rifampin and protocatechuic-acid

rifampin has been researched along with protocatechuic-acid* in 2 studies

Other Studies

2 other study(ies) available for rifampin and protocatechuic-acid

ArticleYear
Improvement of pro-oxidant capacity of protocatechuic acid by esterification.
    PloS one, 2014, Volume: 9, Issue:10

    Pro-oxidant effects of phenolic compounds are usually correlated to the one-electron redox potential of the phenoxyl radicals. Here we demonstrated that, besides their oxidizability, hydrophobicity can also be a decisive factor. We found that esterification of protocatechuic acid (P0) provoked a profound influence in its pro-oxidant capacity. The esters bearing alkyl chains containing two (P2), four (P4) and seven (P7) carbons, but not the acid precursor (P0), were able to exacerbate the oxidation of trolox, α-tocopherol and rifampicin. This effect was also dependent on the catechol moiety, since neither gallic acid nor butyl gallate showed any pro-oxidant effects. A comparison was also made with apocynin, which is well-characterized regarding its pro-oxidant properties. P7 was more efficient than apocynin regarding co-oxidation of trolox. However, P7 was not able to co-oxidize glutathione and NADH, which are targets of the apocynin radical. A correlation was found between pro-oxidant capacity and the stability of the radicals, as suggested by the intensity of the peak current in the differential pulse voltammetry experiments. In conclusion, taking into account that hydroquinone and related moieties are frequently found in biomolecules and quinone-based chemotherapeutics, our demonstration that esters of protocatechuic acid are specific and potent co-catalysts in their oxidations may be very relevant as a pathway to exacerbate redox cycling reactions, which are usually involved in their biological and pharmacological mechanisms of action.

    Topics: Acetophenones; alpha-Tocopherol; Antioxidants; Chromans; Electrochemical Techniques; Esterification; Glutathione; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxybenzoates; Hydroxylation; Kinetics; Metabolic Networks and Pathways; NAD; Oxidants; Oxidation-Reduction; Rifampin

2014
Substrate-induction of veratric acid O-demethylase in Nocardia sp.
    Acta biochimica Polonica, 1984, Volume: 31, Issue:4

    Nocardia sp. demethylates veratric acid to vanillic and isovanillic acids, and subsequently to protocatechuic acid. The accumulation of specific mRNA observed during incubation of Nocardia sp. cells with substrate, as well as the effect of inhibitors of transcription and translation point to the inducible character of demethylation processes.

    Topics: Chloramphenicol; Dactinomycin; Enzyme Induction; Hydroxybenzoates; Nocardia; Oxidoreductases; Oxidoreductases, O-Demethylating; Rifampin; RNA, Bacterial; RNA, Messenger; Vanillic Acid

1984