ridostin and 10-carboxymethyl-9-acridanone

Search for drugs efficient in prophylaxis and treatment of dangerous infections (especially arboviral ones) is rather actual, since no specific therapy is available. Many-year investigations of interferon inductors showed that they had immunomodulating, antiviral and antiinflammatory effects and were low toxic. The present study demonstrated that the protective effect was the following: Venezuelan equine encephalitis (VEE)--cycloferon > amixin = ridostin, Rift Valley fever (RVF)--cycloferon > amixin > ridostin, predator pox (PP)--cycloferon > amixin = ridostin, that was obvious that cycloferon was the most active agent in the treatment of VEE, RVF and PP, thus making it possible to acknowledge its priority in prophylaxis and therapy of dangerous viral infections (DVI). Ribavirin in combination with cycloferon solution or cycloferon tablets provided shorter periods of the fever, minimized the intoxication syndrome, promoted earlier resolution of hemorrhagic eruption and lowered the frequency of complications, which was in favour of the disease prognosis.

Topics: Acridines; Adolescent; Adult; Aged; Animals; Antiviral Agents; Dengue; Encephalomyelitis, Venezuelan Equine; Female; Hemorrhagic Fever, Crimean; Humans; Interferon Inducers; Ixodes; Male; Mice; Middle Aged; Ribavirin; Rift Valley Fever; RNA, Double-Stranded; RNA, Fungal; Tilorone; Young Adult

We studied in vitro production of interferon-alpha and interferon-gamma by peripheral blood leukocytes from 15 patients with multiple sclerosis. The priming effects of interferon preparations weakly correlated with interferon-alpha production by leukocytes from patients with multiple sclerosis, but negatively correlated with interferon-gamma production. The effects of interferon inducers in most cases positively correlated with its spontaneous production. We found a weak positive correlation between the priming effect of natural interferon-alpha and the effect of recombinant interferons. There were positive or strong positive correlations between the effects of recombinant interferons on leukocytes from patients with multiple sclerosis. The relationship between the effects of medicinal interferon inducers and interferon preparation varied from negative to strong positive correlations. These data suggest that correlation analysis can be used for dynamic control and elaboration of methods for combined immunotherapy of multiple sclerosis with various interferon preparations or interferon and its inducers.

Topics: Acridines; Adult; Cells, Cultured; Enterotoxins; Female; Humans; Interferon alpha-2; Interferon beta-1a; Interferon beta-1b; Interferon Inducers; Interferon-alpha; Interferon-beta; Interferon-gamma; Interferons; Leukocytes, Mononuclear; Male; Middle Aged; Multiple Sclerosis; Newcastle disease virus; Recombinant Proteins; RNA, Double-Stranded; RNA, Fungal; Tilorone