ribulose-5-phosphate and arabinose-5-phosphate

ribulose-5-phosphate has been researched along with arabinose-5-phosphate* in 1 studies

Other Studies

1 other study(ies) available for ribulose-5-phosphate and arabinose-5-phosphate

ArticleYear
A direct spectropolarimetric assay of arabinose 5-phosphate isomerase.
    Analytical biochemistry, 2021, 06-01, Volume: 622

    Arabinose 5-phosphate isomerase (API) catalyzes the reversible isomerization of Ribulose 5-phosphate (Ru5P) to Arabinose 5-Phosphate (Ar5P) for the production of 3-deoxy-2-octulosonic acid 8-phosphate (KDO), a component of bacterial lipopolysaccharide (LPS) of gram-negative bacteria. API is an attractive target for therapeutic development against gram-negative bacterial pathogens. The current assay method of API activity utilizes a general reaction for keto sugar determination in a secondary, 3-h color development reaction with 25 N sulfuric acid which poses hazard to both personnel and instrumentation. We therefore aimed to develop a more user friendly assay of the enzyme. Since Ru5P absorbs in the UV region and contains at least 2 chiral centers, it can be expected to display circular dichroism (CD). A wavelength scan revealed indeed Ru5P displays a pronounced negative ellipticity of 30,560 mDeg M

    Topics: Aldose-Ketose Isomerases; Bacterial Proteins; Catalysis; Circular Dichroism; Enzyme Assays; Francisella tularensis; Lipopolysaccharides; Pentosephosphates; Ribulosephosphates; Substrate Specificity; Sugar Acids; Sugar Phosphates

2021
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