reynosin and dehydrocostus-lactone

To screen the potential hepatotoxic components in Chinese herb medicine Aucklandiae Radix.. The potential hepatotoxic components were screened using HepG2 cells labeled with fluorescein diacetate from 25 fractions of Aucklandiae Radix, in which the hepatotoxic compounds were further identified with GC-MS.. Ten potential hepatotoxic fractions were screened. The identification results by GC-MS indicated that the main compounds in C09 were dehydrocostuslactone, santamarine (or magnolialide) and reynosin, and in C11 were α-costol and elemol.. Dehydrocostuslactone, santamarine (or magnolialide), reynosin, α-costol and elemol are potential hepatotoxic compounds in Aucklandiae Radix.

Topics: Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lactones; Sesquiterpenes

To study the chemical constituents of Dolomiaea souliei.. Various chromatographic techniques were adopted to separate the constituents, and the spectrum analysis was made to identify their structures.. Seventeen compounds were isolated and identified as: dehydrocostus lactone (1), costunolide (2), mokko lactone (3), santamarine(4), reynosin (5), 4alpha-hydroxy-4beta-methyldihydrocostol (6), sulfocostunolide A (7), beta-costic acid (8), beta-cyclocostunolide (9), vladinol A (10), ursolic acid (11), betulinic acid (12), betulin (13), dibutyl terephthalate (14), dibutyl phthalate (15), uridine (16), and emodin (17).. Compounds 6-9 and 12-17 were obtained from this genus for the first time, and compound 11 was obtained from this plant for the first time.

Topics: 4-Butyrolactone; Asteraceae; Betulinic Acid; Emodin; Lactones; Pentacyclic Triterpenes; Sesquiterpenes; Triterpenes; Ursolic Acid