rhodamine 123 has been researched along with verapamil in 202 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.98) | 18.7374 |
| 1990's | 61 (30.20) | 18.2507 |
| 2000's | 75 (37.13) | 29.6817 |
| 2010's | 56 (27.72) | 24.3611 |
| 2020's | 6 (2.97) | 2.80 |
| Authors | Studies |
|---|---|
| Cescon, DW; Hansen, MD; Hoj, JP; Siddiqui-Jain, A | 1 |
| Chao, MW; Lai, MJ; Liou, JP; Liu, YM; Pan, SL; Teng, CM; Tu, HJ; Wu, CH; Wu, YW; Yu, SC | 1 |
| Engel, K; Wang, J | 1 |
| Wang, J | 1 |
| Arias, IM; Gatmaitan, Z; Hsing, S | 1 |
| Kamo, N; Komatsubara, M; Miyauchi, S | 1 |
| Bauer, HC; Hegmann, EJ; Kerbel, RS | 1 |
| Aszalos, A; Currier, SJ; Gottesman, MM; Padmanabhan, R; Pine, PS; Schoenlein, PV; Weaver, JL | 1 |
| Schluesener, HJ | 1 |
| Clodfelter, K; Coon, JS; Knudson, W; Lu, B; Weinstein, RS | 1 |
| Gan, L; Krag, DN; Tao, SZ; Theon, AP; Wardell, J | 1 |
| Dmitrevskaya, TV; Neyfakh, AA; Serpinskaya, AS | 1 |
| Krishan, A; Lampidis, TJ; Planas, L; Tapiero, H | 1 |
| Krishan, A; Lampidis, TJ; Munck, JN; Tapiero, H | 1 |
| Goi, K; Ichihara, T; Koizumi, S; Konishi, M; Matsukawa, H; Mizutani, S; Wada, H | 1 |
| Frey, T; Haugland, RP; Yue, S | 1 |
| Davey, MW; Davey, RA; Kidman, AD; Marks, DC | 1 |
| Bello-Reuss, E; Ernest, S | 1 |
| Bates, SE; Dickstein, B; Fojo, AT; Lee, JS; Spolyar, M | 1 |
| Chardonnet, Y; Chignol, MC; Lizard, G; Schmitt, D | 1 |
| Alken, P; Muscheck, M; Nebe, CT; Pilch, H; Rassweiler, J; Seemann, O; Siegsmund, M | 1 |
| Brezden, CB; Hedley, DW; Rauth, AM | 1 |
| Carbone, R; Chen, HX; Dannies, PS; Hochberg, RB; Jancis, EM | 1 |
| Canitrot, Y; Lahmy, S; Laurent, G; Lautier, D; Salmon, JM | 1 |
| Kuo, MT; Lampidis, TJ; Savaraj, N; Teeter, LD; Wu, CJ; Zhao, JY | 1 |
| Georges, E; Nare, B; Prichard, RK | 1 |
| Altmayr, F; Andreesen, R; Diddens, H; Rastetter, J; Reichle, A | 1 |
| Beery, E; Halabe, E; Kornfeld, J; Landau, O; Nordenberg, J; Novogrodsky, A; Shafran, M; Sidi, Y; Wasserman, L | 1 |
| Ausiello, DA; Cabantchik, ZI; Greger, R; Klein, P; Koslowsky, T; Kunzelmann, K; Slotki, IN | 1 |
| Canitrot, Y; Lautier, D; Salmon, JM; Viallet, P | 1 |
| Bines, SD; Chong, AS; Coon, JS; Gebel, HM; Markham, PN | 1 |
| Baumgartner, G; Hamilton, G; Schirmböck, M; Sherwood, ER; Thalhammer, T; Theyer, G | 1 |
| Carbone, R; Dannies, PS; Jancis, EM; Loechner, KJ | 1 |
| Bertho, AL; Farina, M; Gomes, FC; Gueiros-Filho, FJ; Lins, U; Lopes, UG; Viola, JP; Wirth, DF | 1 |
| Eisterer, W; Hilbe, W; Hofmann, J; Ludescher, C; Thaler, J | 1 |
| Aracil, M; Barbacid, MM; Márquez, G; Mira, E; Quesada, AR | 1 |
| Broxterman, HJ; Eekman, CA; Feller, N; Lankelma, J; Löwenberg, B; Ossenkoppele, GJ; Pinedo, HM; Schoester, M; Schuurhuis, GJ; Sonneveld, P; Währer, DC | 1 |
| Cheng, AL; Hsieh, CY; Hsieh, TS; Lai, MK; Pu, YS; Su, IJ; Tsai, TC; Tseng, NF | 1 |
| Abe, A; Kaidoh, K; Kamo, N; Miyauchi, S; Nara, T; Tanabu, S | 1 |
| Assaraf, YG; Eytan, GD; Oren, G; Regev, R | 1 |
| Chen, S; Combs, J; Hoffman, R; Tsukamoto, A; Uchida, N; Zanjani, E | 1 |
| Fernández Puentes, JL; García Grávalos, MD; Quesada, AR | 1 |
| Ambudkar, SV; Gottesman, MM; Hrycyna, CA; Pastan, I; Ramachandra, M | 1 |
| Davey, MW; Davey, RA; Hargrave, RM | 1 |
| Chen, G; Dumontet, C; Durán, GE; Jaffrézou, JP; Lacayo, NJ; Sikic, BI; Steger, KA | 1 |
| Alken, P; Köhrmann, KU; Kreukler, C; Nebe, T; Siegsmund, MJ; Steidler, A | 1 |
| Bakos, E; Klein, I; Müller, M; Sarkadi, B; Szabó, K; Váradi, A; Welker, E | 1 |
| Hayes, ML; Joiner, KA; Luft, BJ; Silverman, JA | 1 |
| Catovsky, D; Matutes, E; Maynadié, M | 1 |
| Bertrán, J; García-López, J; Pétriz, J; Sánchez, J | 1 |
| Coelho, AM; Dobbin, JA; Harab, RC; Maia, RC; Rumjanek, VM; Vasconcelos, FC | 1 |
| Courtois, A; Fardel, O; Guillouzo, A; Lecureur, V; Payen, L | 1 |
| Haberl, I; Hamilton, G; Schaufler, K; Swatonek, H; Thalhammer, T; Theyer, G; Ulsperger, E; Wenzl, E | 1 |
| Béliveau, R; Jetté, L; Murphy, GF | 1 |
| Aszalos, A; Weaver, JL | 1 |
| Döppenschmitt, S; Langguth, P; Regårdh, CG; Spahn-Langguth, H | 1 |
| Beck, JF; Boer, R; Buchholz, F; Gekeler, V; Niethammer, D; Sanders, KH; Ulrich, WR | 1 |
| de Giuli, R; Lehnert, M; Twentyman, PR | 1 |
| Fukuda, T; Hasegawa, R; Murakami, T; Nagai, J; Takano, M; Yumoto, R | 1 |
| Büssing, A; Pfüller, U; Schaller, G; Schietzel, M; Stein, GM; Wagner, B; Wagner, M | 1 |
| Aycardi, J; Chambrier, P; Kerboeuf, D; Le Vern, Y | 1 |
| Matha, V; Podsiadlowski, L; Vilcinskas, A | 1 |
| Méndez-Vidal, C; Quesada, AR | 1 |
| Abulrob, AG; Gumbleton, M | 1 |
| Cichorek, M; Kozłowska, K; Witkowski, JM; Zarzeczna, M | 1 |
| De Moerloose, B; Dhooge, C; Philippé, J | 1 |
| Back, DJ; Eagling, VA; Profit, L | 1 |
| Serrão, MP; Soares-Da-Silva, P | 1 |
| Fujita, R; Ishikawa, M; Sasaki, K; Takayanagi, M; Takayanagi, Y | 1 |
| Alvaro, D; Boyer, JL; Fraioli, F; Gigliozzi, A; Lee, J; Mennone, A; Sundaram, P | 1 |
| Blom-Roosemalen, MC; Breimer, DD; de Boer, AG; van der Sandt, IC | 1 |
| Krishan, A | 1 |
| Hu, Y; Lampidis, TJ; Moraes, CT; Priebe, W; Savaraj, N | 1 |
| Cho, CW; Henthorn, T; Liu, Y; Ng, KY; Yan, X | 1 |
| Abulrob, AN; Bryce, R; Gumbleton, M; Mason, M | 1 |
| Murakami, T; Nagai, J; Nasu, R; Sanemasa, M; Takano, M; Yumoto, R | 1 |
| Benet, LZ; Lantz, MV; Parasrampuria, DA | 1 |
| Hamada, A; Nakano, M; Ohmura, T; Oyama, N; Shiraki, N; Tokunaga, J | 1 |
| Greenblatt, DJ; Perloff, MD; Störmer, E; von Moltke, LL | 1 |
| Azevedo, I; Keating, E; Martel, F | 1 |
| Appert, HE; Howard, JM; Iwamura, T; Liu, B; Staren, ED | 1 |
| Auchère, D; Banide, H; Farinotti, R; Lacour, B; Leroy, C; Tardivel, S; Veau, C | 1 |
| Hirsch-Ernst, KI; Kahl, GF; Rustenbeck, I; Ziemann, C | 1 |
| Foth, H; Köhler, C; Lehmann, T; Taege, C; Weidauer, E | 1 |
| Cohen, D; Uchiyama-Kokubu, N; Watanabe, T | 1 |
| Cho, CW; Cobb, WN; Henthorn, TK; Lillehei, KO; Liu, Y; Ng, KY; Yan, X | 1 |
| Greenblatt, DJ; Perloff, MD; Shader, RI; Störmer, E; von Moltke, LL | 1 |
| Cox, DS; Eddington, ND; Gao, H; Raje, S; Scott, KR | 1 |
| Anagnostopoulos, N; Androutsos, G; Galanopoulos, A; Kalmantis, T; Meletis, J; Paterakis, G; Rombos, Y; Sagriotis, A; Symeonidis, A; Tiniakou, M; Tsimberidou, AM; Yataganas, X; Zoumbos, N | 1 |
| Bates, SE; Dietel, M; Hohenberger, P; Jordan, A; Lage, H; Litman, T; Stein, U; Walther, W | 1 |
| Eaves, CJ; Leung, FY; Uchida, N | 1 |
| Pajeva, IK; Wiese, M | 1 |
| Calado, RT; Carneiro, JJ; Falcão, RP; Garcia, AB; Machado, CG | 1 |
| Einicker-Lamas, M; Garcia-Abreu, J; Miranda, K; Morales, MM; Oliveira, AJ; Oliveira, MM; Silva, FL | 1 |
| Gerloff, T; Mrozikiewicz, PM; Oselin, K; Pähkla, R; Roots, I | 1 |
| Bähr, O; Duffner, F; Meyermann, R; Rieger, J; Weller, M; Wick, W | 1 |
| Maia, RC; Marques-Santos, LF; Oliveira, JG; Rumjanek, VM | 1 |
| Burt, H; Jackson, J; Zastre, J | 1 |
| Annaert, PP; Brouwer, KL | 1 |
| Jankovicová, K; Kopecký, O; Krejsek, J | 1 |
| Liu, GQ; Yang, ZY | 1 |
| Balkay, L; Krasznai, Z; Krasznai, ZT; Márián, T; Szabó-Péli, J; Trón, L | 1 |
| Bailly, C; Cuevas, C; Kluza, J; Lansiaux, A; Otero, G; Tardy, C; Vanhuyse, M | 1 |
| Hayashi, M; Iida, A; Tomita, M | 1 |
| Davoren, M; Hartl, MG; Kilemade, M; Lyng, FM; Mothersill, C; O'brien, NM; O'halloran, J; Sheehan, D; Shúilleabháin, SN; Van Pelt, FN | 1 |
| Balkay, L; Esik, O; Galuska, L; Hernádi, Z; Krasznai, Z; Krasznai, ZT; Márián, T; Szabó, G; Szabó-Péli, J; Trón, L | 1 |
| He, L; Ji, BS; Liu, GQ | 1 |
| He, Y; Zeng, S | 1 |
| Balimane, P; Kadiyala, P; Olah, T; Smalley, J; Xin, B | 1 |
| Inoue-Murayama, M; Iwasaki, T; Kawabata, A; Momoi, Y | 1 |
| Hoffer, M; Werle, M | 1 |
| Halliday, GM; Ishri, RK; Menzies, S | 1 |
| Bertelsen, KM; Greenblatt, DJ; von Moltke, LL | 1 |
| Hao, D; Stein, WD; Wang, Y; Yang, L | 1 |
| Chattopadhyay, A; Dey, S; Fong, WF; Shen, XL; Wan, CK; Zhu, GY | 1 |
| Hayashi, M; Idota, Y; Iida, A; Takizawa, Y; Tomita, M | 1 |
| Bian, S; Cho, HJ; Chung, SJ; Kim, DD; Kim, JS; Lee, MK; Li, H; Lin, H; Roh, HJ; Shim, CK | 1 |
| Ambudkar, SV; Calcagno, AM; Gottesman, MM; Kim, IW; Kimchi-Sarfaty, C; Oh, JM; Sauna, ZE | 1 |
| Itamoto, K; Kadosawa, T; Nakaichi, M; Nakamoto, Y; Okuda, M; Sasaki, N; Takahashi, T; Takeshita, Y; Taura, Y; Une, S | 1 |
| Cheon, EP; Han, CY; Han, HK; Kang, KW; Lee, J | 1 |
| Ackerley, C; Clarke, DM; De Rosa, MF; Ito, S; Lingwood, C; Wang, B | 1 |
| Ambudkar, SV; Barnett, D; Bates, SE; Finley, EM; Fojo, T; Oldham, RK; Robey, RW; Shukla, S | 1 |
| Gassner, B; Gekle, M; Kelleher, DK; Thews, O | 1 |
| Liu, HY; Liu, X; Liu, XD; Liu, YC; Wang, GJ; Xie, L; Yang, HW; Zhang, DM | 1 |
| Sun, F; Xia, ZL; Yao, TW; Ying, JY; Zeng, S | 1 |
| Berardi, F; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Perrone, R | 1 |
| Lopez, P; Sánchez, Mdel C; Vélez, R; Yamamura, Y | 1 |
| Li, B; Li, Q; Lu, Y; Ma, L; Pang, T; Wakabayashi, S; Wang, J; Xiong, D | 1 |
| Chmielewski, J; Emmert, D; Hrycyna, CA; Pires, MM | 1 |
| Chen, SG; Li, GY; Liu, JZ; Wang, CB; Wang, LX; Zhang, B | 1 |
| De Blasio, A; Di Fiore, R; Ferrante, RD; Giuliano, M; Messina, C; Pirozzi, G; Santulli, A; Tesoriere, G; Tirino, V; Vento, R | 1 |
| He, L; Xia, YZ; Yan, M; Zhang, LY; Zhao, C | 1 |
| Chatterjee, M; Mandal, G; Saha, P; Sarkar, A; Singh, N; Sundar, S | 1 |
| Baer, KN; Damaré, CL; Kaddoumi, AK | 1 |
| Carballo, MA; Cortada, CM; Gil, A; Goncalves, S; Rubio, MC; Sambuelli, A | 1 |
| Hayashi, M; Kishimoto, H; Takizawa, Y; Tomita, M | 2 |
| Kawami, M; Nagai, J; Otani, Y; Takano, M; Tanda, M; Yumoto, R | 1 |
| Li, L; Liu, GQ; Xu, HB | 2 |
| Bennani-Baiti, B; Gabor, F; Modha, M; Neuhaus, W; Noe, CR; Stessl, M; Strizsik, E; Toegel, S; Viernstein, H; Winkler, J; Wirth, M | 1 |
| Chen, X; Dai, J; Li, H; Li, Y; Qu, R; Su, F; Wang, H; Yin, D; Zhang, Y | 1 |
| Baum, L; Kwan, P; Zhang, C; Zuo, Z | 1 |
| Junyaprasert, VB; Kawami, M; Nagai, J; Patanasethanont, D; Soonthornchareonnon, N; Sripanidkulchai, BO; Takano, M; Yumoto, R | 1 |
| Allen, J; Bebawy, M; Kota, BP; Roufogalis, BD; Tran, VH | 1 |
| Arnoult, C; Barattin, R; Bourges, K; Boutonnat, J; D'Hardemare, AD; Gerby, B; Hardy, G; Olivares, J; Ronot, X | 1 |
| Ai, H; Gu, Y; Hao, G; Li, Y; Peng, Y; Sun, J; Wang, G; Wu, X; Zhang, J; Zhang, X; Zheng, Y; Zhou, F | 1 |
| Carsetti, R; D'Amelio, R; Diamanti, AP; Germano, V; Giorda, E; Laganà, B; Podestà, E; Rosado, M; Scarsella, M | 1 |
| Chen, WQ; Fu, LW; Liang, YJ; Mi, YJ; Su, XD; Wang, F; Xiang, QF; Zheng, LS | 1 |
| Wang, XD; Zeng, S | 1 |
| Catania, VA; Mottino, AD; Perdomo, VG; Rigalli, JP; Ruiz, ML; Villanueva, SS | 1 |
| Behravan, J; Hanafi-Bojd, MY; Iranshahi, M; Kalalinia, F; Mosaffa, F; Tehrani, SO | 1 |
| Abuznait, AH; Kaddoumi, A; Patrick, SG | 1 |
| Cai-Hong, Z; Fang, M; Jin-Hua, J; Li, H; Ning, W; Qing-Duan, W; Xiao-Juan, G; Yan, Z | 1 |
| Huang, WL; Lan, XB; Li, YM; Qian, H; Zou, ZH | 1 |
| Boucau, MC; Cecchelli, R; Dehouck, L; Dehouck, MP; Fenart, L; Gosselet, F; Sevin, E; Tardivel, M; Uzbekov, R; Vandenhaute, E | 1 |
| Du, GH; Mei, C; Qi, Y; Sun, X; Sun, XB; Yang, ZH | 1 |
| Deng, S; Wan, W; Wu, Y; Yen, TC; Yu, C; Zhang, B | 1 |
| Fukuda, M; Mizutani, T; Mochizuki, W; Morikawa, R; Nagaishi, T; Nakamura, T; Nemoto, Y; Nozaki, K; Okamoto, R; Tsuchiya, K; Watanabe, M; Yamauchi, Y; Yui, S | 1 |
| Andrews, FM; Linardi, RL; Stokes, AM | 1 |
| Chula, S; Hang, L; Jianning, S; Shi, R; Yinying, B | 1 |
| Fang, W; Geng, X; Li, Y; Lv, P; Sha, L; Shang, E; Yang, Q | 1 |
| Han, HK; Kang, KW; Lee, MY; Lee, YJ; Oh, SJ | 1 |
| Chen, WM; Chen, ZS; Fu, LW; Fung, KP; Lan, P; Li, YJ; Peng, YH; Ruan, ZX; Shu, C; Wang, J; Yao, Z; Ye, WC; Yiu, A; Zhang, DM | 1 |
| Bleier, BS; Feldman, RE; Han, X; Hoang, JD; Iqbal, H; Nocera, AL | 1 |
| Chiou, MH; Hsieh, YW; Huang, CL; Hung, CC; Lane, HY; Teng, YN | 1 |
| Baum, L; Chanteux, H; Kwan, P; Zhang, C; Zuo, Z | 1 |
| Cen, J; Darshika, KN; Fang, W; Feng, Y; Hu, Y; Huang, W; Li, Y | 1 |
| Cen, J; He, L; Ji, BS; Liu, L | 1 |
| Carpini, GD; Ghanem, CI; Luquita, MG; Mottino, AD; Novak, A; Rubio, MC; Ruiz, ML | 1 |
| Adkins, CE; Bohn, KA; Lockman, PR; Manda, VK; Mittapalli, RK | 1 |
| Junco, JJ; Kim, DJ; Liang, H; Malik, G; Mancha, A; Slaga, TJ; Wei, SJ | 1 |
| Fang, W; Feng, Y; Hu, Y; Huang, W; Kodithuwakku, ND; Li, Y; Zhang, Y | 1 |
| Cheng, H; Dong, X; Ruan, M; Yu, B; Yu, Y | 1 |
| Antoniou, M; Austrup, J; Christodoulou, V; Dedet, JP; Ntais, P; Pratlong, F | 1 |
| Li, M; Ma, B; Sun, G; Sun, J; Sun, X; Wang, J; Xu, H | 1 |
| Fukami, T; Suzuki, T; Tomono, K | 1 |
| Ambudkar, SV; Horger, KS; Liu, H; Mayer, M; Rao, DK; Sept, D; Shukla, S | 1 |
| Chen, XG; Dai, JG; Hu, JP; Jia, YF; Li, Y; Mei, M; Ren, JH; Xie, D; Zhang, Y | 1 |
| de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M | 1 |
| Amaral, L; Csonka, Á; Gajdács, M; Hajós, G; Horváth, Á; Molnár, J; Riedl, Z; Spengler, G; Takács, D; Windt, T | 1 |
| Bernkop-Schnürch, A; Laffleur, F; Netsomboon, K | 1 |
| Hua, F; Li, M; Li, Y; Wang, HX; Yu, XM; Zhu, CJ; Zhu, XL | 1 |
| Marques, SS; Miró, M; Pávek, P; Segundo, MA; Sklenářová, H; Solich, P; Zelená, L | 1 |
| Ma, S; Miao, P; Miao, Q; Wang, Z; Zhang, Y; Zhao, Y | 1 |
| Bhutto, ZA; Dong, L; Guo, D; Guo, L; Guo, T; He, F; Huang, J; Wang, L; Zhang, H | 1 |
| Burhenne, J; Fricker, G; Mylius, P; Schubert, R; Weinheimer, M | 1 |
| Li, D; Liu, M; Sun, J; Wang, X; Zeng, Z; Zhang, X; Zhang, Y; Zhao, J | 1 |
| Govitrapong, P; Jumnongprakhon, P; Sivasinprasasn, S; Tocharus, C; Tocharus, J | 1 |
| Dong, W; Guan, XJ; Liang, XL; Liao, ZG; Yang, M; Zhang, J; Zhao, GW | 1 |
| Kamioka, H; Mizoi, K; Ogihara, T; Seto, S; Yano, K | 1 |
| Handzlik, J; Kaczor, A; Kincses, A; Latacz, G; Nové, M; Spengler, G; Szymańska, E | 1 |
| Horstkotte, B; Miró, M; Pávek, P; Rosecká, M; Sklenářová, H; Solich, P | 1 |
| Hung, CC; Lan, YH; Lin, KI; Lin, YC; Teng, YN; Thang, TD | 1 |
| Huang, BH; Huang, SY; Hung, CC; Lee, TE; Teng, YN; Wu, IT; Wu, TS | 1 |
| Abdel-Gaber, SA; El-Daly, M; Ibrahim, ARN; Jacob, S; Kandeel, M; Morsy, MA; Shinu, P; Venugopala, KN | 1 |
| Santoni-Rugiu, E; Silverman, JA | 1 |
| Dintaman, JM; Kim, AE; Silverman, JA; Waddell, DS | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Globisch, C; Kassack, MU; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
1 review(s) available for rhodamine 123 and verapamil
| Article | Year |
|---|---|
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Topics: Animals; Biogenic Amines; Humans; Plasma Membrane Neurotransmitter Transport Proteins; Xenobiotics | 2016 |
2 trial(s) available for rhodamine 123 and verapamil
| Article | Year |
|---|---|
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Factors; Biological Transport; Cell Line; Cell Line, Tumor; Cyclosporins; Depsipeptides; Fluorescent Dyes; Fluorouracil; Humans; Insecta; Multidrug Resistance-Associated Proteins; Neoplasms; Paclitaxel; Prazosin; Quinolines; Rhodamine 123; Verapamil; Vinblastine | 2008 |
Cyclosporine diminishes multidrug resistance in K562/ADM cells and improves complete remission in patients with acute myeloid leukemia.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Survival; Cyclosporine; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorescent Dyes; Humans; Idarubicin; Inhibitory Concentration 50; K562 Cells; Leukemia, Myeloid, Acute; Male; Rhodamine 123; Time Factors; Treatment Outcome; Verapamil | 2009 |
199 other study(ies) available for rhodamine 123 and verapamil
| Article | Year |
|---|---|
Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization.
Topics: Amides; Animals; Cell Line, Tumor; Cell Proliferation; Dogs; Dose-Response Relationship, Drug; Humans; Mice; Microsomes, Liver; Microtubules; Molecular Structure; Neoplasms, Experimental; Polymerization; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship | 2018 |
Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo.
Topics: Afatinib; Animals; Antineoplastic Agents; Benzamides; Cell Cycle Checkpoints; Cell Line; Cell Membrane Permeability; Cell Movement; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Drug Stability; ErbB Receptors; Half-Life; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Rats; Resorcinols; Transplantation, Heterologous | 2021 |
Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Dogs; Equilibrative Nucleoside Transport Proteins; Humans; Membrane Transport Proteins; Nerve Tissue Proteins; Organic Cation Transport Proteins; Tyramine | 2005 |
The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Colchicine; Daunorubicin; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Ileum; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Membrane Glycoproteins; Microvilli; Rats; Rats, Inbred Strains; Rhodamine 123; Rhodamines; Temperature; Verapamil | 1992 |
In archaebacteria, there is a doxorubicin efflux pump similar to mammalian P-glycoprotein.
Topics: Animals; Archaea; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bacillus subtilis; Biological Transport, Active; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Division; Diltiazem; Doxorubicin; Drug Resistance, Microbial; Drug Synergism; Flow Cytometry; Fluorescent Dyes; Mammals; Membrane Glycoproteins; Nifedipine; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1992 |
Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Capillaries; Cells, Cultured; Cyclosporine; Drug Resistance; Endothelium, Vascular; Humans; Membrane Glycoproteins; Mice; Rhodamine 123; Rhodamines; Swine; Verapamil | 1992 |
Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Daunorubicin; Doxorubicin; Drug Resistance; Humans; KB Cells; Lasers; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Rhodamine 123; Rhodamines; Transfection; Verapamil | 1991 |
Transforming growth factors type beta inhibit multidrug transport in rat astrocyte cell lines.
Topics: Animals; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bone Morphogenetic Proteins; Cell Line; Doxorubicin; Membrane Glycoproteins; Proteins; Rats; Rhodamine 123; Rhodamines; Transforming Growth Factor beta; Verapamil; Vincristine | 1991 |
Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance.
Topics: Carcinoma, Squamous Cell; Cell Membrane Permeability; Chromatography, Gel; Colchicine; Doxorubicin; Drug Resistance; Humans; Polyethylene Glycols; Rhodamine 123; Rhodamines; Stearic Acids; Tumor Cells, Cultured; Verapamil; Vinblastine | 1991 |
Relationship between cellular accumulation of rhodamine 123 (R123) and cytotoxicity in B16 melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Resistance; Melanoma, Experimental; Mitochondria; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Xanthenes | 1989 |
The membrane transport system responsible for multidrug resistance is operating in nonresistant cells.
Topics: Animals; Biological Transport, Active; Cell Line, Transformed; Cell Membrane; Cricetinae; Drug Resistance; Fibroblasts; Fluorescent Dyes; Microscopy, Fluorescence; Mitochondria; Reserpine; Rhodamine 123; Rhodamines; Trifluoperazine; Verapamil | 1988 |
Reversal of intrinsic resistance to adriamycin in normal cells by verapamil.
Topics: Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Female; Humans; Rhodamine 123; Rhodamines; Verapamil | 1986 |
Reversal of resistance to rhodamine 123 in adriamycin-resistant Friend leukemia cells.
Topics: Animals; Doxorubicin; Drug Resistance; Friend murine leukemia virus; Leukemia, Experimental; Rhodamine 123; Rhodamines; Verapamil; Xanthenes | 1985 |
Flow cytometric functional analysis of multidrug resistance by Fluo-3: a comparison with rhodamine-123.
Topics: Alkaloids; Aniline Compounds; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Benzylisoquinolines; Calcium Channel Blockers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Dyes; Gene Expression; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Xanthenes | 1995 |
Dyes providing increased sensitivity in flow-cytometric dye-efflux assays for multidrug resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Burkitt Lymphoma; Calcium Channel Blockers; Coloring Agents; Drug Resistance, Multiple; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Leukemia P388; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Promyelocytic, Acute; Mice; Rhodamine 123; Rhodamines; Sensitivity and Specificity; Tumor Cells, Cultured; Verapamil | 1995 |
Expression of multidrug resistance in response to differentiation in the K562 human leukaemia cell line.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Butyrates; Butyric Acid; Cell Differentiation; Cell Survival; Colchicine; Drug Resistance, Multiple; Epirubicin; Humans; Leukemia; Phenotype; Rhodamine 123; Rhodamines; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1995 |
Expression and function of P-glycoprotein in a mouse kidney cell line.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cell Polarity; Cricetinae; Cyclosporine; Epithelium; Homeostasis; Immunologic Techniques; Kidney; Kidney Tubules, Proximal; Mice; Mice, Transgenic; Rhodamine 123; Rhodamines; RNA, Messenger; Verapamil | 1995 |
Differential modulation of P-glycoprotein transport by protein kinase inhibition.
Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Carrier Proteins; Cyclosporine; Dactinomycin; Dihydropyridines; Drug Resistance; Humans; Isoenzymes; Membrane Glycoproteins; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine | 1993 |
Active cell membrane mechanisms involved in the exclusion of Rh 123 allow distinction between normal and tumoral cells.
Topics: Cell Membrane; Cells, Cultured; Drug Resistance, Multiple; Fibroblasts; Flow Cytometry; Humans; Neoplasms; Probenecid; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1994 |
Establishment and characterization of a multidrug-resistant human bladder carcinoma cell line RT112/D21.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Cell Division; Doxorubicin; Drug Resistance, Multiple; Humans; Immunohistochemistry; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Verapamil | 1995 |
Constitutive expression of P-glycoprotein as a determinant of loading with fluorescent calcium probes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium; CHO Cells; Cricetinae; Cricetulus; Cyclosporine; Cytosol; Female; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Humans; Indoles; Rhodamine 123; Rhodamines; Verapamil | 1994 |
Rapid stimulation of rhodamine 123 efflux from multidrug-resistant KB cells by progesterone.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Daunorubicin; Drug Resistance; Exocytosis; Fluorescent Dyes; Humans; Membrane Glycoproteins; Membrane Potentials; Mice; Progesterone; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Up-Regulation; Verapamil | 1993 |
Staining with Hoechst 33342 and rhodamine 123: an attempt to detect multidrug resistant phenotype cells in leukemia.
Topics: Adult; Aged; Antigens, CD; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Carrier Proteins; Drug Resistance; Female; Flow Cytometry; Fluorescent Dyes; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Male; Membrane Glycoproteins; Middle Aged; Phenotype; Rhodamine 123; Rhodamines; Verapamil | 1993 |
Two multidrug-resistant Friend leukemic cell lines selected with different drugs exhibit overproduction of different P-glycoproteins.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Doxorubicin; Drug Resistance; Friend murine leukemia virus; Gene Expression Regulation, Leukemic; Leukemia, Experimental; Membrane Glycoproteins; Retroviridae Infections; Rhodamine 123; Rhodamines; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Virus Infections; Verapamil | 1994 |
Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Carrier Proteins; Colchicine; Drug Resistance; Humans; Membrane Glycoproteins; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vincristine | 1994 |
Chemomodulation of drugs involved in multidrug resistance in chronic lymphatic leukemia of the B-cell type.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Daunorubicin; Drug Resistance; Flow Cytometry; Humans; Immunophenotyping; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Glycoproteins; Neoplasm Proteins; Rhodamine 123; Rhodamines; Verapamil; Vincristine | 1994 |
Novobiocin modulates colchicine sensitivity in parental and multidrug-resistant B16 melanoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Clone Cells; Colchicine; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Melanoma, Experimental; Mice; Novobiocin; Phenotype; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |
Effects of P-glycoprotein expression on cyclic AMP and volume-activated ion fluxes and conductances in HT-29 colon adenocarcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlorides; Colforsin; Colonic Neoplasms; Cyclic AMP; Humans; In Vitro Techniques; Ion Channel Gating; Osmolar Concentration; Potassium; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1994 |
Modulation of rhodamine 123 uptake by nigericin in sensitive and multidrug resistant leukemic cells.
Topics: Animals; Antimetabolites, Antineoplastic; Doxorubicin; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Friend murine leukemia virus; Humans; Intracellular Membranes; Leukemia; Leukemia, Erythroblastic, Acute; Membrane Potentials; Mice; Mitochondria; Nigericin; Phenotype; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Tumor Virus Infections; Verapamil; Vinblastine | 1994 |
Diverse multidrug-resistance-modification agents inhibit cytolytic activity of natural killer cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Drug Resistance; Humans; Killer Cells, Natural; Membrane Glycoproteins; Propylamines; Rhodamine 123; Rhodamines; Verapamil | 1993 |
Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Doxorubicin; Drug Resistance; Humans; Male; Membrane Glycoproteins; Phenotype; Prostatic Neoplasms; Rhodamine 123; Rhodamines; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1993 |
Estradiol induction of rhodamine 123 efflux and the multidrug resistance pump in rat pituitary tumor cells.
Topics: Animals; Cyclosporins; Drug Resistance; Estradiol; Pituitary Neoplasms; Rats; Rhodamine 123; Rhodamines; RNA, Messenger; Tumor Cells, Cultured; Verapamil | 1993 |
Leishmania amazonensis: multidrug resistance in vinblastine-resistant promastigotes is associated with rhodamine 123 efflux, DNA amplification, and RNA overexpression of a Leishmania mdr1 gene.
Topics: Animals; Antiprotozoal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; DNA, Protozoan; Doxorubicin; Drug Resistance, Multiple; Electrophoresis, Gel, Pulsed-Field; Gene Amplification; Genes, Protozoan; Leishmania; Molecular Probe Techniques; Phenotype; Rhodamine 123; Rhodamines; RNA, Protozoan; Verapamil; Vinblastine | 1995 |
Decreased potency of MDR-modulators under serum conditions determined by a functional assay.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD8-Positive T-Lymphocytes; Cyclosporine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Rhodamine 123; Rhodamines; Verapamil | 1995 |
Chemosensitization and drug accumulation assays as complementary methods for the screening of multidrug resistance reversal agents.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; Leukemia P388; Mice; Rhodamine 123; Rhodamines; Verapamil | 1996 |
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity.
Topics: Acute Disease; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cryopreservation; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Feasibility Studies; Fluorescent Dyes; Humans; Leukemia; Leukemia, Myeloid; Neoplasm Proteins; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Rhodamine 123; Rhodamines; Sensitivity and Specificity; Verapamil; Vincristine | 1996 |
Combined cytotoxic effects of tamoxifen and chemotherapeutic agents on bladder cancer cells: a potential use in intravesical chemotherapy.
Topics: Administration, Intravesical; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Cell Division; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Sequence Data; Rhodamine 123; Rhodamines; Tamoxifen; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Verapamil | 1996 |
Rhodamine 123 efflux transporter in Haloferax volcanii is induced when cultured under 'metabolic stress' by amino acids: the efflux system resembles that in a doxorubicin-resistant mutant.
Topics: Adenosine Triphosphate; Amino Acids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Culture Media; Dicyclohexylcarbodiimide; Doxorubicin; Drug Resistance, Microbial; Halobacteriaceae; Leucine; Membrane Potentials; Rhodamine 123; Rhodamines; Verapamil | 1996 |
The role of passive transbilayer drug movement in multidrug resistance and its modulation.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Drug Resistance, Multiple; Drug Synergism; Fluorescent Dyes; Lipid Bilayers; Liposomes; Rhodamine 123; Rhodamines; Substrate Specificity; Verapamil | 1996 |
Primitive human hematopoietic cells displaying differential efflux of the rhodamine 123 dye have distinct biological activities.
Topics: Adult; Animals; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Cell Division; Flow Cytometry; Hematopoiesis; Hematopoietic Stem Cells; Humans; Mice; Mice, SCID; Rhodamine 123; Rhodamines; Sheep; Thy-1 Antigens; Transplantation, Heterologous; Verapamil | 1996 |
Polyaromatic alkaloids from marine invertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by P-glycoprotein.
Topics: Adenocarcinoma; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Colonic Neoplasms; Cricetinae; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia P388; Lung Neoplasms; Mice; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1996 |
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Topics: 3T3 Cells; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Bone Neoplasms; Cell Membrane; Colchicine; Drug Resistance, Multiple; Genetic Vectors; Humans; Mice; Nicardipine; Onium Compounds; Organophosphorus Compounds; Osteosarcoma; Point Mutation; Prazosin; Recombinant Fusion Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Vaccinia virus; Verapamil; Vinblastine | 1996 |
Comparison of drug accumulation in P-glycoprotein-expressing and MRP-expressing human leukaemia cells.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Buthionine Sulfoximine; Calcium Channel Blockers; Cyclosporins; Daunorubicin; Humans; Idarubicin; Leukemia, T-Cell; Multidrug Resistance-Associated Proteins; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1996 |
Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Cell Survival; Cyclosporins; Dihydropyridines; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Multiple; Humans; Neoplasm Proteins; Phenotype; Polymerase Chain Reaction; Prazosin; Rhodamine 123; Rhodamines; Sarcoma; Vault Ribonucleoprotein Particles; Verapamil | 1997 |
Multidrug resistance in androgen-independent growing rat prostate carcinoma cells is mediated by P-glycoprotein.
Topics: Androgens; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Fluorescent Dyes; Genes, MDR; Male; Methotrexate; Neoplasms, Hormone-Dependent; Paclitaxel; Prostatic Neoplasms; Rats; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1997 |
Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Binding Sites; Calcium Channel Blockers; Consensus Sequence; DNA, Complementary; Drug Resistance, Multiple; Fluoresceins; Genetic Vectors; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nucleopolyhedroviruses; Recombinant Fusion Proteins; Rhodamine 123; Rhodamines; Spodoptera; Structure-Activity Relationship; Valinomycin; Verapamil | 1997 |
Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Chlorocebus aethiops; Coccidiostats; Cyclosporine; Cyclosporins; Enzyme Inhibitors; Female; Immunosuppressive Agents; Mice; Peptidylprolyl Isomerase; Rhodamine 123; Rhodamines; Sensitivity and Specificity; Toxoplasma; Verapamil; Vero Cells | 1997 |
Quantification of P-glycoprotein in chronic lymphocytic leukemia by flow cytometry.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Doxorubicin; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluorescent Dyes; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Neoplasm Proteins; Neuraminidase; Rhodamine 123; Rhodamines; Sensitivity and Specificity; Verapamil | 1997 |
Comparative effect of verapamil, cyclosporin A and SDZ PSC 833 on rhodamine 123 transport and cell cycle in vinblastine-resistant Chinese hamster ovary cells overexpressing P-glycoprotein.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Cycle; Cell Line; CHO Cells; Cricetinae; Cyclosporine; Cyclosporins; DNA; Drug Resistance, Neoplasm; Flow Cytometry; Immunosuppressive Agents; Rhodamine 123; Rhodamines; Verapamil; Vinblastine | 1997 |
Comparison between anthracyclines and rhodamine-123 accumulation in chronic lymphoid leukemia: effect of cyclosporin A and verapamil.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Drug Resistance, Multiple; Female; Flow Cytometry; Fluorescent Dyes; Humans; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1998 |
Induction of multidrug resistance gene expression in rat liver cells in response to acute treatment by the DNA-damaging agent methyl methanesulfonate.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Cells, Cultured; Cytochrome P-450 CYP1A1; DNA Damage; Drug Resistance, Multiple; Gene Expression Regulation; Liver; Methyl Methanesulfonate; Mutagens; Rats; Rats, Sprague-Dawley; Rhodamine 123; Rhodamines; RNA, Messenger; Up-Regulation; Verapamil | 1998 |
P-glycoprotein-mediated multidrug resistance is modulated by pretreatment with chemosensitizers in HCT-8 carcinoma cells in vitro.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Ileal Neoplasms; Ileocecal Valve; Kinetics; Phosphorylation; Rhodamine 123; Rhodamines; Tamoxifen; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Verapamil; Vinblastine | 1998 |
Drug binding to P-glycoprotein is inhibited in normal tissues following SDZ-PSC 833 treatment.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Brain; Calcium Channel Blockers; Capillaries; Cyclosporine; Cyclosporins; Drug Interactions; Fluorescent Dyes; Injections, Subcutaneous; Iodine Radioisotopes; Kidney; Liver; Male; Microvilli; Photoaffinity Labels; Prazosin; Rats; Rats, Sprague-Dawley; Rhodamine 123; Rhodamines; Verapamil; Vinblastine | 1998 |
Estimation of drug resistance by flow cytometry.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Flow Cytometry; Genistein; Leukemia L5178; Mice; Probenecid; Recombinant Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Verapamil | 1998 |
Radioligand-binding assay employing P-glycoprotein-overexpressing cells: testing drug affinities to the secretory intestinal multidrug transporter.
Topics: Adrenergic beta-Antagonists; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Caco-2 Cells; Calcium Channel Blockers; Fluorescent Dyes; Humans; Kinetics; Propanolamines; Radioligand Assay; Reproducibility of Results; Rhodamine 123; Rhodamines; Tritium; Verapamil; Vinblastine | 1998 |
Rhodamine 123 efflux modulation in the presence of low or high serum from CD56+ hematopoietic cells or CD34+ leukemic blasts by B9309-068, a newly designed pyridine derivative.
Topics: Acridines; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blood Proteins; Calcium Channel Blockers; CD56 Antigen; Cyclosporins; Dihydropyridines; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Dyes; Gene Expression; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Morpholines; Multidrug Resistance-Associated Proteins; Pyrimidines; Rhodamine 123; Rhodamines; Tetrahydroisoquinolines; Verapamil | 1998 |
Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Assay; Breast Neoplasms; Cyclosporine; Female; Humans; Rhodamine 123; Sensitivity and Specificity; Verapamil | 1996 |
Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells.
Topics: Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Caco-2 Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Erythromycin; GABA Modulators; Humans; Ketoconazole; Midazolam; Oxidoreductases, N-Demethylating; Rhodamine 123; Substrate Specificity; Vasodilator Agents; Verapamil | 1998 |
Characterisation of granulocyte stimulation by thionins from European mistletoe and from wheat.
Topics: Antimicrobial Cationic Peptides; Calcium Channel Blockers; Escherichia coli; Europe; Fluorescein-5-isothiocyanate; Granulocytes; Humans; Mistletoe; Phagocytosis; Plant Preparations; Plant Proteins; Plants, Medicinal; Respiratory Burst; Rhodamine 123; Ribosome Inactivating Proteins, Type 2; Toxins, Biological; Verapamil | 1999 |
Flow cytometry analysis of drug transport mechanisms in Haemonchus contortus susceptible or resistant to anthelmintics.
Topics: Animals; Anthelmintics; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Drug Resistance, Multiple; Flow Cytometry; Haemonchus; Kinetics; Ovum; Rhodamine 123; Thiabendazole; Verapamil | 1999 |
Detection of a P-glycoprotein related pump in Chironomus larvae and its inhibition by verapamil and cyclosporin A.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Chironomidae; Cyclosporine; Immunohistochemistry; Insecticide Resistance; Larva; Rhodamine 123; Verapamil; Xenobiotics | 1998 |
Reversal of P-glycoprotein-mediated multidrug resistance in vitro by AV200, a new ardeemin derivative.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Heterocyclic Compounds, 3-Ring; Humans; Paclitaxel; Rhodamine 123; Tumor Cells, Cultured; Verapamil; Vincristine | 1998 |
Transport of phosphatidylcholine in MDR3-negative epithelial cell lines via drug-induced MDR1 P-glycoprotein.
Topics: 4-Chloro-7-nitrobenzofurazan; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Doxorubicin; Drug Resistance, Neoplasm; Epithelial Cells; Flow Cytometry; Fluorescent Dyes; Humans; Kinetics; Phenotype; Phosphatidylcholines; Rhodamine 123; RNA, Messenger; Tumor Cells, Cultured; Verapamil | 1999 |
Diversity of the plasma membrane properties of transplantable hamster melanomas with regard to the expression of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membrane; Cell Size; Cricetinae; Flow Cytometry; Fluorescent Dyes; Male; Melanoma, Amelanotic; Melanoma, Experimental; Melanosis; Mesocricetus; Neoplasm Transplantation; Rhodamine 123; Verapamil | 1999 |
Discordance of P-glycoprotein expression and function in acute leukemia.
Topics: Adolescent; Adult; Age Factors; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow; Child; Child, Preschool; Female; Flow Cytometry; Genes, MDR; Humans; Infant; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Rhodamine 123; Verapamil | 1999 |
Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Flow Cytometry; Fluorescent Dyes; HIV Protease Inhibitors; Humans; Indinavir; Lymphocytes; Nelfinavir; Rhodamine 123; Ritonavir; Saquinavir; Temperature; Verapamil | 1999 |
Outward transfer of dopamine precursor L-3,4-dihydroxyphenylalanine (L-dopa) by native and human P-glycoprotein in LLC-PK(1) and LLC-GA5 col300 renal cells.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Line; Dopamine; Fluoresceins; Fluorescent Dyes; Humans; Kidney; Kinetics; Levodopa; LLC-PK1 Cells; Proteins; Rhodamine 123; Swine; Verapamil; Vinblastine | 2000 |
Enhancement of doxorubicin activity in multidrug-resistant cells by mefloquine.
Topics: Affinity Labels; Antibiotics, Antineoplastic; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Calcium Channel Blockers; Coloring Agents; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Mefloquine; Phenotype; Rhodamine 123; Tumor Cells, Cultured; Verapamil | 2000 |
Molecular identification and functional characterization of Mdr1a in rat cholangiocytes.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Bile Ducts; Cell Division; Cell Membrane; Cytosol; Drug Resistance, Multiple; In Vitro Techniques; Isoquinolines; Kinetics; Male; Microscopy, Confocal; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Tetrahydroisoquinolines; Transcription, Genetic; Vanadates; Verapamil | 2000 |
Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cell Polarity; Cimetidine; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Kinetics; LLC-PK1 Cells; Rhodamine 123; Swine; Tumor Cells, Cultured; Verapamil | 2000 |
Monitoring of cellular resistance to cancer chemotherapy: drug retention and efflux.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Calcium Channel Blockers; Cell Membrane Permeability; Chlorpromazine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Dyes; Humans; Mice; Rhodamine 123; Staining and Labeling; Tumor Cells, Cultured; Verapamil | 2001 |
Rho(0) tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugs.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Division; DNA, Mitochondrial; Doxorubicin; Drug Interactions; Fluorescent Dyes; Humans; Mitochondria; Models, Biological; Rhodamine 123; Tumor Cells, Cultured; Tumor Stem Cell Assay; Verapamil | 2000 |
Carrier-mediated uptake of rhodamine 123: implications on its use for MDR research.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Drug Resistance, Multiple; Humans; Rhodamine 123; Tumor Cells, Cultured; Verapamil | 2000 |
The effect of fatty acids and analogues upon intracellular levels of doxorubicin in cells displaying P-glycoprotein mediated multidrug resistance.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Humans; Rhodamine 123; Tumor Cells, Cultured; Verapamil | 2000 |
Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Blotting, Western; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Erythromycin; Intestinal Absorption; Intestines; Liver; Male; Midazolam; Oxidoreductases, N-Demethylating; Rats; Rats, Wistar; Rhodamine 123; Substrate Specificity; Verapamil | 2001 |
A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Separation; Cyclosporine; Enzyme Inhibitors; Fluorescent Dyes; Humans; Immunosuppressive Agents; Lymphocytes; Quinidine; Rhodamine 123; Tacrolimus; Verapamil | 2001 |
Increase in doxorubicin cytotoxicity by inhibition of P-glycoprotein activity with lomerizine.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Doxorubicin; Drug Resistance, Multiple; Fluoresceins; Humans; K562 Cells; Piperazines; Rhodamine 123; Verapamil | 2001 |
Methadone inhibits rhodamine123 transport in Caco-2 cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Drug Interactions; Humans; Methadone; Rhodamine 123; Verapamil | 2001 |
Effect of P-glycoprotein modulators on the human extraneuronal monoamine transporter.
Topics: 1-Methyl-4-phenylpyridinium; Arginine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Cations; Cell Line; Cyclosporine; Daunorubicin; Dose-Response Relationship, Drug; Histidine; Humans; Organic Cation Transport Proteins; Rhodamine 123; Time Factors; Tritium; Tyramine; Verapamil; Vinblastine | 2001 |
Mechanisms of taxotere-related drug resistance in pancreatic carcinoma.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Docetaxel; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Dyes; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Paclitaxel; Pancreatic Neoplasms; Rhodamine 123; RNA, Messenger; Taxoids; Tubulin; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Verapamil | 2001 |
Effect of chronic renal failure on the expression and function of rat intestinal P-glycoprotein in drug excretion.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Creatinine; Cyclosporine; Intestinal Mucosa; Jejunum; Kidney Failure, Chronic; Male; Mannitol; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Rhodamine 123; RNA, Messenger; Verapamil | 2001 |
Inhibitors of mdr1-dependent transport activity delay accumulation of the mdr1 substrate rhodamine 123 in primary rat hepatocyte cultures.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cyclosporine; Enzyme Inhibitors; Excipients; Fluorescent Dyes; Hepatocytes; Male; Octoxynol; Rats; Rats, Wistar; Rhodamine 123; Vanadates; Verapamil | 2001 |
Expression of MRP1 and related transporters in human lung cells in culture.
Topics: Adult; Aged; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blotting, Western; Calcium Channel Blockers; Epithelial Cells; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Individuality; Lung; Lung Neoplasms; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Pulmonary Alveoli; Rats; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Tumor Cells, Cultured; Verapamil | 2001 |
Intracellular levels of two cyclosporin derivatives valspodar (PSC 833) and cyclosporin a closely associated with multidrug resistance-modulating activity in sublines of human colorectal adenocarcinoma HCT-15.
Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Division; Colorectal Neoplasms; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Inhibitory Concentration 50; Intracellular Fluid; Rhodamine 123; Tumor Cells, Cultured; Verapamil | 2001 |
Ultrasound-Induced hyperthermia increases cellular uptake and cytotoxicity of P-glycoprotein substrates in multi-drug resistant cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Division; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Hyperthermia, Induced; Rhodamine 123; Tumor Cells, Cultured; Ultrasonic Therapy; Verapamil | 2001 |
Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.
Topics: Adenocarcinoma; Anthracenes; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blotting, Western; Caco-2 Cells; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Humans; Hypericum; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Perylene; Protein Kinase C; Rhodamine 123; Ritonavir; Time Factors; Tumor Cells, Cultured; Verapamil | 2001 |
Influence of multidrug resistance (MDR) proteins at the blood-brain barrier on the transport and brain distribution of enaminone anticonvulsants.
Topics: Aniline Compounds; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Blood-Brain Barrier; Brain; Capillaries; Cattle; Cyclohexanones; Endothelium, Vascular; Humans; Injections, Intravenous; Male; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Probenecid; Rhodamine 123; Tissue Distribution; Tumor Cells, Cultured; Verapamil | 2001 |
Evaluation of the clinical relevance of the expression and function of P-glycoprotein, multidrug resistance protein and lung resistance protein in patients with primary acute myelogenous leukemia.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow Transplantation; Calcium Channel Blockers; Carbocyanines; Combined Modality Therapy; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Fluoresceins; Fluorescent Dyes; Genistein; Humans; Idarubicin; Immunophenotyping; Leukemia, Myeloid; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Probenecid; Prognosis; Prospective Studies; Rhodamine 123; Survival Analysis; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Verapamil | 2002 |
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Calcium Channel Blockers; DNA Primers; DNA-Binding Proteins; Doxorubicin; Drug Resistance, Multiple; Fluorescent Dyes; Gastrointestinal Neoplasms; Gene Expression Regulation; Genes, MDR; Hot Temperature; Humans; Indenes; Mitoxantrone; Multidrug Resistance-Associated Proteins; MutS Homolog 3 Protein; Mycotoxins; Neoplasm Proteins; Propionates; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; RNA, Neoplasm; Stomach Neoplasms; Verapamil | 2002 |
Liver and marrow of adult mdr-1a/1b(-/-) mice show normal generation, function, and multi-tissue trafficking of primitive hematopoietic cells.
Topics: Animals; Antigens, Differentiation; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Biological Transport; Bone Marrow Cells; Colony-Forming Units Assay; Fluorescent Dyes; Genes, MDR; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Liver; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, Mutant Strains; Mice, SCID; Rhodamine 123; Verapamil | 2002 |
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine | 2002 |
Age-related changes of P-glycoprotein-mediated rhodamine 123 efflux in normal human bone marrow hematopoietic stem cells.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bone Marrow; Child; Fluorescent Dyes; Hematopoietic Stem Cells; Humans; Middle Aged; Reference Values; Rhodamine 123; Verapamil | 2003 |
P-glycoprotein-like protein contributes to cadmium resistance in Euglena gracilis.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Cadmium; Cell Division; Dose-Response Relationship, Drug; Drug Resistance; Euglena gracilis; Membrane Transport Proteins; Microscopy, Fluorescence; Rhodamine 123; Temperature; Verapamil | 2003 |
MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4 Antigens; CD56 Antigen; Exons; Genes, MDR; Humans; In Vitro Techniques; Killer Cells, Natural; Lymphocytes; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Rhodamine 123; Rifampin; T-Lymphocytes, Helper-Inducer; Verapamil | 2003 |
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endothelial Cells; Flow Cytometry; Glioma; Humans; Immunohistochemistry; Indomethacin; Multidrug Resistance-Associated Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 2003 |
Mitotracker green is a P-glycoprotein substrate.
Topics: Aldehydes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Size; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescence; Fluorescent Dyes; Humans; K562 Cells; Mitochondria; Rhodamine 123; Time Factors; Trifluoperazine; Verapamil | 2003 |
Evidence for modulation of P-glycoprotein-mediated efflux by methoxypolyethylene glycol-block-Polycaprolactone amphiphilic diblock copolymers.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Drug Carriers; Endocytosis; Fluorescent Dyes; Humans; Isoquinolines; Microscopy, Confocal; Polyesters; Polyethylene Glycols; Polymers; Rhodamine 123; Verapamil | 2004 |
Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Culture Techniques; Cells, Cultured; Collagenases; Digoxin; Drug Interactions; Hepatocytes; Male; Progesterone; Quercetin; Quinidine; Rats; Rats, Wistar; Rhodamine 123; Verapamil | 2005 |
[Multidrug resistance of leukemia cells to cytostatics--the functional fluorescent dye efflux assay evaluated by flow cytometry].
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Dyes; Humans; K562 Cells; Leukemia, Experimental; Rhodamine 123; Verapamil | 2001 |
Effect of p-glycoprotein inhibitor combinations on drug efflux from rat brain microvessel endothelial cells.
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Blood-Brain Barrier; Calcium Channel Blockers; Capillaries; Cerebrovascular Circulation; Cyclosporine; Doxorubicin; Drug Synergism; Endothelial Cells; Fluorescent Dyes; Immunosuppressive Agents; Pharmaceutical Preparations; Rats; Rhodamine 123; Verapamil | 2004 |
Effects of miltefosine on membrane permeability and accumulation of [99mTc]-hexakis-2-methoxyisobutyl isonitrile, 2-[18F]fluoro-2-deoxy-D-glucose, daunorubucin and rhodamine123 in multidrug-resistant and sensitive cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane Permeability; Daunorubicin; Drug Resistance, Multiple; Fluorodeoxyglucose F18; Humans; Membrane Fluidity; Mice; NIH 3T3 Cells; Phosphorylcholine; Rhodamine 123; Technetium Tc 99m Sestamibi; Verapamil | 2005 |
Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Cycle; Coumarins; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Fluoresceins; Heterocyclic Compounds, 4 or More Rings; Isoquinolines; Leukemia P388; Membrane Potentials; Mice; Mitochondria; Rhodamine 123; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Verapamil | 2005 |
Regional difference in P-glycoprotein function in rat intestine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colon; Ileum; Intestinal Absorption; Intestinal Mucosa; Intestines; Jejunum; Male; Rats; Rats, Wistar; Rhodamine 123; Verapamil; Water | 2005 |
Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Cells, Cultured; Drug Resistance, Multiple; Environmental Pollutants; Epidermis; Gene Expression Regulation; Geologic Sediments; Immunohistochemistry; Microscopy, Confocal; Models, Biological; Oncorhynchus mykiss; Protein Transport; Rhodamine 123; Verapamil; Xenobiotics | 2005 |
Biphasic accumulation kinetics of [99mTc]-hexakis-2-methoxyisobutyl isonitrile in tumour cells and its modulation by lipophilic P-glycoprotein ligands.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cricetinae; Cyclosporine; Drug Resistance, Multiple; Fluorine Radioisotopes; Gluconates; Humans; Intracellular Membranes; Ligands; Membrane Fluidity; Membrane Potentials; Mice; Mitochondria; Permeability; Rhodamine 123; Technetium Tc 99m Sestamibi; Verapamil | 2005 |
Reversal of p-glycoprotein-mediated multidrug resistance by CJX1, an amlodipine derivative, in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.
Topics: Amlodipine; Analysis of Variance; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Therapy; Flow Cytometry; Fluorescence; Humans; K562 Cells; Neoplasms; Rhodamine 123; Tetrazolium Salts; Thiazoles; Time Factors; Verapamil | 2005 |
Transport characteristics of rutin deca (H-) sulfonate sodium across Caco-2 cell monolayers.
Topics: Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cyclosporine; Drug Interactions; Flavones; Humans; Hydrogen-Ion Concentration; Models, Biological; Rhodamine 123; Rutin; Temperature; Verapamil | 2005 |
Development of an on-line extraction turbulent flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples.
Topics: Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Dexamethasone; Etoposide; Furosemide; Humans; Metoprolol; Nadolol; Pharmaceutical Preparations; Propranolol; Quinidine; Rhodamine 123; Spectrometry, Mass, Electrospray Ionization; Sulfasalazine; Verapamil | 2006 |
Canine mdr1 gene mutation in Japan.
Topics: Animals; DNA Primers; Dogs; Gene Frequency; Genes, MDR; Japan; Leukocytes, Mononuclear; Mutation, Missense; Rhodamine 123; Verapamil | 2005 |
Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Chitosan; Dose-Response Relationship, Drug; Electric Impedance; Glutathione; Guinea Pigs; Ileum; In Vitro Techniques; Reproducibility of Results; Rhodamine 123; Sulfhydryl Compounds; Terfenadine; Verapamil | 2006 |
Verapamil induces upregulation of P-glycoprotein expression on human monocyte derived dendritic cells.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Differentiation; Cell Line, Tumor; Dendritic Cells; Hematologic Neoplasms; Humans; Macrophages; Monocytes; Rhodamine 123; Streptococcus pyogenes; Up-Regulation; Verapamil | 2006 |
Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Dogs; Humans; Indomethacin; N-Methyl-3,4-methylenedioxyamphetamine; Probenecid; Progesterone; Propionates; Quinolines; Rhodamine 123; Ritonavir; Verapamil | 2006 |
A kinetic study of Rhodamine123 pumping by P-glycoprotein.
Topics: Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Humans; K562 Cells; Kinetics; Rhodamine 123; Verapamil | 2006 |
Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydrolysis; Lignans; Prazosin; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Vanadates; Verapamil; Vinblastine | 2006 |
Improvement of intestinal absorption of P-glycoprotein substrate by D-tartaric acid.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cardiovascular Agents; Colon; Daunorubicin; Diffusion Chambers, Culture; Fluorescent Dyes; Ileum; Injections, Intravenous; Intestinal Absorption; Jejunum; Male; Rats; Rats, Wistar; Rhodamine 123; Tartrates; Verapamil | 2006 |
Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies.
Topics: Actins; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bronchi; Cell Culture Techniques; Cells, Cultured; Electric Impedance; Epithelial Cells; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Gene Expression; Humans; Permeability; Phalloidine; Rhodamine 123; RNA, Messenger; Verapamil | 2007 |
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Membrane; Chlorocebus aethiops; Codon; Cyclosporine; Genes, MDR; Haplotypes; HeLa Cells; Humans; Mutagenesis, Site-Directed; Polymorphism, Single Nucleotide; Protein Biosynthesis; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Sirolimus; Substrate Specificity; Transfection; Verapamil | 2007 |
Expression of the MDR1 gene and P-glycoprotein in canine mast cell tumor cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line, Tumor; Dog Diseases; Dogs; Flow Cytometry; Fluorescent Dyes; Gene Expression; Genes, MDR; Mastocytoma; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; Verapamil | 2007 |
Role of hypoxia-inducible factor-alpha in hepatitis-B-virus X protein-mediated MDR1 activation.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Line, Tumor; Hypoxia-Inducible Factor 1, alpha Subunit; Rats; Recombinant Proteins; Rhodamine 123; Trans-Activators; Verapamil; Viral Regulatory and Accessory Proteins | 2007 |
Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog.
Topics: Adamantane; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Calcium Channel Blockers; Cell Membrane; Cell Polarity; Cyclosporine; Dogs; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endocytosis; Enzyme Inhibitors; Fluorescent Dyes; Golgi Apparatus; Humans; Intestinal Mucosa; Neoplasms; Protein Binding; Protein Structure, Secondary; Protein Synthesis Inhibitors; Protein Transport; Rhodamine 123; Shiga Toxins; Time Factors; Trihexosylceramides; Up-Regulation; Verapamil; Vinblastine | 2008 |
Activity of drug efflux transporters in tumor cells under hypoxic conditions.
Topics: Acidosis; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Fluorescent Dyes; Isotonic Solutions; Male; Multidrug Resistance-Associated Proteins; Prostatic Neoplasms; Rats; Rhodamine 123; Ringer's Solution; Time Factors; Verapamil | 2008 |
Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbamazepine; Cells, Cultured; Cerebral Arteries; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelial Cells; Immunosuppressive Agents; Indicators and Reagents; Microcirculation; Phenobarbital; Phenytoin; Rats; Rhodamine 123; Sodium Channel Blockers; Time; Up-Regulation; Valproic Acid; Verapamil | 2008 |
[Interaction between (E)-2-(4-(diethylamino methyl) benzylidene)-5,6-dimethoxy-2,3-dihydroinden-one and P-glycoprotein].
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Interactions; Humans; Indenes; Prohibitins; Rhodamine 123; Verapamil | 2007 |
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chemistry, Pharmaceutical; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Guinea Pigs; Humans; Ileum; Models, Chemical; Rhodamine 123; Tamoxifen; Verapamil | 2008 |
A new procedure for the quantitative assessment of p-glycoprotein efflux pump associated with human T lymphocytes.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cocaine-Related Disorders; Flow Cytometry; Fluorescent Dyes; Humans; Rhodamine 123; T-Lymphocytes; Up-Regulation; Verapamil | 2008 |
Down-regulation of P-glycoprotein expression by sustained intracellular acidification in K562/Dox cells.
Topics: Acids; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cation Transport Proteins; Cell Line; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Guanidines; Humans; Hydrogen-Ion Concentration; K562 Cells; Rhodamine 123; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones; Verapamil | 2008 |
Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dimerization; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Molecular Structure; Paclitaxel; Prazosin; Quinine; Rhodamine 123; Verapamil | 2009 |
Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment.
Topics: Adolescent; Adult; Apoptosis; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Biomarkers; Calcium Channel Blockers; Cell Differentiation; Cell Line, Tumor; Cell Shape; Child; Drug Resistance, Multiple; Enzyme Inhibitors; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Humans; Neoplastic Stem Cells; Osteosarcoma; Rhodamine 123; Verapamil; Young Adult | 2009 |
Inhibition of P-glycoprotein function by procyanidine on blood-brain barrier.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biflavonoids; Blood-Brain Barrier; Catechin; Cells, Cultured; Endothelial Cells; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Pinus; Plant Extracts; Proanthocyanidins; Rats; Rhodamine 123; Verapamil | 2009 |
Functionality of drug efflux pumps in antimonial resistant Leishmania donovani field isolates.
Topics: Adenosine Triphosphate; Animals; Antimony; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Fluoresceins; Humans; Leishmania donovani; Leishmaniasis, Visceral; Multidrug Resistance-Associated Proteins; Ofloxacin; Probenecid; Protozoan Proteins; Rhodamine 123; Verapamil | 2009 |
Investigation of the multixenobiotic resistance mechanism in the freshwater fishes western mosquitofish, Gambusia affinis, and bluegill sunfish, Lepomis macrochirus.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers; Blotting, Western; Fishes; Fresh Water; Rhodamine 123; Species Specificity; Verapamil; Water Pollutants, Chemical; Xenobiotics | 2009 |
[P-glycoprotein functional activity in peripheral blood lymphocytes in ulcerative colitis].
Topics: Adult; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Colitis, Ulcerative; Female; Flow Cytometry; Humans; Immunosuppressive Agents; Infliximab; Lymphocytes; Male; Mercaptopurine; Multidrug Resistance-Associated Proteins; Rhodamine 123; Verapamil | 2009 |
Effect of intestinal ischaemia/reperfusion on P-glycoprotein-mediated ileal excretion of rhodamine 123 in the rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Gene Expression; Ileum; Male; Membrane Transport Proteins; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Rhodamine 123; Verapamil | 2009 |
Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2.
Topics: Doxorubicin; Drug Resistance, Neoplasm; Hep G2 Cells; Humans; Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Independent; Paclitaxel; Probenecid; Rhodamine 123; RNA, Messenger; Sodium Azide; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfobromophthalein; Verapamil | 2009 |
Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cimetidine; Cyclosporine; Kidney; Liver; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reperfusion Injury; Rhodamine 123; Tetraethylammonium; Verapamil | 2009 |
Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Dyes; Humans; K562 Cells; Leukemia, Myeloid; Pregnenediones; Rhodamine 123; Verapamil | 2009 |
Blood-brain barrier cell line PBMEC/C1-2 possesses functionally active P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Blotting, Western; Capillary Permeability; Cell Line; Central Nervous System Agents; Doxorubicin; Fluorescence; Fluorescent Dyes; Gene Knockdown Techniques; Microscopy, Fluorescence; Oligonucleotides, Antisense; Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Swine; Verapamil | 2010 |
Syl611, a novel semisynthetic taxane derivative, reverses multidrug resistance by p-glycoprotein inhibition and facilitating inward transmembrane action.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; KB Cells; Paclitaxel; Permeability; Rhodamine 123; Taxoids; Verapamil | 2010 |
In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein.
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Calcium Channel Blockers; Cell Line; Dose-Response Relationship, Drug; Ethosuximide; Humans; In Vitro Techniques; Phenobarbital; Phenytoin; Rhodamine 123; Verapamil | 2010 |
Effect of Thai plant extracts on P-glycoprotein function and viability in paclitaxel-resistant HepG2 cells.
Topics: Annonaceae; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Hep G2 Cells; Herbal Medicine; Humans; Multidrug Resistance-Associated Proteins; Paclitaxel; Phytotherapy; Plant Extracts; Rhodamine 123; Rutaceae; Thailand; Tumor Cells, Cultured; Verapamil | 2010 |
Characterization of PXR mediated P-glycoprotein regulation in intestinal LS174T cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Membrane; Drug Interactions; Humans; Intestinal Mucosa; Intestines; Pregnane X Receptor; Receptors, Steroid; Rhodamine 123; Rifampin; RNA, Messenger; Verapamil | 2010 |
Iodination increases the activity of verapamil derivatives in reversing PGP multidrug resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Cycle; Cyclosporine; Daunorubicin; Drug Resistance, Neoplasm; Drug Synergism; Humans; K562 Cells; Male; Myocytes, Cardiac; Rats; Rats, Wistar; Rhodamine 123; Verapamil | 2010 |
20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Digoxin; Etoposide; Ginsenosides; Herb-Drug Interactions; Humans; Ileum; Male; Rats; Rats, Sprague-Dawley; Rhodamine 123; Terfenadine; Verapamil | 2010 |
Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A: modulation of P-glycoprotein function.
Topics: Adult; Arthritis, Psoriatic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Sedimentation; C-Reactive Protein; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Drug Resistance; Female; Humans; Immunosuppressive Agents; Joints; Male; Methotrexate; Middle Aged; Rhodamine 123; Sulfasalazine; T-Lymphocytes; Treatment Outcome; Verapamil | 2011 |
Reversal of multidrug resistance by guggulsterone in drug-resistant MCF-7 cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Humans; Multidrug Resistance-Associated Proteins; Pregnenediones; Rhodamine 123; Verapamil | 2011 |
Effect of BIBF 1120 on reversal of ABCB1-mediated multidrug resistance.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Indoles; Phosphorylation; Proto-Oncogene Proteins c-akt; Rhodamine 123; Verapamil | 2011 |
The transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37/MDR1 cells.
Topics: Acridines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzyl Alcohols; Biological Transport; Blood-Brain Barrier; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; Drug Resistance, Multiple; Gastrodia; Glucosides; Humans; Plants, Medicinal; Prohibitins; Rhodamine 123; Tetrahydroisoquinolines; Verapamil | 2010 |
Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Hep G2 Cells; Humans; Mineralocorticoid Receptor Antagonists; Polymerase Chain Reaction; Pregnane X Receptor; Receptors, Steroid; Rhodamine 123; RNA, Messenger; Spironolactone; Up-Regulation; Verapamil | 2011 |
Farnesiferol A from Ferula persica and galbanic acid from Ferula szowitsiana inhibit P-glycoprotein-mediated rhodamine efflux in breast cancer cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Line, Tumor; Coumarins; Drug Resistance, Neoplasm; Female; Ferula; Humans; Plant Extracts; Plant Roots; Rhodamine 123; Sesquiterpenes; Verapamil | 2011 |
Exposure of LS-180 cells to drugs of diverse physicochemical and therapeutic properties up-regulates P-glycoprotein expression and activity.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cell Line, Tumor; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Gene Expression; Humans; Pentylenetetrazole; Pharmaceutical Preparations; Phloroglucinol; Rhodamine 123; Rifampin; Stimulation, Chemical; Terpenes; Up-Regulation; Verapamil | 2011 |
Using rhodamine 123 accumulation in CD8 cells as a surrogate indicator to study the P-glycoprotein modulating effect of cepharanthine hydrochloride in vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cyclosporine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Dyes; Fluorouracil; Humans; Indicators and Reagents; Liver Neoplasms; Mice; Rhodamine 123; Tumor Cells, Cultured; Verapamil; Xenograft Model Antitumor Assays | 2011 |
Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Inhibitory Concentration 50; K562 Cells; Molecular Targeted Therapy; Nitric Oxide; Rhodamine 123; Tetrahydroisoquinolines; Triazoles; Verapamil | 2011 |
Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes.
Topics: Actins; Animals; Animals, Newborn; Antigens; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Claudin-5; Claudins; Coculture Techniques; Endothelial Cells; gamma-Glutamyltransferase; Gene Expression; Membrane Proteins; Microscopy, Electron, Transmission; Models, Biological; Muscle, Smooth, Vascular; Neuroglia; Occludin; Pericytes; Phosphoproteins; Proteoglycans; Rats; Receptor, Platelet-Derived Growth Factor beta; Rhodamine 123; Verapamil; Vimentin; Zonula Occludens-1 Protein | 2011 |
Uptake characteristics of pinocembrin and its effect on p-glycoprotein at the blood-brain barrier in in vitro cell experiments.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cyclosporine; Dose-Response Relationship, Drug; Flavanones; Neuroprotective Agents; Rats; Rhodamine 123; Verapamil | 2012 |
Evaluation of the relationship between [18F]FDG and P-glycoprotein expression: an experimental study.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Female; Fluorodeoxyglucose F18; Gene Expression Regulation, Neoplastic; Humans; Mice; Positron-Emission Tomography; Prohibitins; Rhodamine 123; Technetium Tc 99m Sestamibi; Verapamil | 2012 |
Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Cell Culture Techniques; Cells, Cultured; Fluorescent Dyes; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Models, Biological; Pharmacokinetics; Rhodamine 123; Verapamil | 2012 |
The effect of P-glycoprotein on methadone hydrochloride flux in equine intestinal mucosa.
Topics: Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Horses; Intestinal Absorption; Intestinal Mucosa; Jejunum; Methadone; Rhodamine 123; Verapamil | 2013 |
The effects of notoginsenoside R₁ on the intestinal absorption of geniposide by the everted rat gut sac model.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Ginsenosides; Intestinal Absorption; Intestinal Mucosa; Iridoids; Male; Rats; Rats, Wistar; Rhodamine 123; Verapamil | 2012 |
Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Calcium Channel Blockers; Capillaries; Chromatography, High Pressure Liquid; Endothelial Cells; Flow Cytometry; Fluorescent Dyes; Hypoxia, Brain; Immunohistochemistry; Indicators and Reagents; Intercellular Adhesion Molecule-1; Male; Mass Spectrometry; Matrix Metalloproteinase 9; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhodamine 123; Verapamil | 2013 |
Menadione serves as a substrate for P-glycoprotein: implication in chemosensitizing activity.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Dogs; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluorescent Dyes; Humans; Madin Darby Canine Kidney Cells; MCF-7 Cells; Quinidine; Rhodamine 123; Transfection; Verapamil; Vitamin K 3 | 2013 |
Bipiperidinyl derivatives of 23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Paclitaxel; Piperidines; Rhodamine 123; Triterpenes; Verapamil; Vincristine | 2013 |
P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytokines; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Fluorescent Dyes; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-6; Interleukin-8; Lipopolysaccharides; Nasal Cavity; Rhodamine 123; Thymic Stromal Lymphopoietin; Verapamil | 2013 |
Functional impact of ABCB1 variants on interactions between P-glycoprotein and methadone.
Topics: Analysis of Variance; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Fluoresceins; Genetic Variation; HEK293 Cells; Humans; Immunoblotting; Inhibitory Concentration 50; Kinetics; Methadone; Mutagenesis, Site-Directed; Real-Time Polymerase Chain Reaction; Rhodamine 123; Verapamil | 2013 |
Potential role for human P-glycoprotein in the transport of lacosamide.
Topics: Acetamides; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Lacosamide; Quinolines; Rhodamine 123; RNA, Messenger; Swine; Time Factors; Transfection; Tritium; Verapamil | 2013 |
HZ08 inhibits the multi-drug resistance on multiple sites as the substrate of p-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Humans; Intracellular Space; Isoquinolines; K562 Cells; Rhodamine 123; Verapamil | 2013 |
Interaction of CJY, an isoflavone, with ATPase of P-glycoprotein in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.
Topics: Adenosine Triphosphatases; Amlodipine; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Neoplasm; Humans; Isoflavones; K562 Cells; Rhodamine 123; Verapamil | 2013 |
Acetaminophen inhibits intestinal p-glycoprotein transport activity.
Topics: Acetaminophen; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Cell Line, Tumor; Cyclosporins; Digoxin; Enterocytes; Hep G2 Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Permeability; Rats; Rats, Wistar; Rhodamine 123; Verapamil | 2013 |
Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood-brain barrier.
Topics: Algorithms; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autoradiography; Blood-Brain Barrier; Calcium Channel Blockers; Cells, Cultured; Data Interpretation, Statistical; Fluorescent Dyes; Green Fluorescent Proteins; Image Processing, Computer-Assisted; Kinetics; Linear Models; Male; Microscopy, Fluorescence; Perfusion; Propionates; Quinolines; Rats; Rats, Inbred F344; Reference Standards; Rhodamine 123; Verapamil; Xanthenes | 2013 |
Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Survival; Cyclosporine; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Mice; Resveratrol; Rhodamine 123; Skin Neoplasms; Stilbenes; Triterpenes; Ursolic Acid; Verapamil | 2013 |
The inhibitory and combinative mechanism of HZ08 with P-glycoprotein expressed on the membrane of Caco-2 cell line.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport; Caco-2 Cells; Cell Membrane; Chromatography, Liquid; Dibenzocycloheptenes; Doxorubicin; Drug Resistance, Multiple; Humans; Isoquinolines; Mass Spectrometry; Microscopy, Fluorescence; Quinolines; Rhodamine 123; RNA, Small Interfering; Verapamil | 2014 |
The mechanism of the opening of the blood-brain barrier by borneol: a pharmacodynamics and pharmacokinetics combination study.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Camphanes; Male; Multidrug Resistance-Associated Proteins; Rats; Rats, Sprague-Dawley; Rhodamine 123; Verapamil | 2013 |
Frequency of MDR1-related p-gp overexpression in Greek Leishmania isolates.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Flow Cytometry; Fluorescent Dyes; Greece; Humans; Leishmania; Protozoan Proteins; Rhodamine 123; Verapamil | 2014 |
Permeability of rhynchophylline across human intestinal cell in vitro.
Topics: ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Cell Survival; Drugs, Chinese Herbal; Electric Impedance; Humans; Indole Alkaloids; Intestinal Absorption; Intestinal Mucosa; Intestines; Kinetics; Oxindoles; Permeability; Rhodamine 123; Up-Regulation; Verapamil | 2014 |
Possible involvement of cationic-drug sensitive transport systems in the blood-to-brain influx and brain-to-blood efflux of amantadine across the blood-brain barrier.
Topics: 1-Methyl-4-phenylpyridinium; Amantadine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cell Line; Cyclosporine; Ion Pumps; Male; Microinjections; Quinidine; Rats; Rhodamine 123; Tritium; Verapamil | 2015 |
Hydrogel-assisted functional reconstitution of human P-glycoprotein (ABCB1) in giant liposomes.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding, Competitive; Biological Transport; Cell Membrane; Cell Membrane Permeability; Diffusion; Fluorescent Dyes; Humans; Hydrogels; Kinetics; Lepidoptera; Models, Statistical; Patch-Clamp Techniques; Protein Binding; Proteolipids; Rhodamine 123; Sepharose; Transgenes; Verapamil | 2015 |
[Resistance reversal effect of a novel taxane compound NPB304 and its collaboration with verapamil].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; MCF-7 Cells; Rhodamine 123; Taxoids; Verapamil | 2014 |
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; In Vitro Techniques; Intestinal Mucosa; Isoquinolines; Ketoconazole; Male; Quinazolines; Quinidine; Rats, Wistar; Rhodamine 123; Verapamil | 2015 |
Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines.
Topics: Adenocarcinoma; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Colonic Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Phenothiazines; Rhodamine 123; Verapamil | 2015 |
P-glycoprotein inhibitors: synthesis and in vitro evaluation of a preactivated thiomer.
Topics: Acrylic Resins; ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Drug Delivery Systems; Humans; Nicotinic Acids; Rhodamine 123; Sulfhydryl Compounds; Verapamil | 2016 |
Stereoselective Regulation of P-gp Activity by Clausenamide Enantiomers in Caco-2, KB/KBv and Brain Microvessel Endothelial Cells.
Topics: Animals; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Caco-2 Cells; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Drugs, Chinese Herbal; Endothelial Cells; Epithelial Cells; Gene Expression Regulation; Humans; Lactams; Lignans; Rats; Rhodamine 123; Stereoisomerism; Verapamil | 2015 |
Fully automatic flow-based device for monitoring of drug permeation across a cell monolayer.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Automation; Biological Transport; Epithelial Cells; Flow Injection Analysis; Humans; Kinetics; Rhodamine 123; Verapamil | 2016 |
In vitro potential modulation of baicalin and baicalein on P-glycoprotein activity and expression in Caco-2 cells and rat gut sacs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Dose-Response Relationship, Drug; Down-Regulation; Flavanones; Flavonoids; Fluorescein; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Male; Molecular Structure; Permeability; Rats, Sprague-Dawley; Rhodamine 123; Structure-Activity Relationship; Time Factors; Verapamil | 2016 |
Abcb1 in Pigs: Molecular cloning, tissues distribution, functional analysis, and its effect on pharmacokinetics of enrofloxacin.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cloning, Molecular; Dogs; Enrofloxacin; Fluoroquinolones; Gene Expression Profiling; Intestinal Mucosa; Madin Darby Canine Kidney Cells; Phylogeny; Rhodamine 123; Sequence Homology, Amino Acid; Swine; Verapamil | 2016 |
The application of P-gp inhibiting phospholipids as novel oral bioavailability enhancers - An in vitro and in vivo comparison.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Caco-2 Cells; Drug Delivery Systems; Humans; Intestinal Absorption; Male; Phosphatidylcholines; Phospholipids; Polysorbates; Rats, Wistar; Rhodamine 123; Ritonavir; Surface-Active Agents; Verapamil | 2017 |
A Novel Model of P-Glycoprotein Inhibitor Screening Using Human Small Intestinal Organoids.
Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Biological Transport; Drug Evaluation, Preclinical; Humans; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Membrane Transport Modulators; Mitotane; Models, Biological; Organoids; Rhodamine 123; RNA, Messenger; Tissue Culture Techniques; Verapamil | 2017 |
Activation of melatonin receptor (MT1/2) promotes P-gp transporter in methamphetamine-induced toxicity on primary rat brain microvascular endothelial cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cells, Cultured; Central Nervous System Stimulants; Endothelial Cells; Melatonin; Methamphetamine; Microvessels; Neuroprotective Agents; Rats; Reactive Nitrogen Species; Reactive Oxygen Species; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Rhodamine 123; Tryptamines; Verapamil | 2017 |
Reversal Effect of Oxypeucedanin on P-glycoprotein-mediated Drug Transport.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Docetaxel; Dogs; Drug Resistance, Multiple; Fluorescent Dyes; Furocoumarins; Gene Expression; Kinetics; Madin Darby Canine Kidney Cells; Molecular Docking Simulation; Rhodamine 123; RNA, Messenger; Taxoids; Verapamil; Vincristine | 2018 |
Testosterone and androstenedione are endogenous substrates of P-glycoprotein.
Topics: Adenosine Triphosphatases; Androstenedione; Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Cell Culture Techniques; Cell Line; Cell Membrane; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Protein Binding; Rhodamine 123; Risk; Suicide; Swine; Testosterone; Verapamil | 2019 |
Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Imidazoles; In Vitro Techniques; Inhibitory Concentration 50; Lymphoma, T-Cell; Mice; Models, Molecular; Molecular Docking Simulation; Morpholines; Rhodamine 123; Structure-Activity Relationship; Verapamil | 2020 |
3D printed permeation module to monitor interaction of cell membrane transporters with exogenic compounds in real-time.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Madin Darby Canine Kidney Cells; Membrane Transport Proteins; Printing, Three-Dimensional; Rhodamine 123; Verapamil | 2021 |
A novel flavonoid from Fissistigma cupreonitens, 5‑hydroxy‑7,8‑dimethoxyflavanone, competitively inhibited the efflux function of human P-glycoprotein and reversed cancer multi-drug resistance.
Topics: Annonaceae; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; Fluoresceins; Humans; Molecular Docking Simulation; Phytochemicals; Rhodamine 123; Verapamil | 2021 |
Cinnamophilin overcomes cancer multi-drug resistance via allosterically modulating human P-glycoprotein on both drug binding sites and ATPase binding sites.
Topics: Adenosine Triphosphatases; Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Cycle; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Guaiacol; Humans; Lignans; Molecular Docking Simulation; Rhodamine 123; Verapamil | 2021 |
Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein-In Silico and In Vitro Evidence.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carnosine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Molecular Docking Simulation; Rhodamine 123; Verapamil | 2022 |
Functional characterization of the rat mdr1b encoded P-glycoprotein: not all inducing agents are substrates.
Topics: 3T3 Cells; Aflatoxin B1; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Hydroxyacetylaminofluorene; Liver; Male; Mice; Rats; Rats, Inbred F344; Rhodamine 123; Rhodamines; RNA, Messenger | 1997 |
Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein.
Topics: 3T3 Cells; Animals; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Cyclosporine; HIV Protease Inhibitors; Mice; Rhodamine 123; Rhodamines; Saquinavir | 1998 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
New functional assay of P-glycoprotein activity using Hoechst 33342.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluoresceins; Humans; Microscopy, Fluorescence; Molecular Structure; Principal Component Analysis; Time Factors | 2007 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |