ritalinic acid has been researched along with methylphenidate in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (20.75) | 18.7374 |
| 1990's | 5 (9.43) | 18.2507 |
| 2000's | 8 (15.09) | 29.6817 |
| 2010's | 25 (47.17) | 24.3611 |
| 2020's | 4 (7.55) | 2.80 |
| Authors | Studies |
|---|---|
| Hungund, BL; Iden, CR | 1 |
| Hanna, M; Hungund, BL; Winsberg, BG | 1 |
| Cahn, YP; Hill, BM; Hill, JG; Soldin, SJ; Swanson, JM | 1 |
| Milberg, RM; Rinehart, KL; Sleator, EK; Sprague, RL | 1 |
| Hubbard, JW; Korchinski, ED; Midha, KK; Srinivas, NR | 1 |
| Hubbard, JW; Midha, KK; Srinivas, NR | 1 |
| Aoyama, T; Honda, Y; Kotaki, H; Nakagawa, F | 1 |
| Kotaki, H; Nakagawa, F; Nakajima, K; Saitoh, Y | 1 |
| Hall, P | 1 |
| Janowsky, AJ; Paul, SM; Rafferty, MF; Rice, KC; Schweri, MM; Skolnick, P | 1 |
| Hammond, KB; Rodgerson, DO; Wells, R | 1 |
| Breese, GR; Ellington, K; Gualtieri, CT; Kilts, C; Kraemer, G; Mueller, RA; Patrick, K; Wargin, W | 1 |
| Chan, YP; Logan, W; Macleod, SM; Soldin, SS; Swanson, JM; Thiessen, JJ | 1 |
| Carnicero, M; De La Torre, R; Segura, J; Solans, A | 1 |
| Diamond, F; Logan, BK; Markowitz, JS; Patrick, KS | 1 |
| Bajic, S; Doerge, DR; Fogle, CM; McCullagh, M; Paule, MG | 1 |
| Boulton, DW; Carson, SW; DeVane, CL; Gill, HS; Markowitz, JS; Nahas, Z; Risch, SC | 1 |
| Barbarin, N; Black, R; Henion, J; Mawhinney, DB | 1 |
| FANTONI, A; VEGETO, A | 1 |
| Deng, Y; Fang, J; McKay, G; Zhang, J | 1 |
| Khetani, VD; Scheffler, MR; Stirling, DI; Stypinski, D; Teo, SK; Thomas, SD; Wu, A | 1 |
| De Boeck, G; del Mar Ramirez Fernandez, M; Laloup, M; Lopez-Rivadulla, M; Samyn, N; Wallemacq, P; Wood, M | 1 |
| Chen, JJ; Dobrovolsky, VN; Doerge, DR; Lin, CJ; Manjanatha, MG; Mattison, DR; McGarrity, LG; Morris, SM; Shaddock, JG; Shelton, SD; Twaddle, NW | 1 |
| Balcioglu, A; Bhide, PG; Biederman, J; McCarthy, D; Ren, JQ; Spencer, TJ | 1 |
| Farrè, M; García-Algar, O; Marchei, E; Pacifici, R; Pellegrini, M; Pichini, S; Vall, O | 1 |
| Farré, M; Garcia-Algar, O; Marchei, E; Pacifici, R; Pardo, R; Pellegrini, M; Pichini, S | 2 |
| Kauert, GF; Koehm, M; Toennes, SW | 1 |
| Letzel, M; Schüssler, W; Sengl, M; Weiss, K | 1 |
| Abe, K; Ikeda, R; Kikura-Hanajiri, R; Kuroda, N; Nakashima, K; Wada, M | 1 |
| Josefsson, M; Rydberg, I | 1 |
| Florkowski, CM; George, PM; Moore, GA; Paterson, SM | 1 |
| Linnet, K; Rasmussen, HB; Thomsen, R | 1 |
| Becker, B; Burgard, DA; Dinglasan-Panlilio, MJ; Ferrell, R; Fuller, R | 1 |
| Ametamey, SM; Milicevic Sephton, S; Schweizer, WB; Werner, IA; Wyss, S | 1 |
| Beck, O; Franck, J; Sandqvist, S; Stephanson, N | 1 |
| Guber, S; Herrmann, C; Ippisch, J; Paul, M; Schultis, W | 1 |
| Atayee, RS; Best, BM; Jiang, JY; Ma, JD; Morello, CM | 1 |
| Gahr, M; Kölle, MA | 1 |
| Doerge, DR; Fisher, JW; Gearhart, JM; Mattison, DR; Morris, SM; Paule, MG; Ruark, CD; Slikker, W; Twaddle, NC; Vitiello, B; Yang, X; Young, JF | 1 |
| Aigbirhio, FI; Berry, D; Caprioli, D; Dalley, JW; Ferrari, V; Fryer, TD; Hong, YT; Jupp, B; McNabb, C; Robbins, TW; Sawiak, SJ; Wharton, L; Williamson, DJ | 1 |
| Covaci, A; Erratico, C; Negreira, N; van Nuijs, AL | 1 |
| Chrzanowski, Ł; Cichocka, D; Corvini, PF; Čvančarová, M; Woźniak-Karczewska, M | 1 |
| Corvini, PF; Čvančarová, M; Elisashvili, V; Kobakhidze, A | 1 |
| Biscaldi, M; Clement, HW; Fleischhaker, C; Geffert, C; Lukačin, R; Preiskorn, J; Rauh, R; Schulz, E; Studer, S | 1 |
| Benson, D; Hartmann, P; Hovda, L; Knych, HK; McKemie, DS; Seminoff, K | 1 |
| Arroyo-Mora, LE; DeCaprio, AP; Gnagy, E; Leon, LA; Mulet, CT | 1 |
| Choi, H; Jang, M; Kang, S; Kim, J; Shin, I; Yang, W | 1 |
| Andersson, PL; Brodin, T; Lindberg, RH; McCallum, ES | 1 |
| Baranowski, D; Chrzanowski, Ł; Corvini, PF; Čvančarová, M; Framski, G; Marczak, Ł; Woźniak-Karczewska, M | 1 |
| Ackehed, G; Arvidsson, M; Beck, O; Dahl, ML; Nordin, K; Rosenborg, S | 1 |
| Arantes, ACF; Campos, EG; Chinaglia, KO; Costa, JL; Cunha, KFD; Kahl, JMM; Rodrigues, LC | 1 |
| Kronstrand, R; Smith, C; Swortwood, MJ; Vikingsson, S | 1 |
5 trial(s) available for ritalinic acid and methylphenidate
| Article | Year |
|---|---|
Methylphenidate hydrochloride given with or before breakfast: II. Effects on plasma concentration of methylphenidate and ritalinic acid.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Biological Availability; Child; Double-Blind Method; Drug Administration Schedule; Fasting; Half-Life; Humans; Intestinal Absorption; Kinetics; Male; Methylphenidate; Time Factors | 1983 |
Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers.
Topics: Adolescent; Adult; Area Under Curve; Central Nervous System Stimulants; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Female; Half-Life; Humans; Male; Mass Spectrometry; Methylphenidate; Middle Aged; Phenotype; Polymorphism, Genetic; Quinidine | 2000 |
A single-dose, two-way crossover, bioequivalence study of dexmethylphenidate HCl with and without food in healthy subjects.
Topics: Adult; Area Under Curve; Biological Availability; Central Nervous System Stimulants; Cross-Over Studies; Dexmethylphenidate Hydrochloride; Fasting; Female; Food-Drug Interactions; Half-Life; Humans; Intestinal Absorption; Male; Methylphenidate; Postprandial Period; Stereoisomerism; Therapeutic Equivalency | 2004 |
Influence of ethanol on the pharmacokinetics of methylphenidate's metabolites ritalinic acid and ethylphenidate.
Topics: Adult; Biotransformation; Central Nervous System Depressants; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Drug Interactions; Ethanol; Female; Humans; In Vitro Techniques; Liver; Male; Mass Spectrometry; Methylphenidate; Middle Aged; Reference Standards; Young Adult | 2010 |
Interindividual and Intraindividual Variation of Methylphenidate Concentrations in Serum and Saliva of Patients With Attention-Deficit/Hyperactivity Disorder.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Drug Monitoring; Female; Humans; Hydrogen-Ion Concentration; Male; Methylphenidate; Middle Aged; Saliva; Young Adult | 2018 |
48 other study(ies) available for ritalinic acid and methylphenidate
| Article | Year |
|---|---|
A chemical ionization selected ion monitoring assay for methylphenidate and ritalinic acid.
Topics: Child; Child Behavior Disorders; Gas Chromatography-Mass Spectrometry; Humans; Methylphenidate | 1979 |
A sensitive gas chromatographic method for the determination of methylphenidate (Ritalin) and its major metabolite alpha-phenyl-2-piperidine acetic acid (ritalinic acid) in human plasma using nitrogen-phosphorous detector.
Topics: Child; Child Behavior Disorders; Chromatography, Gas; Humans; Methylphenidate | 1978 |
A liquid-chromatographic analysis for ritalinic acid [alpha-phenyl-alpha-(2-piperidyl) acetic acid] in serum.
Topics: Chromatography, High Pressure Liquid; Humans; Methylphenidate; Spectrophotometry, Ultraviolet | 1979 |
A reproducible gas chromatographic mass spectrometric assay for low levels of methylphenidate and ritalinic acid in blood and urine.
Topics: Adult; Child; Chromatography, Gas; Female; Humans; Hyperkinesis; Male; Mass Spectrometry; Methylphenidate | 1975 |
Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.
Topics: Administration, Oral; Adolescent; Adult; Humans; Injections, Intravenous; Male; Methylphenidate; Stereoisomerism; Time Factors | 1992 |
Enantioselective gas chromatographic assay with electron-capture detection for dl-ritalinic acid in plasma.
Topics: Chromatography, Gas; Electrochemistry; Humans; Male; Methylphenidate; Quality Control; Stereoisomerism | 1990 |
Kinetic analysis of enantiomers of threo-methylphenidate and its metabolite in two healthy subjects after oral administration as determined by a gas chromatographic-mass spectrometric method.
Topics: Administration, Oral; Adult; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Indicators and Reagents; Male; Methylphenidate; Reference Values; Stereoisomerism | 1990 |
Determination of methylphenidate and its main metabolite in plasma by gas chromatography-chemical ionization mass spectrometry.
Topics: Adult; Animals; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Male; Methylphenidate; Rabbits | 1986 |
Dispensing errors: Ritalin v. ritodrine.
Topics: Humans; Medication Errors; Methylphenidate; Ritodrine | 1986 |
[3H]Threo-(+/-)-methylphenidate binding to 3,4-dihydroxyphenylethylamine uptake sites in corpus striatum: correlation with the stimulant properties of ritalinic acid esters.
Topics: Animals; Binding Sites; Corpus Striatum; Dopamine; Filtration; Male; Methylphenidate; Rats; Rats, Inbred Strains; Sodium Chloride; Stereoisomerism; Synaptic Membranes; Tissue Distribution | 1985 |
Gas-liquid chromatographic procedure for measurement of methylphenidate hydrochloride and its metabolite, ritalinic acid, in urine.
Topics: Child; Chromatography, Gas; Evaluation Studies as Topic; Humans; Hyperkinesis; Methods; Methylphenidate; Time Factors | 1974 |
Pharmacokinetics of methylphenidate in man, rat and monkey.
Topics: Adult; Animals; Child; Haplorhini; Humans; Hyperkinesis; Kinetics; Male; Methylphenidate; Rats; Species Specificity; Time Factors | 1983 |
Simultaneous detection of methylphenidate and its main metabolite, ritalinic acid, in doping control.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Male; Methylphenidate; Substance Abuse Detection | 1994 |
Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.
Topics: Adult; Alcohol Drinking; Dose-Response Relationship, Drug; Drug Overdose; Drug Synergism; Female; Gas Chromatography-Mass Spectrometry; Humans; Liver; Methylphenidate; Suicide | 1999 |
Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry.
Topics: Animals; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Female; Indicators and Reagents; Macaca mulatta; Male; Mass Spectrometry; Methylphenidate; Spectrophotometry, Ultraviolet | 2000 |
High-throughput selected reaction monitoring liquid chromatography-mass spectrometry determination of methylphenidate and its major metabolite, ritalinic acid, in rat plasma employing monolithic columns.
Topics: Animals; Chromatography, Liquid; Mass Spectrometry; Methylphenidate; Rats; Reproducibility of Results | 2003 |
[alpha-Phenyl-2-piperidineacetic acid methyl ester in the treatment of singultus during surgery].
Topics: Hiccup; Humans; Methylphenidate; Surgical Procedures, Operative | 1958 |
Enantioselective analysis of ritalinic acids in biological samples by using a protein-based chiral stationary phase.
Topics: Animals; Buffers; Carboxylesterase; Catalysis; Chromatography, High Pressure Liquid; Dogs; Humans; Hydrolysis; Methylphenidate; Plasma; Proteins; Solutions; Stereoisomerism | 2003 |
Liquid chromatography-tandem mass spectrometry method for the simultaneous analysis of multiple hallucinogens, chlorpheniramine, ketamine, ritalinic acid, and metabolites, in urine.
Topics: Chlorpheniramine; Chromatography, High Pressure Liquid; Hallucinogens; Humans; Illicit Drugs; Ketamine; Methylphenidate; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry | 2007 |
Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice.
Topics: Animals; Body Weight; Chromatography, Liquid; Dose-Response Relationship, Drug; Feeding Behavior; Hypoxanthine Phosphoribosyltransferase; Liver; Male; Methylphenidate; Mice; Mutagenicity Tests; Organ Size; Spectrometry, Mass, Electrospray Ionization | 2008 |
Plasma and brain concentrations of oral therapeutic doses of methylphenidate and their impact on brain monoamine content in mice.
Topics: Administration, Oral; Animals; Biogenic Monoamines; Biological Availability; Brain; Central Nervous System Stimulants; Corpus Striatum; Frontal Lobe; Male; Methylphenidate; Mice; Plasma; Stereoisomerism | 2009 |
Pharmacokinetics of methylphenidate in oral fluid and sweat of a pediatric subject.
Topics: Central Nervous System Stimulants; Child; Delayed-Action Preparations; Drug Monitoring; Humans; Male; Methylphenidate; Saliva; Sweat | 2010 |
Correlation between methylphenidate and ritalinic acid concentrations in oral fluid and plasma.
Topics: Adult; Chromatography, Liquid; Humans; Hydrogen-Ion Concentration; Male; Methylphenidate; Reference Values; Spectrometry, Mass, Electrospray Ionization; Young Adult | 2010 |
Usefulness of sweat testing for the detection of methylphenidate after fast- and extended-release drug administration: a pilot study.
Topics: Central Nervous System Stimulants; Delayed-Action Preparations; Dose-Response Relationship, Drug; Humans; Male; Methylphenidate; Pilot Projects; Substance Abuse Detection; Sweat; Young Adult | 2010 |
Occurrence and fate of the human pharmaceutical metabolite ritalinic acid in the aquatic system.
Topics: Carbamazepine; Central Nervous System Stimulants; Environmental Monitoring; Fresh Water; Methylphenidate; Models, Chemical; Waste Disposal, Fluid | 2010 |
HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection.
Topics: Animals; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Luminescent Measurements; Male; Methylphenidate; Oxalates; Rats; Rats, Wistar | 2011 |
Determination of methylphenidate and ritalinic acid in blood, plasma and oral fluid from adolescents and adults using protein precipitation and liquid chromatography tandem mass spectrometry--a method applied on clinical and forensic investigations.
Topics: Adolescent; Adult; Blood; Body Fluids; Calibration; Chromatography, Liquid; Female; Humans; Male; Methylphenidate; Middle Aged; Plasma; Proteins; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry | 2011 |
Determination of methylphenidate and its metabolite ritalinic acid in urine by liquid chromatography/tandem mass spectrometry.
Topics: Chromatography, Liquid; Humans; Limit of Detection; Methylphenidate; Reproducibility of Results; Tandem Mass Spectrometry | 2012 |
Enantioselective determination of methylphenidate and ritalinic acid in whole blood from forensic cases using automated solid-phase extraction and liquid chromatography-tandem mass spectrometry.
Topics: Adolescent; Adult; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Female; Forensic Toxicology; Humans; Limit of Detection; Male; Methylphenidate; Middle Aged; Reproducibility of Results; Solid Phase Extraction; Stereoisomerism; Substance Abuse Detection; Tandem Mass Spectrometry; Young Adult | 2012 |
Potential trends in Attention Deficit Hyperactivity Disorder (ADHD) drug use on a college campus: wastewater analysis of amphetamine and ritalinic acid.
Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Chromatography, Liquid; Drug Utilization; Humans; Methylphenidate; Self Medication; Solid Phase Extraction; Stress, Psychological; Students; Tandem Mass Spectrometry; United States; Wastewater; Young Adult | 2013 |
Preparation and structural analysis of (±)-threo-ritalinic acid.
Topics: Crystallography, X-Ray; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methylphenidate; Molecular Structure; Stereoisomerism | 2013 |
Determination of amphetamine and methylphenidate in exhaled breath of patients undergoing attention-deficit/hyperactivity disorder treatment.
Topics: Adult; Amphetamine; Attention Deficit Disorder with Hyperactivity; Chromatography, Liquid; Exhalation; Female; Humans; Male; Mass Spectrometry; Methylphenidate; Middle Aged; Substance Abuse Detection; Ultrasonography | 2014 |
Analysis of new designer drugs and common drugs of abuse in urine by a combined targeted and untargeted LC-HR-QTOFMS approach.
Topics: Algorithms; Alkaloids; Benzodioxoles; Chromatography, Liquid; Data Mining; Databases, Factual; Designer Drugs; Humans; Ketamine; Limit of Detection; Liquid-Liquid Extraction; Mass Spectrometry; Methylphenidate; Pyrrolidines; Reproducibility of Results; Substance Abuse Detection; Synthetic Cathinone | 2014 |
Evaluation of concomitant methylphenidate and opioid use in patients with pain.
Topics: Analgesics, Opioid; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Drug Utilization; Humans; Limit of Detection; Methylphenidate; Pain; Retrospective Studies | 2014 |
Methylphenidate intoxication: somnolence as an uncommon clinical symptom and proof of overdosing by increased serum levels of ritalinic acid.
Topics: Adult; Central Nervous System Stimulants; Disorders of Excessive Somnolence; Humans; Male; Methylphenidate | 2014 |
Development of a physiologically based model to describe the pharmacokinetics of methylphenidate in juvenile and adult humans and nonhuman primates.
Topics: Adipose Tissue; Administration, Oral; Adolescent; Adult; Animals; Biological Availability; Biotransformation; Brain; Central Nervous System Stimulants; Child; Gonads; Humans; Intestine, Small; Liver; Macaca mulatta; Male; Methylphenidate; Models, Biological; Models, Statistical; Myocardium | 2014 |
Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum.
Topics: Animals; Central Nervous System Stimulants; Corpus Striatum; Dopamine Uptake Inhibitors; Impulsive Behavior; Male; Methylphenidate; Positron-Emission Tomography; Rats; Receptors, Dopamine D2; Receptors, Dopamine D3 | 2015 |
Identification of in vitro metabolites of ethylphenidate by liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.
Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Methylphenidate; Microsomes, Liver; Tandem Mass Spectrometry | 2016 |
Bacterial isolates degrading ritalinic acid-human metabolite of neuro enhancer methylphenidate.
Topics: Actinomycetales; Arthrobacter; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Humans; Methylphenidate; Molecular Structure | 2018 |
Biotransformation of ritalinic acid by laccase in the presence of mediator TEMPO.
Topics: Alcohols; Aldehydes; Biotransformation; Cyclic N-Oxides; Enzymes, Immobilized; Laccase; Methylphenidate; Oxidation-Reduction; Trametes | 2018 |
L- and D-threo ethylphenidate concentrations, pharmacokinetics, and pharmacodynamics in horses.
Topics: Animals; Central Nervous System Stimulants; Chromatography, Liquid; Female; Heart Rate; Horses; Limit of Detection; Male; Methylphenidate; Random Allocation; Tandem Mass Spectrometry | 2018 |
Rapid quantitative analysis of methylphenidate and ritalinic acid in oral fluid by liquid chromatography triple quadrupole mass spectrometry (LC-QqQ-MS).
Topics: Attention Deficit Disorder with Hyperactivity; Child, Preschool; Chromatography, Liquid; Drug Stability; Humans; Limit of Detection; Methylphenidate; Reproducibility of Results; Saliva; Tandem Mass Spectrometry | 2018 |
Simultaneous determination of methylphenidate and ritalinic acid in hair using LC-MS/MS.
Topics: Central Nervous System Stimulants; Chromatography, Liquid; Hair; Humans; Limit of Detection; Methylphenidate; Substance Abuse Detection; Substance-Related Disorders; Tandem Mass Spectrometry | 2019 |
Stability and uptake of methylphenidate and ritalinic acid in nine-spine stickleback (Pungitius pungitius) and water louse (Asellus aquaticus).
Topics: Animals; Biological Transport; Humans; Isopoda; Methylphenidate; Phthiraptera; Smegmamorpha; Water; Water Pollutants, Chemical | 2019 |
Biodegradation of ritalinic acid by Nocardioides sp. - Novel imidazole-based alkaloid metabolite as a potential marker in sewage epidemiology.
Topics: Biodegradation, Environmental; Biomarkers; Imidazoles; Methylphenidate; Nocardioides; Wastewater-Based Epidemiological Monitoring | 2020 |
Pharmacokinetics of methylphenidate and ritalinic acid in plasma correlations with exhaled breath and oral fluid in healthy volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Breath Tests; Central Nervous System Stimulants; Chromatography, Liquid; Female; Humans; Male; Medication Adherence; Methylphenidate; Stereoisomerism; Tandem Mass Spectrometry; Young Adult | 2020 |
Development of analytical method for the determination of methylphenidate, the analog ethylphenidate and their metabolite ritalinic acid in oral fluid samples by micro-QuEChERS and liquid chromatography-tandem mass spectrometry.
Topics: Central Nervous System Stimulants; Chromatography, Liquid; Humans; Methylphenidate; Tandem Mass Spectrometry | 2022 |
Chiral separation and quantitation of methylphenidate, ethylphenidate, and ritalinic acid in blood using supercritical fluid chromatography.
Topics: Chromatography, Supercritical Fluid; Methylphenidate; Stereoisomerism | 2023 |