rifampin and hexadecanedioic-acid

rifampin has been researched along with hexadecanedioic-acid* in 1 studies

Other Studies

1 other study(ies) available for rifampin and hexadecanedioic-acid

Article	Year
Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:8 Multiple endogenous compounds have been proposed as candidate biomarkers to monitor organic anion transporting polypeptide (OATP) function in preclinical species or humans. Previously, we demonstrated that coproporphyrins (CPs) I and III are appropriate clinical markers to evaluate OATP inhibition and recapitulate clinical drug-drug interactions (DDIs). In the present study, we investigated bile acids (BAs) dehydroepiandrosterone sulfate (DHEAS), hexadecanedioate (HDA), and tetradecanedioate (TDA) in plasma as endogenous probes for OATP inhibition and compared these candidate probes to CPs. All probes were determined in samples from a single study that examined their behavior and their association with rosuvastatin (RSV) pharmacokinetics after administration of an OATP inhibitor rifampin (RIF) in healthy subjects. Among endogenous probes examined, RIF significantly increased maximum plasma concentration ( Topics: Adolescent; Adult; Area Under Curve; Bile Acids and Salts; Biological Transport; Biomarkers; Cell Line; Coproporphyrins; Dehydroepiandrosterone Sulfate; Drug Interactions; Healthy Volunteers; HEK293 Cells; Humans; Male; Middle Aged; Organic Anion Transporters; Palmitic Acids; Rifampin; Rosuvastatin Calcium; Young Adult	2017

Article

Year

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.

Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:8

Multiple endogenous compounds have been proposed as candidate biomarkers to monitor organic anion transporting polypeptide (OATP) function in preclinical species or humans. Previously, we demonstrated that coproporphyrins (CPs) I and III are appropriate clinical markers to evaluate OATP inhibition and recapitulate clinical drug-drug interactions (DDIs). In the present study, we investigated bile acids (BAs) dehydroepiandrosterone sulfate (DHEAS), hexadecanedioate (HDA), and tetradecanedioate (TDA) in plasma as endogenous probes for OATP inhibition and compared these candidate probes to CPs. All probes were determined in samples from a single study that examined their behavior and their association with rosuvastatin (RSV) pharmacokinetics after administration of an OATP inhibitor rifampin (RIF) in healthy subjects. Among endogenous probes examined, RIF significantly increased maximum plasma concentration (

Topics: Adolescent; Adult; Area Under Curve; Bile Acids and Salts; Biological Transport; Biomarkers; Cell Line; Coproporphyrins; Dehydroepiandrosterone Sulfate; Drug Interactions; Healthy Volunteers; HEK293 Cells; Humans; Male; Middle Aged; Organic Anion Transporters; Palmitic Acids; Rifampin; Rosuvastatin Calcium; Young Adult

2017