Compounds > rhein-9-anthrone
Page last updated: 2024-09-03

rhein-9-anthrone and indomethacin

rhein-9-anthrone has been researched along with indomethacin in 5 studies

Compound Research Comparison

Studies
(rhein-9-anthrone)		Trials
(rhein-9-anthrone)		Recent Studies (post-2010)
(rhein-9-anthrone)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
240229,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyrhein-9-anthrone (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kuwano, S; Miyawaki, Y; Nishikawa, A; Yagi, T; Yamauchi, K1
de Witte, P; Geboes, K; Lemli, J; Meulemans, A; Nijs, G; Schuurkes, J2
Kuwano, S; Yagi, T; Yamauchi, K1
Ikarashi, N; Ishii, M; Kon, R; Kusunoki, Y; Machida, Y; Nagoya, C; Ochiai, W; Sugita, K; Sugiyama, K; Takayama, T; Ueda, H1

Other Studies

5 other study(ies) available for rhein-9-anthrone and indomethacin

ArticleYear
Suppression of the purgative action of rhein anthrone, the active metabolite of sennosides A and B, by indomethacin in rats.
    The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:5

    Topics: Animals; Anthracenes; Anthraquinones; Cathartics; Colon; Diarrhea; Dinoprostone; Electrolytes; Female; Gastrointestinal Transit; Indomethacin; Mucus; Rats; Rats, Inbred Strains; Senna Extract; Sennosides; Water

1991
In vitro demonstration of a positive effect of rhein anthrone on peristaltic reflex of guinea pig ileum.
    Pharmacology, 1993, Volume: 47 Suppl 1

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anthracenes; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Male; Muscle Contraction; Peristalsis; Prostaglandins; Reflex

1993
Influence of rhein anthrone on peristaltic reflex of guinea-pig isolated ileum: involvement of prostaglandins.
    British journal of pharmacology, 1993, Volume: 108, Issue:1

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anthracenes; Anthraquinones; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Peristalsis; Prostaglandins

1993
Suppression of the purgative action of rhein anthrone, the active metabolite of sennosides A and B, by calcium channel blockers, calmodulin antagonists and indomethacin.
    Pharmacology, 1993, Volume: 47 Suppl 1

    Topics: Animals; Anthracenes; Anthraquinones; Calcium; Calcium Channel Blockers; Calmodulin; Cathartics; Colon; Diarrhea; Drug Therapy, Combination; Female; Gastrointestinal Motility; Gastrointestinal Transit; Indomethacin; Intestinal Secretions; Rats; Rats, Wistar; Senna Extract; Sennosides

1993
Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.
    Journal of ethnopharmacology, 2014, Feb-27, Volume: 152, Issue:1

    Topics: Animals; Anthracenes; Aquaporin 3; Cell Line; Colon; Colonic Neoplasms; Diarrhea; Dinoprostone; HT29 Cells; Humans; Indomethacin; Intestinal Mucosa; Laxatives; Macrophage Activation; Male; Rats; Rats, Wistar; Rheum; Senna Extract; Sennosides

2014