ridinilazole has been researched along with bis-benzimidazole* in 1 studies
1 review(s) available for ridinilazole and bis-benzimidazole
| Article | Year |
|---|---|
Symmetric bis-benzimidazoles as DNA minor groove-binding agents with anti-tumour and antibacterial activity, and the evolution of the drug ridinilazole for the treatment of Clostridium difficile infections.
We report the synthesis of a range of symmetrical bis-benzimidazoles (BBZ) which possess anticancer and antibacterial activities. One of these BBZs has specific activity against Clostridium difficile and is currently in a phase 3 clinical evaluation as the drug ridinilazole. X-ray and computer modelling studies showed that BBZs typically exhibit high specificity for oligonucleotide sequences that occur in the minor groove of DNA. Topics: Anti-Bacterial Agents; Antineoplastic Agents; Benzimidazoles; Cell Proliferation; Cell Survival; Clostridium Infections; Crystallography, X-Ray; DNA; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyridines | 2022 |