retrofractamide-a and pellitorine

retrofractamide-a has been researched along with pellitorine* in 2 studies

Other Studies

2 other study(ies) available for retrofractamide-a and pellitorine

Article	Year
Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti. Natural product research, 2012, Volume: 26, Issue:22 The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined. On the basis of 24-h LD(50) values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4 µg/♀) followed by guineensine (1.9 µg/♀), retrofractamide A (2.4 µg/♀) and pipercide (3.2 µg/♀). LD(50) value of chlorpyrifos was 0.03 µg/♀. Against female A. aegypti, the insecticidal activity was more pronounced in pellitorine (0.17 µg/♀) than in retrofractamide A (1.5 µg/♀), guineensine (1.7 µg/♀), and pipercide (2.0 µg/♀). LD(50) value of chlorpyrifos was 0.0014 µg/♀. Topics: Aedes; Alkaloids; Alkenes; Amides; Animals; Benzodioxoles; Culex; Fatty Acids, Unsaturated; Female; Heterocyclic Compounds, 2-Ring; Insecticides; Male; Piper nigrum; Piperidines; Polyunsaturated Alkamides	2012
ACAT inhibition of alkamides identified in the fruits of Piper nigrum. Phytochemistry, 2007, Volume: 68, Issue:6 In this study, via a bioactivity-guided fractionation of MeOH extracts of the fruits of Piper nigrum, alkamide (5) and five previously-identified alkamides were isolated. Their structures were elucidated via spectroscopic analysis ((1)H, (13)C NMR and ESI-MS), as follows: retrofractamide A (1), pipercide (2), piperchabamide D (3), pellitorin (4), dehydroretrofractamide C (5) and dehydropipernonaline (6). The IC(50) values determined for the compounds were 24.5 (1), 3.7 (2), 13.5 (3), 40.5 (4), 60 (5) and 90 microM (6), according to the results of an ACAT enzyme assay system using rat liver microsomes. These compounds all inhibited cholesterol esterification in HepG2 cells. Topics: Amides; Animals; Benzodioxoles; Cell Line, Tumor; Cholesterol Esters; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Fruit; Humans; Magnetic Resonance Spectroscopy; Microsomes, Liver; Molecular Structure; Organic Chemicals; Piper nigrum; Piperidines; Plant Extracts; Polyunsaturated Alkamides; Rats; Spectrometry, Mass, Electrospray Ionization; Sterol O-Acyltransferase	2007

Article

Year

Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti.

Natural product research, 2012, Volume: 26, Issue:22

The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined. On the basis of 24-h LD(50) values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4 µg/♀) followed by guineensine (1.9 µg/♀), retrofractamide A (2.4 µg/♀) and pipercide (3.2 µg/♀). LD(50) value of chlorpyrifos was 0.03 µg/♀. Against female A. aegypti, the insecticidal activity was more pronounced in pellitorine (0.17 µg/♀) than in retrofractamide A (1.5 µg/♀), guineensine (1.7 µg/♀), and pipercide (2.0 µg/♀). LD(50) value of chlorpyrifos was 0.0014 µg/♀.

Topics: Aedes; Alkaloids; Alkenes; Amides; Animals; Benzodioxoles; Culex; Fatty Acids, Unsaturated; Female; Heterocyclic Compounds, 2-Ring; Insecticides; Male; Piper nigrum; Piperidines; Polyunsaturated Alkamides

2012

ACAT inhibition of alkamides identified in the fruits of Piper nigrum.

Phytochemistry, 2007, Volume: 68, Issue:6

In this study, via a bioactivity-guided fractionation of MeOH extracts of the fruits of Piper nigrum, alkamide (5) and five previously-identified alkamides were isolated. Their structures were elucidated via spectroscopic analysis ((1)H, (13)C NMR and ESI-MS), as follows: retrofractamide A (1), pipercide (2), piperchabamide D (3), pellitorin (4), dehydroretrofractamide C (5) and dehydropipernonaline (6). The IC(50) values determined for the compounds were 24.5 (1), 3.7 (2), 13.5 (3), 40.5 (4), 60 (5) and 90 microM (6), according to the results of an ACAT enzyme assay system using rat liver microsomes. These compounds all inhibited cholesterol esterification in HepG2 cells.

Topics: Amides; Animals; Benzodioxoles; Cell Line, Tumor; Cholesterol Esters; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Fruit; Humans; Magnetic Resonance Spectroscopy; Microsomes, Liver; Molecular Structure; Organic Chemicals; Piper nigrum; Piperidines; Plant Extracts; Polyunsaturated Alkamides; Rats; Spectrometry, Mass, Electrospray Ionization; Sterol O-Acyltransferase

2007