ribavirin has been researched along with tiazofurin in 268 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 94 (35.07) | 18.7374 |
| 1990's | 99 (36.94) | 18.2507 |
| 2000's | 65 (24.25) | 29.6817 |
| 2010's | 9 (3.36) | 24.3611 |
| 2020's | 1 (0.37) | 2.80 |
| Authors | Studies |
|---|---|
| Allen, LB; Campbell, MT; Pickering, MV; Robins, RK; Sidwell, RW; Srivastava, PC; Streeter, DG; Witkowski, JT | 1 |
| Crippen, GM; Ghose, AK; McKernan, PA; Revankar, GR; Robins, RK; Smee, DF | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Nagai, M; Natsumeda, Y; Weber, G | 1 |
| Ban, J; Weber, G | 1 |
| Nagai, M; Nakamura, H; Natsumeda, Y; Szekeres, T; Weber, G | 1 |
| Gharehbaghi, K; Jayaram, HN; Jayaram, NH; Krohn, K; Paull, KD; Rieser, J | 1 |
| Harada, T; Hatakeyama, K; Kagamiyama, H | 1 |
| Goldstein, BM; Li, H | 1 |
| Chiba, P; Felzmann, T; Fritzer, M; Pillwein, K; Szekeres, T | 1 |
| Jayaram, HN; Weber, G; Zhen, W | 2 |
| Bosze, P; Eble, JN; Eckhardt, S; Ehrlich, CE; Look, KY; Natsumeda, Y; Olah, E; Prajda, N; Stehman, FB; Sutton, GP | 1 |
| Cho-Chung, YS; Szekeres, T; Weber, G | 1 |
| Jayaram, HN; Murayama, K; Pillwein, K; Weber, G; Zhen, W | 1 |
| Burling, FT; Gabrielsen, B; Goldstein, BM; Hallows, WH; Phelan, MJ | 1 |
| Engeler, GP; Hoffman, R; Jayaram, HN; Kneebone, P; Lapis, E; Paulik, E; Tricot, G; Weber, G; Zhen, W | 1 |
| Farley, BA; Goldstein, BM; Leary, JF; Levy, PC; Marquez, VE; Rowley, PT | 1 |
| Plunkett, W; Saunders, PP | 1 |
| Cooney, DA; Goldstein, BM; Jayaram, HN; Marquez, VE; Weber, G; Zhen, W | 1 |
| Weber, G | 5 |
| Eble, JN; Hoffman, R; Jayaram, HN; Nagai, M; Natsumeda, Y; Paulik, E; Tricot, G; Weber, G; Zhen, WN | 1 |
| Brown, TD; Burris, HA; Havlin, KA; O'Rourke, TJ; Rodriguez, GI; Wall, JG; Weiss, GR | 1 |
| Albukrek, D; Fux, A; Hadar, T; Nordenberg, J; Novogrodsky, A; Sidi, Y; Wasserman, L | 1 |
| Bhandal, AK; Carter, DL; Moore, DC; Studzinski, GP | 1 |
| Eble, JN; Hoffman, R; Ichikawa, S; Jayaram, HN; Nagai, M; Nakamura, H; Natsumeda, Y; Paulik, E; Weber, G; Zhen, WN | 1 |
| Burling, FT; Gabrielsen, B; Goldstein, BM | 1 |
| Kharbanda, SM; Kufe, DW; Sherman, ML | 1 |
| Collart, FR; Henning-Chubb, C; Huberman, E; Kiguchi, K | 2 |
| Irino, S; Natsumeda, Y; Weber, G; Yamada, Y; Yamaji, Y | 1 |
| Goto, H; Ogasawara, N; Yamada, Y; Yoshino, M | 1 |
| Bell, JE; Goldstein, BM; Marquez, VE | 1 |
| Financsek, I; Jarai, G; Kote, Z; Lapis, E; Natsumeda, Y; Olah, E; Weber, G; Yamaji, Y | 1 |
| Ahluwalia, G; Bondoc, LL; Cooney, DA; Currens, MJ; Ford, H; Fridland, A; Johns, DG; Mitsuya, H | 1 |
| Sartorelli, AC; Sokoloski, JA | 2 |
| Cappellacci, L; Cristalli, G; Franchetti, P; Grifantini, M; Nocentini, G; Vittori, S | 1 |
| Alvarez, E; Robins, RK; Saunders, PP; Spindler, CD; Tan, MT | 1 |
| Ausserer, B; Chiba, P; Czermak, B; Gersdorf, E; Goebl, R; Knoflach, A; Murr, C; Pillwein, K; Schuchter, K; Stockhammer, G | 1 |
| Jolley, WB; Matsumoto, SS; Parandoosh, Z; Robins, RK; Rubalcava, B | 1 |
| Hoffman, R; Jayaram, HN; Tricot, G; Weber, G | 1 |
| Cheson, BD; Grem, JL; Hawkins, MJ; King, SA; Rubinstein, L; Shoemaker, DD | 1 |
| Jayaram, HN; Nagai, M; Natsumeda, Y; Paulik, E; Weber, G; Yamaji, Y; Zhen, WN | 1 |
| Bayne, JH; Grever, MR; Hanauske, AR; Jayaram, HN; Melink, TJ; Phillips, JL; Sarosy, G; Von Hoff, DD | 1 |
| Lapis, K; Paku, S; Pápay, J | 1 |
| Maroun, JA; Stewart, DJ | 1 |
| Natsumeda, Y; Pillwein, K; Weber, G | 1 |
| Arteaga, CL; Brown, TD; Craig, JB; Harman, GS; Koeller, JM; Kuhn, JG; Von Hoff, DD; Weiss, GR | 1 |
| Cottam, HB; Fujitaki, JM; Matsumoto, SS; Ojo-Amaize, E; Parandoosh, Z; Revankar, GR; Robins, RK; Rubalcava, B; Smee, DF; Willis, RC | 1 |
| English, D; Hoffman, R; Rizzo, MT; Tricot, G | 1 |
| Belei, M; Parandoosh, Z; Robins, RK; Rubalcava, B | 1 |
| Hoffman, R; Jayaram, HN; Natsumeda, Y; Tricot, GJ; Weber, G; Yamada, Y; Yamaji, Y | 1 |
| Heerema, N; Hoffman, R; Jayaram, HN; Kneebone, P; Lapis, E; Natsumeda, Y; Nichols, CR; Tricot, GJ; Weber, G | 1 |
| Connor, JD; Lemas, V; Page, T; Yu, AL; Yu, J | 1 |
| Ikegami, T; Natsumeda, Y; Weber, G | 1 |
| Hoffman, R; Jayaram, HN; Lapis, E; Natsumeda, Y; Olah, E; Prajda, N; Tricot, GJ; Weber, G; Yamaji, Y; Zhen, WN | 1 |
| Kuttan, R | 1 |
| Carney, WP; Kharbanda, SM; Kufe, DW; Miyazaki, K; Sherman, ML; Spriggs, DR; Takeyama, H | 1 |
| Farkas, I; Gáborjányi, R; Kovács, L; Nagy, PD | 1 |
| Blair, OC; Carbone, R; Sartorelli, AC; Sokoloski, JA | 1 |
| Beery, E; Nordenberg, J; Novogrodsky, A; Panet, C; Sidi, Y; Wasserman, L | 1 |
| Carr, DT; Dhingra, HM; Glisson, BS; Holoye, PY; Jeffries, D; Lee, JS; Murphy, WK; Umsawasdi, T | 1 |
| Ahluwalia, GS; Carney, DN; Cooney, DA; Jayaram, HN; Johns, DG | 1 |
| Ahluwalia, GS; Cooney, DA; Dion, RL; Gebeyehu, G; Jayaram, HN; Johns, DG; Kelley, JA; Marquez, VE; Van Cott, A; Wilson, YA | 1 |
| Lee, HJ; Nguyen, BT; Pawlak, K; Robins, RK; Sadée, W | 1 |
| Faderan, MA; Jayaram, HN; Lui, MS; Pillwein, K; Weber, G | 1 |
| Blair, OC; Sartorelli, AC; Sokoloski, JA | 1 |
| Leyland-Jones, B; O'Dwyer, PJ; Stewart, JA; Wagner, BH | 1 |
| Ahluwalia, GS; Cooney, DA; Jayaram, HN; Johns, DG; Marquez, VE | 1 |
| Wright, DG | 1 |
| Colliton, JW; Mendel, DB; Witters, LA | 1 |
| Kuttan, R; Saunders, P | 1 |
| Natsumeda, Y; Weber, G; Yamada, Y; Yamaji, Y | 1 |
| Hollan, SR; Horanyi, M; Ikegami, T; Kote, Z; Kremmer, T; Natsumeda, Y; Olah, E; Paulik, E; Sugar, J; Szelenyi, J | 1 |
| Kharbanda, SM; Kufe, DW; Sherman, ML; Spriggs, DR | 1 |
| Hoffman, R; Jayaram, HN; Lapis, E; Natsumeda, Y; Tricot, GJ; Weber, G; Yamada, Y; Yamaji, Y | 1 |
| Colman, MS; Kufe, DW; Shafman, TD; Sherman, ML | 1 |
| Connelly, MC; Fridland, A; Robbins, TJ | 1 |
| Jayaram, HN; Pillwein, K; Weber, G | 1 |
| Kuttan, K; Nirmala, K; Vasudevan, DM | 1 |
| Balducci, L; Hardy, CL | 1 |
| Emrani, J; Hashimoto, Y; Ikegami, T; Natsumeda, Y; Prajda, N; Reardon, MA; Szondy, S; Weber, G | 1 |
| Goldstein, BM; Mao, DT; Marquez, VE | 1 |
| Baguley, BC; Ching, LM; Finlay, GJ; Wilson, WR | 1 |
| Hoffman, R; Jayaram, HN; Lapis, E; Nichols, CR; Pennington, K; Tricot, GJ; Weber, G | 1 |
| Dimery, IW; Hong, WK; Krakoff, IH; McCarthy, K; Neidhart, JA | 1 |
| Diala, ES; Jacobsen, SJ; Mangum, JH; Nyhan, WL; Page, T; Robins, RK | 1 |
| Green, RM; Maroun, JA; Stewart, DJ | 1 |
| Bieser, W; Fiebig, HH; Henss, H; Lohr, GW; Schmid, JR | 1 |
| Cripps, C; Eisenhauer, E; Maksymiuk, A; Maroun, JA | 1 |
| Harrison, SD; O'Dwyer, PJ; Trader, MW | 1 |
| Hoffman, R; Jayaram, HN; Nichols, CR; Pillwein, K; Weber, G | 1 |
| Hacker, MP; Hartshorn, JN; Roberts, JD; Tong, WP | 1 |
| Robins, RK; Saunders, PP; Spindler, CD; Tan, MT | 1 |
| Culham, CA; Hartshorn, JN; Haugh, LD; Krakoff, IR; McCormack, JJ; Newman, RA; Roberts, JD; Stewart, JA; Young, JA | 1 |
| Boldizsár, M; Kremmer, T; Oláh, E | 1 |
| Jayaram, HN | 1 |
| Faderan, MA; Jayaram, HN; Lui, MS; Natsumeda, Y; Pillwein, K; Reardon, MA; Weber, G | 1 |
| Ogawa, M | 1 |
| Berger, NA; Berger, SJ; Catino, DM; Petzold, SJ; Robins, RK | 1 |
| Bishop, J; Coates, A; Fox, R; Grygiel, J; Raghavan, D; Sampson, D; Woods, R | 1 |
| Berry, DA; Besserer, JA; Boritzki, TJ; Cook, PD; Fry, DW; Jackson, RC; Leopold, WR | 1 |
| Balis, FM; Collins, JM; Grygiel, JJ; Lester, CM; Poplack, DG | 1 |
| Koeller, JM; Tormey, DC; Trump, DL; Tutsch, KD | 1 |
| Boldt, DH; Clark, GM; Hersh, MR; Kuhn, JG; Melink, TJ; Patton, TF; Siegler, R; Sternson, LA; Von Hoff, DD | 1 |
| DiSaia, PJ; Kucera, PR; Micha, JP; Preve, CU; Rettenmaier, MA; Stratton, JA | 1 |
| Cysyk, RL; Mao, DT; Marquez, VE; Monks, A | 1 |
| Balis, FM; Cogliano-Shutta, NA; Ettinger, LJ; Heideman, RL; Holcenberg, JS; Lange, BJ; Packer, RJ; Sallan, SE; Smithson, WA; Zimm, S | 1 |
| Gupta, RS; Mehta, KD | 1 |
| Batist, G; Collins, JM; Eddy, JL; Fine, RL; Grygiel, J; Ihde, DC; Jayaram, HN; Jenkins, JF; Kerr, IG; Klecker, RW | 1 |
| Betts, CR; Cooney, DA; Gebeyehu, G; Jayaram, HN; Johns, DG; Kelley, JA; Marquez, VE | 1 |
| Cooney, DA; Dion, RL; Glazer, RI; Jayaram, HN; Johns, DG; Robins, RK; Srivastava, PC | 1 |
| Kuttan, R; Robins, RK; Saunders, PP | 1 |
| Cooney, DA; Glazer, RI; Jayaram, HN; Johns, DG; Smith, AL | 1 |
| Ahluwalia, GS; Cooney, DA; Dion, RL; Gebeyehu, G; Jayaram, HN; Johns, DG; Kelley, JA; Marquez, VE; Robins, RK | 1 |
| Robins, RK; Streeter, DG | 1 |
| Ahluwalia, GS; Cooney, DA; Jayaram, HN; Johns, DG; Plowman, JP | 1 |
| Faderan, MA; Jayaram, HN; Liepnieks, JJ; Lui, MS; Natsumeda, Y; Olah, E; Weber, G | 1 |
| Canonico, PG; Huggins, JW; Robins, RK | 1 |
| Cooney, DA; Gebeyehu, G; Glazer, RI; Jayaram, HN; Johns, DG; Kelley, JA; Marquez, VE; Van Cott, AC; Zwelling, LA | 1 |
| Earle, MF; Glazer, RI | 1 |
| Kuttan, R; Lai, MM; Robins, RK; Saunders, PP | 1 |
| Elliott, WL; Faderan, MA; Liepnieks, JJ; Lui, MS; Natsumeda, Y; Weber, G | 1 |
| Cooney, DA; Davignon, JP; Davis, RD; Jayaram, HN; Johns, DG; Malspeis, L; Marsoni, S; O'Dwyer, PJ; Plowman, J; Shoemaker, DD | 1 |
| Boyd, VL; Jacobsen, SJ; Mangum, JH; Nyhan, WL; Page, TT; Robins, RK; Smejkal, RM | 1 |
| Cysyk, RL; Karle, JM; Monks, A; Wolfe, RM | 1 |
| Alexandre, V; Amélia, M; Caner, J; Vicente, M | 1 |
| Cooney, D; Kutzmits, R | 1 |
| Ardalan, B; Chandrasekaran, B | 1 |
| Repta, AJ; Riley, CM; Sternson, LA | 1 |
| Revankar, GR; Robins, RK; Srivastava, PC | 1 |
| Meltzer, NM; Sternson, LA | 1 |
| Collins, JM; Klecker, RW | 1 |
| Faderan, MA; Liepnieks, JJ; Lui, MS; Weber, G | 1 |
| Narayanan, VL; Paull, KD; Plowman, J; Robins, RK; Srivastava, PC | 1 |
| Cooney, DA; Dion, RL; Glazer, RI; Jayaram, HN; Johns, DG | 1 |
| Boswell, HS; Burgess, GS; Collart, FR; Gharehbaghi, K; Huberman, E; Jayaram, HN; Litz-Jackson, S | 1 |
| Bavelloni, A; Cataldi, A; Marmiroli, S; Vitale, M; Weber, G; Zamai, L; Zauli, G | 1 |
| Barzi, A; Cappellacci, L; Carrell, C; Franchetti, P; Goldstein, BM; Grifantini, M; Jayaram, HN; Nocentini, G; O'Connor, A; Yang, H | 1 |
| Look, KY; Prajda, N; Singhal, RL; Sledge, GW; Weber, G; Yeh, YA | 1 |
| Barnabei, O; Capitani, S; Cocco, L; Gilmour, RS; Manzoli, FA; Maraldi, NM; Martelli, AM; Mazzotti, G | 1 |
| Billi, AM; Cocco, L; Gilmour, RS; Manzoli, L; Martelli, AM; Matteucci, A; Rubbini, S; Weber, G | 1 |
| Prajda, N; Singhal, RL; Weber, G | 1 |
| Collart, F; Glesne, D; Huberman, E | 1 |
| Balzarini, J; Bohman, C; De Clercq, E; Fridland, A; Herdewijn, P; Horská, K; Karlsson, A; Van Aerschot, A; Votruba, I; Wang, L | 1 |
| Abonyi, M; Hata, Y; Prajda, N; Singhal, RL; Weber, G | 1 |
| Markovic, N; Markovic, O; Markovic, S; Roberts, J | 1 |
| Chiba, P; Gharehbaghi, K; Lhotka, C; Pillwein, K; Ressmann, G; Schuchter, K; Szalay, SM; Szekeres, T | 1 |
| Olah, E; Sledge, GW; Weber, G; Wendel, JJ; Yeh, YA | 1 |
| Findenig, G; Fritzer, M; Lhotka, C; Schön, HJ; Szekeres, T | 1 |
| Prajda, N; Weber, G | 1 |
| Cooney, DA; Gharehbaghi, K; Hao, Z; Jayaram, HN; Krohn, K; Paull, KD; Sreenath, A; Szekeres, T | 1 |
| Look, KY; Singhal, RL; Sledge, GW; Weber, G; Yeh, YA | 1 |
| Elford, HL; Findenig, G; Fritzer, M; Gharehbaghi, K; Jayaram, HN; Lhotka, C; Schoen, HJ; Strobl, H; Szekeres, T | 1 |
| Hata, Y; Prajda, N; Weber, G | 1 |
| Gharehbaghi, K; Jayaram, HN; Zhen, W | 1 |
| Chiba, P; Fritzer, M; Gharehbaghi, K; Goldenberg, H; Pillwein, K; Szekeres, T | 1 |
| Cappellacci, L; Franchetti, P; Goldstein, BM; Grifantini, M; Hallows, WH; Langs, DA; Li, H | 1 |
| Carrell, HL; Goldstein, BM; Hallows, WH; Li, H; Marquez, VE; Pankiewicz, KW; Punzi, JS; Watanabe, KA | 1 |
| Hata, Y; Natsumeda, Y; Weber, G | 1 |
| Cermak, B; Chiba, P; Gharehbaghi, K; Jayaram, HN; Knoflach, A; Pillwein, K; Ressmańn, G; Schuchter, K; Szalay, SM; Szekeres, T | 1 |
| Cairncross, JG; Eisenhauer, E; Langleben, A; Macdonald, DR; Stewart, DJ | 1 |
| Billi, AM; Cocco, L; Gilmour, RS; Martelli, AM; Weber, G | 1 |
| Goldstein, BM; Kennedy, SD; Li, H | 1 |
| Burling, FT; Goldstein, BM | 1 |
| Monden, Y; Prajda, N; Taniki, T; Weber, G | 1 |
| Weber, G; Yeh, YA | 1 |
| Christopherson, RI; Clark, JM; Dunn, IS; Musk, P; Parsons, PG; Rose, SE; Szabados, E; Thompson, D | 1 |
| Jovanović, SS; Marković, ID; Mitrović, DM; Rakić, LM; Redzić, ZB; Rosić, MA | 1 |
| Bocsi, J; Jeney, A; Ladányi, A; Lapis, K; Paku, S; Pogány, G; Rśó, E; Tímár, J; Tóvári, J | 1 |
| Alvarez, E; Arimilli, S; Krohn, K; Muhs, MA; Saunders, PP; Surve-lyer, R | 1 |
| Barnabei, O; Capitani, S; Cocco, L; Gilmour, RS; Manzoli, FA; Maraldi, NM; Mazzotti, G | 1 |
| Beery, E; Goldwasser, I; Nordenberg, J; Sidi, Y; Zoref-Shani, E | 1 |
| Chisena, CA; Cysyk, RL; Hyman, R; Monks, A | 1 |
| Cinti, C; Falcieri, E; Gobbi, P; Santi, S; Vitale, M; Weber, G; Zamai, L; Zauli, G | 1 |
| Aguinaga, PM; Chakrabarti, P; Hatcher, FM; Talley, CJ; Turner, EA | 1 |
| Shipitsyn, AV; Shirokova, EA | 1 |
| Boulton, S; Durkacz, BW; Kyle, S | 1 |
| Csokay, B; Li, W; Look, KY; Olah, E; Prajda, N; Shen, F; Weber, G; Yang, H; Yeh, A | 1 |
| Keserû, GM; Makara, GM | 1 |
| Guttmann, RP; Johnson, GV; Lesort, M; Zhang, J | 1 |
| Li, W; Shen, F; Weber, G | 1 |
| Guttmann, RP; Johnson, GV; Zhang, J | 1 |
| Li, W; Weber, G | 2 |
| Shen, F; Weber, G | 1 |
| Columbaro, M; Falcieri, E; Ghibellini, D; Gobbi, P; Luchetti, F; Mariani, AR; Vitale, M; Zamai, L; Zauli, G | 1 |
| Joksimović, J; Juranić, I; Juranić, Z; Radulović, S | 1 |
| Herenyiova, M; Shen, F; Weber, G | 1 |
| Cooney, DA; Grusch, M; Jayaram, HN; Krupitza, G | 1 |
| Franchetti, P; Grifantini, M | 1 |
| Li, W; Prajda, N; Shen, F; Weber, G; Yang, H | 1 |
| Digits, JA; Hedstrom, L | 1 |
| Dedović, N; Dimitrijević, B; Savovski, K; Vranić, V | 1 |
| Barascut, JL; Cappellacci, L; Dukhan, D; Franchetti, P; Goldstein, BM; Grifantini, M; Imbach, JL; Jayaram, HN; Marchetti, S; Yalowitz, JA | 1 |
| Gasic, JM; Isakovic, A; Markovic, ID; Rakic, LM; Redzic, ZB; Segal, MB | 1 |
| Abonyi, M; Li, W; Look, KY; Prajda, N; Shen, DF; Weber, G; Yang, H | 1 |
| Averett, D; Bandaru, R; Ramasamy, KS | 1 |
| Borea, PA; Cappellacci, L; Costa, B; Franchetti, P; Grifantini, M; Marchetti, S; Martini, C; Varani, K | 1 |
| Drabek, K; Medić-Mijacević, L; Pesić, M; Pietrzkowski, Z; Piperski, V; Rakić, L; Ruzdijić, S | 1 |
| Cappellacci, L; Franchetti, P; Goldstein, BM; Grifantini, M; Jayaram, HN; Marchetti, S; Yalowitz, JA | 1 |
| Grifantini, M | 1 |
| Raicevic, N; Samardzic, T; Stosic-Grujicic, S; Trajkovic, V | 1 |
| Binns, DD; Grishin, NV; Kurnasov, O; Marquez, VE; Osterman, AL; Tomchick, DR; Zhang, H; Zhou, T | 1 |
| Goldstein, BM; Jayaram, HN; Lesiak-Watanabe, K; Pankiewicz, KW; Watanabe, KA | 1 |
| Gharehbaghi, K; Grünberger, W; Jayaram, HN | 1 |
| Novotny, L; Sedlak, J; Szekeres, T | 1 |
| Jäger, W; Salamon, A; Szekeres, T | 1 |
| Arguello, F; Greene, JF; Jayaram, HN; Yalowitz, JA | 1 |
| Bumbasirevic, V; Maksimovic-Ivanic, D; Markovic, M; Mostarica-Stojkovic, M; Ramic, Z; Savic-Radojevic, A; Stosic-Grujicic, S | 1 |
| Dacevic, M; Jokanovic, M; Mandic, L; Pejanovic, V; Piperski, V; Ristic, S; Tasic, J | 1 |
| Jayaram, HN; Pankiewicz, K; Patterson, SE; Yalowitz, JA | 1 |
| Hasmann, M; Nuessler, V; Pelka-Fleischer, R; Pogrebniak, A; Schemainda, I | 1 |
| De Abreu, RA; Lambooy, LH; Trueworthy, RC; van Gennip, AH; van Kuilenburg, AB; Vogels-Mentink, TM | 1 |
| Yamaoka, T | 1 |
| Begley, DJ; Dacevic, MP; Isakovic, AJ; Pejanovic, VM; Rakic, LM; Redzic, ZB; Segal, MB; Tasic, JS; Ugliesic-Kilibarda, DD | 1 |
| Clark, JL; Lostia, S; Otto, MJ; Pankiewicz, KW; Patterson, SE; Stuyver, LJ; Watanabe, KA | 1 |
| Atkinson, HD; Bogdanovic, A; Colovic, M; Jankovic, G; Milenkovic, P; Sefer, D; Suvajdzic, N | 1 |
| Kökeny, S; Olah, E; Orbán, TI; Shen, F; Weber, G | 1 |
| Bogdanović, G; Kojić, V; Popsavin, M; Popsavin, V; Spaić, S; Torović, L | 1 |
| Dacevic, M; Jokanovic, M; Petrovic, L; Piperski, V; Ristic, S; Tasic, J | 1 |
| Chun, MW; Jeong, LS; Kim, MJ; Liang, CW | 1 |
| Dimitrijević, B; Dramićanin, T; Jokanović, M; Jozanov-Stankov, O; Medić, L; Popov-Celeketić, D; Savovski, K; Subota, V; Vranić-Mandusić, V | 1 |
| Janać, B; Jokanović, M; Pesić, V; Piperski, V; Rakić, L; Ristić, S; Ruzdijić, S; Stukalov, P; Tasić, J; Veskov, R | 1 |
| Bray, M; Endy, TP; Paragas, J; Whitehouse, CA | 1 |
| Guillén Schlippe, YV; Hedstrom, L; Riera, TV; Seyedsayamdost, MR | 1 |
| Black, PL; Goldstein, BM; Jayaram, HN; Pankiewicz, KW; Patterson, SE; Risal, D; Schinazi, RF; Stuyver, LJ | 1 |
| Bieganowski, P; Brenner, C | 1 |
| Hedstrom, L; Li, C; Riera, T; Striepen, B; Umejiego, NN | 1 |
| Boosalis, MS; Malek, K; Mitchell, BS; Waraska, K; Wright, DG | 1 |
| Boosalis, M; Malek, K; Waraska, K; Wright, DG | 1 |
| Cass, CE; Damaraju, VL; Jayaram, HN; Mowles, D; Ng, AM; Visser, F; Young, JD; Zhang, J | 1 |
| Floryk, D; Giometti, CS; Huberman, E; Tollaksen, SL | 1 |
| Demajo, MA; Korićanac, LB; Popović, NM; Ristić-Fira, AM; Ruzdijić, SD; Todorović, DV | 1 |
| Bauer, W; Erker, T; Fritzer-Szekeres, M; Hoechtl, T; Horvath, Z; Illmer, C; Jaeger, W; Madlener, S; Saiko, P; Szekeres, T | 2 |
| Bajin-Katić, K; Kovacević, Z; Oros, J | 1 |
| Lavrnja, I; Medic-Mijacević, L; Mostarica-Stojković, M; Nedeljković, N; Peković, S; Rakić, L; Stojiljkovi, M; Stojkov, D; Stosic-Grujicić, S; Subasic, S | 1 |
| Ghadiri, MR; Horne, WS; van Maarseveen, JH | 1 |
| Chiacchio, U; Iannazzo, D; Mates, JA; Merino, P; Rescifina, A; Romeo, G; Saita, MG; Tejero, T | 1 |
| Chun, MW; Jeong, LS; Kim, MJ; Shin, JH | 1 |
| Bogdanović, G; Kojić, V; Popsavin, M; Popsavin, V; Svircev, M; Torović, L | 1 |
| Dacević, M; Gunić, E; Medić-Mijacević, L; Pejanović, V; Piperski, V; Popsavin, M; Popsavin, V; Tasić, J; Ugljesić-Kilibarda, D | 1 |
| Bozsik, A; Keszei, M; Kökény, S; Oláh, E; Papp, J | 1 |
| Bogdanović, G; Kojić, V; Popsavin, M; Popsavin, V; Spaić, S; Svircev, M | 3 |
| D'Anna, F; Panattoni, A; Triolo, E | 1 |
| Khan, JA; Tong, L; Xiang, S | 1 |
| Arterburn, JB; Bartolucci, A; Chung, DH; Jonsson, CB; Parker, WB; Sun, Y | 1 |
| Bennett, EM; Bonnac, L; Chen, L; Felczak, K; Gao, G; Hedstrom, L; Jayaram, HN; Pankiewicz, KW; Patterson, SE; Wilson, D | 1 |
| Bjelobaba, I; Dacic, S; Jovanovic, S; Lavrnja, I; Mostarica-Stojkovic, M; Nedeljkovic, N; Pekovic, S; Rakic, L; Stojiljkovic, M; Stojkov, D; Stosic-Grujicic, S | 1 |
| Amri, A; Borden, KL; Culjkovic, B; Tan, K | 1 |
| Aldrich, C; Bennett, E; Cappellacci, L; Chen, L; Di Stefano, M; Felczak, K; Franchetti, P; Grifantini, M; Magni, G; Mazzola, F; Pankiewicz, KW; Petrelli, R; Sham, YY; Wilson, D; Yu, JS | 1 |
| De Clercq, E; Koszytkowska-Stawińska, M; Mironiuk-Puchalska, E; Naesens, L; Sas, W | 1 |
| Antony, AC; Jani, MB; Jayaram, HN; Jayaram, NH; Khan, RA; Kusumanchi, P; Tang, Y; Zhang, Y | 1 |
| Luvisi, A; Panattoni, A; Rinaldelli, E; Triolo, E | 1 |
| Moreira, ME; Pitaluga, AN; Traub-Csekö, YM | 1 |
| Aleksić, L; Bogdanović, G; Jakimov, D; Kojić, V; Popsavin, M; Popsavin, V; Spaić, S; Svirčev, M; Torović, L | 1 |
| Bumbasirevic, V; Dulovic, M; Isakovic, A; Isakovic, AM; Kravic-Stevovic, T; Markovic, I; Trajkovic, V | 1 |
| Aleksić, L; Jakimov, D; Kojić, V; Kovačević, I; Popsavin, M; Popsavin, V; Spaić, S; Svirčev, M; Zelenović, BS | 1 |
| Bechaieb, R; El-Fattah, WA; Ferjani, H; Fettouhi, M | 1 |
27 review(s) available for ribavirin and tiazofurin
| Article | Year |
|---|---|
Metabolism and action of purine nucleoside analogs.
Topics: 2-Chloroadenosine; Adenosine; Cladribine; Deoxyadenosines; Guanine; Guanosine; Humans; Purine Nucleosides; Ribavirin; Vidarabine | 1991 |
New anticancer agents.
Topics: Alkaloids; Animals; Antineoplastic Agents; Azacitidine; Biphenyl Compounds; Chrysenes; Deoxycytidine; Echinomycin; Epirubicin; Etanidazole; Flavonoids; Gemcitabine; Guanidines; Humans; Idarubicin; Menogaril; Mitoguazone; Neoplasms; Nitroimidazoles; Nogalamycin; Organoplatinum Compounds; Paclitaxel; Pentostatin; Polymers; Propylene Glycols; Ribavirin; Sulfonylurea Compounds; Trimetrexate; Vidarabine Phosphate | 1991 |
Regulation of de novo and salvage pathways in chemotherapy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Humans; Leukemia; Pyrimidines; Ribavirin; Thymidine Kinase; Thymidylate Synthase; Zidovudine | 1991 |
Tiazofurin: biological effects and clinical uses.
Topics: Antineoplastic Agents; Drug Evaluation; Humans; IMP Dehydrogenase; Leukemia; Ribavirin; Ribonucleosides | 1990 |
Clinical toxicity associated with tiazofurin.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Evaluation; Female; Heart Diseases; Humans; Infusions, Intravenous; Leukopenia; Male; Nausea; Neoplasms; Ribavirin; Ribonucleosides; Ulcer; Vomiting | 1990 |
Tiazofurin action in leukemia: evidence for down-regulation of oncogenes and synergism with retinoic acid.
Topics: Animals; Antineoplastic Agents; Cell Line; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Oncogenes; Proto-Oncogenes; Ribavirin; Ribonucleosides; Tretinoin; Tumor Cells, Cultured | 1990 |
New anticancer agents.
Topics: Acetamides; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Flavonoids; Gallium; Humans; Mitolactol; Mitoxantrone; Organoplatinum Compounds; Pentostatin; Quinazolines; Ribavirin; Trimetrexate; Vidarabine Phosphate | 1987 |
Aminothiadiazole: an antineoplastic thiadiazole.
Topics: Allopurinol; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Evaluation; Drug Evaluation, Preclinical; Humans; IMP Dehydrogenase; Mice; Neoplasms, Experimental; Purines; Rats; Ribavirin; Thiadiazoles | 1986 |
[Current status of clinical results of new antitumor drugs].
Topics: Aminoacridines; Amsacrine; Anthracyclines; Anthraquinones; Antibiotics, Antineoplastic; Antineoplastic Agents; Aziridines; Benzoquinones; Carboplatin; Carubicin; Cisplatin; Daunorubicin; Doxorubicin; Eflornithine; Epirubicin; Humans; Idarubicin; Mitoxantrone; Naphthacenes; Neoplasms; Organoplatinum Compounds; Ornithine; Ribavirin | 1985 |
Tiazofurin: a new antitumor agent.
Topics: Animals; Antineoplastic Agents; Humans; Mice; Ribavirin; Ribonucleosides; Uric Acid | 1984 |
Nuclear inositol lipid cycle and differentiation.
Topics: Animals; Cell Differentiation; Cell Nucleus; Diglycerides; Dimethyl Sulfoxide; Erythrocytes; Inositol 1,4,5-Trisphosphate; Leukemia, Erythroblastic, Acute; Mice; Phosphatidylinositol Phosphates; Ribavirin; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases | 1995 |
Antimetabolites reduce the activities of enzymes with short half-lives in addition to inhibiting their specific targets.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Cycloheximide; Enzyme Inhibitors; Fluorouracil; Half-Life; Humans; Isoxazoles; Methotrexate; Prodrugs; Purines; Pyrimidines; Ribavirin; Signal Transduction | 1994 |
Regulation and role of inosine-5'-monophosphate dehydrogenase in cell replication, malignant transformation, and differentiation.
Topics: Animals; Bacteria; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Neoplastic; Conserved Sequence; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; IMP Dehydrogenase; Isoenzymes; Mycophenolic Acid; Ribavirin; Sequence Homology, Amino Acid; Tumor Cells, Cultured | 1994 |
Role of differentiation induction in action of purine antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Deoxycytidine; Gemcitabine; Humans; Leukemia; Oncogenes; Ribavirin | 1994 |
Inositol lipid cycle and autonomous nuclear signalling.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Nucleus; Immunohistochemistry; Isoenzymes; Lipid Metabolism; Phosphatidylinositols; Phospholipase C beta; Protein Kinase C; Ribavirin; Signal Transduction; Type C Phospholipases | 1996 |
Role of purine metabolism in regulation of signal transduction in human carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Deoxyguanine Nucleotides; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Inosine Monophosphate; Leukemia; Neoplasms; Purines; Ribavirin; Signal Transduction | 1998 |
Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.
Topics: Antineoplastic Agents; Apoptosis; cdc25 Phosphatases; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Guanosine Triphosphate; HL-60 Cells; Humans; IMP Dehydrogenase; Leukemia, Myeloid; Neoplasms; Nucleosides; Organoselenium Compounds; Ovarian Neoplasms; Protein Tyrosine Phosphatases; Ribavirin; Ribonucleosides; RNA, Messenger; Time Factors; Tumor Cells, Cultured | 1999 |
Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents.
Topics: Antineoplastic Agents; Antiviral Agents; Humans; IMP Dehydrogenase; Inhibitory Concentration 50; K562 Cells; Mycophenolic Acid; Nucleosides; Organoselenium Compounds; Oxazoles; Ribavirin; Ribonucleosides; Ribose; Tumor Cells, Cultured | 1999 |
Tiazofurine ICN Pharmaceuticals.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Contraindications; Drugs, Investigational; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Neoplasms; Ribavirin; Structure-Activity Relationship | 2000 |
Benzamide riboside, a recent inhibitor of inosine 5'-monophosphate dehydrogenase induces transferrin receptors in cancer cells.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Apoptosis; Cell Division; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; IMP Dehydrogenase; Iron; Leukemia, Myeloid; Nucleosides; Receptors, Transferrin; Ribavirin; Tumor Cells, Cultured | 2002 |
Metabolism of the novel IMP dehydrogenase inhibitor benzamide riboside.
Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; Enzyme Inhibitors; Forecasting; Humans; IMP Dehydrogenase; Isoenzymes; K562 Cells; Liver; Nucleosides; Rats; Ribavirin | 2002 |
Toxicity and efficacy of benzamide riboside in cancer chemotherapy models.
Topics: Animals; Antineoplastic Agents; Cell Survival; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; IMP Dehydrogenase; Leukemia L1210; Mice; Mice, Nude; Nucleosides; Ribavirin; Tumor Cells, Cultured | 2002 |
[IMP dehydrogenase].
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Feedback, Physiological; Genes, Dominant; Guanosine Monophosphate; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Mycophenolic Acid; Pigment Epithelium of Eye; Protein Conformation; Protein Structure, Tertiary; Purine Nucleotides; Retinal Degeneration; Ribavirin; Ribonucleosides | 2003 |
Targeting signal transduction.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Cell Line, Tumor; Guanosine Triphosphate; Humans; Ligands; Neoplasms; Ribavirin; Signal Transduction | 2003 |
Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.
Topics: Catalysis; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Molecular Mimicry; Molecular Structure; Mycophenolic Acid; NAD; Ribavirin; Ribonucleosides | 2004 |
Down-regulation of increased signal transduction capacity in human cancer cells.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Cell Proliferation; Down-Regulation; Drug Synergism; Genistein; Half-Life; Humans; Inositol 1,4,5-Trisphosphate; Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Quercetin; Ribavirin; Signal Transduction; Tamoxifen; Tumor Cells, Cultured; Type C Phospholipases | 2005 |
Modulation of cancer pathways by inhibitors of guanylate metabolism.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Guanosine Monophosphate; Humans; IMP Dehydrogenase; Neoplasms; Ribavirin; Signal Transduction | 2006 |
4 trial(s) available for ribavirin and tiazofurin
| Article | Year |
|---|---|
Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient.
Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Blast Crisis; Blotting, Northern; Down-Regulation; Gene Expression Regulation; Genes, ras; Guanosine Triphosphate; Humans; Hypoxanthine; Hypoxanthines; IMP Dehydrogenase; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Pilot Projects; Ribavirin; RNA; Uric Acid | 1991 |
Aminothiadiazole: an antineoplastic thiadiazole.
Topics: Allopurinol; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Evaluation; Drug Evaluation, Preclinical; Humans; IMP Dehydrogenase; Mice; Neoplasms, Experimental; Purines; Rats; Ribavirin; Thiadiazoles | 1986 |
Phase II trial of tiazofurin in recurrent squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Clinical Trials as Topic; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Ribavirin; Ribonucleosides | 1987 |
Phase II study of tiazofurin in gliomas in adults. A National Cancer Institute of Canada study.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Female; Glioblastoma; Humans; Male; Ribavirin | 1993 |
238 other study(ies) available for ribavirin and tiazofurin
| Article | Year |
|---|---|
Synthesis and antiviral activity of certain thiazole C-nucleosides.
Topics: Animals; Antiviral Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cytopathogenic Effect, Viral; Female; Mice; Parainfluenza Virus 3, Human; Paramyxoviridae Infections; Purine Nucleotides; Rhinovirus; Ribavirin; Ribonucleosides; Simplexvirus; Structure-Activity Relationship; Thiazoles | 1977 |
Analysis of the in vitro antiviral activity of certain ribonucleosides against parainfluenza virus using a novel computer aided receptor modeling procedure.
Topics: Antiviral Agents; Binding Sites; Chemical Phenomena; Chemistry; Chemistry, Physical; Computer Simulation; Drug Design; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Structure; Parainfluenza Virus 3, Human; Receptors, Virus; Respirovirus; Ribonucleosides; Structure-Activity Relationship | 1989 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Proliferation-linked regulation of type II IMP dehydrogenase gene in human normal lymphocytes and HL-60 leukemic cells.
Topics: Blotting, Northern; Cell Division; Dimethyl Sulfoxide; Gene Expression; Guanosine; Humans; IMP Dehydrogenase; Leukemia, Myeloid; Lymphocyte Activation; Lymphocytes; Ribavirin; RNA, Messenger; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1992 |
Synergistic action of tiazofurin and difluorodeoxycytidine on differentiation and cytotoxicity.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Line; Cell Survival; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Gemcitabine; Humans; IMP Dehydrogenase; Kinetics; Leukemia, Promyelocytic, Acute; Liver Neoplasms, Experimental; Models, Biological; Ovarian Neoplasms; Pancreatic Neoplasms; Rats; Ribavirin; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Stem Cell Assay | 1992 |
Regulation of GTP biosynthesis.
Topics: Animals; Cell Differentiation; Cell Division; Colonic Neoplasms; Evaluation Studies as Topic; GMP Reductase; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Hypoxanthine; Hypoxanthines; IMP Dehydrogenase; Inosine Monophosphate; Leukemia, Promyelocytic, Acute; Liver Neoplasms, Experimental; NADH, NADPH Oxidoreductases; Ribavirin; Tumor Cells, Cultured | 1992 |
Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; IMP Dehydrogenase; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Structure; Nucleosides; Ribavirin; Ribonucleotides | 1992 |
IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells.
Topics: Animals; Antineoplastic Agents; Biopterins; GTP Cyclohydrolase; Guanine; Guanosine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Kinetics; Mycophenolic Acid; Neuroblastoma; PC12 Cells; Ribavirin; Thiadiazoles; Tumor Cells, Cultured | 1992 |
Carboxamide group conformation in the nicotinamide and thiazole-4-carboxamide rings: implications for enzyme binding.
Topics: Adenine Nucleotides; Amides; Antineoplastic Agents; Crystallography; Enzyme Inhibitors; IMP Dehydrogenase; Molecular Conformation; NADP; Niacinamide; Ribavirin; Stereoisomerism; Structure-Activity Relationship | 1992 |
Cell cycle dependent regulation of IMP dehydrogenase activity and effect of tiazofurin.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Ribavirin; Tumor Cells, Cultured | 1992 |
Antitumor activity of tiazofurin in human colon carcinoma HT-29.
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Male; Mice; Mice, Nude; Ribavirin; Tumor Cells, Cultured | 1992 |
Inhibition by tiazofurin of inosine 5'-phosphate dehydrogenase (IMP DH) activity in extracts of ovarian carcinomas.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Middle Aged; Ovarian Neoplasms; Ovary; Ribavirin; Tissue Extracts | 1992 |
Action of tiazofurin and 8-Cl-cAMP in human colon and pancreatic cancer cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Synergism; Humans; IMP Dehydrogenase; Pancreatic Neoplasms; Ribavirin; Signal Transduction; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1992 |
Schedule-dependent synergistic action of tiazofurin and dipyridamole on hepatoma 3924A cells.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Survival; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Liver Neoplasms, Experimental; Ribavirin; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1992 |
Structures of the 4-cyano and 4-methylamidate analogs of tiazofurin.
Topics: Antineoplastic Agents; Molecular Structure; Ribavirin; Ribonucleosides; Thiazoles; X-Ray Diffraction | 1992 |
Clinical pharmacokinetic study of tiazofurin administered as a 1-hour infusion.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Blast Crisis; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ribavirin | 1992 |
Induction of HL60 cell differentiation by tiazofurin and its analogues: characterization and efficacy.
Topics: Cell Differentiation; Cell Line; Flow Cytometry; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Ribavirin; Structure-Activity Relationship | 1991 |
Cytotoxicity of tiazofurin and its arabinose and xylose analogues in K562 cells.
Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Arabinonucleosides; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; IMP Dehydrogenase; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nucleosides; Ribavirin | 1991 |
IMP dehydrogenase and GTP as targets in human leukemia treatment.
Topics: Adult; Aged; Allopurinol; Antineoplastic Agents; Female; Genes, myc; Genes, ras; Guanosine Triphosphate; Humans; IMP Dehydrogenase; In Vitro Techniques; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Ribavirin; Tumor Cells, Cultured | 1991 |
Novobiocin-induced anti-proliferative and differentiating effects in melanoma B16.
Topics: Animals; Antineoplastic Agents; Cell Count; Cell Differentiation; Cell Division; Drug Screening Assays, Antitumor; Melanoma, Experimental; Mycophenolic Acid; Novobiocin; Phenotype; Ribavirin | 1992 |
Inhibition by 1,25 dihydroxyvitamin D3 of chemically induced erythroid differentiation of K562 leukemia cells.
Topics: Animals; Calcitriol; Cell Differentiation; Cell Division; Cell Line; Cytarabine; Humans; Kinetics; Leukemia, Experimental; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Receptors, Calcitriol; Receptors, Steroid; Ribavirin; RNA, Messenger; Time Factors | 1991 |
Structures of the 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy analogs of tiazofurin.
Topics: Crystallization; Molecular Structure; Ribavirin; X-Ray Diffraction | 1991 |
Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Membrane; Cholera Toxin; Dinoprostone; Enzyme Activation; GTP-Binding Proteins; Guanine Nucleotides; Humans; IMP Dehydrogenase; Inositol Phosphates; Ketone Oxidoreductases; Leukemia, Myeloid, Acute; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Ribavirin; Ribonucleosides; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
Cell differentiation and altered IMP dehydrogenase expression induced in human T-lymphoblastoid leukemia cells by mycophenolic acid and tiazofurin.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Survival; Gene Expression; Guanosine; Humans; Hypoxanthine; Hypoxanthines; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Leukemia-Lymphoma, Adult T-Cell; Mycophenolic Acid; Ribavirin; Ribonucleosides; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Synergistic action of tiazofurin and retinoic acid on differentiation and colony formation of HL-60 leukemia cells.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Dose-Response Relationship, Drug; Drug Synergism; Guanosine; Humans; IMP Dehydrogenase; Leukemia, Promyelocytic, Acute; Molecular Structure; Phenotype; Ribavirin; Ribonucleosides; Time Factors; Tretinoin; Tumor Cells, Cultured | 1990 |
IMP dehydrogenase and action of antimetabolites in human cultured blast cells.
Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Humans; IMP Dehydrogenase; Inosine Monophosphate; Ketone Oxidoreductases; Kinetics; Leukemia; NAD; Ribavirin; Ribonucleosides | 1990 |
Dehydrogenase binding by tiazofurin anabolites.
Topics: Adenine Nucleotides; Antineoplastic Agents; Binding, Competitive; Computer Simulation; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Models, Chemical; Oxidoreductases; Ribavirin; Ribonucleosides | 1990 |
Down-regulation of c-myc and c-Ha-ras gene expression by tiazofurin in rat hepatoma cells.
Topics: Animals; Cell Division; Down-Regulation; Gene Amplification; Gene Expression; Gene Rearrangement; Genes, ras; Guanosine Triphosphate; IMP Dehydrogenase; Liver Neoplasms, Experimental; Oncogenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Rats; Ribavirin; Ribonucleosides | 1990 |
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the antiviral nucleoside 2' ,3'-dideoxyguanosine.
Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; HIV-1; Humans; IMP Dehydrogenase; Kinetics; Mycophenolic Acid; Nucleotides; Phosphorylation; Ribavirin | 1990 |
Induction of cell differentiation in melanoma cells by inhibitors of IMP dehydrogenase: altered patterns of IMP dehydrogenase expression and activity.
Topics: Biomarkers; Gene Expression Regulation, Neoplastic; Guanosine; Humans; IMP Dehydrogenase; Melanins; Melanoma; Monophenol Monooxygenase; Mycophenolic Acid; Neoplasm Proteins; Ribavirin; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1990 |
Determination of thiazole-4-carboxamide adenine dinucleotide (TAD) levels in mononuclear cells of leukemic patients treated with tiazofurin.
Topics: Adenine Nucleotides; Antineoplastic Agents; Chromatography, High Pressure Liquid; Guanosine Triphosphate; Humans; Leukemia; Monocytes; Reproducibility of Results; Ribavirin; Sensitivity and Specificity | 1991 |
Expression of memory to the terminal differentiation inducing activity of tiazofurin in HL-60 leukemia cells.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; Cell Differentiation; Cell Line; Cycloheximide; DNA Replication; DNA, Neoplasm; Guanosine; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Ribavirin; Ribonucleotides; Thymidine; Tretinoin | 1991 |
Synthesis and antitumor activity of 2-beta-D-ribofuranosyloxazole-4-carboxamide (oxazofurin).
Topics: Animals; Antineoplastic Agents; Humans; In Vitro Techniques; Mice; Neoplasms, Experimental; Oxazoles; Ribavirin; Ribose; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Tiazofurin is phosphorylated by three enzymes from Chinese hamster ovary cells.
Topics: Adenosine Kinase; Adenosine Triphosphate; Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Line; Cricetinae; Cricetulus; Female; Inosine Monophosphate; Kinetics; Niacinamide; Ovary; Phosphorylation; Pyridinium Compounds; Ribavirin; Ribonucleosides | 1990 |
Purine metabolism of human glioblastoma in vivo.
Topics: Brain; Brain Neoplasms; Female; Glioblastoma; Humans; Male; Middle Aged; Purine Nucleosides; Purine Nucleotides; Ribavirin | 1990 |
Changes in diacylglycerol and cyclic GMP during the differentiation of human myeloid leukemia K562 cells.
Topics: Antimetabolites, Antineoplastic; Cell Differentiation; Chromatography, DEAE-Cellulose; Cyclic GMP; Diglycerides; Glycerides; Hemoglobins; Humans; Leukemia, Myeloid; Protein Kinase C; Ribavirin; Tumor Cells, Cultured | 1990 |
Phase I trial and biochemical evaluation of tiazofurin administered on a weekly schedule.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Bone Marrow Diseases; Drug Evaluation; Female; Humans; Male; Middle Aged; Ribavirin; Ribonucleosides | 1990 |
Effectiveness of tiazofurin (NSC 286193) in treating disseminated tumor cells and micrometastases in mice.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Lung Neoplasms; Mice; Models, Biological; Neoplasm Metastasis; Ribavirin; Ribonucleosides; Tumor Cells, Cultured | 1990 |
Phase I study of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193).
Topics: Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Ribavirin; Ribonucleosides | 1990 |
Targets and markers of selective action of tiazofurin.
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Guanine Nucleotides; IMP Dehydrogenase; Liver; Liver Neoplasms, Experimental; NAD; Phosphoribosyl Pyrophosphate; Rats; Rats, Inbred Strains; Ribavirin; Ribonucleosides | 1985 |
Nucleoside and nucleotide modulation of genetic expression--a new approach to chemotherapy.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Down-Regulation; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Humans; Nucleosides; Nucleotides; Organoselenium Compounds; Phosphorylation; Ribavirin; Ribonucleosides; Selenium; Signal Transduction; Tumor Cells, Cultured | 1989 |
Involvement of guanine nucleotides in superoxide release by fluoride-treated neutrophils. Implications for a role of a guanine nucleotide regulatory protein.
Topics: Adenine Nucleotides; Digitonin; GTP-Binding Proteins; Guanine Nucleotides; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Ribavirin; Signal Transduction; Sodium Fluoride; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Tiazofurin and selenazofurin induce depression of cGMP and phosphatidylinositol pathway in L1210 leukemia cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Caenorhabditis elegans Proteins; Carrier Proteins; Cyclic GMP; Diglycerides; Guanosine Triphosphate; Inosine Monophosphate; Leukemia L1210; Mice; Organoselenium Compounds; Phorbol 12,13-Dibutyrate; Phosphates; Phosphatidylinositols; Protein Kinase C; Receptors, Drug; Ribavirin; Ribonucleosides; Selenium | 1989 |
IMP dehydrogenase: inhibition by the anti-leukemic drug, tiazofurin.
Topics: Adenine Nucleotides; Antineoplastic Agents; Blast Crisis; Female; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; NADP; Ribavirin; Ribonucleosides | 1989 |
Biochemically directed therapy of leukemia with tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity.
Topics: Antimetabolites, Antineoplastic; Blast Crisis; Blood Cell Count; Bone Marrow; Enzyme Inhibitors; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Ribavirin; Ribonucleosides | 1989 |
Induction of erythroid differentiation in K562 cells by inhibitors of inosine monophosphate dehydrogenase.
Topics: Cell Compartmentation; Cell Division; Erythropoiesis; Hemoglobins; Humans; IMP Dehydrogenase; In Vitro Techniques; Ketone Oxidoreductases; Leukemia, Erythroblastic, Acute; Mycophenolic Acid; Purine Nucleotides; Ribavirin; Ribonucleosides; Tumor Cells, Cultured | 1989 |
Recovery of the activities of IMP dehydrogenase and GMP synthase after treatment with tiazofurin and acivicin in hepatoma cells in vitro.
Topics: Animals; Carbon-Nitrogen Ligases; Cycloheximide; Drug Interactions; IMP Dehydrogenase; Isoxazoles; Ketone Oxidoreductases; Ligases; Liver Neoplasms, Experimental; Oxazoles; Ribavirin; Ribonucleosides; Time Factors; Tumor Cells, Cultured | 1989 |
Clinical and molecular impact of inhibition of IMP dehydrogenase activity by tiazofurin.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Division; Cell Line; Guanosine; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia, Promyelocytic, Acute; Liver Neoplasms, Experimental; Rats; Ribavirin; Ribonucleosides; Tretinoin; Tumor Cells, Cultured | 1989 |
Unique bioactivation of tiazofurin--studies with resistant cells.
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Line; Drug Resistance; Ribavirin; Ribonucleosides | 1989 |
Effects of tiazofurin on globin and proto-oncogene expression in K562 erythroleukemia cells.
Topics: Actins; Antineoplastic Agents; Cell Division; Cell Line; Gene Expression; Genes; Globins; Hemoglobins; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Proto-Oncogene Mas; Proto-Oncogenes; Ribavirin; Ribonucleosides; Tumor Cells, Cultured | 1989 |
Critical issues in chemotherapy with tiazofurin.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Down-Regulation; Drug Interactions; Female; Genes, ras; Guanine; Humans; Hypoxanthine; Hypoxanthines; Leukemia; Liver Neoplasms, Experimental; Male; Middle Aged; Ribavirin; Ribonucleosides; Tretinoin; Tumor Cells, Cultured; Uric Acid | 1989 |
Antiviral activity of tiazofurine against barley stripe mosaic virus.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Hordeum; Mosaic Viruses; Plant Diseases; Ribavirin; Ribonucleosides; Triticum; Virus Replication | 1989 |
Induction of the differentiation of synchronized HL-60 leukemia cells by tiazofurin.
Topics: Cell Cycle; Cell Differentiation; Cell Separation; Centrifugation; Humans; Leukemia, Promyelocytic, Acute; Ribavirin; Ribonucleosides; Tumor Cells, Cultured | 1989 |
Growth inhibition and induction of phenotypic alterations by tiazofurin: differential effects on MCF-7 breast cancer and HBL-100 breast cell lines.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Division; Cell Line; Female; Guanosine Triphosphate; Humans; Milk, Human; Mycophenolic Acid; Ribavirin; Ribonucleosides; Tumor Cells, Cultured | 1989 |
Phase II study of tiazofurin (NSC 286193) in the treatment of advanced small cell bronchogenic carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Ribavirin; Ribonucleosides | 1988 |
Relationships between the cytotoxicity of tiazofurin and its metabolism by cultured human lung cancer cells.
Topics: Adenine Nucleotides; Antineoplastic Agents; Cell Line; Cells, Cultured; Cytotoxicity Tests, Immunologic; Humans; IMP Dehydrogenase; Lung Neoplasms; Purine Nucleotides; Pyrimidine Nucleotides; Ribavirin; Ribonucleosides; Sepharose; Tumor Stem Cell Assay | 1985 |
Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.
Topics: Animals; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Leukemia P388; Mice; NAD; Organoselenium Compounds; Ribavirin; Ribonucleosides; Selenium | 1985 |
Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture.
Topics: Adenosine Triphosphate; Animals; Cell Division; Cells, Cultured; DNA, Neoplasm; Guanine; Guanylate Kinases; Hypoxanthine Phosphoribosyltransferase; IMP Dehydrogenase; Ketone Oxidoreductases; Lymphoma; Mice; Mycophenolic Acid; Nucleoside-Diphosphate Kinase; Nucleoside-Phosphate Kinase; Organoselenium Compounds; Ribavirin; Ribonucleosides; RNA, Neoplasm; Selenium; Tritium; Uridine | 1985 |
Effects of the inhibitors of IMP dehydrogenase, tiazofurin and mycophenolic acid, on glycoprotein metabolism.
Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Glucosamine; Glycoproteins; Guanosine; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Mannose; Mycophenolic Acid; Ribavirin; Ribonucleosides; Sarcoma 180; Tritium | 1985 |
Mechanism of resistance to tiazofurin in hepatoma 3924A.
Topics: Adenosine Monophosphate; Animals; Antineoplastic Agents; Biological Transport; Cell Cycle; Cell Line; Drug Resistance; Guanine; Guanosine Monophosphate; IMP Dehydrogenase; Inosine Monophosphate; Liver Neoplasms, Experimental; Nicotinamide-Nucleotide Adenylyltransferase; Rats; Ribavirin; Ribonucleosides | 1986 |
Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5'-phosphate dehydrogenase.
Topics: Cell Cycle; Cell Differentiation; Cell Line; Dolichol Monophosphate Mannose; Glycoproteins; Guanosine; Guanosine Triphosphate; Hematopoiesis; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia, Myeloid, Acute; Mycophenolic Acid; Organoselenium Compounds; Phagocytosis; Ribavirin; Ribonucleosides; Selenium | 1986 |
Studies on the mechanism of action of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide). VI. Biochemical and pharmacological studies on the degradation of thiazole-4-carboxamide adenine dinucleotide (TAD).
Topics: Adenine Nucleotides; Animals; Chromatography, High Pressure Liquid; Colonic Neoplasms; IMP Dehydrogenase; Leukemia P388; Male; Mice; Phosphoric Diester Hydrolases; Ribavirin; Ribonucleosides | 1986 |
A role for guanine ribonucleotides in the regulation of myeloid cell maturation.
Topics: Cell Differentiation; Cell Line; Dimethylformamide; Guanine; Guanine Nucleotides; Guanosine; Hematopoiesis; Humans; IMP Dehydrogenase; Leukemia, Myeloid, Acute; Ribavirin; Tretinoin | 1987 |
Modulation of acetyl-CoA carboxylase by inhibitors of IMP dehydrogenase: implications for insulin regulation.
Topics: Acetyl-CoA Carboxylase; Adenosine Triphosphate; Adipose Tissue; Animals; Enzyme Activation; Epinephrine; Guanosine Triphosphate; IMP Dehydrogenase; Insulin; Ketone Oxidoreductases; Kinetics; Ligases; Male; Rats; Ribavirin | 1987 |
Inhibitors of inosinate dehydrogenase.
Topics: Allosteric Site; Animals; Binding Sites; Binding, Competitive; Cell Line; Cricetinae; Cricetulus; Female; Fibroblasts; IMP Dehydrogenase; Ketone Oxidoreductases; NAD; Ovary; Protein Binding; Ribavirin; Ribonucleotides | 1987 |
Synergistic cytotoxic effect of tiazofurin and ribavirin in hepatoma cells.
Topics: Animals; Cell Line; Cell Survival; Drug Synergism; Guanosine Monophosphate; IMP Dehydrogenase; Liver Neoplasms, Experimental; Organoselenium Compounds; Purines; Rats; Ribavirin; Ribonucleosides; Selenium | 1988 |
Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells.
Topics: Antimetabolites, Antineoplastic; Cell Differentiation; Cell Line; Genes, ras; Guanosine Triphosphate; Hemoglobins; Humans; IMP Dehydrogenase; Kinetics; Leukemia, Myeloid; Ribavirin; Ribonucleosides; Transcription, Genetic | 1988 |
Effects of tiazofurin on protooncogene expression during HL-60 cell differentiation.
Topics: Cell Differentiation; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia, Promyelocytic, Acute; Proto-Oncogenes; Ribavirin; Ribonucleosides; Transcription, Genetic; Tumor Cells, Cultured | 1988 |
Enzyme-pattern-targeted chemotherapy with tiazofurin and allopurinol in human leukemia.
Topics: Adenine; Aged; Allopurinol; Animals; Drug Evaluation; Female; Guanine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia; Leukemia, Myeloid, Acute; Liver Neoplasms, Experimental; Male; Middle Aged; Rats; Ribavirin; Ribonucleosides; Tumor Cells, Cultured | 1988 |
Tiazofurin induction of mouse erythroleukemia cell hemoglobin production in the absence of commitment or changes in protooncogene expression.
Topics: Animals; Blotting, Northern; Cell Division; Cell Line; Dimethyl Sulfoxide; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Proto-Oncogenes; Ribavirin; Ribonucleosides; Transcription, Genetic | 1989 |
Tiazofurin metabolism in human lymphoblastoid cells: evidence for phosphorylation by adenosine kinase and 5'-nucleotidase.
Topics: 5'-Nucleotidase; Adenosine Kinase; Adenosine Triphosphate; Amides; Biotransformation; Cell Line; Drug Resistance; Humans; Inosine Monophosphate; Lymphocytes; Nucleotidases; Phosphorylation; Phosphotransferases; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Substrate Specificity | 1986 |
Studies of purine and tiazofurin metabolism in drug sensitive human chronic myelogenous leukemia K 562 cells.
Topics: Carbon Radioisotopes; Formates; Humans; Leukemia, Myeloid; Purine Nucleotides; Ribavirin; Ribonucleosides; Tumor Cells, Cultured | 1988 |
Antitumor activity of liposomal encapsulated tiazofurin and its NAD-analogue.
Topics: Animals; Antineoplastic Agents; Drug Carriers; Liposomes; Mice; Ribavirin; Ribonucleosides | 1988 |
Advanced Lewis lung carcinoma cured by tiazofurin as a system to study delayed hemopoietic effects of cancer.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Hematopoietic Stem Cells; Hematopoietic System; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Ribavirin; Ribonucleosides | 1988 |
Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin.
Topics: Animals; Aspartate Carbamoyltransferase; Bone Marrow; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Deoxycytidine Kinase; Isoxazoles; Ligases; Orotidine-5'-Phosphate Decarboxylase; Oxazoles; Rats; Ribavirin; Ribonucleoside Diphosphate Reductase; Ribonucleosides; Thymidine Monophosphate; Thymidylate Synthase | 1988 |
Ara-tiazofurin: conservation of structural features in an unusual thiazole nucleoside.
Topics: Chemical Phenomena; Chemistry; Molecular Conformation; Ribavirin; Ribonucleosides; Structure-Activity Relationship; Thiazoles; X-Ray Diffraction | 1988 |
Resistance of cultured Lewis lung carcinoma cell lines to tiazofurin.
Topics: Animals; Cell Line; Clone Cells; Colony-Forming Units Assay; Drug Resistance; Flow Cytometry; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Ribavirin; Ribonucleosides; Tumor Stem Cell Assay | 1987 |
Hematological and biochemical action of tiazofurin (NSC 286193) in a case of refractory acute myeloid leukemia.
Topics: Antineoplastic Agents; Bone Marrow; Guanosine Triphosphate; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Ribavirin; Ribonucleosides | 1987 |
Synergistic activity of purine metabolism inhibitors in cultured human tumor cells.
Topics: 3-Deazauridine; Antimetabolites, Antineoplastic; Cell Division; Cells, Cultured; Drug Synergism; Humans; Inosine; Neoplasms; Ribavirin | 1987 |
Clinical pharmacology of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193).
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Creatinine; Drug Evaluation; Erythrocytes; Humans; Kinetics; Middle Aged; Ribavirin; Ribonucleosides | 1986 |
Colony assay with human tumor xenografts, murine tumors and human bone marrow. Potential for anticancer drug development.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Division; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Dose-Response Relationship, Drug; In Vitro Techniques; Mice; Mice, Nude; Neoplasms, Experimental; Ribavirin; Transplantation, Heterologous; Triazoles | 1987 |
Phase II study of tiazofurin in colorectal cancer: a National Cancer Institute of Canada Study.
Topics: Adult; Aged; Colonic Neoplasms; Drug Evaluation; Female; Humans; Male; Middle Aged; Rectal Neoplasms; Ribavirin; Ribonucleosides | 1987 |
Therapeutic synergism of tiazofurin and selected antitumor drugs against sensitive and resistant P388 leukemia in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Female; Leukemia P388; Leukemia, Experimental; Mice; Phosphonoacetic Acid; Ribavirin; Ribonucleosides; Thioguanine | 1986 |
Selective sensitivity to tiazofurin of human leukemic cells.
Topics: Adenine Nucleotides; Adult; Aged; Antineoplastic Agents; Female; Guanosine Triphosphate; Humans; Leukemia; Leukocytes; Male; Middle Aged; Ribavirin; Ribonucleosides | 1986 |
Metabolism of tiazofurin by human erythrocytes and mononuclear blood cells in vitro.
Topics: Antineoplastic Agents; Cells, Cultured; Erythrocytes; Humans; Leukocytes; Phosphorylation; Ribavirin; Ribonucleosides | 1986 |
Use of tiazofurin to enhance the metabolism and cytotoxic activities of analogues of guanine, guanosine, and deoxyguanosine.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Deoxyguanosine; Female; Guanine; Guanosine; Guanosine Triphosphate; Hypoxanthine Phosphoribosyltransferase; Ovary; Ribavirin; Ribonucleosides | 1987 |
Phase I trial of tiazofurin administered by i.v. bolus daily for 5 days, with pharmacokinetic evaluation.
Topics: Adult; Aged; Allopurinol; Antimetabolites, Antineoplastic; Creatine Kinase; Drug Administration Schedule; Drug Evaluation; Female; Headache; Hemoglobins; Humans; Hypoxanthines; Isoenzymes; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Nausea; Purines; Ribavirin; Ribonucleosides; Uric Acid; Xanthine; Xanthines | 1987 |
Potentiation of antimetabolite action by dibromodulcitol in cell culture.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Drug Synergism; Hydroxamic Acids; Isoxazoles; Liver Neoplasms, Experimental; Mitolactol; Pyrazoles; Rats; Ribavirin; Ribonucleosides; Ribose | 1985 |
Biochemical mechanisms of resistance to tiazofurin.
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Cell Line; Cell Survival; Drug Resistance; Guanine Nucleotides; Humans; Inosine Nucleotides; Leukemia L1210; Leukemia P388; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Nicotinamide-Nucleotide Adenylyltransferase; Rats; Ribavirin; Ribonucleosides | 1985 |
Regulation of purine and pyrimidine metabolism by insulin and by resistance to tiazofurin.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Diabetes Mellitus, Experimental; Drug Resistance; Gene Expression Regulation; Insulin; Liver; Liver Neoplasms, Experimental; Male; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Rats, Inbred Strains; Ribavirin; Ribonucleosides | 1985 |
Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by the synthetic "C" nucleoside analogs, tiazofurin and selenazofurin. A new strategy for cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Leukemia L1210; Mice; NAD; Nucleoside Diphosphate Sugars; Organoselenium Compounds; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Ribavirin; Ribonucleosides; Selenium | 1985 |
Phase I and pharmacokinetic study of tiazofurin (NSC 286193) administered by 5-day continuous infusion.
Topics: Adult; Chromatography, High Pressure Liquid; Conjunctivitis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Female; Humans; Kinetics; Male; Middle Aged; Neoplasms; Neutropenia; Ribavirin; Ribonucleosides | 1986 |
Biochemical and antitumor activity of tiazofurin and its selenium analog (2-beta-D-ribofuranosyl-4-selenazolecarboxamide).
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Humans; Mice; Neoplasms; Nucleic Acids; Organoselenium Compounds; Ribavirin; Ribonucleosides; Ribonucleotides; Selenium | 1985 |
Pharmacokinetics of tiazofurin in the plasma and cerebrospinal fluid of rhesus monkeys.
Topics: Animals; Antineoplastic Agents; Kinetics; Macaca mulatta; Metabolic Clearance Rate; Ribavirin; Ribonucleosides | 1985 |
Phase I clinical study with pharmacokinetic analysis of 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193) administered as a five-day infusion.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Creatine Kinase; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Neoplasms; Nervous System; Purines; Ribavirin; Ribonucleosides; Skin | 1985 |
Phase I evaluation and pharmacokinetics of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193).
Topics: Adult; Aged; Antineoplastic Agents; Aspartate Aminotransferases; Bone Marrow; Creatine Kinase; Drug Evaluation; Female; Humans; Kinetics; Lymphocytes; Male; Middle Aged; Neoplasms; Ribavirin; Ribonucleosides; Uric Acid | 1985 |
Action of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) against untreated human ovarian cancers in the murine xenograft assay.
Topics: Animals; Antineoplastic Agents; Female; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Ovarian Neoplasms; Ribavirin; Ribonucleosides | 1985 |
Uptake of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) and analogues by the facilitated transport mechanism of erythrocytes.
Topics: Antineoplastic Agents; Biological Transport; Carbon Radioisotopes; Erythrocytes; Humans; In Vitro Techniques; Kinetics; Nucleosides; Ribavirin; Ribonucleosides; Structure-Activity Relationship; Uridine | 1985 |
Pediatric phase I trial and pharmacokinetic study of tiazofurin (NSC 286193).
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Drug Evaluation; Humans; Kidney; Kinetics; Neoplasms; Ribavirin; Ribonucleosides | 1985 |
Chinese hamster ovary cell mutants specifically affected in the phosphorylation of C-purine nucleosides.
Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Female; Formycins; Ovary; Phosphorylation; Purine Nucleosides; Ribavirin; Time Factors; Tubercidin | 1985 |
Phase I and pharmacokinetic study of tiazofurin (TCAR, NSC 286193) administered by continuous infusion.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Creatine Kinase; Drug Evaluation; Female; Heart; Humans; Kidney Diseases; Kinetics; Male; Middle Aged; Ribavirin; Ribonucleosides; Sleep Stages | 1985 |
The conversion of 2-beta-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
Topics: Adenosine; Animals; Antineoplastic Agents; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Leukemia P388; Male; Mice; NAD; Ribavirin; Ribonucleosides | 1982 |
Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193).
Topics: Animals; Antineoplastic Agents; Carbon-Nitrogen Ligases; Cell Division; Cell Survival; DNA, Neoplasm; Hypoxanthines; IMP Dehydrogenase; Leukemia L1210; Leukemia P388; Ligases; Mice; Ribavirin; Ribonucleosides; Structure-Activity Relationship | 1982 |
Inhibition of inosinate dehydrogenase by metabolites of 2-beta-D-ribofuranosyl thiazole-4-carboxamide.
Topics: Animals; Biotransformation; Cell Line; Cricetinae; Cricetulus; Female; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Mutation; Ovary; Ribavirin; Ribonucleosides | 1982 |
Studies on the mechanism of action of 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193)--II. Relationship between dose level and biochemical effects in P388 leukemia in vivo.
Topics: Animals; Antineoplastic Agents; Guanosine; Hypoxanthines; IMP Dehydrogenase; Kinetics; Leukemia P388; Leukemia, Experimental; Mice; Niacinamide; Nucleic Acids; Ribavirin; Ribonucleosides; Time Factors | 1982 |
Conversion of 2-beta-D-ribofuranosylselenazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
Topics: Animals; Gas Chromatography-Mass Spectrometry; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia P388; Leukemia, Experimental; Mice; NAD; Organoselenium Compounds; Ribavirin; Ribonucleosides; Selenium | 1983 |
Comparative in vitro studies of Tiazofurin and a selenazole analog.
Topics: Animals; Antineoplastic Agents; Cell Survival; IMP Dehydrogenase; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Nucleoside-Diphosphate Kinase; Organoselenium Compounds; Ribavirin; Ribonucleosides; Selenium | 1983 |
Studies on the mechanism of action of 2-beta-D-ribofuranosylthiazole-4-carboxamide--V. Factors governing the response of murine tumors to tiazofurin.
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Biotransformation; Dose-Response Relationship, Drug; Drug Resistance; Female; IMP Dehydrogenase; Male; Mice; Neoplasms, Experimental; Nucleotides; Ribavirin; Ribonucleosides | 1984 |
Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide).
Topics: Animals; Antineoplastic Agents; Cell Line; Deoxyribonucleotides; Guanine Nucleotides; Guanosine Triphosphate; IMP Dehydrogenase; Inosine Monophosphate; Ketone Oxidoreductases; Kinetics; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred ACI; Ribavirin; Ribonucleosides | 1984 |
Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses.
Topics: Antiviral Agents; Arenaviridae; Bunyaviridae; Drug Combinations; Drug Synergism; IMP Dehydrogenase; Organoselenium Compounds; Ribavirin; Ribonucleosides; Selenium; Togaviridae | 1984 |
Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; NAD; Ribavirin; Ribonucleosides; Spectrophotometry | 1983 |
Activity and metabolism of 2-beta-D-ribofuranosylthiazole-4-carboxamide in human lymphoid tumor cells in culture.
Topics: Cell Division; Cell Line; DNA Replication; Guanine Nucleotides; Humans; Lymphoma; Ribavirin; Ribonucleosides; RNA; Time Factors | 1983 |
Action of 2-beta-d-Ribofuranosylthiazole-4-carboxamide (tiazofurin) in Chinese hamster ovary and variant cell lines.
Topics: Animals; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; DNA Replication; Female; Guanine; Ovary; Ribavirin; Ribonucleosides; RNA | 1983 |
Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin.
Topics: Animals; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Drug; IMP Dehydrogenase; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nucleotides; Oxazoles; Pentosephosphates; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Rats; Ribavirin; Ribonucleosides | 1984 |
Novel nucleoside inhibitors of guanosine metabolism as antitumor agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Division; Cell Line; Clone Cells; Drug Synergism; Formates; Guanosine; Humans; Lung Neoplasms; Purines; Ribavirin; Ribonucleosides | 1984 |
Effect of 2-beta-D-ribofuranosylthiazole-4-carboxamide on uptake of nucleosides by cultured L1210 cells.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Leukemia L1210; Nucleosides; Ribavirin; Ribonucleosides; Uridine | 1984 |
Effect of tiazofurin on tomato plants infected with tomato spotted wilt virus.
Topics: Antiviral Agents; Mosaic Viruses; Plant Diseases; Plant Viruses; Plants; Ribavirin; Ribonucleosides | 1984 |
Pharmacology of anticancer drugs.
Topics: Animals; Antineoplastic Agents; Drug Resistance; Drug Synergism; Humans; Mice; Neoplasms, Experimental; Ribavirin | 1984 |
High-performance liquid chromatographic determination of 2-beta-D-ribofuranosylthiazole-4-carboxamide in urine and plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Mice; Mice, Inbred Strains; Ribavirin; Ribonucleosides; Spectrophotometry, Ultraviolet; Time Factors | 1983 |
Analysis of riboxamide in plasma by high-performance liquid chromatography using automated column switching.
Topics: Animals; Autoanalysis; Chromatography, High Pressure Liquid; Dogs; Female; Humans; Kinetics; Ribavirin; Ribonucleosides; Species Specificity | 1983 |
Synthesis and biological activity of nucleosides and nucleotides related to the antitumor agent 2-beta-D-ribofuranosylthiazole-4-carboxamide.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Phosphorylation; Ribavirin; Ribonucleosides | 1984 |
Analysis of riboxamide in urine by high-performance liquid chromatography.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Humans; Male; Ribavirin; Ribonucleosides | 1984 |
Quantification of tiazofurin in plasma by high-performance liquid chromatography.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Erythrocytes; Half-Life; Humans; Kinetics; Mice; Ribavirin; Ribonucleosides | 1984 |
Tiazofurin-induced selective depression of NAD content in hepatoma 3924A.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Liver; Liver Neoplasms, Experimental; Male; NAD; Rats; Rats, Inbred ACI; Ribavirin; Ribonucleosides | 1984 |
2-beta-D-Ribofuranosylthiazole-4-carboxamide, a novel potential antitumor agent for lung tumors and metastases.
Topics: Animals; Antineoplastic Agents; Carcinoma, Bronchogenic; Lung Neoplasms; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Ribavirin; Ribonucleosides | 1982 |
Mechanism of resistance to the oncolytic C-nucleoside 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC-286193).
Topics: Animals; Antineoplastic Agents; Drug Resistance; Guanosine Triphosphate; Leukemia P388; Leukemia, Experimental; Mice; Neoplasm Transplantation; Ribavirin; Ribonucleosides; Time Factors | 1982 |
p210 bcr-abl confers overexpression of inosine monophosphate dehydrogenase: an intrinsic pathway to drug resistance mediated by oncogene.
Topics: Animals; Antineoplastic Agents; Blotting, Northern; Cell Division; Cell Line, Transformed; DNA Replication; Drug Resistance; Fusion Proteins, bcr-abl; Gene Expression; IMP Dehydrogenase; Mice; Oncogenes; Phosphoproteins; Phosphotyrosine; Poly A; Ribavirin; RNA; RNA, Messenger; Thymidine; Tyrosine | 1994 |
Tiazofurin induces a down-modulation of ICAM-1 expression on K562 target cells impairing NK adhesion and killing.
Topics: Antigens, CD; Antineoplastic Agents; CD58 Antigens; Cell Adhesion; Cell Differentiation; Cytotoxicity, Immunologic; Down-Regulation; Humans; Intercellular Adhesion Molecule-1; Killer Cells, Natural; Membrane Glycoproteins; Ribavirin; Tumor Cells, Cultured | 1995 |
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
Topics: Animals; Antineoplastic Agents; Crystallography, X-Ray; Humans; IMP Dehydrogenase; Inosine Monophosphate; Magnetic Resonance Spectroscopy; Mice; NAD; Neoplasms; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured | 1995 |
Regulation of signal transduction.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Cell Division; Diet; Fasting; Female; Humans; Inositol 1,4,5-Trisphosphate; Male; Neoplasms; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Quercetin; Rats; Rats, Wistar; Ribavirin; Signal Transduction; Tumor Cells, Cultured | 1995 |
Phosphoinositide signaling in nuclei of Friend cells: tiazofurin down-regulates phospholipase C beta 1.
Topics: Animals; Antibodies, Monoclonal; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Nucleus; Down-Regulation; Friend murine leukemia virus; Isoenzymes; Leukemia, Erythroblastic, Acute; Mice; Phosphatidylinositols; Phospholipase C beta; Ribavirin; Signal Transduction; Type C Phospholipases | 1995 |
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Deoxyguanine Nucleotides; Guanine; Guanosine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Leukemia L1210; Lymphocytes; Mice; Mycophenolic Acid; Purine Nucleotides; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured | 1993 |
Sequential impact of tiazofurin and ribavirin on the enzymic program of the bone marrow.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Cycloheximide; Deoxycytidine Kinase; Dose-Response Relationship, Drug; GMP Reductase; Hypoxanthine Phosphoribosyltransferase; IMP Dehydrogenase; Male; NADH, NADPH Oxidoreductases; Rats; Rats, Inbred ACI; Ribavirin; Thymidine Kinase | 1993 |
A new assay for intracellular measurement of inosine monophosphate dehydrogenase activity: a guide for better selection of patients for enzyme-targeted chemotherapy.
Topics: Acute Disease; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Therapy, Computer-Assisted; Humans; Image Processing, Computer-Assisted; IMP Dehydrogenase; Leukemia, Experimental; Leukemia, Myeloid; Reference Values; Ribavirin; Tumor Cells, Cultured | 1994 |
Synergistic action of tiazofurin with hypoxanthine and allopurinol in human neuroectodermal tumor cell lines.
Topics: Allopurinol; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Guanosine Monophosphate; Humans; Hypoxanthine; Hypoxanthines; IMP Dehydrogenase; Neuroblastoma; Ribavirin; Tumor Cells, Cultured | 1993 |
Synergistic action of taxol with tiazofurin and methotrexate in human breast cancer cells: schedule-dependence.
Topics: Cell Division; Drug Synergism; Female; Humans; Methotrexate; Paclitaxel; Ribavirin; Tumor Cells, Cultured | 1994 |
[Synergistic cytotoxic effects of chemotherapy in colon tumor cells by simultaneous inhibition of de novo and salvage energy metabolism pathways].
Topics: Allopurinol; Antimetabolites, Antineoplastic; Benzamidines; Cell Line; Cell Survival; Colonic Neoplasms; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Gemcitabine; Humans; Hypoxanthine; Hypoxanthines; Ribavirin; Ribonucleotide Reductases; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1994 |
Targeted and non-targeted actions of anti-cancer drugs.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Cycloheximide; Deoxycytidine Kinase; Fluorouracil; Hypoxanthine Phosphoribosyltransferase; Isoxazoles; Methotrexate; Neoplasms, Experimental; Pyrimidines; Rats; Rats, Inbred Strains; Ribavirin; Thymidine Kinase; Thymidylate Synthase | 1994 |
Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin.
Topics: Antineoplastic Agents; Cell Survival; Glutamate Dehydrogenase; Humans; IMP Dehydrogenase; L-Lactate Dehydrogenase; Malate Dehydrogenase; Nucleosides; Organoselenium Compounds; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured | 1994 |
Coordinated increase in activities of the signal transduction enzymes PI kinase and PIP kinase in human cancer cells.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Division; Depression, Chemical; Down-Regulation; Female; Humans; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Hairless; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Ovary; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Inbred ACI; Ribavirin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells.
Topics: Benzamidines; Cell Differentiation; Cell Division; Deoxyribonucleotides; DNA Replication; DNA, Neoplasm; Drug Synergism; Humans; IMP Dehydrogenase; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Ribavirin; Ribonucleotide Reductases; Ribonucleotides; Tumor Cells, Cultured | 1994 |
Biochemical consequences of resistance to tiazofurin in human myelogenous leukemic K562 cells.
Topics: Adenine Nucleotides; Antineoplastic Agents; Biological Transport; Carbon Radioisotopes; Deoxyribonucleotides; Drug Resistance; Drug Screening Assays, Antitumor; Guanine; Humans; IMP Dehydrogenase; Leukemia, Myeloid; Nicotinamide-Nucleotide Adenylyltransferase; Nucleic Acids; Phosphoric Diester Hydrolases; Phosphorylation; Purine Nucleotides; Ribavirin; Tumor Cells, Cultured | 1993 |
GM-CSF: modulation of biochemical and cytotoxic effects of tiazofurin in HL-60 cells.
Topics: Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Granulocyte-Macrophage Colony-Stimulating Factor; Guanosine Triphosphate; Humans; IMP Dehydrogenase; In Vitro Techniques; Leukemia, Promyelocytic, Acute; Ribavirin; Tumor Cells, Cultured | 1993 |
C-glycosyl bond conformation in oxazofurin: crystallographic and computational studies of the oxazole analogue of tiazofurin.
Topics: Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Crystallization; Crystallography, X-Ray; Electrochemistry; Glycosides; Glycosylation; Models, Molecular; Molecular Conformation; Oxazoles; Ribavirin; Ribose; Structure-Activity Relationship; Thermodynamics | 1994 |
Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Topics: Adenosine Diphosphate; Alcohol Dehydrogenase; Amino Acid Sequence; Animals; Antineoplastic Agents; Binding Sites; Crystallography, X-Ray; Horses; Ligands; Liver; Models, Molecular; Molecular Structure; Organoselenium Compounds; Protein Conformation; Ribavirin; Thiazoles | 1994 |
Tiazofurin decreases Ras-GTP complex in K562 cells.
Topics: Antimetabolites, Antineoplastic; Cell Differentiation; Guanosine; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oncogene Protein p21(ras); Protein Binding; Ribavirin; Tumor Cells, Cultured | 1993 |
Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells.
Topics: Antimetabolites, Antineoplastic; Catecholamines; Cell Differentiation; Cell Survival; Child, Preschool; Female; Humans; Infant; Male; Monophenol Monooxygenase; Neuroblastoma; Pteridines; Purines; Ribavirin; Tumor Cells, Cultured | 1993 |
Tiazofurin-induced changes in inositol lipid cycle in nuclei of Friend erythroleukemia cells.
Topics: Animals; Cell Differentiation; Cell Nucleus; Cytoplasm; Dimethyl Sulfoxide; Kinetics; Leukemia, Experimental; Mice; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Diester Hydrolases; Ribavirin; Tumor Cells, Cultured | 1993 |
Solid-state and solution conformations of isotiazofurin: crystallographic, computational and 1H NMR studies.
Topics: Antineoplastic Agents; Hydrogen Bonding; Isomerism; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Ribavirin; Ribonucleosides; Solutions; Thiazoles; X-Ray Diffraction | 1993 |
A database study of nonbonded intramolecular sulfur-nucleophile contacts.
Topics: Antineoplastic Agents; Databases, Factual; Models, Chemical; Molecular Structure; Nitrogen; Oxygen; Ribavirin; Sulfur; X-Ray Diffraction | 1993 |
Synergistic action of taxol and tiazofurin in human ovarian, pancreatic and lung carcinoma cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma; Carcinoma, Adenosquamous; Cell Division; Drug Screening Assays, Antitumor; Drug Synergism; Female; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Liver Neoplasms, Experimental; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Rats; Ribavirin; Spindle Apparatus; Tumor Cells, Cultured | 1993 |
Growth inhibitory action of brefeldin A with taxol and tiazofurin in human breast carcinoma cells.
Topics: Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Brefeldin A; Cell Division; Cyclopentanes; Drug Synergism; Humans; Macrolides; Paclitaxel; Ribavirin; Tumor Cells, Cultured | 1995 |
Purine deoxynucleoside metabolism in human melanoma cells with a high spontaneous mutation rate.
Topics: Alanine; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Survival; Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxyribonucleotides; HeLa Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Inosine; Magnetic Resonance Spectroscopy; Melanoma; Mutation; Ribavirin; Thioguanine; Tumor Cells, Cultured | 1996 |
Tiazofurine uptake by the isolated guinea pig heart.
Topics: Animals; Antineoplastic Agents; Guinea Pigs; Myocardium; Ribavirin | 1995 |
The antimetabolite Tiazofurin (TR) inhibits glycoconjugate biosynthesis and invasiveness of tumour cells.
Topics: Amino Acid Sequence; Animals; Antimetabolites, Antineoplastic; Cell Adhesion; Cell Movement; Dose-Response Relationship, Drug; Flow Cytometry; Glycoconjugates; Humans; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplasms; Ribavirin; Tumor Cells, Cultured | 1996 |
Metabolism and action of benzamide riboside in Chinese hamster ovary cells.
Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Drug Resistance; Enzyme Inhibitors; NAD; Nucleosides; Phosphorylation; Ribavirin | 1996 |
Inhibition of B16 melanoma cell proliferation and alterations in p21 ras expression induced by interceptors of signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lovastatin; Melanoma; Proto-Oncogene Proteins p21(ras); Ribavirin; Signal Transduction; Tumor Cells, Cultured | 1996 |
Tiazofurin enhances the anabolism and toxicity of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Fluorouracil; Leukemia L1210; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Phosphoribosyl Pyrophosphate; Ribavirin | 1996 |
IMP dehydrogenase inhibitor, tiazofurin, induces apoptosis in K562 human erythroleukemia cells.
Topics: Apoptosis; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; Guanosine Triphosphate; Humans; Hypoxanthine; IMP Dehydrogenase; Leukemia, Erythroblastic, Acute; Ribavirin; Tumor Cells, Cultured | 1997 |
Tiazofurin-induced autosecretion of IL-6 and hemoglobin production in K562 human leukemia cells.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Division; Hemoglobins; Humans; Interleukin-6; Leukemia; Ribavirin; Tumor Cells, Cultured | 1997 |
[Ribonucleoside-5'-monophosphates with disubstituted phosphate residue do not interact with human inosine monophosphate dehydrogenase].
Topics: Allosteric Regulation; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Inosine Monophosphate; Ribavirin; Substrate Specificity | 1997 |
Low nicotinamide mononucleotide adenylyltransferase activity in a tiazofurin-resistant cell line: effects on NAD metabolism and DNA repair.
Topics: Animals; Antineoplastic Agents; Carcinogens; Cell Division; Dacarbazine; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Leukemia L1210; Methylnitronitrosoguanidine; Mice; NAD; Nicotinamide-Nucleotide Adenylyltransferase; Ribavirin; Temozolomide | 1997 |
Regulation of the signal transduction program by drugs.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Genistein; Humans; IMP Dehydrogenase; Inositol 1,4,5-Trisphosphate; Neoplasms; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Quercetin; Rats; Ribavirin; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases | 1997 |
On the conformation of tiazofurin analogues.
Topics: Antimetabolites, Antineoplastic; Molecular Conformation; Ribavirin; Structure-Activity Relationship | 1997 |
Modulation of the in situ activity of tissue transglutaminase by calcium and GTP.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents; Calcium; Calcium Channel Agonists; Calpain; Carbachol; Diazomethane; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Ionomycin; Ionophores; Marine Toxins; Muscarinic Agonists; Oligopeptides; Oxocins; Receptors, Retinoic Acid; Retinoid X Receptors; Ribavirin; Thapsigargin; Transcription Factors; Transglutaminases; Tumor Cells, Cultured | 1998 |
Tissue transglutaminase is an in situ substrate of calpain: regulation of activity.
Topics: Antineoplastic Agents; Calcium; Calpain; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Proteinase Inhibitors; Diazomethane; Enzyme Inhibitors; Enzyme Precursors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Marine Toxins; Neuroblastoma; Oligopeptides; Oxocins; Ribavirin; Substrate Specificity; tau Proteins; Transglutaminases; Tumor Cells, Cultured | 1998 |
Synergistic action of tiazofurin and genistein in human ovarian carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma; Drug Screening Assays, Antitumor; Drug Synergism; Female; Genistein; Growth Inhibitors; Humans; Ovarian Neoplasms; Ribavirin; Tumor Cells, Cultured | 1998 |
Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Cell Differentiation; Cell Survival; Culture Media; Drug Synergism; Genistein; Humans; Leukemia; Ribavirin; Signal Transduction; Tumor Cells, Cultured | 1998 |
Tamoxifen downregulates signal transduction and is synergistic with tiazofurin in human breast carcinoma MDA-MB-435 cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Down-Regulation; Drug Synergism; Female; Humans; Inhibitory Concentration 50; Inositol 1,4,5-Trisphosphate; Ribavirin; Signal Transduction; Tamoxifen; Tumor Cells, Cultured | 1998 |
Lineage-related susceptibility of human hemopoietic cell lines to apoptosis.
Topics: Apoptosis; Camptothecin; Cell Line; Cold Temperature; DNA Fragmentation; Hematopoiesis; Hematopoietic System; Hot Temperature; Humans; Microscopy, Electron; Ribavirin; Staurosporine | 1999 |
The mechanism of 8-Cl-cAMP action.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Blood; Cell Division; Cell Survival; Culture Media; Dipyridamole; Enzyme Inhibitors; HeLa Cells; Humans; K562 Cells; Kinetics; Melanoma, Experimental; Mice; Ribavirin; Tumor Cells, Cultured | 1998 |
Synergistic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin in human ovarian carcinoma cells.
Topics: Antineoplastic Agents; Cell Cycle; Down-Regulation; Drug Synergism; Female; Humans; Inositol 1,4,5-Trisphosphate; Ovarian Neoplasms; Quercetin; Ribavirin; Signal Transduction; Tumor Cells, Cultured | 1999 |
Amplification of signal transduction capacity and down-regulation by drugs.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Differentiation; Cell Division; Colonic Neoplasms; Down-Regulation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Genistein; Humans; Inositol Phosphates; Liver Neoplasms, Experimental; Neoplasms; Ovarian Neoplasms; Phosphoric Monoester Hydrolases; Rats; Ribavirin; Signal Transduction; Tamoxifen; Tumor Cells, Cultured | 1999 |
Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase.
Topics: Adenosine Diphosphate; Animals; Cricetinae; Cricetulus; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Mutagenesis, Site-Directed; Mycophenolic Acid; NAD; Ribavirin; Spectrometry, Fluorescence; Tritrichomonas foetus; Tryptophan | 2000 |
Hematological toxicity associated with tiazofurin-influence on erythropoiesis.
Topics: Alopecia; Anemia; Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Blood Cells; Bone Marrow Cells; Cachexia; Cell Count; Coma; Dose-Response Relationship, Drug; Erythropoiesis; Hematocrit; Hemoglobins; Lung; Male; Rats; Rats, Wistar; Ribavirin; Spleen; Splenomegaly; Survival Rate | 2000 |
Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Furans; Glycosylation; Humans; IMP Dehydrogenase; Magnetic Resonance Spectroscopy; Molecular Conformation; Ribavirin; Ribonucleosides; Ribose; Structure-Activity Relationship; Thermodynamics; Thiophenes; Tumor Cells, Cultured | 2000 |
The kinetics of tiazofurin uptake by the isolated perfused choroid plexus of the sheep.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Choroid Plexus; Perfusion; Ribavirin; Sheep | 2000 |
Signal transduction and biochemical targeting of ovarian carcinoma.
Topics: Cell Survival; Drug Synergism; Female; Genistein; Humans; Ovarian Neoplasms; Quercetin; Ribavirin; Signal Transduction | 2000 |
A new synthetic methodology for tiazofurin.
Topics: Antineoplastic Agents; Chromatography, Thin Layer; Magnetic Resonance Spectroscopy; Ribavirin | 2000 |
C-nucleoside analogues of furanfurin as ligands to A1 adenosine receptors.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adipocytes; Animals; Antineoplastic Agents; Binding, Competitive; Blood Platelets; Brain; Cattle; Combinatorial Chemistry Techniques; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Membranes; Oxazoles; Protein Binding; Rats; Receptors, Purinergic P1; Ribavirin; Ribonucleosides; Ribose; Structure-Activity Relationship | 2000 |
8-Cl-cAMP and tiazofurin affect vascular endothelial growth factor production and glial fibrillary acidic protein expression in human glioblastoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Differentiation; Cell Division; Endothelial Growth Factors; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Lymphokines; Ribavirin; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).
Topics: Antineoplastic Agents; Cell Division; Humans; Imidazoles; IMP Dehydrogenase; K562 Cells; Monosaccharides; Ribavirin | 2001 |
Tumor cell-specific inhibition of inducible nitric oxide synthase activation by tiazofurin.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Interferon Regulatory Factor-1; Interferon-gamma; Lipopolysaccharides; Mice; Neoplasms; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphoproteins; Ribavirin; RNA, Messenger | 2001 |
Sir Hans A. Krebs Centenary Lecture: cancer and clinical targeting.
Topics: Animals; Antineoplastic Agents; Apoptosis; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Down-Regulation; Guanosine Triphosphate; History, 20th Century; Humans; Ischemia; Kidney Neoplasms; Leukemia; Models, Biological; Neoplasms; Ribavirin; Signal Transduction; Time Factors; Tumor Cells, Cultured | 2001 |
Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
Topics: Amino Acid Sequence; Antineoplastic Agents; Binding Sites; Biotransformation; Catalysis; Humans; Models, Molecular; Molecular Sequence Data; Nicotinamide-Nucleotide Adenylyltransferase; Protein Conformation; Ribavirin; Sequence Homology, Amino Acid; Substrate Specificity | 2002 |
The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.
Topics: Antineoplastic Agents; Cell Survival; Humans; IMP Dehydrogenase; NAD; Niacinamide; Organoselenium Compounds; Pyridinium Compounds; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured | 2002 |
Studies on the mechanism of action of benzamide riboside: a novel inhibitor of IMP dehydrogenase.
Topics: Antineoplastic Agents; Cell Survival; Central Nervous System Neoplasms; Humans; IMP Dehydrogenase; Isoenzymes; Nucleosides; Organoselenium Compounds; Ribavirin; Ribonucleosides; Sarcoma; Tumor Cells, Cultured | 2002 |
Down-regulation of experimental allergic encephalomyelitis in DA rats by tiazofurin.
Topics: Animals; Cell Adhesion; Cell Division; Central Nervous System; Dose-Response Relationship, Drug; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Female; Immune System; Immunosuppressive Agents; Male; Multiple Sclerosis; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Myelitis; Rats; Rats, Inbred Strains; Ribavirin; T-Lymphocytes | 2002 |
Simultaneous LC determination of tiazofurin, its acetyl and benzoyl esters and their active metabolite thiazole-4-carboxamide adenine dinucleotide in biological samples.
Topics: Adenine Nucleotides; Animals; Chromatography, High Pressure Liquid; Esters; Rats; Ribavirin; Tumor Cells, Cultured | 2002 |
Cytotoxicity and cellular differentiation activity of methylenebis(phosphonate) analogs of tiazofurin and mycophenolic acid adenine dinucleotide in human cancer cell lines.
Topics: Adenine Nucleotides; Antineoplastic Agents; Cell Differentiation; Diphosphonates; Dose-Response Relationship, Drug; HT29 Cells; Humans; K562 Cells; Mycophenolic Acid; Ribavirin | 2002 |
Cytoprotective features of selenazofurin in hematopoietic cells.
Topics: Antineoplastic Agents; Cell Death; Cell Line; Cell Survival; Chlorambucil; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Monocytic, Acute; Methylnitronitrosoguanidine; Organoselenium Compounds; Ribavirin; Ribonucleosides | 2002 |
Combination therapy in childhood leukaemia: in vitro studies of thiopurines and inhibitors of purine metabolism on apoptosis.
Topics: Annexin A5; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Survival; Child; Coloring Agents; Humans; Leukemia; Mercaptopurine; Methotrexate; Models, Biological; Purines; Ribavirin; Thioguanine; Time Factors; Tumor Cells, Cultured | 2003 |
The linkage of glucose to tiazofurin decreases in vitro uptake into rat glioma C6 cells.
Topics: Animals; Antimetabolites, Antineoplastic; Binding, Competitive; Cell Membrane; Chromatography, High Pressure Liquid; Deoxyglucose; Dipyridamole; Glioma; Glucose; Kinetics; Rats; Ribavirin; Tumor Cells, Cultured | 2002 |
Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents.
Topics: Animals; Cattle; Cell Line; Computer Systems; Culture Media, Conditioned; Diarrhea Viruses, Bovine Viral; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanosine Triphosphate; IMP Dehydrogenase; Kidney; Molecular Structure; Mycophenolic Acid; NAD; Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; Ribonucleosides; Viral Plaque Assay; Virus Replication | 2002 |
In vitro sensitivity of hematopoietic progenitors to tiazofurin in refractory acute myeloid leukemia and in the blast crisis of chronic myeloid leukemia.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Blast Crisis; Blood Cells; Bone Marrow Cells; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Hematopoietic Stem Cells; Humans; Inhibitory Concentration 50; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Male; Middle Aged; Neoplastic Stem Cells; Ribavirin; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2003 |
De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties.
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Glucose; Humans; Ribavirin | 2003 |
HPLC determination of tiazofurin in the rat brain.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Male; Rats; Rats, Wistar; Ribavirin | 2003 |
Synthesis of 2-(3'-azido- and 3'-amino-3'-deoxy-beta-D-ribofuranosyl)thiazole-4-carboxamide.
Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Nucleosides; Ribavirin | 2003 |
Erythrocytotoxicity of tiazofurin in vivo and in vitro detected by scanning probe microscopy.
Topics: Animals; Antimetabolites, Antineoplastic; Catalase; Erythrocyte Count; Erythrocytes; Flow Cytometry; Glutathione Peroxidase; Male; Microscopy, Scanning Probe; Rats; Reticulocytes; Ribavirin; Thiobarbituric Acid Reactive Substances | 2004 |
The effects of tiazofurin on basal and amphetamine-induced motor activity in rats.
Topics: Amphetamine; Animals; Dose-Response Relationship, Drug; Male; Motor Activity; Rats; Rats, Wistar; Ribavirin | 2004 |
A simple assay for determining antiviral activity against Crimean-Congo hemorrhagic fever virus.
Topics: Animals; Antiviral Agents; Azauridine; Cell Line; Chlorocebus aethiops; Coloring Agents; Cricetinae; Fibroblasts; Hemorrhagic Fever Virus, Crimean-Congo; Humans; Microbial Sensitivity Tests; Neutral Red; Organoselenium Compounds; Ribavirin; Ribonucleosides; Staining and Labeling; Vero Cells; Viral Plaque Assay; Virus Replication | 2004 |
Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction.
Topics: Adenosine Diphosphate; Alanine; Amino Acid Substitution; Animals; Arginine; Binding Sites; Cattle; Conserved Sequence; Deuterium Exchange Measurement; Enzyme Inhibitors; Hydrolysis; IMP Dehydrogenase; Kinetics; Mutagenesis, Site-Directed; Mycophenolic Acid; Phenylalanine; Point Mutation; Protein Binding; Ribavirin; Ribonucleosides; Ribonucleotides; Solvents; Substrate Specificity; Tritrichomonas foetus; Tyrosine; Xanthine | 2004 |
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.
Topics: Chromosomes, Human, Pair 9; Energy Metabolism; Evolution, Molecular; Fungi; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; NAD; Niacinamide; Nucleosides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Ribavirin; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 2004 |
Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cryptosporidium parvum; Dose-Response Relationship, Drug; Drug Design; Escherichia coli; Gene Transfer Techniques; Genetic Complementation Test; Humans; IMP Dehydrogenase; Kinetics; Models, Biological; Models, Chemical; Molecular Sequence Data; Mycophenolic Acid; Phylogeny; Protein Conformation; Recombinant Proteins; Ribavirin; Sequence Homology, Amino Acid; Time Factors | 2004 |
Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia. Part I. In vivo studies.
Topics: Adult; Aged; Antineoplastic Agents; Enzyme Inhibitors; Female; Genes, abl; Humans; IMP Dehydrogenase; Leukemia, Myeloid, Acute; Male; Middle Aged; Ribavirin; Treatment Outcome | 2004 |
Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia. Part II. In vitro studies.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; IMP Dehydrogenase; In Vitro Techniques; K562 Cells; Ribavirin; RNA, Messenger | 2004 |
Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside.
Topics: Animals; Biological Transport; Cell Survival; Female; Humans; IMP Dehydrogenase; Membrane Transport Proteins; Nucleosides; Oocytes; Protein Isoforms; Recombinant Proteins; Ribavirin; Saccharomyces cerevisiae; Uridine; Xenopus laevis | 2005 |
Differentiation of human prostate cancer PC-3 cells induced by inhibitors of inosine 5'-monophosphate dehydrogenase.
Topics: Amino Acid Sequence; Antibiotics, Antineoplastic; Cell Differentiation; Cell Division; Cell Line, Tumor; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Male; Molecular Sequence Data; Mycophenolic Acid; Prostatic Neoplasms; Ribavirin; Vacuoles | 2004 |
Inhibition of B16 mouse melanoma cell growth and induction of apoptotic cell death with 8-chloroadenosine-3',5'-monophosphate and tiazofurin.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Apoptosis; Base Sequence; Cell Division; Cell Line, Tumor; DNA Primers; Melanoma, Experimental; Mice; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin | 2004 |
Synergistic action of resveratrol, an ingredient of wine, with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Differentiation; Cytarabine; Deoxyribonucleotides; DNA; Drug Synergism; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Resveratrol; Ribavirin; Ribonucleotide Reductases; Stilbenes | 2005 |
[Application of tiazofurin in the study of regulation of AMP deaminase in intact malignant cells].
Topics: AMP Deaminase; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Guanosine; Guanosine Triphosphate; Liver Neoplasms, Experimental; Mice; Rats; Rats, Sprague-Dawley; Ribavirin; Tumor Cells, Cultured | 2002 |
Combination of nucleoside analogues tiazofurin and ribavirin downregulates experimental autoimmune encephalomyelitis.
Topics: Animals; Down-Regulation; Drug Combinations; Encephalomyelitis, Autoimmune, Experimental; Freund's Adjuvant; Humans; Multiple Sclerosis; Rats; Ribavirin; Spinal Cord; Time Factors | 2005 |
Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides.
Topics: Heterocyclic Compounds; Molecular Structure; Peptides, Cyclic; Ribavirin | 2005 |
Zinc(II) triflate-controlled 1,3-dipolar cycloadditions of C-(2-thiazolyl)nitrones: application to the synthesis of a novel isoxazolidinyl analogue of tiazofurin.
Topics: Alkenes; Azo Compounds; Circular Dichroism; Magnetic Resonance Spectroscopy; Molecular Structure; Nitrogen Oxides; Oxidation-Reduction; Propanols; Ribavirin; Stereoisomerism; Zinc Compounds | 2005 |
Synthesis of 3'-deoxy-3'-C-hydroxymethyl analogues of tiazofurin and ribavirin.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Furans; Models, Chemical; Molecular Biology; Nucleic Acid Conformation; Nucleosides; Ribavirin; Xylose | 2005 |
Synthesis and antiproliferative activity of two new tiazofurin analogues with 2'-amido functionalities.
Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Ribavirin | 2006 |
Synthesis and biological activity of some new 5'-O-acyl tiazofurin derivatives.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Cell Survival; Chemical Phenomena; Chemistry, Physical; DNA, Neoplasm; Drug Screening Assays, Antitumor; Humans; In Situ Nick-End Labeling; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Ribavirin; Spectrophotometry, Infrared; Structure-Activity Relationship | 2006 |
Metabolic regulation and chemotherapy.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Guanosine Monophosphate; Homeostasis; Humans; Neoplasms; Ribavirin | 2006 |
2-(3-Amino-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide: a new tiazofurin analogue with potent antitumour activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HeLa Cells; Humans; In Vitro Techniques; Molecular Conformation; Ribavirin; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2006 |
Resveratrol, an ingredient of wine, acts synergistically with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Cytarabine; Drug Screening Assays, Antitumor; Drug Synergism; Free Radical Scavengers; Free Radicals; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Resveratrol; Ribavirin; Stilbenes | 2006 |
Antiviral activity of tiazofurin and mycophenolic acid against Grapevine leafroll-associated virus 3 in Vitis vinifera explants.
Topics: Closteroviridae; Enzyme-Linked Immunosorbent Assay; Mycophenolic Acid; Plant Diseases; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; RNA Viruses; Vitis | 2007 |
Synthesis and antitumour activity of new tiazofurin analogues bearing a 2,3-anhydro functionality in the furanose ring.
Topics: Antineoplastic Agents; Furans; IMP Dehydrogenase; Ribavirin | 2007 |
Crystal structure of human nicotinamide riboside kinase.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Antineoplastic Agents; Binding Sites; Catalysis; Crystallography, X-Ray; Escherichia coli; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Mutation; Nicotinamide Mononucleotide; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Structure, Secondary; Ribavirin; Sequence Homology, Amino Acid; Substrate Specificity | 2007 |
Ribavirin reveals a lethal threshold of allowable mutation frequency for Hantaan virus.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Dose-Response Relationship, Drug; Gene Frequency; Genome, Viral; Guanosine Triphosphate; Hantaan virus; Mutation; Mycophenolic Acid; Organoselenium Compounds; Ribavirin; Ribonucleosides; RNA, Viral; Vero Cells | 2007 |
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
Topics: Adenosine Monophosphate; Antineoplastic Agents; Diphosphonates; Drug Screening Assays, Antitumor; Humans; IMP Dehydrogenase; Isoenzymes; K562 Cells; Models, Molecular; Mycophenolic Acid; NAD; Protein Binding; Ribavirin | 2007 |
Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: clinical and histopathological evaluation.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Central Nervous System; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Gliosis; Immunosuppression Therapy; Male; Multiple Sclerosis; Myelin Sheath; Rats; Ribavirin; Treatment Outcome; Wallerian Degeneration | 2008 |
Ribavirin targets eIF4E dependent Akt survival signaling.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Apoptosis; Biological Transport; Cell Cycle Proteins; Cell Line, Tumor; Eukaryotic Initiation Factor-4E; Humans; Mice; Nuclear Proteins; Proto-Oncogene Proteins c-akt; Regulon; Ribavirin; RNA, Messenger | 2008 |
Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.
Topics: Adenosine; Binding Sites; Disulfides; Humans; Models, Molecular; Molecular Conformation; Mycobacterium tuberculosis; NAD; Phosphotransferases (Alcohol Group Acceptor); Ribavirin | 2009 |
Synthesis of novel aza-analogues of tiazofurin with 2-[5,5-bis(hydroxymethyl)pyrrolidin-2-yl] framework as sugar mimic.
Topics: Animals; Antiviral Agents; Aza Compounds; Carbohydrates; Chlorocebus aethiops; Cysteine; DNA Viruses; Fibroblasts; HeLa Cells; Humans; Molecular Mimicry; Pyrrolidines; Ribavirin; RNA Viruses; Vero Cells | 2012 |
Synthesis and in vitro antitumour screening of 2-(β-D-xylofuranosyl)thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol moiety as a sugar mimic.
Topics: Antineoplastic Agents; Carbohydrates; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Humans; Inhibitory Concentration 50; Molecular Mimicry; Molecular Structure; Nucleosides; Ribavirin; Thiazoles; Xylose | 2012 |
Nicotinamide mononucleotide adenylyltransferase2 overexpression enhances colorectal cancer cell-kill by Tiazofurin.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Drug Carriers; Drug Resistance, Neoplasm; Fluoresceins; Folic Acid Transporters; Gene Expression; Gene Knockdown Techniques; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Isoenzymes; Nanoparticles; Nicotinamide-Nucleotide Adenylyltransferase; Protein Transport; Ribavirin; RNA, Small Interfering; Transfection | 2013 |
In vivo inhibition of trans-plasma membrane electron transport by antiviral drugs in grapevine.
Topics: Antiviral Agents; Electron Transport; Enzyme Activation; Membrane Potentials; Membrane Transport Proteins; Oseltamivir; Oxidation-Reduction; Oxidoreductases; Plant Proteins; Ribavirin; Vitis | 2013 |
A putative role for inosine 5' monophosphate dehydrogenase (IMPDH) in Leishmania amazonensis programmed cell death.
Topics: Animals; Apoptosis; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heat-Shock Response; IMP Dehydrogenase; Leishmania mexicana; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mycophenolic Acid; Nucleosides; Purine Nucleotides; Ribavirin; RNA, Protozoan | 2015 |
Synthesis and in vitro antitumour activity of tiazofurin analogues with nitrogen functionalities at the C-2' position.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Ribavirin; Structure-Activity Relationship | 2016 |
Autophagy suppression sensitizes glioma cells to IMP dehydrogenase inhibition-induced apoptotic death.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Enzyme Inhibitors; Glioma; Humans; IMP Dehydrogenase; Phosphorylation; Proto-Oncogene Proteins c-akt; Ribavirin; RNA Interference; Signal Transduction | 2017 |
Structure based design, synthesis and in vitro antitumour activity of tiazofurin stereoisomers with nitrogen functions at the C-2' or C-3' positions.
Topics: Antineoplastic Agents; Cell Survival; Drug Design; Humans; K562 Cells; Nitrogen; Ribavirin; Stereoisomerism; Structure-Activity Relationship | 2019 |
Broad-band luminescence involving fluconazole antifungal drug in a lead-free bismuth iodide perovskite: Combined experimental and computational insights.
Topics: Antifungal Agents; Bismuth; Calcium Compounds; Crystallography, X-Ray; Density Functional Theory; Fluconazole; Iodides; Lead; Luminescence; Models, Molecular; Molecular Conformation; Oxides; Powders; Ribavirin; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Titanium; Vibration; X-Ray Diffraction | 2020 |