rifampin and 9-benzyl-2-chloro-6-(2-furyl)purine

rifampin has been researched along with 9-benzyl-2-chloro-6-(2-furyl)purine* in 1 studies

Other Studies

1 other study(ies) available for rifampin and 9-benzyl-2-chloro-6-(2-furyl)purine

Article	Year
Synthesis and antimycobacterial activity of 6-arylpurines: the requirements for the N-9 substituent in active antimycobacterial purines. Journal of medicinal chemistry, 2002, Mar-14, Volume: 45, Issue:6 6-Arylpurines carrying a variety of substituents in the 9-position were prepared by Stille coupling between appropriately substituted 6-chloropurines and aryl(tributyl)tin, and the compounds were screened for antibacterial activity against Mycobacterium tuberculosis H(37)Rv. The lowest minimum inhibitory concentration value, 0.78 microg/mL, was found for 9-benzyl-2-chloro-6-(2-furyl)purine. This compound exhibited relatively low cytotoxicity, and it was active against several singly drug-resistant strains of M. tuberculosis. Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Colony Count, Microbial; Furans; Humans; Macrophages; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Purines; Vero Cells	2002

Article

Year

Synthesis and antimycobacterial activity of 6-arylpurines: the requirements for the N-9 substituent in active antimycobacterial purines.

Journal of medicinal chemistry, 2002, Mar-14, Volume: 45, Issue:6

6-Arylpurines carrying a variety of substituents in the 9-position were prepared by Stille coupling between appropriately substituted 6-chloropurines and aryl(tributyl)tin, and the compounds were screened for antibacterial activity against Mycobacterium tuberculosis H(37)Rv. The lowest minimum inhibitory concentration value, 0.78 microg/mL, was found for 9-benzyl-2-chloro-6-(2-furyl)purine. This compound exhibited relatively low cytotoxicity, and it was active against several singly drug-resistant strains of M. tuberculosis.

Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Colony Count, Microbial; Furans; Humans; Macrophages; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Purines; Vero Cells

2002