retinol-palmitate and precirol

retinol-palmitate has been researched along with precirol* in 1 studies

Other Studies

1 other study(ies) available for retinol-palmitate and precirol

Article	Year
A retinyl palmitate-loaded solid lipid nanoparticle system: effect of surface modification with dicetyl phosphate on skin permeation in vitro and anti-wrinkle effect in vivo. International journal of pharmaceutics, 2013, Aug-16, Volume: 452, Issue:1-2 Surface-modified solid lipid nanoparticles (SLNs) containing retinyl palmitate (Rpal) were prepared by the hot-melt method using Gelucire 50/13(®) and Precirol ATO5(®). Dicetyl phosphate (DCP) was added to negatively charge the surfaces of the SLNs and thereby enhance the skin distribution properties of Rpal. In vitro skin permeation and in vivo anti-aging studies were performed using SLNs dispersed in a hydrogel. The SLNs were under 100 nm in size with an even polydispersity index (PDI), and the high absolute zeta-potential value was sufficient to maintain the colloidal stability of the SLNs. DCP-modified negative SLNs (DCPmod-SLNs) enhanced the skin distribution of Rpal 4.8-fold and delivered Rpal to a greater depth than did neutral SLNs. The in vivo anti-wrinkle effect of the DCPmod-SLN formulation was Rpal dose-dependent. However, the anti-wrinkle effects of the DCPmod-SLN formulations were significantly different from that of the negative control and effectively prevented the reduction of elastin and superoxide dismutase by UV irradiation. In conclusion, the DCPmod-SLN system presented is a good candidate for topical Rpal delivery. Topics: Acrylic Resins; Animals; Antioxidants; Diacetyl; Diglycerides; Diterpenes; Drug Carriers; Fats; Female; In Vitro Techniques; Male; Mice; Mice, Hairless; Nanoparticles; Oils; Organophosphorus Compounds; Particle Size; Rats; Rats, Sprague-Dawley; Retinyl Esters; Skin; Skin Absorption; Skin Aging; Surface Properties; Vitamin A	2013

Article

Year

A retinyl palmitate-loaded solid lipid nanoparticle system: effect of surface modification with dicetyl phosphate on skin permeation in vitro and anti-wrinkle effect in vivo.

International journal of pharmaceutics, 2013, Aug-16, Volume: 452, Issue:1-2

Surface-modified solid lipid nanoparticles (SLNs) containing retinyl palmitate (Rpal) were prepared by the hot-melt method using Gelucire 50/13(®) and Precirol ATO5(®). Dicetyl phosphate (DCP) was added to negatively charge the surfaces of the SLNs and thereby enhance the skin distribution properties of Rpal. In vitro skin permeation and in vivo anti-aging studies were performed using SLNs dispersed in a hydrogel. The SLNs were under 100 nm in size with an even polydispersity index (PDI), and the high absolute zeta-potential value was sufficient to maintain the colloidal stability of the SLNs. DCP-modified negative SLNs (DCPmod-SLNs) enhanced the skin distribution of Rpal 4.8-fold and delivered Rpal to a greater depth than did neutral SLNs. The in vivo anti-wrinkle effect of the DCPmod-SLN formulation was Rpal dose-dependent. However, the anti-wrinkle effects of the DCPmod-SLN formulations were significantly different from that of the negative control and effectively prevented the reduction of elastin and superoxide dismutase by UV irradiation. In conclusion, the DCPmod-SLN system presented is a good candidate for topical Rpal delivery.

Topics: Acrylic Resins; Animals; Antioxidants; Diacetyl; Diglycerides; Diterpenes; Drug Carriers; Fats; Female; In Vitro Techniques; Male; Mice; Mice, Hairless; Nanoparticles; Oils; Organophosphorus Compounds; Particle Size; Rats; Rats, Sprague-Dawley; Retinyl Esters; Skin; Skin Absorption; Skin Aging; Surface Properties; Vitamin A

2013