rifampin has been researched along with alatrofloxacin* in 1 studies
1 other study(ies) available for rifampin and alatrofloxacin
| Article | Year |
|---|---|
A comparative study on the efficacy of the new quinolone alatrofloxacin in the treatment of experimental legionellosis in guinea pigs.
The in vivo efficacy of trovafloxacin, intraperitoneally administered as alatrofloxacin (CP-116,517), was assessed and compared with that of erythromycin, alone or in combination with rifampicin, in a model of Legionella pneumophila pneumonia in guinea pigs. Trovafloxacin (5 mg/kg administered as alatrofloxacin once daily for 7 days) gave a survival rate of 100% in infected animals. Clearance of bacteria and of bacteria-induced lesions from lungs was achieved by day 6 post-inoculation. The lungs of trovafloxacin-treated animals remained free of bacteria at day 28 post-challenge. Trovafloxacin proved as effective as erythromycin administered intraperitoneally, but was superior to erythromycin alone. or in combination with rifampicin, when given orally. Topics: Administration, Oral; Animals; Anti-Infective Agents; Drug Evaluation, Preclinical; Drug Therapy, Combination; Erythromycin; Female; Fluoroquinolones; Guinea Pigs; Injections, Intraperitoneal; Legionella pneumophila; Legionnaires' Disease; Lung; Microbial Sensitivity Tests; Prodrugs; Random Allocation; Rifampin | 1998 |