Page last updated: 2024-08-16

ribavirin and mycophenolic acid

ribavirin has been researched along with mycophenolic acid in 102 studies

Research

Studies (102)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (10.78)	18.7374
1990's	12 (11.76)	18.2507
2000's	39 (38.24)	29.6817
2010's	33 (32.35)	24.3611
2020's	7 (6.86)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Ferguson, DM; Forshey, BM; Goodell, JR; Puig-Basagoiti, F; Shi, PY	1
Chu, YK; Chung, DH; Jonsson, CB; Parker, WB; Sun, Y	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E	1
Boido, V; Collu, G; Fermeglia, M; Ibba, C; La Colla, P; Loddo, R; Paneni, MS; Posocco, P; Pricl, S; Secci, B; Sparatore, F; Tasso, B; Tonelli, M; Vazzana, I	1
Gahan, ME; Keller, PA; Mahalingam, S; Stevens, AJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Blois, S; Boido, V; Giliberti, G; Ibba, C; La Colla, P; Loddo, R; Novelli, F; Paglietti, G; Pricl, S; Sanna, G; Simone, M; Sparatore, F; Tasso, B; Tonelli, M	1
Gao, RM; Li, SY; Li, YH; Li, ZR; Peng, ZG; Shan, GZ; Wu, LT; Zhang, DJ; Zhong, ZJ; Zuo, LM	1
Keller, PA; Mahalingam, S; Rashad, AA	1
Boido, V; Busonera, B; Farci, P; Giliberti, G; Ibba, C; La Colla, P; Loddo, R; Novelli, F; Sanna, G; Sparatore, A; Sparatore, F; Tasso, B; Tonelli, M; Vazzana, I	1
Atzori, EM; Biava, M; Collu, G; Delogu, I; Desideri, N; Droghini, P; Fioravanti, R; Ibba, C; Loddo, R; Sanna, G	1
Boido, V; Collu, G; Delogu, I; Giliberti, G; La Colla, P; Loddo, R; Novelli, F; Sparatore, A; Sparatore, F; Tasso, B; Tonelli, M	1
Behnam, MA; Boldescu, V; Klein, CD; Nitsche, C	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Atzori, EM; Briguglio, I; Carta, A; Collu, G; Corona, P; Delogu, I; Desideri, N; Fermeglia, M; Ibba, R; La Colla, P; Laurini, E; Loddo, R; Piras, S; Pricl, S	1
Kumarasamy, D; Maity, S; Mookerjee, M; Naesens, L; Nanjappan, S; Neyts, J; Rocha-Pereira, J; Roy, BG	1
Cichero, E; Costi, MP; Gazzarrini, S; Loddo, R; Moroni, A; Naesens, L; Santucci, M; Tasso, B; Tonelli, M	1
Aquino, TM; Araújo-Júnior, JX; da Silva-Júnior, EF; Leoncini, GO; Rodrigues, ÉES	1
Atzori, EM; Carta, A; Collu, G; Delogu, I; Desideri, N; Fioravanti, R; Loddo, R	1
Andrei, G; Pertusati, F; Pileggi, E; Schols, D; Serpi, M; Snoeck, R	1
Agard, DA; Ashworth, A; Barrio-Hernandez, I; Batra, J; Beltrao, P; Bennett, MJ; Bohn, M; Bouhaddou, M; Braberg, H; Broadhurst, DJ; Cai, Y; Cakir, M; Calviello, L; Cavero, DA; Chang, JCJ; Chorba, JS; Craik, CS; d'Enfert, C; Dai, SA; Eckhardt, M; Emerman, M; Fabius, JM; Fletcher, SJ; Floor, SN; Foussard, H; Frankel, AD; Fraser, JS; Fujimori, DG; Ganesan, SJ; García-Sastre, A; Gordon, DE; Gross, JD; Guo, JZ; Haas, K; Haas, P; Hernandez-Armenta, C; Hiatt, J; Huang, XP; Hubert, M; Hüttenhain, R; Ideker, T; Jacobson, M; Jang, GM; Jura, N; Kaake, RM; Kim, M; Kirby, IT; Klippsten, S; Koh, C; Kortemme, T; Krogan, NJ; Kuzuoglu-Ozturk, D; Li, Q; Liboy-Lugo, J; Lin, Y; Liu, X; Liu, Y; Lou, K; Lyu, J; Mac Kain, A; Malik, HS; Mathy, CJP; McGregor, MJ; Melnyk, JE; Memon, D; Meyer, B; Miorin, L; Modak, M; Moreno, E; Mukherjee, S; Naing, ZZC; Noack, J; O'Meara, MJ; O'Neal, MC; Obernier, K; Ott, M; Peng, S; Perica, T; Pilla, KB; Polacco, BJ; Rakesh, R; Rathore, U; Rezelj, VV; Richards, AL; Roesch, F; Rosenberg, OS; Rosenthal, SB; Roth, BL; Roth, TL; Ruggero, D; Safari, M; Sali, A; Saltzberg, DJ; Savar, NS; Schwartz, O; Sharp, PP; Shen, W; Shengjuler, D; Shi, Y; Shoichet, BK; Shokat, KM; Soucheray, M; Stroud, RM; Subramanian, A; Swaney, DL; Taunton, J; Tran, QD; Trenker, R; Tummino, TA; Tutuncuoglu, B; Ugur, FS; Vallet, T; Venkataramanan, S; Verba, KA; Verdin, E; Vignuzzi, M; von Zastrow, M; Wang, HY; Wankowicz, SA; Wenzell, NA; White, KM; Xu, J; Young, JM; Zhang, Z; Zhou, Y	1
Chen, J; Chen, W; Choudhry, N; Xu, D; Yang, Z; Zanin, M; Zhao, X	1
Johnson, GS; Mukku, VR	1
Brox, L; Henderson, JF; Lowe, JK	1
Harada, T; Hatakeyama, K; Kagamiyama, H	1
Albukrek, D; Fux, A; Hadar, T; Nordenberg, J; Novogrodsky, A; Sidi, Y; Wasserman, L	1
Scheidel, LM; Stollar, V	1
Collart, FR; Henning-Chubb, C; Huberman, E; Kiguchi, K	2
Ahluwalia, G; Bondoc, LL; Cooney, DA; Currens, MJ; Ford, H; Fridland, A; Johns, DG; Mitsuya, H	1
Connor, JD; Lemas, V; Page, T; Yu, AL; Yu, J	1
Beery, E; Nordenberg, J; Novogrodsky, A; Panet, C; Sidi, Y; Wasserman, L	1
Lee, HJ; Nguyen, BT; Pawlak, K; Robins, RK; Sadée, W	1
Sartorelli, AC; Sokoloski, JA	1
Blair, OC; Sartorelli, AC; Sokoloski, JA	1
Durbin, RK; Scheidel, LM; Stollar, V	1
Kerr, SJ	1
Herrmann, B; Kaiser, WA; Keppler, DO	1
Malinoski, F; Stollar, V	1
Collart, F; Glesne, D; Huberman, E	1
Balzarini, J; Bohman, C; De Clercq, E; Fridland, A; Herdewijn, P; Horská, K; Karlsson, A; Van Aerschot, A; Votruba, I; Wang, L	1
Liao, HJ; Stollar, V	1
Andrei, G; De Clercq, E; Neyts, J	1
Rosenblum, CI; Stollar, V	1
Franchetti, P; Grifantini, M	1
Digits, JA; Hedstrom, L	1
De Clercq, E; Neyts, J; Ying, C	1
Beames, B; Brasky, KM; Chavez, D; Guerra, B; Hong, Z; Lanford, RE; Lau, JY	1
Bray, M; Huggins, JW; Smee, DF	1
Morrey, JD; Sidwell, RW; Smee, DF; Tseng, C	1
Jayaram, HN; Pankiewicz, K; Patterson, SE; Yalowitz, JA	1
Luecke, H; Prosise, GL	1
Yamaoka, T	1
Clark, JL; Lostia, S; Otto, MJ; Pankiewicz, KW; Patterson, SE; Stuyver, LJ; Watanabe, KA	1
Baroudy, BM; Liu, R; Malcolm, BA; Reyes, GR; Zhou, S	1
Airaksinen, A; Domingo, E; Menéndez-Arias, L; Pariente, N	1
Guillén Schlippe, YV; Hedstrom, L; Riera, TV; Seyedsayamdost, MR	1
Black, PL; Goldstein, BM; Jayaram, HN; Pankiewicz, KW; Patterson, SE; Risal, D; Schinazi, RF; Stuyver, LJ	1
Carroll, KL; Illichmann, M; Stangl, JR; Striker, R	1
Hedstrom, L; Li, C; Riera, T; Striepen, B; Umejiego, NN	1
Coombs, KM; Hermann, LL; Robertson, CM	1
Borroto-Esoda, K; Feng, J; Furman, P; Jeffrey, J; Myrick, F	1
Floryk, D; Giometti, CS; Huberman, E; Tollaksen, SL	1
Ascher, NA; Bollinger, K; Khalili, M; Roberts, JP; Shergill, AK; Straley, S; Terrault, NA	1
Balzarini, J; De Clercq, E; Leyssen, P; Neyts, J	1
Bernstein, DE; Brown, RS; Herrine, SK; Lentz, E; Ondovik, MS; Te, H	1
Hodo, Y; Honda, M; Kaneko, S; Mizukoshi, E; Nakamoto, Y; Sakai, A; Tsuji, K; Yamashita, T	1
Chang, J; Gudima, S; Nie, X; Taylor, J	1
Bailey, K; Barnard, DL; Carson, DA; Cottam, HB; Day, CW; Heiner, M; Hoopes, J; Lauridsen, L; Lee, J; Li, JK; Montgomery, R; Sidwell, RW; Winslow, S	1
Cameron, CE; Houng, HS; Padmanabhan, R; Takhampunya, R; Ubol, S	1
Colonno, R; De Clercq, E; Neyts, J; Ying, C	1
D'Anna, F; Panattoni, A; Triolo, E	1
Arterburn, JB; Bartolucci, A; Chung, DH; Jonsson, CB; Parker, WB; Sun, Y	1
Bennett, EM; Bonnac, L; Chen, L; Felczak, K; Gao, G; Hedstrom, L; Jayaram, HN; Pankiewicz, KW; Patterson, SE; Wilson, D	1
Alobeid, B; Gaglio, PJ; Mears, JG; Schecter, JM	1
Casassus-Buihle, D; Chauveau, E; Fraudin, A; Oddes, B; Reffet, A; Terrier, F	1
Pockros, PJ; Shields, WW	1
Colucci, G; Grandaliano, G; Manno, C; Schena, FP	1
Günther, S; Neyts, J; Ölschläger, S	1
Desai, A; Madhusudana, SN; Ravi, V; Sebastian, L; Sriram, D; Yogeeswari, P	1
Bahra, M; Boas-Knoop, S; Eurich, D; Kiessling, A; Neuhaus, P; Neuhaus, R; Neumann, UP; Puhl, G; Trautwein, C; Wasmuth, H; Yahyazadeh, A	1
Domingo, E; Esteban, JI; Grande-Pérez, A; Gregori, J; Ortega-Prieto, AM; Perales, C; Quer, J; Sheldon, J; Tejero, H	1
Chan, JF; Chan, KH; Chen, H; Dai, J; Hayden, FG; Kao, RY; Li, CP; Li, PT; Mok, FK; To, KK; Yuen, KY; Zheng, BJ	1
Aboge, GO; Cao, S; Igarashi, I; Kamyingkird, K; Masatani, T; Moumouni, PF; Nishikawa, Y; Suzuki, H; Terkawi, MA; Xuan, X; Zhou, M	1
Chen, K; Debing, Y; Janssen, HL; Metselaar, HJ; Neyts, J; Pan, Q; Peppelenbosch, MP; Van Der Laan, LJ; Wang, Y; Zhou, X	1
Hui, DS; Memish, ZA; Zumla, A	1
Broekman, M; Drenth, JP; Gluud, C; Lamers, MH	1
Moreira, ME; Pitaluga, AN; Traub-Csekö, YM	1
Egawa, H; Hashimoto, E; Kogiso, T; Kotera, Y; Omori, A; Shiratori, K; Taniai, M; Tokushige, K; Yamamoto, M	1
Felczak, K; Metselaar, HJ; Pan, Q; Pankiewicz, KW; Peppelenbosch, MP; Raat, NJ; Shokrollahi, E; Sprengers, D; van der Laan, LJ; Wang, W; Wang, Y; Xu, L; Zhou, X	1
Gorard, D; Rait, S; Shahid, S; Sharples, E	1
Chang, KO; Dang, W; Felczak, K; Koopmans, MPG; Metselaar, HJ; Pan, Q; Pankiewicz, KW; Peppelenbosch, MP; Sprengers, D; Su, J; van der Laan, LJW; Wang, W; Wang, Y; Yin, Y	1
Feld, JJ; Jacobson, I; Pawlotsky, JM; Poordad, F; Sulkowski, M; Tatsch, F	1
Cai, X; Chang, QY; Guo, FC; Li, XR; Ma, XX; Pan, Q; Zhou, JH	1
Hirai, K; Kawano, M; Kihira-Nakanishi, S; Komada, H; Nishio, M; O'Brien, M; Sakai-Sugino, K; Tsurudome, M; Uematsu, J; Yamamoto, H	1
Li, Y; Miao, Z; Pan, Q; Peppelenbosch, MP; Wang, Y; Yu, P	1
Chen, S; de Ruiter, PE; Li, P; Pan, Q; Peppelenbosch, MP; van der Laan, LJW; Verstegen, MMA; Wang, Y; Yin, Y	1
de Man, RA; Kainov, DE; Li, P; Li, Y; Ma, Z; Pan, Q; Peppelenbosch, MP; Yu, P; Zhang, R	1
Hall, WW; Nobori, H; Orba, Y; Sanaki, T; Sato, A; Sawa, H; Shishido, T; Toba, S; Uemura, K	1
Biswas, A; Fiches, GN; Kenney, AD; Li, TW; Liu, H; Martinez-Sobrido, L; Park, JG; Que, J; Santoso, N; Yount, JS; Zhao, W; Zhou, D; Zhu, J	1

Reviews

11 review(s) available for ribavirin and mycophenolic acid

Article	Year
The medicinal chemistry of dengue fever. Journal of medicinal chemistry, 2009, Dec-24, Volume: 52, Issue:24 Topics: Antiviral Agents; Dengue; Dengue Virus; Humans; Models, Molecular; Viral Proteins	2009
The Medicinal Chemistry of Dengue Virus. Journal of medicinal chemistry, 2016, 06-23, Volume: 59, Issue:12 Topics: Antiviral Agents; Chemistry, Pharmaceutical; Dengue; Dengue Virus; Humans; Molecular Conformation; Structure-Activity Relationship	2016
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The medicinal chemistry of Chikungunya virus. Bioorganic & medicinal chemistry, 2017, 08-15, Volume: 25, Issue:16 Topics: Animals; Antiviral Agents; Biological Products; Chemistry, Pharmaceutical; Chikungunya Fever; Chikungunya virus; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship	2017
Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Journal of medicinal chemistry, 2020, 11-25, Volume: 63, Issue:22 Topics: Antiviral Agents; China; Coronavirus Protease Inhibitors; COVID-19; COVID-19 Drug Treatment; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; SARS-CoV-2; Small Molecule Libraries	2020
Regulation and role of inosine-5'-monophosphate dehydrogenase in cell replication, malignant transformation, and differentiation. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Animals; Bacteria; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Neoplastic; Conserved Sequence; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; IMP Dehydrogenase; Isoenzymes; Mycophenolic Acid; Ribavirin; Sequence Homology, Amino Acid; Tumor Cells, Cultured	1994
Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents. Current medicinal chemistry, 1999, Volume: 6, Issue:7 Topics: Antineoplastic Agents; Antiviral Agents; Humans; IMP Dehydrogenase; Inhibitory Concentration 50; K562 Cells; Mycophenolic Acid; Nucleosides; Organoselenium Compounds; Oxazoles; Ribavirin; Ribonucleosides; Ribose; Tumor Cells, Cultured	1999
[IMP dehydrogenase]. Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1 Topics: Animals; Antineoplastic Agents; Antiviral Agents; Feedback, Physiological; Genes, Dominant; Guanosine Monophosphate; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Mycophenolic Acid; Pigment Epithelium of Eye; Protein Conformation; Protein Structure, Tertiary; Purine Nucleotides; Retinal Degeneration; Ribavirin; Ribonucleosides	2003
Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target. Current medicinal chemistry, 2004, Volume: 11, Issue:7 Topics: Catalysis; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Molecular Mimicry; Molecular Structure; Mycophenolic Acid; NAD; Ribavirin; Ribonucleosides	2004
Severe acute respiratory syndrome vs. the Middle East respiratory syndrome. Current opinion in pulmonary medicine, 2014, Volume: 20, Issue:3 Topics: Age Distribution; Animals; Antiviral Agents; Camelus; Chiroptera; Coronavirus; Coronavirus Infections; Cross Infection; Diagnosis, Differential; Disease Progression; Female; Humans; Immunity, Innate; Infectious Disease Incubation Period; Interferons; Lung; Male; Middle East; Mycophenolic Acid; Public Health; Radiography; Real-Time Polymerase Chain Reaction; Ribavirin; Severe Acute Respiratory Syndrome; Sex Distribution; Viral Load	2014
Aminoadamantanes versus other antiviral drugs for chronic hepatitis C. The Cochrane database of systematic reviews, 2014, Jun-17, Issue:6 Topics: Amantadine; Antiviral Agents; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferon-gamma; Mycophenolic Acid; Randomized Controlled Trials as Topic; Ribavirin	2014

Trials

2 trial(s) available for ribavirin and mycophenolic acid

Article	Year
Applicability, tolerability and efficacy of preemptive antiviral therapy in hepatitis C-infected patients undergoing liver transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, Volume: 5, Issue:1 Topics: Adult; Aged; Antiviral Agents; Biopsy; Erythropoietin; Female; Granulocyte Colony-Stimulating Factor; Growth Substances; Hepatitis C; Humans; Immunocompromised Host; Immunosuppressive Agents; Interferon alpha-2; Interferon-alpha; Interferons; Liver; Liver Diseases; Liver Transplantation; Male; Middle Aged; Mycophenolic Acid; Polyethylene Glycols; Prednisone; Recombinant Proteins; Ribavirin; Tacrolimus; Time Factors	2005
Peginterferon alpha-2a combination therapies in chronic hepatitis C patients who relapsed after or had a viral breakthrough on therapy with standard interferon alpha-2b plus ribavirin: a pilot study of efficacy and safety. Digestive diseases and sciences, 2005, Volume: 50, Issue:4 Topics: Alanine Transaminase; Amantadine; Antiviral Agents; Drug Therapy, Combination; Female; Genotype; Hemoglobins; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Mycophenolic Acid; Pilot Projects; Polyethylene Glycols; Recombinant Proteins; Recurrence; Retreatment; Ribavirin; Treatment Outcome; Viral Load	2005

Article

Year

Applicability, tolerability and efficacy of preemptive antiviral therapy in hepatitis C-infected patients undergoing liver transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, Volume: 5, Issue:1

Topics: Adult; Aged; Antiviral Agents; Biopsy; Erythropoietin; Female; Granulocyte Colony-Stimulating Factor; Growth Substances; Hepatitis C; Humans; Immunocompromised Host; Immunosuppressive Agents; Interferon alpha-2; Interferon-alpha; Interferons; Liver; Liver Diseases; Liver Transplantation; Male; Middle Aged; Mycophenolic Acid; Polyethylene Glycols; Prednisone; Recombinant Proteins; Ribavirin; Tacrolimus; Time Factors

2005

Peginterferon alpha-2a combination therapies in chronic hepatitis C patients who relapsed after or had a viral breakthrough on therapy with standard interferon alpha-2b plus ribavirin: a pilot study of efficacy and safety.

Digestive diseases and sciences, 2005, Volume: 50, Issue:4

Topics: Alanine Transaminase; Amantadine; Antiviral Agents; Drug Therapy, Combination; Female; Genotype; Hemoglobins; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Mycophenolic Acid; Pilot Projects; Polyethylene Glycols; Recombinant Proteins; Recurrence; Retreatment; Ribavirin; Treatment Outcome; Viral Load

2005

Other Studies

89 other study(ies) available for ribavirin and mycophenolic acid

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Identification of compounds with anti-West Nile Virus activity. Journal of medicinal chemistry, 2006, Mar-23, Volume: 49, Issue:6 Topics: Acridines; Animals; Antiviral Agents; Chlorocebus aethiops; Pyrazoles; Quinolines; Structure-Activity Relationship; Vero Cells; Virus Replication; West Nile virus; Xanthenes	2006
Activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of IMP dehydrogenase. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Guanosine; Guanosine Triphosphate; Hantaan virus; IMP Dehydrogenase; Mycophenolic Acid; Nucleotides; Ribavirin; RNA, Viral; Time Factors; Vero Cells; Virus Replication	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2 Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship	2009
Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives. Bioorganic & medicinal chemistry, 2009, Jul-01, Volume: 17, Issue:13 Topics: Amino Acid Sequence; Animals; Antiviral Agents; Azo Compounds; Cell Line; Cell Survival; Diarrhea Viruses, Bovine Viral; DNA Viruses; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Respiratory Syncytial Viruses; RNA Viruses; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Triazenes; Viral Core Proteins	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives. Bioorganic & medicinal chemistry, 2010, Apr-15, Volume: 18, Issue:8 Topics: Animals; Antiviral Agents; Benzimidazoles; Cell Line; Chlorocebus aethiops; Cricetinae; DNA Viruses; Humans; RNA Viruses; Small Molecule Libraries; Structure-Activity Relationship; Vero Cells	2010
Synthesis and antiviral activity of a novel class of (5-oxazolyl)phenyl amines. European journal of medicinal chemistry, 2013, Volume: 69 Topics: Aniline Compounds; Antiviral Agents; Dose-Response Relationship, Drug; Enterovirus; Hepacivirus; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship	2013
Chikungunya virus: emerging targets and new opportunities for medicinal chemistry. Journal of medicinal chemistry, 2014, Feb-27, Volume: 57, Issue:4 Topics: Alphavirus Infections; Chikungunya Fever; Chikungunya virus; Disease Outbreaks; Europe; Humans; Models, Molecular	2014
Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents. Bioorganic & medicinal chemistry, 2014, Sep-01, Volume: 22, Issue:17 Topics: Animals; Antiviral Agents; Benzimidazoles; Cattle; Cell Line; Cell Proliferation; Cell Survival; Chlorocebus aethiops; Cricetinae; Dose-Response Relationship, Drug; Enterovirus; Humans; Microbial Sensitivity Tests; Molecular Structure; Poliovirus; Respiratory Syncytial Viruses; Structure-Activity Relationship; Vero Cells; Virus Replication	2014
N-((1,3-Diphenyl-1H-pyrazol-4-yl)methyl)anilines: A novel class of anti-RSV agents. Bioorganic & medicinal chemistry letters, 2015, Jun-01, Volume: 25, Issue:11 Topics: Aniline Compounds; Antiviral Agents; Cell Line; Humans; Pyrazoles; Respiratory Syncytial Viruses; Virus Replication	2015
Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5. Bioorganic & medicinal chemistry, 2015, Nov-01, Volume: 23, Issue:21 Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Cricetinae; DNA Viruses; Dogs; Enterovirus B, Human; Humans; RNA Viruses; Structure-Activity Relationship; Triazoles; Virus Replication	2015
A combined in silico/in vitro approach unveils common molecular requirements for efficient BVDV RdRp binding of linear aromatic N-polycyclic systems. European journal of medicinal chemistry, 2016, Jul-19, Volume: 117 Topics: Animals; Antiviral Agents; Binding Sites; Bovine Virus Diarrhea-Mucosal Disease; Cattle; Diarrhea Viruses, Bovine Viral; Hydrogen Bonding; Models, Molecular; Polycyclic Aromatic Hydrocarbons; RNA-Dependent RNA Polymerase	2016
Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones. Bioorganic & medicinal chemistry letters, 2017, 01-15, Volume: 27, Issue:2 Topics: Animals; Antiviral Agents; Bunyaviridae; Cats; Chlorocebus aethiops; Dextran Sulfate; DNA Viruses; Dogs; HeLa Cells; Humans; Mycophenolic Acid; Pyrimidinones; Ribavirin; RNA Viruses; Vero Cells	2017
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus. European journal of medicinal chemistry, 2017, Jul-28, Volume: 135 Topics: Antiviral Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Influenza A Virus, H1N1 Subtype; Influenza B virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Proguanil; Respiratory Syncytial Viruses; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines	2017
Inhibitors of Yellow Fever Virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: Design, synthesis and antiviral evaluation. European journal of medicinal chemistry, 2017, Dec-01, Volume: 141 Topics: Animals; Antiviral Agents; Cattle; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Drug; Drug Design; Haplorhini; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Structure-Activity Relationship; Virus Replication; Yellow fever virus	2017
Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs. Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12 Topics: Antiviral Agents; Cell Line; DNA Viruses; Drug Stability; Humans; Nucleosides; Organophosphonates; Prodrugs; RNA Viruses; Structure-Activity Relationship	2018
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature, 2020, Volume: 583, Issue:7816 Topics: Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Cloning, Molecular; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunity, Innate; Mass Spectrometry; Molecular Targeted Therapy; Pandemics; Pneumonia, Viral; Protein Binding; Protein Biosynthesis; Protein Domains; Protein Interaction Mapping; Protein Interaction Maps; Receptors, sigma; SARS-CoV-2; SKP Cullin F-Box Protein Ligases; Vero Cells; Viral Proteins	2020
Evidence in intact cells for an involvement of GTP in the activation of adenylate cyclase. The Journal of biological chemistry, 1979, Jan-10, Volume: 254, Issue:1 Topics: Adenosine Triphosphate; Adenylyl Cyclases; Cell Line; Cholera Toxin; Cyclic AMP; Enzyme Activation; Guanosine Triphosphate; Isoproterenol; Kinetics; Mycophenolic Acid; Prostaglandins E; Ribavirin	1979
Consequences of inhibition of guanine nucleotide synthesis by mycophenolic acid and virazole. Cancer research, 1977, Volume: 37, Issue:3 Topics: Adenosine Triphosphate; Cell Division; Cells, Cultured; Cytosine Nucleotides; DNA, Neoplasm; Guanine Nucleotides; Guanosine Triphosphate; IMP Dehydrogenase; Lymphoma; Mycophenolic Acid; Neoplasm Proteins; Neoplasms, Experimental; Ribavirin; Ribonucleosides; RNA, Neoplasm; Thymine Nucleotides; Uracil Nucleotides	1977
IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells. The Journal of biological chemistry, 1992, Oct-15, Volume: 267, Issue:29 Topics: Animals; Antineoplastic Agents; Biopterins; GTP Cyclohydrolase; Guanine; Guanosine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Kinetics; Mycophenolic Acid; Neuroblastoma; PC12 Cells; Ribavirin; Thiadiazoles; Tumor Cells, Cultured	1992
Novobiocin-induced anti-proliferative and differentiating effects in melanoma B16. British journal of cancer, 1992, Volume: 65, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Count; Cell Differentiation; Cell Division; Drug Screening Assays, Antitumor; Melanoma, Experimental; Mycophenolic Acid; Novobiocin; Phenotype; Ribavirin	1992
Mutations that confer resistance to mycophenolic acid and ribavirin on Sindbis virus map to the nonstructural protein nsP1. Virology, 1991, Volume: 181, Issue:2 Topics: Aedes; Amino Acid Sequence; Animals; Base Sequence; Capsid; Cloning, Molecular; Drug Resistance, Microbial; Genes, Viral; Molecular Sequence Data; Mutation; Mycophenolic Acid; Phenotype; Ribavirin; RNA, Messenger; Sindbis Virus; tRNA Methyltransferases; Viral Core Proteins; Viral Nonstructural Proteins	1991
Cell differentiation and altered IMP dehydrogenase expression induced in human T-lymphoblastoid leukemia cells by mycophenolic acid and tiazofurin. Experimental cell research, 1990, Volume: 187, Issue:1 Topics: Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Survival; Gene Expression; Guanosine; Humans; Hypoxanthine; Hypoxanthines; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Leukemia-Lymphoma, Adult T-Cell; Mycophenolic Acid; Ribavirin; Ribonucleosides; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1990
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the antiviral nucleoside 2' ,3'-dideoxyguanosine. Biochemical and biophysical research communications, 1990, Sep-28, Volume: 171, Issue:3 Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; HIV-1; Humans; IMP Dehydrogenase; Kinetics; Mycophenolic Acid; Nucleotides; Phosphorylation; Ribavirin	1990
Induction of cell differentiation in melanoma cells by inhibitors of IMP dehydrogenase: altered patterns of IMP dehydrogenase expression and activity. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1990, Volume: 1, Issue:6 Topics: Biomarkers; Gene Expression Regulation, Neoplastic; Guanosine; Humans; IMP Dehydrogenase; Melanins; Melanoma; Monophenol Monooxygenase; Mycophenolic Acid; Neoplasm Proteins; Ribavirin; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured	1990
Induction of erythroid differentiation in K562 cells by inhibitors of inosine monophosphate dehydrogenase. Cancer research, 1989, Oct-15, Volume: 49, Issue:20 Topics: Cell Compartmentation; Cell Division; Erythropoiesis; Hemoglobins; Humans; IMP Dehydrogenase; In Vitro Techniques; Ketone Oxidoreductases; Leukemia, Erythroblastic, Acute; Mycophenolic Acid; Purine Nucleotides; Ribavirin; Ribonucleosides; Tumor Cells, Cultured	1989
Growth inhibition and induction of phenotypic alterations by tiazofurin: differential effects on MCF-7 breast cancer and HBL-100 breast cell lines. European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:5 Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Division; Cell Line; Female; Guanosine Triphosphate; Humans; Milk, Human; Mycophenolic Acid; Ribavirin; Ribonucleosides; Tumor Cells, Cultured	1989
Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture. Cancer research, 1985, Volume: 45, Issue:11 Pt 1 Topics: Adenosine Triphosphate; Animals; Cell Division; Cells, Cultured; DNA, Neoplasm; Guanine; Guanylate Kinases; Hypoxanthine Phosphoribosyltransferase; IMP Dehydrogenase; Ketone Oxidoreductases; Lymphoma; Mice; Mycophenolic Acid; Nucleoside-Diphosphate Kinase; Nucleoside-Phosphate Kinase; Organoselenium Compounds; Ribavirin; Ribonucleosides; RNA, Neoplasm; Selenium; Tritium; Uridine	1985
Effects of the inhibitors of IMP dehydrogenase, tiazofurin and mycophenolic acid, on glycoprotein metabolism. Molecular pharmacology, 1985, Volume: 28, Issue:6 Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Glucosamine; Glycoproteins; Guanosine; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Mannose; Mycophenolic Acid; Ribavirin; Ribonucleosides; Sarcoma 180; Tritium	1985
Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5'-phosphate dehydrogenase. Cancer research, 1986, Volume: 46, Issue:5 Topics: Cell Cycle; Cell Differentiation; Cell Line; Dolichol Monophosphate Mannose; Glycoproteins; Guanosine; Guanosine Triphosphate; Hematopoiesis; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia, Myeloid, Acute; Mycophenolic Acid; Organoselenium Compounds; Phagocytosis; Ribavirin; Ribonucleosides; Selenium	1986
Sindbis virus mutants resistant to mycophenolic acid and ribavirin. Virology, 1987, Volume: 158, Issue:1 Topics: Aedes; Animals; Clone Cells; DNA-Directed RNA Polymerases; Drug Resistance, Microbial; Guanosine Triphosphate; Mutation; Mycophenolic Acid; Nucleotidyltransferases; Ribavirin; Ribonucleosides; Sindbis Virus; Thiadiazoles	1987
Ribavirin induced differentiation of murine erythroleukemia cells. Molecular and cellular biochemistry, 1987, Volume: 77, Issue:2 Topics: Benzidines; Cell Differentiation; Cell Line; Friend murine leukemia virus; Globins; Guanine; Guanosine; Leukemia, Erythroblastic, Acute; Mycophenolic Acid; Ribavirin; Ribonucleosides; RNA, Messenger	1987
Selective guanosine phosphate deficiency in hepatoma cells induced by inhibitors of IMP dehydrogenase. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1980, Volume: 361, Issue:10 Topics: Animals; Cell Division; Cell Line; Female; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Liver Neoplasms, Experimental; Mice; Mycophenolic Acid; Ribavirin; Ribonucleosides; Uridine Monophosphate	1980
Inhibitors of IMP dehydrogenase prevent sindbis virus replication and reduce GTP levels in Aedes albopictus cells. Virology, 1981, Apr-30, Volume: 110, Issue:2 Topics: Aedes; Amanitins; Animals; Cells, Cultured; Dactinomycin; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Mycophenolic Acid; Niacinamide; Phosphorylation; Ribavirin; Ribonucleosides; Sindbis Virus; Thiadiazoles; Vesicular stomatitis Indiana virus; Virus Replication	1981
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis. The Journal of biological chemistry, 1993, Nov-25, Volume: 268, Issue:33 Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Deoxyguanine Nucleotides; Guanine; Guanosine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Leukemia L1210; Lymphocytes; Mice; Mycophenolic Acid; Purine Nucleotides; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured	1993
Reversal of the antiviral activity of ribavirin against Sindbis virus in Ae. albopictus mosquito cells. Antiviral research, 1993, Volume: 22, Issue:4 Topics: Aedes; Animals; Antiviral Agents; Cell Division; Cells, Cultured; Floxuridine; Isoleucine; Methionine; Mycophenolic Acid; Ribavirin; Sindbis Virus	1993
The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:12 Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Drug Synergism; Guanine; Guanosine Triphosphate; Herpesviridae; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; Humans; Immunosuppressive Agents; Mycophenolic Acid; Ribavirin; Thymidine Kinase; Vero Cells; Viral Plaque Assay	1998
SVMPA, a mutant of sindbis virus resistant to mycophenolic acid and ribavirin, shows an increased sensitivity to chick interferon. Virology, 1999, Jun-20, Volume: 259, Issue:1 Topics: Animals; Antiviral Agents; Chickens; Drug Resistance, Microbial; Genome, Viral; Interferons; Microbial Sensitivity Tests; Mutation; Mycophenolic Acid; Recombinant Proteins; Ribavirin; Sindbis Virus	1999
Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase. Biochemistry, 2000, Feb-22, Volume: 39, Issue:7 Topics: Adenosine Diphosphate; Animals; Cricetinae; Cricetulus; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Mutagenesis, Site-Directed; Mycophenolic Acid; NAD; Ribavirin; Spectrometry, Fluorescence; Tritrichomonas foetus; Tryptophan	2000
Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus. Antiviral research, 2000, Volume: 48, Issue:2 Topics: Acyclovir; Antiviral Agents; Cell Line; Dideoxynucleosides; Dioxolanes; Drug Synergism; Filaggrin Proteins; Guanine; Guanosine; Hepatitis B; Hepatitis B virus; Humans; Mycophenolic Acid; Purine Nucleosides; Ribavirin; Virus Replication	2000
Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. Journal of virology, 2001, Volume: 75, Issue:17 Topics: Animals; Antiviral Agents; Cells, Cultured; Disease Models, Animal; Flaviviridae; Guanosine; Hepatitis, Viral, Animal; Hepatocytes; Mycophenolic Acid; Polymerase Chain Reaction; Ribavirin; RNA, Viral; Saguinus; Virus Replication	2001
Antiviral activity and mode of action studies of ribavirin and mycophenolic acid against orthopoxviruses in vitro. Antiviral chemistry & chemotherapy, 2001, Volume: 12, Issue:6 Topics: 3T3 Cells; Animals; Antiviral Agents; Chlorocebus aethiops; Guanosine Triphosphate; IMP Dehydrogenase; Inhibitory Concentration 50; Mice; Mycophenolic Acid; Orthopoxvirus; Ribavirin; Time Factors; Vero Cells; Virus Replication	2001
Identification of active antiviral compounds against a New York isolate of West Nile virus. Antiviral research, 2002, Volume: 55, Issue:1 Topics: Amides; Animals; Antiviral Agents; Azauridine; Chlorocebus aethiops; Cytidine; Cytopathogenic Effect, Viral; Enzyme Inhibitors; Inhibitory Concentration 50; Mycophenolic Acid; New York; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thiouridine; Vero Cells; Virus Replication; West Nile virus	2002
Cytotoxicity and cellular differentiation activity of methylenebis(phosphonate) analogs of tiazofurin and mycophenolic acid adenine dinucleotide in human cancer cell lines. Cancer letters, 2002, Jul-08, Volume: 181, Issue:1 Topics: Adenine Nucleotides; Antineoplastic Agents; Cell Differentiation; Diphosphonates; Dose-Response Relationship, Drug; HT29 Cells; Humans; K562 Cells; Mycophenolic Acid; Ribavirin	2002
Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism. Journal of molecular biology, 2003, Feb-14, Volume: 326, Issue:2 Topics: Animals; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Inosine Monophosphate; Kinetics; Models, Molecular; Mycophenolic Acid; NAD; Protein Conformation; Ribavirin; Ribonucleotides; Tritrichomonas foetus; Xanthine	2003
Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents. Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:6 Topics: Animals; Cattle; Cell Line; Computer Systems; Culture Media, Conditioned; Diarrhea Viruses, Bovine Viral; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanosine Triphosphate; IMP Dehydrogenase; Kidney; Molecular Structure; Mycophenolic Acid; NAD; Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; Ribonucleosides; Viral Plaque Assay; Virus Replication	2002
The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA. Virology, 2003, Jun-05, Volume: 310, Issue:2 Topics: Antimetabolites; Carbamates; Cell Line, Transformed; Enzyme Inhibitors; Genome, Viral; Guanosine; Hepacivirus; Humans; IMP Dehydrogenase; Mutation; Mycophenolic Acid; Phenylurea Compounds; Replicon; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; RNA; RNA, Viral; Transfection; Virus Replication	2003
Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis. Virology, 2003, Jul-05, Volume: 311, Issue:2 Topics: Animals; Antiviral Agents; Cell Line; Cricetinae; Foot-and-Mouth Disease Virus; Guanosine; Kidney; Mutagenesis; Mycophenolic Acid; Ribavirin; Virus Replication	2003
Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction. Biochemistry, 2004, Apr-20, Volume: 43, Issue:15 Topics: Adenosine Diphosphate; Alanine; Amino Acid Substitution; Animals; Arginine; Binding Sites; Cattle; Conserved Sequence; Deuterium Exchange Measurement; Enzyme Inhibitors; Hydrolysis; IMP Dehydrogenase; Kinetics; Mutagenesis, Site-Directed; Mycophenolic Acid; Phenylalanine; Point Mutation; Protein Binding; Ribavirin; Ribonucleosides; Ribonucleotides; Solvents; Substrate Specificity; Tritrichomonas foetus; Tyrosine; Xanthine	2004
Effect of antimetabolite immunosuppressants on Flaviviridae, including hepatitis C virus. Transplantation, 2004, Feb-27, Volume: 77, Issue:4 Topics: Animals; Antimetabolites; Antiviral Agents; Azathioprine; Cattle; Cell Line; Diarrhea Viruses, Bovine Viral; Dose-Response Relationship, Drug; Hepacivirus; Immunosuppressive Agents; Mercaptopurine; Mycophenolic Acid; Replicon; Ribavirin; Thioguanine; Virus Replication	2004
Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. The Journal of biological chemistry, 2004, Sep-24, Volume: 279, Issue:39 Topics: Amino Acid Sequence; Animals; Binding Sites; Cryptosporidium parvum; Dose-Response Relationship, Drug; Drug Design; Escherichia coli; Gene Transfer Techniques; Genetic Complementation Test; Humans; IMP Dehydrogenase; Kinetics; Models, Biological; Models, Chemical; Molecular Sequence Data; Mycophenolic Acid; Phylogeny; Protein Conformation; Recombinant Proteins; Ribavirin; Sequence Homology, Amino Acid; Time Factors	2004
Mycophenolic acid inhibits avian reovirus replication. Antiviral research, 2004, Volume: 64, Issue:1 Topics: Animals; Antiviral Agents; Cell Line; Guanosine; Mycophenolic Acid; Orthoreovirus, Avian; Quail; Ribavirin; Virus Replication	2004
In vitro combination of amdoxovir and the inosine monophosphate dehydrogenase inhibitors mycophenolic acid and ribavirin demonstrates potent activity against wild-type and drug-resistant variants of human immunodeficiency virus type 1. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:11 Topics: Antibiotics, Antineoplastic; Antiviral Agents; Cell Line; Cloning, Molecular; Dioxolanes; DNA, Mitochondrial; Drug Combinations; Drug Resistance, Viral; Drug Synergism; Enzyme Inhibitors; HIV Protease; HIV-1; Humans; IMP Dehydrogenase; Mycophenolic Acid; Purine Nucleosides; Recombinant Proteins; Ribavirin; RNA, Viral	2004
Differentiation of human prostate cancer PC-3 cells induced by inhibitors of inosine 5'-monophosphate dehydrogenase. Cancer research, 2004, Dec-15, Volume: 64, Issue:24 Topics: Amino Acid Sequence; Antibiotics, Antineoplastic; Cell Differentiation; Cell Division; Cell Line, Tumor; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Male; Molecular Sequence Data; Mycophenolic Acid; Prostatic Neoplasms; Ribavirin; Vacuoles	2004
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. Journal of virology, 2005, Volume: 79, Issue:3 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Guanosine Triphosphate; IMP Dehydrogenase; Microbial Sensitivity Tests; Mycophenolic Acid; Parainfluenza Virus 3, Human; Ribavirin; Ribonucleosides; Vero Cells; Virus Replication; Yellow fever virus	2005
Pure red cell aplasia associated with concomitant use of mycophenolate mofetil and ribavirin in post-transplant recurrent hepatitis C. Transplant international : official journal of the European Society for Organ Transplantation, 2006, Volume: 19, Issue:2 Topics: Antiviral Agents; Hepatitis C; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Mycophenolic Acid; Recurrence; Red-Cell Aplasia, Pure; Ribavirin	2006
Action of inhibitors on accumulation of processed hepatitis delta virus RNAs. Journal of virology, 2006, Volume: 80, Issue:7 Topics: Amanitins; Antiviral Agents; Cell Line; Dactinomycin; Dichlororibofuranosylbenzimidazole; Dose-Response Relationship, Drug; Genome, Viral; Hepatitis Delta Virus; Humans; Mycophenolic Acid; Polyadenylation; Ribavirin; RNA, Messenger; RNA, Viral; Virus Replication	2006
Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral research, 2006, Volume: 71, Issue:1 Topics: Animals; Antiviral Agents; Caco-2 Cells; Cell Survival; Chlorocebus aethiops; Cytokines; Cytopathogenic Effect, Viral; Female; Humans; IMP Dehydrogenase; Lung; Mice; Mice, Inbred BALB C; Mycophenolic Acid; Oligonucleotide Array Sequence Analysis; Ribavirin; Ribonucleosides; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Specific Pathogen-Free Organisms; Vero Cells; Virus Replication	2006
Inhibition of dengue virus replication by mycophenolic acid and ribavirin. The Journal of general virology, 2006, Volume: 87, Issue:Pt 7 Topics: Animals; Antiviral Agents; Cell Line; Dengue Virus; Haplorhini; Humans; Mycophenolic Acid; Ribavirin; RNA-Dependent RNA Polymerase; RNA, Viral; Virus Replication	2006
Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir. Antiviral research, 2007, Volume: 73, Issue:3 Topics: Cell Line; DNA-Directed DNA Polymerase; DNA, Viral; Drug Synergism; Drug Therapy, Combination; Guanine; Hepacivirus; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Mycophenolic Acid; Ribavirin; RNA-Directed DNA Polymerase	2007
Antiviral activity of tiazofurin and mycophenolic acid against Grapevine leafroll-associated virus 3 in Vitis vinifera explants. Antiviral research, 2007, Volume: 73, Issue:3 Topics: Closteroviridae; Enzyme-Linked Immunosorbent Assay; Mycophenolic Acid; Plant Diseases; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; RNA Viruses; Vitis	2007
Ribavirin reveals a lethal threshold of allowable mutation frequency for Hantaan virus. Journal of virology, 2007, Volume: 81, Issue:21 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Dose-Response Relationship, Drug; Gene Frequency; Genome, Viral; Guanosine Triphosphate; Hantaan virus; Mutation; Mycophenolic Acid; Organoselenium Compounds; Ribavirin; Ribonucleosides; RNA, Viral; Vero Cells	2007
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues. Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23 Topics: Adenosine Monophosphate; Antineoplastic Agents; Diphosphonates; Drug Screening Assays, Antitumor; Humans; IMP Dehydrogenase; Isoenzymes; K562 Cells; Models, Molecular; Mycophenolic Acid; NAD; Protein Binding; Ribavirin	2007
Anti-erythropoietin antibody-mediated pure red cell aplasia in a living donor liver transplant recipient treated for hepatitis C virus. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2007, Volume: 13, Issue:11 Topics: Anemia; Antibodies; Antiviral Agents; Epoetin Alfa; Erythropoietin; Graft Rejection; Hematinics; Hepatitis C; Humans; Immunocompromised Host; Immunosuppressive Agents; Interferon alpha-2; Interferon-alpha; Liver Transplantation; Living Donors; Male; Middle Aged; Mycophenolic Acid; Polyethylene Glycols; Prednisone; Recombinant Proteins; Red-Cell Aplasia, Pure; Ribavirin; Secondary Prevention; Tacrolimus	2007
[Development of a myasthenia crisis during interferon treatment for chronic C hepatitis]. Gastroenterologie clinique et biologique, 2007, Volume: 31, Issue:12 Topics: Aged; Antiviral Agents; Cholinesterase Inhibitors; Follow-Up Studies; Glucocorticoids; Hepatitis C, Chronic; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Interferon-alpha; Male; Myasthenia Gravis; Mycophenolic Acid; Prednisone; Pyridostigmine Bromide; Ribavirin	2007
Ribavirin analogs. Clinics in liver disease, 2009, Volume: 13, Issue:3 Topics: Anemia, Hemolytic; Antiviral Agents; Carbamates; Hepacivirus; Hepatitis C; Humans; IMP Dehydrogenase; Mycophenolic Acid; Phenylurea Compounds; Ribavirin	2009
Cryoglobulinemic membranoproliferative glomerulonephritis: beyond conventional therapy. Clinical nephrology, 2011, Volume: 75, Issue:4 Topics: Adrenal Cortex Hormones; Aged; Angiotensin II Type 1 Receptor Blockers; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Biphenyl Compounds; Cryoglobulinemia; Female; Glomerulonephritis, Membranoproliferative; Humans; Immunologic Factors; Interferon alpha-2; Interferon-alpha; Irbesartan; Male; Middle Aged; Mycophenolic Acid; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Rituximab; Tetrazoles	2011
Depletion of GTP pool is not the predominant mechanism by which ribavirin exerts its antiviral effect on Lassa virus. Antiviral research, 2011, Volume: 91, Issue:2 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Ebolavirus; Guanosine; Guanosine Triphosphate; IMP Dehydrogenase; Lassa virus; Mycophenolic Acid; Ribavirin; Ribonucleosides; Vero Cells; Virus Replication	2011
Combination of N-methylisatin-β-thiosemicarbazone derivative (SCH16) with ribavirin and mycophenolic acid potentiates the antiviral activity of SCH16 against Japanese encephalitis virus in vitro. Letters in applied microbiology, 2012, Volume: 55, Issue:3 Topics: Animals; Antiviral Agents; Cells, Cultured; Drug Synergism; Encephalitis Virus, Japanese; Indoles; Mycophenolic Acid; Pentoxifylline; Ribavirin; Swine; Thiosemicarbazones	2012
YKL-40-gene polymorphism affects acute cellular rejection and fibrosis progression after transplantation for hepatitis C virus-induced liver disease. Journal of gastroenterology and hepatology, 2013, Volume: 28, Issue:1 Topics: Adipokines; Adult; Antiviral Agents; Chitinase-3-Like Protein 1; Cyclosporine; Disease Progression; Drug Therapy, Combination; End Stage Liver Disease; Female; Genotype; Graft Rejection; Hepacivirus; Hepatitis C; Humans; Immunosuppressive Agents; Interferon alpha-2; Interferon-alpha; Lectins; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Mycophenolic Acid; Polyethylene Glycols; Polymorphism, Single Nucleotide; Recombinant Proteins; Ribavirin; Sex Factors; Statistics, Nonparametric; Tacrolimus; Time Factors; Young Adult	2013
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis. PloS one, 2013, Volume: 8, Issue:8 Topics: Antiviral Agents; Cell Line, Tumor; Guanosine Triphosphate; Hepacivirus; Hepatocytes; Humans; Inhibitory Concentration 50; Mutagenesis; Mutagens; Mutation Rate; Mycophenolic Acid; Ribavirin; RNA, Viral; Serial Passage	2013
Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus. The Journal of infection, 2013, Volume: 67, Issue:6 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Communicable Diseases, Emerging; Coronavirus; Coronavirus Infections; Disease Outbreaks; Drug Discovery; High-Throughput Screening Assays; Humans; Interferons; Mycophenolic Acid; Ribavirin; Vero Cells; Viral Load; Viral Plaque Assay	2013
Mycophenolic acid, mycophenolate mofetil, mizoribine, ribavirin, and 7-nitroindole inhibit propagation of Babesia parasites by targeting inosine 5'-monophosphate dehydrogenase. The Journal of parasitology, 2014, Volume: 100, Issue:4 Topics: Animals; Babesia; Cattle; Enzyme Inhibitors; Female; IMP Dehydrogenase; Inhibitory Concentration 50; Mice; Mice, Inbred ICR; Mycophenolic Acid; Ribavirin; Ribonucleosides	2014
Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus. Gastroenterology, 2014, Volume: 146, Issue:7 Topics: Antiviral Agents; Calcineurin; Calcineurin Inhibitors; Cell Line, Tumor; Cyclophilin A; Cyclophilins; Cyclosporine; Dose-Response Relationship, Drug; HEK293 Cells; Hepatitis E; Hepatitis E virus; Hepatitis, Chronic; Humans; Immunosuppressive Agents; Mycophenolic Acid; Ribavirin; RNA Interference; RNA, Viral; Time Factors; Transfection; Virus Replication	2014
A putative role for inosine 5' monophosphate dehydrogenase (IMPDH) in Leishmania amazonensis programmed cell death. Experimental parasitology, 2015, Volume: 149 Topics: Animals; Apoptosis; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heat-Shock Response; IMP Dehydrogenase; Leishmania mexicana; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mycophenolic Acid; Nucleosides; Purine Nucleotides; Ribavirin; RNA, Protozoan	2015
Mycophenolate mofetil may induce prolonged severe anemia during pegylated-interferon/ribavirin/simeprevir therapy in liver transplant recipients. Clinical journal of gastroenterology, 2015, Volume: 8, Issue:3 Topics: Aged; Anemia; Antiviral Agents; Erythrocyte Transfusion; Female; Hepatitis C, Chronic; Humans; Immunocompromised Host; Immunosuppressive Agents; Interferon-alpha; Liver Transplantation; Middle Aged; Mycophenolic Acid; Recurrence; Ribavirin; Simeprevir; Tacrolimus	2015
Cross Talk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:5 Topics: Antiviral Agents; Cell Line, Tumor; Guanosine; Hepatitis E virus; Humans; Immunity, Cellular; IMP Dehydrogenase; Interferon-alpha; Mycophenolic Acid; Nucleotides; Ribavirin; Uridine; Virus Replication	2016
Chronic hepatitis in the transplant patient. British journal of hospital medicine (London, England : 2005), 2017, Jul-02, Volume: 78, Issue:7 Topics: Aged; Alanine Transaminase; Antiviral Agents; Graft Rejection; Hepatitis E; Hepatitis E virus; Hepatitis, Chronic; Humans; Immunocompromised Host; Immunoglobulin M; Immunosuppressive Agents; Kidney Transplantation; Male; Mycophenolic Acid; Polycystic Kidney Diseases; Polymerase Chain Reaction; Ribavirin; RNA, Viral; Tacrolimus; Viral Load	2017
Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:11 Topics: Antiviral Agents; Calcineurin; Calcineurin Inhibitors; Caliciviridae Infections; Cell Line; Cyclosporine; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Mycophenolic Acid; Norovirus; Ribavirin; Tacrolimus; Tacrolimus Binding Protein 1A; Virus Replication	2017
Response to Cytoplasmic rods and rings in ribavirin and Cytoplasmic rods and rings in mycophenolic acid treatment. Liver international : official journal of the International Association for the Study of the Liver, 2017, Volume: 37, Issue:11 Topics: Cytoplasm; Hepatitis C, Chronic; Humans; Interferon-alpha; Mycophenolic Acid; Ribavirin	2017
The IMPDH inhibitors, ribavirin and mycophenolic acid, inhibit peste des petits ruminants virus infection. Veterinary research communications, 2018, Volume: 42, Issue:4 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Drug Synergism; Drug Therapy, Combination; Guanosine; Mycophenolic Acid; Peste-des-Petits-Ruminants; Peste-des-petits-ruminants virus; Ribavirin; Vero Cells; Virus Replication	2018
Inhibitions of human parainfluenza virus type 2 replication by ribavirin and mycophenolate mofetil are restored by guanosine and S-(4-nitrobenzyl)-6-thioinosine. Drug discoveries & therapeutics, 2019, Volume: 13, Issue:6 Topics: Animals; Antiviral Agents; Cell Line; Guanosine; Macaca mulatta; Mycophenolic Acid; Parainfluenza Virus 2, Human; Ribavirin; RNA, Viral; Thioinosine; Virus Internalization; Virus Replication	2019
2'-Fluoro-2'-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705. Archives of virology, 2020, Volume: 165, Issue:11 Topics: Amides; Animals; Antiviral Agents; Caliciviridae Infections; Cell Line; Deoxycytidine; Humans; Mice; Mycophenolic Acid; Norovirus; Pyrazines; RAW 264.7 Cells; Ribavirin; Virus Replication	2020
Rotavirus Infection and Cytopathogenesis in Human Biliary Organoids Potentially Recapitulate Biliary Atresia Development. mBio, 2020, 08-25, Volume: 11, Issue:4 Topics: Antibodies, Neutralizing; Antigens, Viral; Antiviral Agents; Biliary Atresia; Capsid Proteins; Cytopathogenic Effect, Viral; Host Microbial Interactions; Humans; Interferon-alpha; Mycophenolic Acid; Organoids; Ribavirin; Rotavirus Infections	2020
Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation. Antiviral research, 2020, Volume: 184 Topics: Antiviral Agents; Cell Line; Deoxycytidine; Drug Evaluation, Preclinical; Drug Repositioning; Drug Synergism; Gemcitabine; Gene Expression Regulation; Hepatitis E; Hepatitis E virus; Host Microbial Interactions; Humans; Interferon-alpha; Janus Kinases; Mycophenolic Acid; Phosphorylation; Pyrimidine Nucleosides; Response Elements; Ribavirin; Signal Transduction; STAT1 Transcription Factor; Virus Replication	2020
Identification of quinolone derivatives as effective anti-Dengue virus agents. Antiviral research, 2020, Volume: 184 Topics: A549 Cells; Amino Acid Substitution; Animals; Antiviral Agents; Cell Line; Cell Survival; Dengue Virus; Humans; Methyltransferases; Mutation; Mycophenolic Acid; Quinolones; Ribavirin; RNA, Viral; Virus Replication	2020
SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling. Frontiers in immunology, 2022, Volume: 13 Topics: Bortezomib; COVID-19; Cytokines; Exoribonucleases; Humans; IMP Dehydrogenase; Inosine; Interleukin-6; Interleukin-8; Mycophenolic Acid; NF-kappa B; Oxidoreductases; Proteomics; Ribavirin; SARS-CoV-2; Viral Nonstructural Proteins	2022