Compounds > ro 03-7894
Page last updated: 2024-09-05

ro 03-7894 and isoproterenol

ro 03-7894 has been researched along with isoproterenol in 7 studies

Compound Research Comparison

Studies
(ro 03-7894)		Trials
(ro 03-7894)		Recent Studies (post-2010)
(ro 03-7894)		Studies
(isoproterenol)		Trials
(isoproterenol)		Recent Studies (post-2010) (isoproterenol)
110030,7808032,640

Protein Interaction Comparison

ProteinTaxonomyro 03-7894 (IC50)isoproterenol (IC50)
Beta-2 adrenergic receptorHomo sapiens (human)0.246
Beta-1 adrenergic receptorHomo sapiens (human)0.333
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.2125
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)1.77
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)0.2125
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)0.2125
Beta-2 adrenergic receptorCanis lupus familiaris (dog)0.6667

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19907 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Malta, E; Molenaar, P1
Broadley, KJ; Nicholson, CD1
Broadley, KJ; Rankin, A1
Baker, SP; Posner, P1
Broadley, KJ; Williams, RG1
Krstew, E; Malta, E; McPherson, GA; Molenaar, P; Raper, C1
McNeill, JH; Siegl, PK1

Other Studies

7 other study(ies) available for ro 03-7894 and isoproterenol

ArticleYear
Analysis of agonist dissociation constants as assessed by functional antagonism in guinea pig left atria.
    Journal of pharmacological methods, 1986, Volume: 15, Issue:2

    Topics: Adenosine; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzofurans; Carbachol; Catechols; Gallopamil; Guinea Pigs; Heart; In Vitro Techniques; Iodine Radioisotopes; Isoproterenol; Kinetics; Male; Myocardial Contraction; Nifedipine; Pindolol; Propanolamines

1986
Dissociation constants of isoprenaline and orciprenaline and their relative efficacies on guinea-pig isolated atria determined by use of an irreversible beta-adrenoceptor antagonist.
    British journal of pharmacology, 1981, Volume: 72, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Benzofurans; Dose-Response Relationship, Drug; Ethanolamines; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Metaproterenol; Myocardial Contraction; Myocardium; Receptors, Adrenergic, beta

1981
Comparison of the apparent irreversible beta-adrenoceptor antagonist Ro 03-7894 with propranolol in cardiac ventricular muscle by pharmacological and radioligand binding techniques.
    Biochemical pharmacology, 1982, Apr-01, Volume: 31, Issue:7

    Topics: Adrenergic beta-Antagonists; Animals; Benzofurans; Binding, Competitive; Cell Membrane; Dihydroalprenolol; Female; Guinea Pigs; Heart; Heart Ventricles; Isoproterenol; Male; Myocardial Contraction; Propranolol; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, beta

1982
The effect of the beta-adrenoreceptor antagonist Ro03-7894 on rat atrial tension development and (-)-[3H]dihydroalprenolol binding to cardiac and lung membranes.
    Life sciences, 1983, Aug-01, Volume: 33, Issue:5

    Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Benzofurans; Cell Membrane; Dihydroalprenolol; Isoproterenol; Kinetics; Lung; Male; Myocardial Contraction; Myocardium; Rats

1983
Temperature-induced changes in dissociation constants (KA) of agonists at cardiac beta-adrenoceptors determined by use of the irreversible antagonist Ro 03-7894.
    British journal of pharmacology, 1983, Volume: 79, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Benzofurans; Female; Guinea Pigs; Heart; Isoproterenol; Male; Metaproterenol; Receptors, Adrenergic, beta; Temperature

1983
Is Ro 03-7894 an irreversible antagonist at beta-adrenoceptor sites?
    British journal of pharmacology, 1984, Volume: 82, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Benzofurans; Calcium Chloride; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Potassium; Refractory Period, Electrophysiological; Reserpine; Trachea; Uterine Contraction

1984
Antagonism with dibenamine, D-600, and Ro 3-7894 to estimate dissociation constants and receptor reserves for cardiac adrenoceptors in isolated rabbit papillary muscles.
    Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:8

    Topics: Animals; Benzofurans; Dibenzylchlorethamine; Female; Gallopamil; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Phenylephrine; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Timolol

1982