rhodanine and pyrimidine

rhodanine has been researched along with pyrimidine* in 2 studies

Other Studies

2 other study(ies) available for rhodanine and pyrimidine

Article	Year
Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors. Bioorganic & medicinal chemistry letters, 2011, Apr-15, Volume: 21, Issue:8 A series of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that some of the synthesized compounds exhibited significant inhibitory activities. Especially, compound 15 bearing a hydroxyethoxyl group at position-4 of phenyl ring exhibited most potent tyrosinase inhibitory activity with IC(50) value of 0.56 mM. The inhibition mechanism analysis of compound 15 demonstrated that the inhibitory effect of the compound on the tyrosinase was irreversible. These results suggested that such compounds might be served as lead compounds for further designing new potential tyrosinase inhibitors. Topics: Agaricales; Enzyme Inhibitors; Monophenol Monooxygenase; Pyrimidines; Rhodanine; Thiazolidinediones; Thiones	2011
SYNTHESIS OF SOME PYRIMIDINE AMINO ACIDS BY THE RHODANINE METHOD AND TESTS VS. THE EHRLICH ASCITES CARCINOMA. Journal of medicinal chemistry, 1965, Volume: 8 Topics: Amino Acids; Animals; Ascites; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Chemistry, Pharmaceutical; Mice; Pharmacology; Proteins; Pyrimidines; Research; Rhodanine; Thiazoles	1965

Article

Year

Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors.

Bioorganic & medicinal chemistry letters, 2011, Apr-15, Volume: 21, Issue:8

A series of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that some of the synthesized compounds exhibited significant inhibitory activities. Especially, compound 15 bearing a hydroxyethoxyl group at position-4 of phenyl ring exhibited most potent tyrosinase inhibitory activity with IC(50) value of 0.56 mM. The inhibition mechanism analysis of compound 15 demonstrated that the inhibitory effect of the compound on the tyrosinase was irreversible. These results suggested that such compounds might be served as lead compounds for further designing new potential tyrosinase inhibitors.

Topics: Agaricales; Enzyme Inhibitors; Monophenol Monooxygenase; Pyrimidines; Rhodanine; Thiazolidinediones; Thiones

2011

SYNTHESIS OF SOME PYRIMIDINE AMINO ACIDS BY THE RHODANINE METHOD AND TESTS VS. THE EHRLICH ASCITES CARCINOMA.

Journal of medicinal chemistry, 1965, Volume: 8

Topics: Amino Acids; Animals; Ascites; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Chemistry, Pharmaceutical; Mice; Pharmacology; Proteins; Pyrimidines; Research; Rhodanine; Thiazoles

1965