rimocidin and dithiane
rimocidin has been researched along with dithiane* in 2 studies
Other Studies
2 other study(ies) available for rimocidin and dithiane
| Article | Year |
|---|---|
(+)-Rimocidin synthetic studies: construction of the C(1-27) aglycone skeleton.
Assembly of the C(1-27) macrocyclic skeleton of rimocidinolide, the aglycone of (+)-rimocidin (1), has been achieved in convergent fashion. Key features of the synthetic strategy entail application of multicomponent Type I Anion Relay Chemistry (ARC), in conjunction with the S(N)2/S(N)2' reaction manifolds of vinyl epoxides, both employing 2-substituted 1,3-dithianes to construct the C(1-19) carbon backbone. Yamaguchi union of a C(20-27) vinyl borate ester, possessing the all-trans triene, with an advanced C(1-19) vinyl iodide followed by macrocyclization via Suzuki-Miyaura cross-coupling completed construction of the C(1-27) rimocidinolide skeleton. Topics: Borates; Carboxylic Acids; Epoxy Compounds; Macrocyclic Compounds; Polyenes; Pyrans; Quinolizines; Stereoisomerism; Sulfur Compounds | 2009 |
(+)-Rimocidin synthetic studies. Construction of an advanced C(1-18) polyol fragment.
[structure: see text] The synthesis of an appropriately functionalized advanced C(1-18) polyol fragment of the mycosamine-glycosylated polyene macrolide, (+)-rimocidin (1), has been achieved in a highly efficient manner. Highlights of the strategy include the S(N)2/S(N)2' addition of dithiane anions to vinyl epoxides and the multicomponent linchpin union of 2-TBS-1,3-dithiane with two advanced epoxides. Topics: Alkaloids; Epoxy Compounds; Polyenes; Polymers; Quinolizines; Stereoisomerism; Sulfur Compounds | 2003 |