rilpivirine has been researched along with doravirine* in 2 studies
1 review(s) available for rilpivirine and doravirine
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.
A novel series of acetamide-substituted derivatives and two prodrugs of doravirine were designed and synthesized as potent HIV-1 NNRTIs by employing the structure-based drug design strategy. In MT-4 cell-based assays using the MTT method, it was found that most of the new compounds exhibited moderate to excellent inhibitory potency against the wild-type (WT) HIV-1 strain with a minimum EC Topics: Acetamides; Anti-HIV Agents; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Prodrugs; Pyridones; Reverse Transcriptase Inhibitors; Triazoles | 2019 |
1 other study(ies) available for rilpivirine and doravirine
| Article | Year |
|---|---|
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
The optimization of a novel series of non-nucleoside reverse transcriptase inhibitors (NNRTI) led to the identification of pyridone 36. In cell cultures, this new NNRTI shows a superior potency profile against a range of wild type and clinically relevant, resistant mutant HIV viruses. The overall favorable preclinical pharmacokinetic profile of 36 led to the prediction of a once daily low dose regimen in human. NNRTI 36, now known as MK-1439, is currently in clinical development for the treatment of HIV infection. Topics: Animals; Anti-HIV Agents; Cells, Cultured; Crystallography, X-Ray; Dogs; Drug Discovery; Drug Resistance, Viral; HIV-1; Humans; Inhibitory Concentration 50; Molecular Structure; Mutation; Pyridones; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Triazoles | 2014 |