Compounds > ribavirin
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ribavirin and guanosine triphosphate

ribavirin has been researched along with guanosine triphosphate in 72 studies

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-199026 (36.11)18.7374
1990's23 (31.94)18.2507
2000's13 (18.06)29.6817
2010's9 (12.50)24.3611
2020's1 (1.39)2.80

Authors

AuthorsStudies
Cameron, CE; Graci, JD; Moriyama, K; Negishi, K; Suzuki, T; Thompson, CN; Watanabe, M1
Johnson, GS; Mukku, VR1
Borek, E; Fujitaki, J; Goswami, BB; Sharma, OK; Smith, RA1
Brox, L; Henderson, JF; Lowe, JK1
Maidhof, A; Müller, WE; Taschner, H; Zahn, RK1
Nagai, M; Nakamura, H; Natsumeda, Y; Szekeres, T; Weber, G1
Harada, T; Hatakeyama, K; Kagamiyama, H1
Chiba, P; Felzmann, T; Fritzer, M; Pillwein, K; Szekeres, T1
Jayaram, HN; Weber, G; Zhen, W2
Bosze, P; Eble, JN; Eckhardt, S; Ehrlich, CE; Look, KY; Natsumeda, Y; Olah, E; Prajda, N; Stehman, FB; Sutton, GP1
Balzarini, J; De Clercq, E; Lee, CK; Schols, D1
Weber, G2
Eble, JN; Hoffman, R; Jayaram, HN; Nagai, M; Natsumeda, Y; Paulik, E; Tricot, G; Weber, G; Zhen, WN1
Fujitaki, JM; Kini, GD; Lee, VM; Matsumoto, SS; Nord, LD; Revankar, GR; Robins, RK; Sanghvi, YS; Sharma, BS; Willis, RC1
Financsek, I; Jarai, G; Kote, Z; Lapis, E; Natsumeda, Y; Olah, E; Weber, G; Yamaji, Y1
Belei, M; Parandoosh, Z; Robins, RK; Rubalcava, B1
Heerema, N; Hoffman, R; Jayaram, HN; Kneebone, P; Lapis, E; Natsumeda, Y; Nichols, CR; Tricot, GJ; Weber, G1
Beery, E; Nordenberg, J; Novogrodsky, A; Panet, C; Sidi, Y; Wasserman, L1
Antonicelli, F; Haye, B; Jacquemin, C; Lambert, B1
Sartorelli, AC; Sokoloski, JA1
Blair, OC; Sartorelli, AC; Sokoloski, JA1
Colliton, JW; Mendel, DB; Witters, LA1
Hollan, SR; Horanyi, M; Ikegami, T; Kote, Z; Kremmer, T; Natsumeda, Y; Olah, E; Paulik, E; Sugar, J; Szelenyi, J1
Hoffman, R; Jayaram, HN; Lapis, E; Natsumeda, Y; Tricot, GJ; Weber, G; Yamada, Y; Yamaji, Y1
Dolin, R1
Durbin, RK; Scheidel, LM; Stollar, V1
Hoffman, R; Jayaram, HN; Lapis, E; Nichols, CR; Pennington, K; Tricot, GJ; Weber, G1
Hoffman, R; Jayaram, HN; Nichols, CR; Pillwein, K; Weber, G1
Robins, RK; Saunders, PP; Spindler, CD; Tan, MT1
Gilbert, BE; Knight, V; Noall, MW; Wray, SK1
Herrmann, B; Kaiser, WA; Keppler, DO1
Malinoski, F; Stollar, V1
Faderan, MA; Jayaram, HN; Liepnieks, JJ; Lui, MS; Natsumeda, Y; Olah, E; Weber, G1
Cooney, DA; Gebeyehu, G; Glazer, RI; Jayaram, HN; Johns, DG; Kelley, JA; Marquez, VE; Van Cott, AC; Zwelling, LA1
Sherwood, A; Stollar, V1
Stridh, S1
Cooney, DA; Dion, RL; Glazer, RI; Jayaram, HN; Johns, DG1
Balzarini, J; Bohman, C; De Clercq, E; Fridland, A; Herdewijn, P; Horská, K; Karlsson, A; Van Aerschot, A; Votruba, I; Wang, L1
Chan, PK; Finch, RA; Revankar, GR1
Chiba, P; Fritzer, M; Gharehbaghi, K; Goldenberg, H; Pillwein, K; Szekeres, T1
Hata, Y; Natsumeda, Y; Weber, G1
Monden, Y; Prajda, N; Taniki, T; Weber, G1
Cinti, C; Falcieri, E; Gobbi, P; Santi, S; Vitale, M; Weber, G; Zamai, L; Zauli, G1
Cappellacci, L; De Montis, A; Franchetti, P; Goldstein, BM; Grifantini, M; Gurudutt, VV; Jayaram, HN; Jones, WD; La Colla, P; Loi, AG; Perra, G; Schneider, BP; Sheikha, GA; Sint, T1
Guttmann, RP; Johnson, GV; Lesort, M; Zhang, J1
Li, W; Shen, F; Weber, G1
Andrei, G; De Clercq, E; Neyts, J1
Cooney, DA; Grusch, M; Jayaram, HN; Krupitza, G1
Averett, DR; Briese, T; Jordan, I; Lipkin, WI1
Braguer, D; Champion, S; Fouchier, F; Marvaldi, J; Vallée, S1
Bray, M; Huggins, JW; Smee, DF1
Clark, JL; Lostia, S; Otto, MJ; Pankiewicz, KW; Patterson, SE; Stuyver, LJ; Watanabe, KA1
Kökeny, S; Olah, E; Orbán, TI; Shen, F; Weber, G1
Lai, MM; Vo, NV; Young, KC1
Balzarini, J; De Clercq, E; Leyssen, P; Neyts, J1
Bajin-Katić, K; Kovacević, Z; Oros, J1
Chu, YK; Chung, DH; Jonsson, CB; Parker, WB; Sun, Y1
Estepa, A; Marroquí, L; Perez, L1
Arterburn, JB; Bartolucci, A; Chung, DH; Jonsson, CB; Parker, WB; Sun, Y1
Arterburn, JB; Chu, YK; Chung, DH; Jonsson, CB; Kumarapperuma, SC; Li, Q; Parker, WB; Ramanathan, HN; Schmaljohn, CS; Smith, J; Spik, K; Sun, Y1
Arterburn, JB; Gonzales, SR; Hanley, KA; Jeselnik, M; Kumarapperuma, SC; McDowell, M1
Cirulli, ET; Fellay, J; Goldstein, DB; Gumbs, CE; Hitomi, Y; McHutchison, JG; Shianna, KV; Thompson, AJ; Urban, TJ1
Günther, S; Neyts, J; Ölschläger, S1
Ando, Y; Kato, I; Kojima, T; Miyawaki, Y; Murata, M; Murate, T; Okuyama, E; Saito, H; Suzuki, A; Takagi, A; Takagi, Y1
Antony, AC; Jani, MB; Jayaram, HN; Jayaram, NH; Khan, RA; Kusumanchi, P; Tang, Y; Zhang, Y1
Domingo, E; Esteban, JI; Grande-Pérez, A; Gregori, J; Ortega-Prieto, AM; Perales, C; Quer, J; Sheldon, J; Tejero, H1
Balzarini, J; Dallmeier, K; Debing, Y; Emerson, SU; Neyts, J; Pan, Q; Wang, Y1
Clayton, CW; Jimmerson, LC; Kiser, JJ; Kottilil, S; MaWhinney, S; Meissner, EG; Sims, Z1
Adamek, L; Brunet, S; Hellstrand, K; Lagging, M; Nilsson, S; Norder, H; Nyström, K; Said, J; Tang, KW; Waldenström, J; Wanrooij, PH; Wind-Rotolo, M1
Elfiky, AA1

Reviews

3 review(s) available for ribavirin and guanosine triphosphate

ArticleYear
Role of purine metabolism in regulation of signal transduction in human carcinoma cells.
    Advances in experimental medicine and biology, 1998, Volume: 431

    Topics: Antimetabolites, Antineoplastic; Deoxyguanine Nucleotides; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Inosine Monophosphate; Leukemia; Neoplasms; Purines; Ribavirin; Signal Transduction

1998
Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.
    Current medicinal chemistry, 1999, Volume: 6, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; cdc25 Phosphatases; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Guanosine Triphosphate; HL-60 Cells; Humans; IMP Dehydrogenase; Leukemia, Myeloid; Neoplasms; Nucleosides; Organoselenium Compounds; Ovarian Neoplasms; Protein Tyrosine Phosphatases; Ribavirin; Ribonucleosides; RNA, Messenger; Time Factors; Tumor Cells, Cultured

1999
Targeting signal transduction.
    Advances in enzyme regulation, 2003, Volume: 43

    Topics: Animals; Antimetabolites; Antineoplastic Agents; Cell Line, Tumor; Guanosine Triphosphate; Humans; Ligands; Neoplasms; Ribavirin; Signal Transduction

2003

Trials

2 trial(s) available for ribavirin and guanosine triphosphate

ArticleYear
Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient.
    Cancer communications, 1991, Volume: 3, Issue:3

    Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Blast Crisis; Blotting, Northern; Down-Regulation; Gene Expression Regulation; Genes, ras; Guanosine Triphosphate; Humans; Hypoxanthine; Hypoxanthines; IMP Dehydrogenase; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Pilot Projects; Ribavirin; RNA; Uric Acid

1991
Antiviral chemotherapy and chemoprophylaxis.
    Science (New York, N.Y.), 1985, Mar-15, Volume: 227, Issue:4692

    Topics: Acyclovir; Adult; Aged; Amantadine; Antiviral Agents; Chickenpox; Clinical Trials as Topic; Cytomegalovirus; Encephalitis; Foscarnet; Guanosine Triphosphate; Herpes Simplex; Herpes Zoster; Herpesviridae Infections; Humans; Infant, Newborn; Infant, Newborn, Diseases; Influenza A virus; Influenza, Human; Phosphonoacetic Acid; Respiratory Tract Infections; Ribavirin; Rimantadine; Vidarabine; Virus Diseases

1985

Other Studies

67 other study(ies) available for ribavirin and guanosine triphosphate

ArticleYear
Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity.
    Journal of medicinal chemistry, 2008, Jan-10, Volume: 51, Issue:1

    Topics: Amides; Antiviral Agents; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Mutation; Organophosphates; Poliovirus; Ribavirin; RNA-Dependent RNA Polymerase; RNA, Viral; Structure-Activity Relationship

2008
Evidence in intact cells for an involvement of GTP in the activation of adenylate cyclase.
    The Journal of biological chemistry, 1979, Jan-10, Volume: 254, Issue:1

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Cell Line; Cholera Toxin; Cyclic AMP; Enzyme Activation; Guanosine Triphosphate; Isoproterenol; Kinetics; Mycophenolic Acid; Prostaglandins E; Ribavirin

1979
The broad spectrum antiviral agent ribavirin inhibits capping of mRNA.
    Biochemical and biophysical research communications, 1979, Aug-13, Volume: 89, Issue:3

    Topics: Guanosine Monophosphate; Guanosine Triphosphate; Kinetics; L Cells; Nucleotidyltransferases; Ribavirin; Ribonucleosides; RNA, Messenger; Uridine Monophosphate

1979
Consequences of inhibition of guanine nucleotide synthesis by mycophenolic acid and virazole.
    Cancer research, 1977, Volume: 37, Issue:3

    Topics: Adenosine Triphosphate; Cell Division; Cells, Cultured; Cytosine Nucleotides; DNA, Neoplasm; Guanine Nucleotides; Guanosine Triphosphate; IMP Dehydrogenase; Lymphoma; Mycophenolic Acid; Neoplasm Proteins; Neoplasms, Experimental; Ribavirin; Ribonucleosides; RNA, Neoplasm; Thymine Nucleotides; Uracil Nucleotides

1977
Virazole (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide; a cytostatic agent.
    Biochemical pharmacology, 1977, Jun-01, Volume: 26, Issue:11

    Topics: Cell Division; Cells, Cultured; Depression, Chemical; DNA; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; Drug Interactions; Guanosine Triphosphate; Polyribosomes; Protein Biosynthesis; Ribavirin; Ribonucleosides; RNA

1977
Regulation of GTP biosynthesis.
    Advances in enzyme regulation, 1992, Volume: 32

    Topics: Animals; Cell Differentiation; Cell Division; Colonic Neoplasms; Evaluation Studies as Topic; GMP Reductase; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Hypoxanthine; Hypoxanthines; IMP Dehydrogenase; Inosine Monophosphate; Leukemia, Promyelocytic, Acute; Liver Neoplasms, Experimental; NADH, NADPH Oxidoreductases; Ribavirin; Tumor Cells, Cultured

1992
IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells.
    The Journal of biological chemistry, 1992, Oct-15, Volume: 267, Issue:29

    Topics: Animals; Antineoplastic Agents; Biopterins; GTP Cyclohydrolase; Guanine; Guanosine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Kinetics; Mycophenolic Acid; Neuroblastoma; PC12 Cells; Ribavirin; Thiadiazoles; Tumor Cells, Cultured

1992
Cell cycle dependent regulation of IMP dehydrogenase activity and effect of tiazofurin.
    Life sciences, 1992, Volume: 51, Issue:16

    Topics: Antimetabolites, Antineoplastic; Cell Cycle; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Ribavirin; Tumor Cells, Cultured

1992
Antitumor activity of tiazofurin in human colon carcinoma HT-29.
    Cancer investigation, 1992, Volume: 10, Issue:6

    Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Male; Mice; Mice, Nude; Ribavirin; Tumor Cells, Cultured

1992
Inhibition by tiazofurin of inosine 5'-phosphate dehydrogenase (IMP DH) activity in extracts of ovarian carcinomas.
    Gynecologic oncology, 1992, Volume: 47, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Middle Aged; Ovarian Neoplasms; Ovary; Ribavirin; Tissue Extracts

1992
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2',3'-dideoxyinosine on human immunodeficiency virus in peripheral blood lymph
    Biochemical and biophysical research communications, 1991, Jul-31, Volume: 178, Issue:2

    Topics: Antiviral Agents; Cells, Cultured; Didanosine; Drug Synergism; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; HIV-1; Humans; Inosine Monophosphate; Kinetics; Lymphocytes; Ribavirin; Ribonucleosides

1991
IMP dehydrogenase and GTP as targets in human leukemia treatment.
    Advances in experimental medicine and biology, 1991, Volume: 309B

    Topics: Adult; Aged; Allopurinol; Antineoplastic Agents; Female; Genes, myc; Genes, ras; Guanosine Triphosphate; Humans; IMP Dehydrogenase; In Vitro Techniques; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Ribavirin; Tumor Cells, Cultured

1991
Inhibition of pyrimidine metabolism in myeloid leukemia cells by triazole and pyrazole nucleosides.
    Biochemical pharmacology, 1990, Feb-01, Volume: 39, Issue:3

    Topics: Adenosine Triphosphate; Cell Division; Guanosine Triphosphate; Hemoglobins; Humans; IMP Dehydrogenase; Inosine Monophosphate; Interphase; Leukemia, Myeloid; Molecular Structure; Orotic Acid; Pyrazoles; Pyrimidine Nucleotides; Ribavirin; Ribonucleosides; Tumor Cells, Cultured; Uridine Triphosphate

1990
Down-regulation of c-myc and c-Ha-ras gene expression by tiazofurin in rat hepatoma cells.
    Cancer biochemistry biophysics, 1990, Volume: 11, Issue:2

    Topics: Animals; Cell Division; Down-Regulation; Gene Amplification; Gene Expression; Gene Rearrangement; Genes, ras; Guanosine Triphosphate; IMP Dehydrogenase; Liver Neoplasms, Experimental; Oncogenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Rats; Ribavirin; Ribonucleosides

1990
Determination of thiazole-4-carboxamide adenine dinucleotide (TAD) levels in mononuclear cells of leukemic patients treated with tiazofurin.
    Biochemical pharmacology, 1991, Jan-15, Volume: 41, Issue:2

    Topics: Adenine Nucleotides; Antineoplastic Agents; Chromatography, High Pressure Liquid; Guanosine Triphosphate; Humans; Leukemia; Monocytes; Reproducibility of Results; Ribavirin; Sensitivity and Specificity

1991
Tiazofurin and selenazofurin induce depression of cGMP and phosphatidylinositol pathway in L1210 leukemia cells.
    Biochemical and biophysical research communications, 1989, Oct-31, Volume: 164, Issue:2

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Caenorhabditis elegans Proteins; Carrier Proteins; Cyclic GMP; Diglycerides; Guanosine Triphosphate; Inosine Monophosphate; Leukemia L1210; Mice; Organoselenium Compounds; Phorbol 12,13-Dibutyrate; Phosphates; Phosphatidylinositols; Protein Kinase C; Receptors, Drug; Ribavirin; Ribonucleosides; Selenium

1989
Biochemically directed therapy of leukemia with tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity.
    Cancer research, 1989, Jul-01, Volume: 49, Issue:13

    Topics: Antimetabolites, Antineoplastic; Blast Crisis; Blood Cell Count; Bone Marrow; Enzyme Inhibitors; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Ribavirin; Ribonucleosides

1989
Growth inhibition and induction of phenotypic alterations by tiazofurin: differential effects on MCF-7 breast cancer and HBL-100 breast cell lines.
    European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:5

    Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Division; Cell Line; Female; Guanosine Triphosphate; Humans; Milk, Human; Mycophenolic Acid; Ribavirin; Ribonucleosides; Tumor Cells, Cultured

1989
Activation of adenylate cyclase in rat fat cells promotes an increase in GTP content which controls the enzyme activity.
    Molecular and cellular endocrinology, 1988, Volume: 55, Issue:2-3

    Topics: Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipose Tissue; Animals; Cyclic AMP; Enzyme Activation; Guanosine Triphosphate; Isoproterenol; Kinetics; Lipolysis; Pertussis Toxin; Phenylisopropyladenosine; Rats; Ribavirin; Virulence Factors, Bordetella

1988
Effects of the inhibitors of IMP dehydrogenase, tiazofurin and mycophenolic acid, on glycoprotein metabolism.
    Molecular pharmacology, 1985, Volume: 28, Issue:6

    Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Glucosamine; Glycoproteins; Guanosine; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Mannose; Mycophenolic Acid; Ribavirin; Ribonucleosides; Sarcoma 180; Tritium

1985
Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5'-phosphate dehydrogenase.
    Cancer research, 1986, Volume: 46, Issue:5

    Topics: Cell Cycle; Cell Differentiation; Cell Line; Dolichol Monophosphate Mannose; Glycoproteins; Guanosine; Guanosine Triphosphate; Hematopoiesis; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia, Myeloid, Acute; Mycophenolic Acid; Organoselenium Compounds; Phagocytosis; Ribavirin; Ribonucleosides; Selenium

1986
Modulation of acetyl-CoA carboxylase by inhibitors of IMP dehydrogenase: implications for insulin regulation.
    Archives of biochemistry and biophysics, 1987, Volume: 252, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adenosine Triphosphate; Adipose Tissue; Animals; Enzyme Activation; Epinephrine; Guanosine Triphosphate; IMP Dehydrogenase; Insulin; Ketone Oxidoreductases; Kinetics; Ligases; Male; Rats; Ribavirin

1987
Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:17

    Topics: Antimetabolites, Antineoplastic; Cell Differentiation; Cell Line; Genes, ras; Guanosine Triphosphate; Hemoglobins; Humans; IMP Dehydrogenase; Kinetics; Leukemia, Myeloid; Ribavirin; Ribonucleosides; Transcription, Genetic

1988
Enzyme-pattern-targeted chemotherapy with tiazofurin and allopurinol in human leukemia.
    Advances in enzyme regulation, 1988, Volume: 27

    Topics: Adenine; Aged; Allopurinol; Animals; Drug Evaluation; Female; Guanine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia; Leukemia, Myeloid, Acute; Liver Neoplasms, Experimental; Male; Middle Aged; Rats; Ribavirin; Ribonucleosides; Tumor Cells, Cultured

1988
Sindbis virus mutants resistant to mycophenolic acid and ribavirin.
    Virology, 1987, Volume: 158, Issue:1

    Topics: Aedes; Animals; Clone Cells; DNA-Directed RNA Polymerases; Drug Resistance, Microbial; Guanosine Triphosphate; Mutation; Mycophenolic Acid; Nucleotidyltransferases; Ribavirin; Ribonucleosides; Sindbis Virus; Thiadiazoles

1987
Hematological and biochemical action of tiazofurin (NSC 286193) in a case of refractory acute myeloid leukemia.
    Cancer research, 1987, Sep-15, Volume: 47, Issue:18

    Topics: Antineoplastic Agents; Bone Marrow; Guanosine Triphosphate; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Ribavirin; Ribonucleosides

1987
Selective sensitivity to tiazofurin of human leukemic cells.
    Biochemical pharmacology, 1986, Jun-15, Volume: 35, Issue:12

    Topics: Adenine Nucleotides; Adult; Aged; Antineoplastic Agents; Female; Guanosine Triphosphate; Humans; Leukemia; Leukocytes; Male; Middle Aged; Ribavirin; Ribonucleosides

1986
Use of tiazofurin to enhance the metabolism and cytotoxic activities of analogues of guanine, guanosine, and deoxyguanosine.
    Cancer research, 1987, Feb-15, Volume: 47, Issue:4

    Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Deoxyguanosine; Female; Guanine; Guanosine; Guanosine Triphosphate; Hypoxanthine Phosphoribosyltransferase; Ovary; Ribavirin; Ribonucleosides

1987
Mode of action of ribavirin: effect of nucleotide pool alterations on influenza virus ribonucleoprotein synthesis.
    Antiviral research, 1985, Volume: 5, Issue:1

    Topics: Guanosine; Guanosine Triphosphate; Nucleotides; Orthomyxoviridae; Ribavirin; Ribonucleoproteins; Ribonucleosides; Virus Replication

1985
Selective guanosine phosphate deficiency in hepatoma cells induced by inhibitors of IMP dehydrogenase.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1980, Volume: 361, Issue:10

    Topics: Animals; Cell Division; Cell Line; Female; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Liver Neoplasms, Experimental; Mice; Mycophenolic Acid; Ribavirin; Ribonucleosides; Uridine Monophosphate

1980
Inhibitors of IMP dehydrogenase prevent sindbis virus replication and reduce GTP levels in Aedes albopictus cells.
    Virology, 1981, Apr-30, Volume: 110, Issue:2

    Topics: Aedes; Amanitins; Animals; Cells, Cultured; Dactinomycin; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Mycophenolic Acid; Niacinamide; Phosphorylation; Ribavirin; Ribonucleosides; Sindbis Virus; Thiadiazoles; Vesicular stomatitis Indiana virus; Virus Replication

1981
Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide).
    The Journal of biological chemistry, 1984, Apr-25, Volume: 259, Issue:8

    Topics: Animals; Antineoplastic Agents; Cell Line; Deoxyribonucleotides; Guanine Nucleotides; Guanosine Triphosphate; IMP Dehydrogenase; Inosine Monophosphate; Ketone Oxidoreductases; Kinetics; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred ACI; Ribavirin; Ribonucleosides

1984
Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.
    Advances in enzyme regulation, 1983, Volume: 21

    Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; NAD; Ribavirin; Ribonucleosides; Spectrophotometry

1983
Evidence that ribavirin is transported in Aedes albopictus cells by the nucleoside transport system.
    Antiviral research, 1984, Volume: 4, Issue:6

    Topics: Aedes; Animals; Biological Transport; Carrier Proteins; Cell Division; Cells, Cultured; Guanosine Triphosphate; Nucleosides; Ribavirin; Ribonucleosides; Sindbis Virus; Virus Replication

1984
Determination of ribonucleoside triphosphate pools in influenza A virus-infected MDCK cells.
    Archives of virology, 1983, Volume: 77, Issue:2-4

    Topics: Adenosine Triphosphate; Animals; Cell Count; Cell Line; Cytidine Triphosphate; Dogs; Guanosine Triphosphate; Influenza A virus; Ribavirin; Ribonucleotides; Uridine Triphosphate

1983
Mechanism of resistance to the oncolytic C-nucleoside 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC-286193).
    Biochemical pharmacology, 1982, Aug-01, Volume: 31, Issue:15

    Topics: Animals; Antineoplastic Agents; Drug Resistance; Guanosine Triphosphate; Leukemia P388; Leukemia, Experimental; Mice; Neoplasm Transplantation; Ribavirin; Ribonucleosides; Time Factors

1982
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.
    The Journal of biological chemistry, 1993, Nov-25, Volume: 268, Issue:33

    Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Deoxyguanine Nucleotides; Guanine; Guanosine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Leukemia L1210; Lymphocytes; Mice; Mycophenolic Acid; Purine Nucleotides; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured

1993
Nucleolar localization of nucleophosmin/B23 requires GTP.
    The Journal of biological chemistry, 1993, Mar-15, Volume: 268, Issue:8

    Topics: Biological Transport; Cell Nucleolus; Guanosine Triphosphate; HeLa Cells; Humans; IMP Dehydrogenase; Nuclear Proteins; Nucleophosmin; Phosphoproteins; Ribavirin

1993
GM-CSF: modulation of biochemical and cytotoxic effects of tiazofurin in HL-60 cells.
    British journal of haematology, 1993, Volume: 84, Issue:3

    Topics: Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Granulocyte-Macrophage Colony-Stimulating Factor; Guanosine Triphosphate; Humans; IMP Dehydrogenase; In Vitro Techniques; Leukemia, Promyelocytic, Acute; Ribavirin; Tumor Cells, Cultured

1993
Tiazofurin decreases Ras-GTP complex in K562 cells.
    Oncology research, 1993, Volume: 5, Issue:4-5

    Topics: Antimetabolites, Antineoplastic; Cell Differentiation; Guanosine; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oncogene Protein p21(ras); Protein Binding; Ribavirin; Tumor Cells, Cultured

1993
Synergistic action of taxol and tiazofurin in human ovarian, pancreatic and lung carcinoma cells.
    Cancer biochemistry biophysics, 1993, Volume: 13, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma; Carcinoma, Adenosquamous; Cell Division; Drug Screening Assays, Antitumor; Drug Synergism; Female; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Liver Neoplasms, Experimental; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Rats; Ribavirin; Spindle Apparatus; Tumor Cells, Cultured

1993
IMP dehydrogenase inhibitor, tiazofurin, induces apoptosis in K562 human erythroleukemia cells.
    Cytometry, 1997, Feb-15, Volume: 30, Issue:1

    Topics: Apoptosis; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; Guanosine Triphosphate; Humans; Hypoxanthine; IMP Dehydrogenase; Leukemia, Erythroblastic, Acute; Ribavirin; Tumor Cells, Cultured

1997
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
    Journal of medicinal chemistry, 1997, May-23, Volume: 40, Issue:11

    Topics: Animals; Antineoplastic Agents; Cell Division; Computer Simulation; Crystallography, X-Ray; Enzyme Inhibitors; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Inosine Monophosphate; Leukemia; Lymphoma; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Structure; Neoplasms; Organoselenium Compounds; Ribavirin; Ribonucleosides; Tumor Cells, Cultured

1997
Modulation of the in situ activity of tissue transglutaminase by calcium and GTP.
    The Journal of biological chemistry, 1998, Jan-23, Volume: 273, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents; Calcium; Calcium Channel Agonists; Calpain; Carbachol; Diazomethane; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Ionomycin; Ionophores; Marine Toxins; Muscarinic Agonists; Oligopeptides; Oxocins; Receptors, Retinoic Acid; Retinoid X Receptors; Ribavirin; Thapsigargin; Transcription Factors; Transglutaminases; Tumor Cells, Cultured

1998
The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:12

    Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Drug Synergism; Guanine; Guanosine Triphosphate; Herpesviridae; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; Humans; Immunosuppressive Agents; Mycophenolic Acid; Ribavirin; Thymidine Kinase; Vero Cells; Viral Plaque Assay

1998
Inhibition of Borna disease virus replication by ribavirin.
    Journal of virology, 1999, Volume: 73, Issue:9

    Topics: Adenosine; Animals; Antiviral Agents; Borna disease virus; Cell Line; Guanosine; Guanosine Triphosphate; Humans; Neuroglia; Oligodendroglia; Rats; Ribavirin; Virus Replication

1999
Ribavirin-induced resistance to heat shock, inhibition of the Ras-Raf-1 pathway and arrest in G(1).
    European journal of pharmacology, 2000, Sep-15, Volume: 404, Issue:1-2

    Topics: Antimetabolites; Cell Division; Cytoskeleton; Flow Cytometry; G1 Phase; Guanosine Triphosphate; Heat-Shock Proteins; Hot Temperature; Humans; Microtubules; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Ribavirin; Signal Transduction; Tumor Cells, Cultured

2000
Sir Hans A. Krebs Centenary Lecture: cancer and clinical targeting.
    Advances in enzyme regulation, 2001, Volume: 41

    Topics: Animals; Antineoplastic Agents; Apoptosis; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Down-Regulation; Guanosine Triphosphate; History, 20th Century; Humans; Ischemia; Kidney Neoplasms; Leukemia; Models, Biological; Neoplasms; Ribavirin; Signal Transduction; Time Factors; Tumor Cells, Cultured

2001
Antiviral activity and mode of action studies of ribavirin and mycophenolic acid against orthopoxviruses in vitro.
    Antiviral chemistry & chemotherapy, 2001, Volume: 12, Issue:6

    Topics: 3T3 Cells; Animals; Antiviral Agents; Chlorocebus aethiops; Guanosine Triphosphate; IMP Dehydrogenase; Inhibitory Concentration 50; Mice; Mycophenolic Acid; Orthopoxvirus; Ribavirin; Time Factors; Vero Cells; Virus Replication

2001
Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents.
    Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:6

    Topics: Animals; Cattle; Cell Line; Computer Systems; Culture Media, Conditioned; Diarrhea Viruses, Bovine Viral; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanosine Triphosphate; IMP Dehydrogenase; Kidney; Molecular Structure; Mycophenolic Acid; NAD; Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; Ribonucleosides; Viral Plaque Assay; Virus Replication

2002
Mutagenic and inhibitory effects of ribavirin on hepatitis C virus RNA polymerase.
    Biochemistry, 2003, Sep-09, Volume: 42, Issue:35

    Topics: Antiviral Agents; DNA-Directed RNA Polymerases; Genome, Viral; Guanosine Triphosphate; Hepacivirus; Humans; Mutation; Purines; Pyrimidines; Ribavirin; RNA; Transcription, Genetic; Viral Proteins

2003
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase.
    Journal of virology, 2005, Volume: 79, Issue:3

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Guanosine Triphosphate; IMP Dehydrogenase; Microbial Sensitivity Tests; Mycophenolic Acid; Parainfluenza Virus 3, Human; Ribavirin; Ribonucleosides; Vero Cells; Virus Replication; Yellow fever virus

2005
[Application of tiazofurin in the study of regulation of AMP deaminase in intact malignant cells].
    Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka, 2002, Issue:47

    Topics: AMP Deaminase; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Guanosine; Guanosine Triphosphate; Liver Neoplasms, Experimental; Mice; Rats; Rats, Sprague-Dawley; Ribavirin; Tumor Cells, Cultured

2002
Activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of IMP dehydrogenase.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Guanosine; Guanosine Triphosphate; Hantaan virus; IMP Dehydrogenase; Mycophenolic Acid; Nucleotides; Ribavirin; RNA, Viral; Time Factors; Vero Cells; Virus Replication

2007
Assessment of the inhibitory effect of ribavirin on the rainbow trout rhabdovirus VHSV by real-time reverse-transcription PCR.
    Veterinary microbiology, 2007, May-16, Volume: 122, Issue:1-2

    Topics: Animals; Antiviral Agents; Carps; Cell Line; Gene Expression Regulation, Viral; Guanosine Triphosphate; Novirhabdovirus; Nucleocapsid Proteins; Oncorhynchus mykiss; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; Time Factors; Transcription, Genetic

2007
Ribavirin reveals a lethal threshold of allowable mutation frequency for Hantaan virus.
    Journal of virology, 2007, Volume: 81, Issue:21

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Dose-Response Relationship, Drug; Gene Frequency; Genome, Viral; Guanosine Triphosphate; Hantaan virus; Mutation; Mycophenolic Acid; Organoselenium Compounds; Ribavirin; Ribonucleosides; RNA, Viral; Vero Cells

2007
Synthesis of 1-beta-D-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus.
    Antiviral research, 2008, Volume: 79, Issue:1

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Female; Genome, Viral; Guanosine; Guanosine Triphosphate; Hemorrhagic Fever with Renal Syndrome; Humans; Mice; Mice, Inbred Strains; Mutation; Nucleosides; Orthohantavirus; Ribavirin; Triazoles; Vero Cells

2008
A novel nucleoside analog, 1-beta-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole (ETAR), exhibits efficacy against a broad range of flaviviruses in vitro.
    Antiviral research, 2010, Volume: 87, Issue:1

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Flavivirus; Guanosine Triphosphate; Imidazoles; Microbial Sensitivity Tests; Nucleosides; Ribavirin; Triazoles; Vero Cells

2010
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function.
    Gastroenterology, 2011, Volume: 140, Issue:4

    Topics: Adenosine Triphosphate; Adenylosuccinate Synthase; Adolescent; Adult; Anemia; Antiviral Agents; Enzyme Activation; Erythrocytes; Genetic Variation; Genotype; Guanosine Triphosphate; Hepatitis C, Chronic; Humans; In Vitro Techniques; Inosine Triphosphatase; Inosine Triphosphate; Pyrophosphatases; Ribavirin; Young Adult

2011
Depletion of GTP pool is not the predominant mechanism by which ribavirin exerts its antiviral effect on Lassa virus.
    Antiviral research, 2011, Volume: 91, Issue:2

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Ebolavirus; Guanosine; Guanosine Triphosphate; IMP Dehydrogenase; Lassa virus; Mycophenolic Acid; Ribavirin; Ribonucleosides; Vero Cells; Virus Replication

2011
Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor VII gene expression.
    The Biochemical journal, 2013, Jan-01, Volume: 449, Issue:1

    Topics: Antimetabolites; Factor VII; Gene Expression Regulation; Guanosine Triphosphate; Hep G2 Cells; Humans; Intracellular Fluid; Ribavirin; Transcription Elongation, Genetic

2013
Nicotinamide mononucleotide adenylyltransferase2 overexpression enhances colorectal cancer cell-kill by Tiazofurin.
    Cancer gene therapy, 2013, Volume: 20, Issue:7

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Drug Carriers; Drug Resistance, Neoplasm; Fluoresceins; Folic Acid Transporters; Gene Expression; Gene Knockdown Techniques; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Isoenzymes; Nanoparticles; Nicotinamide-Nucleotide Adenylyltransferase; Protein Transport; Ribavirin; RNA, Small Interfering; Transfection

2013
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Antiviral Agents; Cell Line, Tumor; Guanosine Triphosphate; Hepacivirus; Hepatocytes; Humans; Inhibitory Concentration 50; Mutagenesis; Mutagens; Mutation Rate; Mycophenolic Acid; Ribavirin; RNA, Viral; Serial Passage

2013
Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:1

    Topics: Antiviral Agents; Cell Line; Guanosine Triphosphate; Hepatitis E virus; Humans; Interferon-alpha; Ribavirin; Virus Replication

2014
Effects of ribavirin/sofosbuvir treatment and ITPA phenotype on endogenous purines.
    Antiviral research, 2017, Volume: 138

    Topics: Adenosine Triphosphate; Anemia, Hemolytic; Female; Guanosine Triphosphate; Hepatitis C, Chronic; Humans; Inosine Triphosphatase; Inosine Triphosphate; Male; Middle Aged; Nucleotides; Phenotype; Polymorphism, Single Nucleotide; Purines; Pyrophosphatases; Retrospective Studies; Ribavirin; Sofosbuvir

2017
Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus.
    Journal of virology, 2018, 10-01, Volume: 92, Issue:19

    Topics: Antiviral Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation; Guanosine Triphosphate; Hepacivirus; Hepatitis B Core Antigens; Hepatocytes; High-Throughput Nucleotide Sequencing; Host-Pathogen Interactions; Humans; Mutagenesis; Nucleotides; Pyrophosphatases; Ribavirin; RNA, Small Interfering; RNA, Viral; Signal Transduction

2018
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.
    Life sciences, 2020, May-01, Volume: 248

    Topics: Adenosine Monophosphate; Alanine; Alphacoronavirus; Amino Acid Sequence; Antiviral Agents; Betacoronavirus; Catalytic Domain; Computational Biology; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Molecular Docking Simulation; Pneumonia, Viral; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Ribavirin; RNA-Dependent RNA Polymerase; SARS-CoV-2; Sequence Alignment; Sequence Homology, Amino Acid; Sofosbuvir; Thermodynamics; Uridine Triphosphate; Viral Proteins

2020