rifampin and xanthorrhizol

rifampin has been researched along with xanthorrhizol* in 1 studies

Other Studies

1 other study(ies) available for rifampin and xanthorrhizol

Article	Year
Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla. Journal of natural products, 2001, Volume: 64, Issue:7 Xanthorrizol (1) and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol (2) were identified as the principal antimicrobial components of a CH(2)Cl(2)-MeOH (1:1) extract derived from Iostephane heterophylla. Compound 2 is a new natural product, but has been synthesized. Both compounds exhibited low level activity (MICs of 16-32 microg/mL) against methicillin-resistant staphylococci and vancomycin-resistant enterococci. They were either inactive or poorly active against Gram-negative bacteria and yeast. Mechanistic studies performed in Escherichia coli imp suggested nonspecific inhibition of DNA, RNA, and protein synthesis by both of these compounds. Compound 1 was tested in an in vivo model; it did not provide protection to mice infected with Staphylococcus aureus. Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Asteraceae; Candida albicans; Disease Models, Animal; DNA; Drug Resistance, Microbial; Enterococcus faecium; Escherichia coli; Female; Magnetic Resonance Spectroscopy; Mexico; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Phenols; Plant Roots; Plants, Medicinal; Protein Biosynthesis; Proteins; RNA; Spectrophotometry, Ultraviolet; Staphylococcus aureus; Vancomycin	2001

Article

Year

Biological and mechanistic activities of xanthorrizol and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol isolated from Iostephane heterophylla.

Journal of natural products, 2001, Volume: 64, Issue:7

Xanthorrizol (1) and 4-(1',5'-dimethylhex-4'-enyl)-2-methylphenol (2) were identified as the principal antimicrobial components of a CH(2)Cl(2)-MeOH (1:1) extract derived from Iostephane heterophylla. Compound 2 is a new natural product, but has been synthesized. Both compounds exhibited low level activity (MICs of 16-32 microg/mL) against methicillin-resistant staphylococci and vancomycin-resistant enterococci. They were either inactive or poorly active against Gram-negative bacteria and yeast. Mechanistic studies performed in Escherichia coli imp suggested nonspecific inhibition of DNA, RNA, and protein synthesis by both of these compounds. Compound 1 was tested in an in vivo model; it did not provide protection to mice infected with Staphylococcus aureus.

Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Asteraceae; Candida albicans; Disease Models, Animal; DNA; Drug Resistance, Microbial; Enterococcus faecium; Escherichia coli; Female; Magnetic Resonance Spectroscopy; Mexico; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Phenols; Plant Roots; Plants, Medicinal; Protein Biosynthesis; Proteins; RNA; Spectrophotometry, Ultraviolet; Staphylococcus aureus; Vancomycin

2001