rifampin has been researched along with caprolactone* in 2 studies
2 other study(ies) available for rifampin and caprolactone
| Article | Year |
|---|---|
Antibiotic impregnation and nanocoating of external ventricular drainage catheters for antibacterial applications: Evaluation of
The most suitable method to treat hydrocephalus disease is to insert a shunt catheter that drains the cerebral spinal fluid (CSF); however, shunt implantation is often associated with various bacterial infections. In this study, antibiotic-loaded nanospheres were prepared using the solvent evaporation technique and coated on an antibiotic-impregnated shunt surface to promote shunt antibacterial properties. Clindamycin (CDM) and rifampicin (RIF) were in combination loaded in a single nanosphere, whereas trimethoprim (TMP) was loaded individually in triblock copolymers [(d,l-lactide-random-ε-caprolactone)-block-poly(ethylene glycol)-block-(d,l-lactide-random-ε-caprolactone)] (PLEC). The drug-loading content, encapsulation efficiency, yield, size, and zeta potential of the antibiotic-loaded nanospheres were measured. The results showed that the drug-loading content of clindamycin- and rifampicin-loaded nanospheres (CDM/RIF-NPs) was approximately 3% and 8%, respectively, at a drug to polymer ratio of 1:2. In addition, trimethoprim-loaded nanospheres (TMP-NPs) showed nearly 7% drug loading at equal drug and polymer ratios. The amount of drug release was determined before and after the coating of nanospheres on the shunt surface. In addition, Topics: Anti-Bacterial Agents; Catheters; Clindamycin; Molecular Docking Simulation; Polymers; Rifampin; Trimethoprim | 2023 |
Antimicrobial activity of synthetic antimicrobial peptides loaded in poly-Ɛ-caprolactone nanoparticles against mycobacteria and their functional synergy with rifampicin.
Topics: Anti-Bacterial Agents; Caproates; Lactones; Mycobacterium tuberculosis; Nanoparticles; Pore Forming Cytotoxic Proteins; Rifampin | 2021 |