rhodanine has been researched along with carbazole* in 2 studies
2 other study(ies) available for rhodanine and carbazole
| Article | Year |
|---|---|
A Fluorescent Turn-On Carbazole-Rhodanine Based Sensor for Detection of Ag
Carbazole - Rhodanine conjugate is an effective fluorescent host for silver ions through fluorometric transformation from green to red color with a hyperchromic emission. An intramolecular charge transfer process derived from carbazole towards rhodanine favors interaction of thiocarbonyl S and carboxylic acid O of the rhodanine moiety towards Ag Topics: Carbazoles; Fluorescence; Fluorescent Dyes; HeLa Cells; Humans; Ions; Optical Imaging; Rhodanine; Silver; Tumor Cells, Cultured | 2019 |
Discovery of novel N-methyl carbazole tethered rhodanine derivatives as direct inhibitors of Mycobacterium tuberculosis InhA.
InhA (Enoyl-ACP reductase) plays a crucial role in the biosynthetic pathway of cell wall synthesis in Mycobacterium tuberculosis (Mtb). Isoniazid (INH) is an important first-line drug, which inhibits InhA. The rapid increase in resistance to INH and currently marketed drugs as well as emergence of MDR-TB and XDR-TB has complicated the diagnosis and treatment of Mtb with ever increasing threat to human kind. Herein, we report novel N-methyl carbazole derivatives as potential anti-TB compounds acting directly via InhA inhibition. All the synthesized final compounds were screened against Mtb virulent cell line H Topics: Antitubercular Agents; Carbazoles; Dose-Response Relationship, Drug; Drug Discovery; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Rhodanine; Structure-Activity Relationship | 2019 |