Page last updated: 2024-09-03

rg 6866 and indomethacin

rg 6866 has been researched along with indomethacin in 4 studies

Compound Research Comparison

Studies
(rg 6866)
Trials
(rg 6866)
Recent Studies (post-2010)
(rg 6866)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
70029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyrg 6866 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chan, WK; Gordon, RJ; Huang, FC; Lee, TD; Lin, CJ; Schnapper, M; Shoupe, TS; Sonnino, PA; Suh, JT; Tan, J1
Derian, CK; Lewis, DF1
Jolly, SR; Movahed, A; Ordoukhani, A1
Jolly, SR; Travis, J; Van Inwegen, RG1

Other Studies

4 other study(ies) available for rg 6866 and indomethacin

ArticleYear
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:8

    Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Guinea Pigs; Humans; Hydroxamic Acids; In Vitro Techniques; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Mice; Neutrophils; Rats; Rats, Inbred Strains

1989
Activation of 15-lipoxygenase by low density lipoprotein in vascular endothelial cells. Relationship to the oxidative modification of low density lipoprotein.
    Prostaglandins, leukotrienes, and essential fatty acids, 1992, Volume: 45, Issue:1

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Animals; Aorta; Arachidonate 15-Lipoxygenase; Benzyl Compounds; Cells, Cultured; Copper; Copper Sulfate; Endothelium, Vascular; Enzyme Activation; Hydroxamic Acids; Hydroxyeicosatetraenoic Acids; Indomethacin; Linoleic Acid; Linoleic Acids; Lipoproteins, LDL; Lipoxygenase Inhibitors; Masoprocol; Oxidation-Reduction; Quinolines; Swine; Umbilical Veins

1992
Effect of neuropeptide Y on isolated rat hearts.
    Pharmacology, 1991, Volume: 43, Issue:3

    Topics: Analysis of Variance; Animals; Benzyl Compounds; Blood Flow Velocity; Coronary Vessels; Heart; Hydroxamic Acids; Indomethacin; Lipoxygenase Inhibitors; Male; Neuropeptide Y; Perfusion; Rats; Rats, Inbred Strains; Vasoconstriction

1991
Effects of 5-lipoxygenase inhibition on cardiac anaphylaxis in isolated guinea pig hearts.
    Pharmacology, 1989, Volume: 38, Issue:6

    Topics: Acetophenones; Anaphylaxis; Animals; Arachidonate Lipoxygenases; Benzoquinones; Benzyl Compounds; Blood Pressure; Cardiomyopathies; Chromones; Coronary Circulation; Guinea Pigs; Heart; Hydroxamic Acids; Hydroxyquinolines; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Myocardium; Quinolines; Quinones; SRS-A; Tetrazoles

1989