-5637)
Trials
(ro 12-5637)
Recent Studies (post-2010)
(ro 12-5637)
Studies
(moclobemide)
Trials
(moclobemide)
Recent Studies (post-2010) (moclobemide)
510788240113

Protein Interaction Comparison

ProteinTaxonomyro 12-5637 (IC50)moclobemide (IC50)
Amine oxidase [flavin-containing] A Rattus norvegicus (Norway rat)7.7
Amine oxidase [flavin-containing] AHomo sapiens (human)4.1522

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's4 (80.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chavinie, J; Francoual, C; Moran, C; Olive, G; Pedarriosse, AM; Pfefen, JP; Pons, G; Schoerlin, MP; Tam, YK1
Bae, KS; Cho, JY; Jang, IJ; Lee, KH; Park, JY; Park, SS; Shin, SG; Yi, SY; Yim, DS; Yu, KS1
Gross, AS; Hoskins, JM; Rivory, LP; Shenfield, GM1
Gross, A; Hoskins, J; Murray, M; Shenfield, G1
Miljkovic, B; Pokrajac, M; Rakic, A; Vucicevic, K1

Trials

1 trial(s) available for ro 12-5637 and moclobemide

ArticleYear
Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19.
    Clinical pharmacology and therapeutics, 2001, Volume: 69, Issue:4

    Topics: Adult; Antidepressive Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzamides; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Genotype; Humans; Mixed Function Oxygenases; Moclobemide; Morpholines; Omeprazole; Polymorphism, Genetic; Random Allocation

2001

Other Studies

4 other study(ies) available for ro 12-5637 and moclobemide

ArticleYear
Moclobemide excretion in human breast milk.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:1

    Topics: Adult; Benzamides; Biological Availability; Biotransformation; Female; Humans; Milk, Human; Moclobemide; Monoamine Oxidase Inhibitors; Morpholines

1990
High-performance liquid chromatography-electrospray ionization mass spectrometry method for the measurement of moclobemide and two metabolites in plasma.
    Journal of chromatography. B, Biomedical sciences and applications, 2001, Apr-25, Volume: 754, Issue:2

    Topics: Antidepressive Agents; Benzamides; Chromatography, High Pressure Liquid; Drug Stability; Humans; Moclobemide; Morpholines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2001
Characterization of moclobemide N-oxidation in human liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:7

    Topics: Benzamides; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Microsomes, Liver; Moclobemide; Models, Chemical; Monoamine Oxidase Inhibitors; Morpholines; Oxygen; Protein Isoforms; Temperature; Time Factors

2001
High-performance liquid chromatographic method for the determination of moclobemide and its two major metabolites in human plasma.
    Journal of pharmaceutical and biomedical analysis, 2007, Mar-12, Volume: 43, Issue:4

    Topics: Benzamides; Blood; Chromatography, High Pressure Liquid; Humans; Moclobemide; Molecular Structure; Morpholines; Sensitivity and Specificity; Spectrophotometry, Ultraviolet

2007