rifampin has been researched along with glycochenodeoxycholate-3-sulfate* in 2 studies
2 other study(ies) available for rifampin and glycochenodeoxycholate-3-sulfate
| Article | Year |
|---|---|
Determination of the endogenous OATP1B biomarkers glycochenodeoxycholate-3-sulfate and chenodeoxycholate-24-glucuronide in human and mouse plasma by a validated UHPLC-MS/MS method.
Topics: Animals; Bile Acids and Salts; Biomarkers; Chenodeoxycholic Acid; Chromatography, High Pressure Liquid; Glucuronides; Glycochenodeoxycholic Acid; Humans; Methanol; Micafungin; Mice; Reproducibility of Results; Rifampin; Tandem Mass Spectrometry; Water | 2022 |
Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers.
To assess the use of glycochenodeoxycholate-3-sulfate (GCDCA-S) and chenodeoxycholate 3- or 24-glucuronide (CDCA-3G or -24G) as surrogate endogenous substrates in the investigation of drug interactions involving OATP1B1 and OATP1B3.. Uptake of GCDCA-S and CDCA-24G was examined in HEK293 cells transfected with cDNA for OATP1B1, OATP1B3, and NTCP and in cryopreserved human hepatocytes. Plasma concentrations of bile acids and their metabolites (GCDCA-S, CDCA-3G, and CDCA-24G) were determined by LC-MS/MS in eight healthy volunteers with or without administration of rifampicin (600 mg, po).. GCDCA-S and CDCA-24G were substrates for OATP1B1, OATP1B3, and NTCP. The uptake of [. We identified GCDCA-S and CDCA-24G as substrates of NTCP, OATP1B1, and OATP1B3. GCDCA-S is a surrogate endogenous probe for the assessment of drug interactions involving hepatic OATP1B1 and OATP1B3. Topics: Adult; Atorvastatin; Bile Acids and Salts; Chenodeoxycholic Acid; Drug Interactions; Glucuronides; Glycochenodeoxycholic Acid; HEK293 Cells; Hepatocytes; Humans; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters, Sodium-Dependent; Pioglitazone; Rifampin; Solute Carrier Organic Anion Transporter Family Member 1B3; Symporters; Taurocholic Acid; Thiazolidinediones; Young Adult | 2017 |