retinol has been researched along with trans-sodium crocetinate in 310 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (4.19) | 18.7374 |
| 1990's | 17 (5.48) | 18.2507 |
| 2000's | 76 (24.52) | 29.6817 |
| 2010's | 157 (50.65) | 24.3611 |
| 2020's | 47 (15.16) | 2.80 |
| Authors | Studies |
|---|---|
| Gainer, JL; Jones, JR; Wallis, DA | 1 |
| Wilkins, ES; Wilkins, MG | 1 |
| Gainer, JL; Wilkins, ES | 1 |
| Gainer, JV | 1 |
| Gainer, JV; Nugent, R | 1 |
| Gainer, JL; Jones, JR | 1 |
| Lin, JK; Shiow, SJ; Wang, CJ | 1 |
| Lin, JK; Shiah, HS; Wang, CJ | 1 |
| Hsu, JD; Lin, JK; Wang, CJ | 1 |
| Gainer, JL; Holloway, GM | 1 |
| Bors, W; Erben-Russ, M; Michel, C; Saran, M | 1 |
| Gainer, JL; Laudeman, T; Longnecker, DE; McKernan, DJ; Seyde, WC | 1 |
| Kamikura, M; Nakazato, K | 1 |
| Mathews-Roth, MM | 1 |
| Belinka, BA; Miller, J; Miller, TL; Moss, ME; Willett, SL | 1 |
| Bors, W; Michel, C; Saran, M | 1 |
| Chu, CY; Huang, JM; Shiow, SJ; Tseng, TH; Wang, CJ | 1 |
| Nair, SC; Panikkar, KR; Parthod, RK | 1 |
| Chang, MC; Lee, MJ; Lin, JK; Wang, CJ | 1 |
| Abe, K; Saito, H; Shoyama, Y; Sugiura, M | 1 |
| Irino, N; Morimoto, S; Nishi, K; Saito, H; Shoyama, Y; Umezaki, Y | 1 |
| Abdullaev, FI | 1 |
| Caraway, DL; Gainer, JL; Rudolph, DB | 1 |
| Cheng, TC; Chou, FP; Kuo, ML; Lin, JK; Liu, JY; Wang, CJ | 1 |
| Cormier, F; Dorion, S; Dufresne, C | 1 |
| Gainer, JL; Graham, MC | 1 |
| Bandoh, S; Miyakoshi, J; Tachiiri, S; Takebe, H; Tsukada, T; Yamaguchi, K | 1 |
| Gainer, JL; Graham, MC; Griffin, AM; Roy, JW | 1 |
| Angiboust, JF; Beljebbar, A; Manfait, M; Morjani, H; Sockalingum, GD | 1 |
| Kwan, YW; Li, N; Lin, G; Min, ZD | 1 |
| Gainer, JL; Nathan, A; Singer, M; Stidwill, RP | 1 |
| Fay, JM; Goel, R; Hsia, CC; Johnson, RL; Wagner, HE; Wagner, PD | 1 |
| Gunasekaran, P; Jagadeeswaran, R; Ramamurty, N; Sakthisekaran, D; Thirunavukkarasu, C | 1 |
| Kanofsky, JR; Sima, PD | 1 |
| Gainer, JL; Giassi, LJ; Gilchrist, MJ; Graham, MC | 1 |
| Goh, E; Martin, G; Neff, AW | 1 |
| Endo, G; Furusawa, N; Kitano, M; Kuroda, K; Ozaki, A; Yamaguchi, H | 1 |
| Gainer, JL; Giassi, LJ; Poynter, AK | 1 |
| Bouvier, F; Camara, B; Mutterer, J; Suire, C | 1 |
| Crerar-Gilbert, A; Endre, ZH; Morgan, TJ; Venkatesh, B; Willgoss, D | 1 |
| Liu, TZ; Qian, ZY | 1 |
| Dhar, A; Longorio, MA; Maxfield, DM; Morrison, DC; Van Way, CW | 1 |
| Alden, T; Helm, GA; Jane, JA; Melon, DE; Okonkwo, DO; Stone, JR; Wagner, J | 1 |
| Abe, T; Hayasaka, S; Hayasaka, Y; Nagaki, Y; Terasawa, K; Zhang, XY | 1 |
| Qian, ZY; Shen, XC | 2 |
| Gainer, JL; Giassi, LJ | 1 |
| Giaccio, M | 1 |
| Gainer, JL; Stennett, AK | 1 |
| Gómez-Gómez, L; Moraga, AR; Nohales, PF; Pérez, JA | 1 |
| Chen, Q; Qian, ZY; Shen, XC; Wang, YJ | 1 |
| Gainer, JL; Murray, RJ; Stennett, AK | 1 |
| Ahmad, AS; Ahmad, M; Ansari, MA; Hoda, MN; Islam, F; Saleem, S; Yousuf, S | 1 |
| Alonso, GL; Blázquez, I; Carmona, M; Díaz-Plaza, EM; Ordoudi, SA; Tsimidou, MZ; Zalacain, A | 2 |
| Asai, A; Nagao, A; Nakano, T; Takahashi, M | 1 |
| Qian, Z; Sheng, L; Tang, F; Zheng, S | 1 |
| Banerjee, SK; Cherian, G; Dhar, A; Dhar, G; Ray, G; Sharma, R | 1 |
| Qian, Z; Shen, X; Wen, N; Xi, L; Zhang, Y | 1 |
| Ellingsen, O; Kemi, OJ | 1 |
| Baek, NI; Kim, DH; Lee, IA; Lee, JH | 1 |
| Qian, Z; Sheng, L; Wen, N; Zheng, S | 1 |
| Alonso, GL; Carmona, M; Novella, JL; Sánchez, AM; Zalacain, A | 1 |
| Li, WN; Liu, J; Qian, ZY; Xiang, M; Zhou, CH | 1 |
| Qian, ZY; Xiang, M; Zheng, SG; Zhou, CH | 1 |
| Ekambaram, G; Magesh, V; Sakthisekaran, D; Selvendiran, K; Singh, JP | 1 |
| Qian, Z; Sheng, L; Shi, Y; Sun, S; Wen, N; Xi, L; Xu, G; Zhang, Y; Zheng, S | 1 |
| Bao, LP; He, SY; Huang, HQ; Liu, PQ; Qian, ZY; Tang, FT; Zheng, SG | 1 |
| Li, W; Liu, J; Qian, Z; Xiang, M; Yang, M; Zhou, C | 1 |
| Alonso, GL; Carmona, M; Salinas, MR; Zalacain, A | 1 |
| Dempsey, GL; Gainer, JL; Stennett, AK | 1 |
| He, SY; Qian, ZY; Tang, FT; Wen, N; Xu, GL; Zhou, CH | 1 |
| He, SY; Qian, ZY; Xiang, M; Zhou, CH | 3 |
| Eyanagi, R; Fujiwara, M; Iwasaki, K; Mishima, K; Ochiai, T; Shimeno, H; Shoyama, Y; Soeda, S; Tanaka, H; Toda, A | 1 |
| Kanakis, CD; Polissiou, MG; Tajmir-Riahi, HA; Tarantilis, PA | 3 |
| Qian, Z; Sun, S; Xi, L; Xu, G; Zhou, C | 1 |
| Gainer, JL; Murray, RJ; Roy, JW; Stennett, AK | 1 |
| Chen, H; Li, L; Xiao, YQ; Zhang, C | 1 |
| Bathaie, SZ; Bolhasani, A; Hoshyar, R; Moosavi-Movahedi, AA; Ranjbar, B; Sabouni, F | 1 |
| Hu, P; Liang, Q; Liu, Q; Luo, G; Wang, Y; Yang, H; Zhang, M | 1 |
| Kunugi, A; Sato, K; Sugimoto, N; Tanamoto, K; Uekusa, Y; Yamazaki, T; Yun, YS | 1 |
| Qian, Z; Wen, N; Xi, L; Zheng, S | 1 |
| Fahlman, A; Kayar, SR; Montcalm-Smith, EA | 1 |
| Alonso, GL; Carmona, M; Ordoudi, SA; Sánchez, AM; Tsimidou, MZ | 1 |
| Alonso, GL; Carmona, M; Carot, JM; Jabaloyes, JM; Sánchez, AM; Zalacain, A | 1 |
| Cui, L; Meng, L | 1 |
| Hamilton, DK; Ionescu, A; Oskouian, RJ; Pouratian, N; Sansur, C; Schlesinger, D; Sheehan, J | 1 |
| Ji, H; Qian, Z; Sheng, L; Shi, Y; Xi, L; Xu, X; Yang, L; Zhao, B | 1 |
| Gainer, JL | 1 |
| Hellenbrand, N; Hensel, A; Lechtenberg, M; Niehues, M; Schepmann, D; Wünsch, B | 1 |
| Alonso, GL; Carmona, M; Prodanov, M; Sánchez, AM | 1 |
| Cheetham, R; Elkholy, S; Fernández, JA; Guardiola, J; Junge, H; Sharaf-Eldin, M; Weathers, P | 1 |
| Dhanapal, S; Ganapathy, E; Konga, D; Peramaiyan, R; Venkatraman, M | 1 |
| Ji, H; Kazi, HA; Qian, Z; Sheng, L; Yang, L; Yang, Y; Zhou, C | 1 |
| DurgaBhavani, K; Magesh, V; Rajendran, P; Sakthisekaran, D; Senthilnathan, P | 1 |
| Li, GL; Li, L; Pang, Z; Xiao, YQ; Zhang, C | 1 |
| Banerjee, S; Banerjee, SK; Campbell, DR; Dhar, A; Dhar, G; Dhar, K; Mehta, S; Van Veldhuizen, P | 1 |
| Befani, CD; Koliakos, GG; Nenadis, N; Ordoudi, SA; Tsimidou, MZ | 1 |
| Alonso, GL; Carmona, M; Maggi, L; Murcia, MA; Tomé, MM; Zalacain, A | 1 |
| Cifarelli, C; Dassoulas, K; Han, S; Jagannathan, J; Olson, C; Rainey, J; Sheehan, J; Sherman, J | 1 |
| Ataka, S; Kajimoto, O; Kajimoto, Y; Kuratsune, H; Mizuma, H; Mizuno, K; Nozaki, S; Shirai, T; Sugino, T; Tahara, T; Tanaka, M; Watanabe, Y | 1 |
| Bariyanga, J; Kanakis, CD; Pappas, C; Polissiou, MG; Tajmir-Riahi, HA; Tarantilis, PA | 1 |
| Bian, ZY; Cai, J; Li, H; Shen, DF; Tang, QZ; Yan, L; Yang, L; Yang, XC; Yi, FF | 1 |
| Han, X; Ji, H; Qian, Z; Sheng, L; Yan, J; Yang, L; Zhang, R; Zhao, B | 1 |
| Duan, JA; Qian, ZY; Shen, XC; Wang, YJ | 1 |
| Lapchak, PA | 1 |
| Clarke, RH; Gainer, JL; Lee, KS; Manabe, H; Okonkwo, DO | 1 |
| Cifarelli, CP; Dassoulas, K; Han, S; Olson, C; Rainey, J; Sheehan, J | 1 |
| Alonso, GL; Anastasaki, EG; Carmona, M; del Campo, CP; Kanakis, CD; Maggi, L; Polissiou, MG; Tarantilis, PA | 1 |
| Alonso, GL; Anastasaki, EG; Carmona, M; Kanakis, CD; Maggi, L; Pappas, C; Polissiou, MG; Zalacain, A | 1 |
| Kajimoto, Y; Kuratsune, H; Nakano, T; Takeno, R; Umigai, N | 1 |
| Ji, H; Qian, Z; Sheng, L; Wang, Y; Xi, L; Yang, L; Yang, R; Zhang, X; Zhao, B | 1 |
| Chryssanthi, DG; Cordopatis, P; Dedes, PG; Karamanos, NK; Lamari, FN | 1 |
| Cho, KH; Hong, JW; Jung, HJ; Jung, WS; Kang, I; Lee, EH; Lee, JY; Min, BD; Nam, KN; Park, JH; Park, SU; Park, YM | 1 |
| Hara, H; Imai, S; Nakanishi, T; Shimazawa, M; Tsuruma, K; Umigai, N; Yamauchi, M | 1 |
| Gadgoli, C; Shelke, S | 1 |
| Jüttner, F; Köster, O; von Elert, E; Watson, SB | 1 |
| Antonio, LS; Morikawa, H; Murakami, K; Nakano, T; Shirotori, M; Ulit, MV; Umigai, N | 1 |
| Cai, Y; Clarke, R; Fitzgerald, M; Lee, KS; Manabe, H; Wang, Y; Yoshimura, R | 1 |
| Li, XY; Li, Z; Lu, JF; Lu, Y; Shen, CH; Wang, HP; Wang, Q; Xia, Q; Ye, ZG | 1 |
| Morrison, D; Qureshi, N; Thomas, A; Van Way, CW; Vernon, K; Yang, R | 1 |
| Cordopatis, P; Efthimiopoulos, S; Lamari, FN; Margarity, M; Papandreou, MA; Tsachaki, M | 1 |
| Berger, F; Hensel, A; Nieber, K | 1 |
| Chryssanthi, DG; Cordopatis, P; Georgakopoulos, CD; Lamari, FN | 1 |
| Erazo-Oliveras, A; Johnson, GA; Lim, J; Muthukrishnan, N; Pellois, JP; Simanek, EE; Srinivasan, D | 1 |
| Anant, S; Dhar, A; Gutheil, WG; Ray, A; Reed, G | 1 |
| Cifarelli, CP; Lee, DH; Martin, J; Monteith, S; Park, DM; Popp, B; Sheehan, JP; Tomlinson, J; Toulmin, S | 1 |
| Bie, X; Chen, Y; Dai, H; Zheng, X | 1 |
| Ali, KH; Cheng, W; Ji, H; Qian, Z; Shen, X; Yang, L; Yang, R; Zhao, B | 1 |
| Ahn, JH; Hernandez, M; Hu, Y; Kim, JR | 1 |
| Chen, Y; Liu, SJ; Yang, ZL; Zhang, LH; Zhang, XT | 1 |
| He, F; Liao, LC; Lin, Y; Qin, Y; Shi, F; Sun, H; Wang, Q; Wang, X; Yang, L; Zhang, L; Zheng, XL; Zhong, YJ | 1 |
| Bauer, T; Eraso, LH; Gainer, JL; Mohler, ER; Thanaporn, PK; Whitten, K | 1 |
| Aritake, K; Huang, ZL; Masaki, M; Shoyama, Y; Tanaka, H; Urade, Y | 1 |
| Ahmad, A; Ahmad, S; Hoda, MN; Ishrat, T; Islam, F; Khan, MB; Moshahid Khan, M; Yusuf, S | 1 |
| Hara, H; Shimazawa, M; Tanaka, J; Tsuruma, K; Umigai, N | 1 |
| Inukai, T; Mizukami, H; Nagatoshi, M; Nagatsu, A; Owaki, M; Sota, M; Terasaka, K | 1 |
| Qian, Z; Wang, Y; Wang, Z; Xi, L; Yan, J; Yang, L | 1 |
| Geromichalos, GD; Lamari, FN; Margarity, M; Papageorgiou, A; Papandreou, MA; Sinakos, Z; Trafalis, DT | 1 |
| Hara, H; Nakanishi, T; Ohno, Y; Shimazawa, M; Tsuruma, K; Umigai, N | 1 |
| Hosseinzadeh, H; Nassiri-Asl, M | 1 |
| Carlucci, G; Chichiriccò, G; Fontecchio, G; Poma, A | 1 |
| Bi, K; Chen, X; Dai, J; Long, Z; Zhao, X | 1 |
| Alonso, GL; García-Diz, L; Maggi, L; Martínez-Tomé, M; Murcia, MA; Sánchez, AM; Serrano-Díaz, J | 1 |
| Cai, E; Cai, XJ; Chen, R; Du, JC; Feng, J; Hu, B; Huang, WF; Li, CY; Li, HH; Wang, F; Wang, J; Wang, QL | 1 |
| Kokkosis, AG; Lamari, FN; Linardaki, ZI; Margarity, M; Orkoula, MG | 1 |
| Shoyama, Y; Tung, NH | 1 |
| Bhattacharjee, B; Chatterjee, J; Karunakar, P; Vijayasarathy, S | 1 |
| Kazakos, G; Lavrentiadou, S; Markala, D; Poutahidis, T; Sapanidou, V; Sinakos, Z; Taitzoglou, I; Tsantarliotou, MP; Zervos, I | 1 |
| Hara, H; Ishizuka, F; Nakamura, S; Ogishima, H; Shimazawa, M; Tsuruma, K; Umigai, N | 1 |
| Hong, YJ; Yang, KS | 1 |
| Galvin, K; Kyriakoudi, A; O'Brien, NM; O'Callaghan, YC; Tsimidou, MZ | 1 |
| Gu, XZ; Li, YT; Ma, YL; Xiao, YQ; Yu, DR; Zhang, C | 1 |
| Hosseinzadeh, H; Mohajeri, SA; Motamedshariaty, VS; Movassaghi, AR; Tashakori-Sabzevar, F | 1 |
| Ahrazem, O; Gómez Gómez, L; Granell, A; Rambla, JL; Rubio Moraga, A | 1 |
| Li, M; Song, Y; Zhu, L | 1 |
| Bathaie, SZ; Hoshyar, R; Miri, H; Sadeghizadeh, M | 1 |
| Hensel, A; Lautenschläger, M; Lechtenberg, M; Sendker, J | 1 |
| Chen, K; Duan, X; He, K; Huang, R; Si, P; Tahir, U; Wang, H; Xiang, G; Xiao, J | 1 |
| Allmaier, G; Koulakiotis, NS; Pittenauer, E; Tsarbopoulos, A | 1 |
| Giddings, JC; Higashino, S; Horikawa, Y; Hyodo, K; Matsuda, K; Sakata, SF; Sasaki, Y; Yamamoto, J | 1 |
| Bathaie, SZ; Farajzade, A; Hoshyar, R | 1 |
| Kim, SC; Kim, SH; Lee, JM; Lee, PC; Park, CB | 1 |
| Jin, J; Kim, YH; Koo, S; Oh, ET; Seo, JA; Su, L | 1 |
| Alonso, GL; Carmona, M; D'Alessandro, AM; Di Cesare, E; Festuccia, C; Gravina, GL; Jannini, EA; Lenzi, A; Llorens, S; Mancini, A; Scarsella, L; Tatone, C | 1 |
| Jiang, W; Kong, LP; Kong, Y; Li, GW; Li, S; Luo, T; Wang, HQ; Zhou, Y | 1 |
| Cai, Y; Clarke, R; Fitzgerald, M; Lee, KS; Manabe, H; Schretter, C; Wang, Y; Yoshimura, R | 1 |
| Fang, C; Liu, C; Sun, J; Wang, Y | 1 |
| Akiyama, H; Inoue, K; Ito, Y; Matsuda, S; Min, JZ; Nishikawa, H; Sugimoto, N; Tada, A; Tanada, C; Todoroki, K; Toyo'oka, T | 1 |
| Deng, J; Xiong, L; Zuo, Z | 1 |
| Alonso, GL; Carmona, M; D'Alessandro, AM; Llorens, S; Mancini, A; Nava, E; Serrano-Díaz, J | 2 |
| Brandt, S; Düfer, M; Galla, HJ; Hensel, A; Hüwel, S; Lautenschläger, M; Riehemann, K; Sendker, J | 1 |
| Inkielewicz-Stepniak, I; Niska, K; Radomski, MW; Santos-Martinez, MJ | 1 |
| Chen, B; Dong, Z; Hou, ZH; Li, CD | 1 |
| Broadhead, GK; Chang, A; Grigg, J; McCluskey, P | 1 |
| Qian, ZY; Ren, YN; Yang, JR; Zhao, MQ; Zheng, SG | 1 |
| Clarke, R; Lee, KS; Schretter, C; Wang, Y | 1 |
| Bai, W; Chen, Q; Wen, A; Xu, Z; Yang, X; Zhou, C; Zhu, X | 1 |
| Anant, S; Dhar, A; Gutheil, W; Harihar, S; Islam, S; Kwatra, D; Padhye, S; Palaniyandi, K; Paul, S; Pradhan, R; Putty, S; Ramalingam, S; Rangarajan, P; Subramaniam, D; Welch, DR | 1 |
| Ahrazem, O; Berman, J; Capell, T; Christou, P; Gómez-Gómez, L; Rubio-Moraga, A; Zhu, C | 1 |
| Kyriakoudi, A; Ordoudi, SA; Tsimidou, MZ | 1 |
| Awaysheh, A; Bend, JR; Chen, D; Lo, A; Rieder, MJ; Rylett, RJ; Xia, XY | 1 |
| Ding, J; Ma, J; Su, J; Zhang, L | 1 |
| Bathaie, SZ; Mahdavifard, S; Nakhjavani, M; Taghikhani, M | 1 |
| Boehm, F; Edge, R; Truscott, TG; Witt, C | 1 |
| Ahrazem, O; Argandoña-Picazo, J; Castillo, R; Gómez-Gómez, L; Rubio-Moraga, A | 1 |
| Huang, ZQ; Jiang, SJ; Li, HN; Li, SH; Li, Y; Ling, Y; Ren, ZQ; Zhang, F; Zhang, Y; Zhou, WE | 1 |
| Chen, G; Chen, Y; Duan, J; Huang, Z; Nan, C; Shan, X; Su, Q; Tao, W; Wang, H; Xue, W | 1 |
| Alebooye Langroodi, F; Hafezi Ghahestani, Z; Hashemi, M; Mokhtarzadeh, A; Ramezani, M | 1 |
| Albero, G; Campanile, G; De Canditiis, C; Gasparrini, B; Neglia, G; Pero, ME; Salzano, A; Zullo, G | 1 |
| Hara, H; Ishisaka, M; Iwawaki, T; Kubo, K; Ohba, T; Shimazawa, M; Tsujii, S; Tsuruma, K; Umigai, N | 1 |
| Fletouris, D; Kourtzelis, I; Lavrentiadou, S; Sapanidou, V; Taitzoglou, I; Theodoridis, A; Tsakmakidis, I; Tsantarliotou, M | 1 |
| Adhikary, A; Banerjee, S; Chakraborty, J; Chakraborty, S; Das, T; Guha, D; Ray, P; Sa, G | 1 |
| Amel Farzad, S; Hashemi, M; Mokhtarzadeh, A; Ramezani, M; Soltani, F | 1 |
| Dawalbhakta, M; Telang, M | 1 |
| Caltagirone, C; Casella, A; Chiurchiù, V; Crispoltoni, L; Del Pino, AM; Kawarai, T; Maccarrone, M; Montecchiani, C; Orlacchio, A; Palmerini, CA; Tiribuzi, R | 1 |
| Huang, W; Kang, C; Liu, W; Qian, Z; Song, L; Sun, Y | 1 |
| Alonso, GL; García-Rodríguez, MV; López-Córcoles, H; Pappas, CS; Polissiou, MG; Tarantilis, PA | 1 |
| Ahrazem, O; Diretto, G; Gómez-Gómez, L; Molina, RV; Pallotti, C; Parra-Vega, V; Prieto, A; Rivas-Sendra, A; Rubio-Moraga, Á; Seguí-Simarro, JM | 1 |
| Aa, J; Chen, T; Fei, F; Feng, S; Geng, J; Huang, J; Li, S; Sun, R; Wang, G; Wang, J; Wang, P; Yang, N; Yu, X; Zhang, Y; Zhao, Y; Zhen, L; Zhu, X; Zhu, Y | 1 |
| Gao, Z; Wang, J; Wang, L; Wu, P; Xiang, M; Yang, R; Zhang, Y | 1 |
| Azarhazin, E; Housaindokht, MR; Izadyar, M | 1 |
| Li, J; Zhang, A | 1 |
| Chai, F; Chen, Y; Liu, H; Mei, X; Wang, Y; Xiao, W; Yao, M; Yuan, Y | 1 |
| Moradzadeh, M; Sadeghnia, HR; Sahebkar, A; Tabarraei, A | 1 |
| Cao, W; Cui, J; Guo, Y; Li, Q; Li, S; Liu, X; Luan, Y; Zhang, D | 1 |
| Bathaie, SZ; Jafarisani, M; Mousavi, MF | 1 |
| Khan, TH; Patel, S; Sarwat, M | 1 |
| Chen, M; Gao, J; Jiang, ZH; Lu, WQ; Luo, P; Ren, XC; Shang, Q; Zhou, XB | 1 |
| Caligiuri, I; Fortunato, S; Granchi, C; Hergenrother, PJ; Lee, HY; Meini, S; Minutolo, F; Rizzolio, F; Tuccinardi, T | 1 |
| Ge, Z; Li, Y; Zhang, W | 1 |
| Hosseinzadeh, H; Rameshrad, M; Razavi, BM | 1 |
| Jiao, X; Li, Y; Liu, Z; Wang, X | 1 |
| An, JB; Chen, HT; Ma, JX; Shang, QL; Wang, HF | 1 |
| Ahrazem, O; Argandoña, J; Diretto, G; Gómez-Gómez, L; Granell, A; Julve, JM; Orzáez, D; Rubio-Moraga, Á | 1 |
| Hosseini, A; Hosseinzadeh, H; Razavi, BM | 1 |
| Hayakawa, T; Hori, S; Inoue, E; Masui, R; Shimizu, Y; Sudoh, K; Tsubonoya, T | 1 |
| Feng, C; Qiao, Y; Wang, X; Zhang, G; Zhao, X | 1 |
| Amini, E; Baharara, J; Golshan, A; Hashemi-Shahri, SH; Mohajeri, SA; Sahebkar, A; Salek, F; Tayarani-Najaran, Z | 1 |
| Chen, M; Chu, Y; Gao, J; Huang, YF; Jiang, ZH; Lu, WQ; Niu, J; Peng, LH; Shang, Q; Wang, MZ | 1 |
| Alonso, GL; Amicarelli, F; Artini, PG; Bonomo, I; Carta, G; D'Alessandro, AM; Di Emidio, G; Falone, S; Provenzani, A; Rossi, G; Sferra, R; Tatone, C; Vetuschi, A | 1 |
| Alonso Salinas, GL; Alonso, GL; Chaouqi, S; Jiménez-Monreal, AM; José Bagur, M; Llorens, S; Martínez-Tomé, M | 1 |
| Loffredo, L; Moras, B; Rey, S | 1 |
| Ahrazem, O; Argandoña, J; Diaz-Perales, A; Garrido-Arandia, M; Gómez-Gómez, L; Pacios, LF; Rubio-Moraga, Á | 1 |
| Avan, A; Ferns, GA; Hassanian, SM; Kermanshahi, B; Kermanshahi, F; Khazaei, M; Khorasanchi, Z; Parizadeh, MR; Ryzhikov, M; Shafiee, M | 1 |
| Farkhondeh, T; Samarghandian, S; Samini, F; Sanati, AR | 1 |
| Al-Babili, S; Aprea, G; Azad, NH; Demurtas, OC; Diretto, G; Ferrante, P; Frigerio, L; Frusciante, S; Giuliano, G; Mi, J; Pietrella, M; Romano, E; Taddei, AR | 1 |
| Dalla, C; Gikas, E; Karkoula, E; Kokras, N; Lemonakis, N; Skaltsounis, AL; Tsarbopoulos, A | 1 |
| Arzi, L; Hoshyar, R; Jafarzadeh, N; Riazi, G; Sadeghizadeh, M | 2 |
| Carducci, F; Cortesi, R; Esposito, E; Huang, N; Mariani, P; Puglia, C; Romeo, G; Simelière, F | 1 |
| D'Archivio, AA; Di Donato, F; Foschi, M; Maggi, MA; Ruggieri, F | 1 |
| Amel Farzad, S; Ghasim, H; Hashemi, M; Kalalinia, F; Pishavar, E; Ramezani, M | 1 |
| Brunetti, L; Chiavaroli, A; Ferrante, C; Leone, S; Leporini, L; Menghini, L; Orlando, G; Recinella, L | 1 |
| Du, TT; Lei, JW; Liang, XK; Tang, WW; Wang, YH; Xie, CX | 1 |
| Cardile, V; Crascì, L; Graziano, ACE; Musumeci, T; Panico, AM; Puglia, C; Puglisi, G; Raciti, G; Salerno, L; Santonocito, D | 1 |
| Angelis, A; Gikas, E; Halabalaki, M; Karkoula, E; Koulakiotis, NS; Skaltsounis, AL; Tsarbopoulos, A | 1 |
| Hu, Q; Jin, J; Liu, P; Qian, W; Sheng, L; Tang, C; Wang, X; Yu, D; Zhang, J; Zhong, Y; Zhou, H; Zhou, Y | 1 |
| de Lima, CB; Dos Santos, EC; Fontes, PK; Gasparrini, B; Ispada, J; Martinho, HS; Milazzotto, MP; Nogueira, MFG; Varchetta, R | 1 |
| Chu, J; Ding, F; He, B; Liu, F; Shao, W; Wu, B | 1 |
| Chen, M; Deng, Q; Gao, K; Guo, H; Liu, F; Zou, X | 1 |
| An, J; Ma, J; Shang, Q; Wang, C; Zhang, H | 1 |
| Mohanty, C; Pradhan, J; Sahoo, SK | 1 |
| Mori, A; Takeda, R; Umigai, N | 1 |
| An, JB; Chen, HT; Ma, JX; Shang, QL; Wang, CX; Wang, HF | 1 |
| Christodoulou, E; Grafakou, ME; Kadoglou, N; Kostomitsopoulos, N; Skaltsa, E; Valsami, G | 1 |
| Colapietro, A; D'Alessandro, AM; Festuccia, C; Mancini, A | 1 |
| Bai, C; Chen, Y; Deng, L; Du, L; Hu, Y; Li, X; Liu, X; Liu, Y; Sun, L; Wang, W; Wang, Z; Xia, Q; Yin, T; Zhang, H | 1 |
| Ikeda, SI; Ishida, A; Jiang, X; Kurihara, T; Miyauchi, M; Mori, K; Torii, H; Tsubota, K | 1 |
| Fu, WB; Li, S; Luo, T; Ouyang, T; Qu, Y; Shen, XY; Wang, HQ | 1 |
| Brown, J; Heitmar, R; Kyrou, I | 1 |
| Chang, G; Chen, Y; Zhang, H; Zhou, W | 1 |
| Chen, J; Chen, R; Chen, W; Chen, X; Hu, C; Li, Q; Liang, N; Pei, W; Tan, H; Xiao, W; Yuan, Y; Zhang, L | 1 |
| Hashemi, M; Hosseinzadeh, H | 1 |
| Alonso, GL; Dizadji, A; Habibi, MK; Kalantari, S; Lorenzo Tendero, C; Moratalla-Lopez, N; Movi, S; Parizad, S; Winter, S | 1 |
| Bi, C; Dai, L; He, P; Sun, Y; Wang, W; Ye, L; Zhang, X; Zhao, D; Zheng, J | 1 |
| Hashemi, M; Kalalinia, F; Neyshaburinezhad, N | 1 |
| Abedimanesh, S; Asghari Jafarabadi, M; Bathaie, SZ; Ostadrahimi, A; Taban Sadeghi, M | 1 |
| Fan, M; Li, N; Li, Y; Qi, X; Qian, H; Wang, L; Zhang, H | 1 |
| Hara, H; Hida, Y; Nakamura, S; Nishinaka, A; Nitta, K; Shimazawa, M | 1 |
| Bharate, SB; Bharate, SS; Reddy, CN; Vishwakarma, RA | 1 |
| Ikeda, SI; Jiang, X; Kurihara, T; Mori, K; Torii, H; Tsubota, K; Yotsukura, E | 1 |
| Alonso, GL; Angelucci, A; Colapietro, A; Festuccia, C; Gravina, GL; Llorens, S; Mancini, A; Martellucci, S; Mattei, V; Vitale, F | 1 |
| Hu, P; Huang, S; Mao, G; Ouyang, L; Shi, C; Yang, M | 1 |
| Chen, M; Chu, Y; Gao, J; Jiang, ZH; Niu, J; Peng, LH; Shang, Q; Wang, MZ | 1 |
| Ayanmanesh, M; Csupor, D; Horváth, A; Khamushi, A; Kiss, T; Mahmoodi Sourestani, M; Mottaghipisheh, J; Tóth, B | 1 |
| Chen, X; Huang, X; Kadota, K; Lu, A; Wong, KH; Xie, Y; Yang, Z; Yao, XS; Yu, Y | 1 |
| Chu, L; Chu, X; Liang, Y; Liu, Y; Ma, D; Wang, H; Zhang, J; Zheng, B | 1 |
| Catalá, MG; Izquierdo, D; Menéndez-Blanco, I; Paramio, MT; Roura, M; Soto-Heras, S | 1 |
| Chuncharunee, A; Limjindaporn, T; Sreekanth, GP; Yenchitsomanus, PT | 1 |
| Chu, L; Chu, X; Han, X; Liang, Y; Liu, P; Shi, J; Xue, Y; Zhang, J; Zheng, B | 1 |
| Arab, FL; Mahmoudi, M; Nikkhah, K; Rastin, M; Tabasi, NS; Yousefi, F | 1 |
| Chen, H; Chen, K; Liang, J; Luo, Y; Sha, W; Wang, J; Zhang, C; Zheng, Z; Zhou, W; Zhuo, Z | 1 |
| Chu, X; Guan, S; Jin, W; Liang, Y; Wang, H; Xue, Y; Zhang, J; Zhang, Y | 1 |
| Chu, L; Chu, X; Gao, Y; Han, X; Li, J; Liang, Y; Shi, J; Zhang, J; Zhao, Z; Zheng, B | 1 |
| Jiang, J; Jiang, S; Jiang, Y; Li, Q; Lin, S; Liu, L; Tong, Y; Wang, P; Xu, Z | 1 |
| Bisti, S; Maggi, MA; Picco, C | 1 |
| Cerdá-Bernad, D; Frutos, MJ; Pastor, JJ; Valero-Cases, E | 1 |
| Alonso, GL; Castellini, C; D'Alessandro, AM; D'Andrea, S; Di Emidio, G; Gravina, GL; Placidi, M; Rea, F; Rossi, G; Tatone, C | 1 |
| Alonso, GL; Alviz, L; Galan-Moya, EM; Llorens, S; Lopez-Rosa, R; Moratalla-López, N; Nava, E; Tebar-García, D | 1 |
| Jain, AS; Joshi, SV; Kharkar, PS; Shah, HM | 1 |
| Li, Y; Qin, S; Shi, M; Wen, YL; Zheng, Z; Zhu, G | 1 |
| Hosseini, SM; Khodaverdi, E; Mehri, S; Mohajeri, SA; Sepahi, S; Soheili, ZS; Tavakkol-Afshari, J | 1 |
| Bordes, A; Lemée, L; Suchareau, M | 1 |
| Banerjee, M; Bernard, A; Chaban, V; Coliat, P; Collange, O; Defuria, J; Delabranche, X; Detappe, A; Dhindsa, N; Diringer, MC; Geng, B; Gizzi, P; Huang, ZR; Khalifa, K; Kim, G; Laurent, N; Mertes, PM; Moyo, V; Niyikiza, C; Pivot, X; Roche, A; Sartori, V; Theodorou, M; Velten, M; Villa, P; Voegelin, M; Xu, ZH | 1 |
| Inoue, E; Ishida, N; Kawasaki, H; Shimizu, Y; Sudo, K; Suzuki, T | 1 |
| Chen, Z; Jiang, Y; Tong, Y; Wang, P | 1 |
| Wang, J; Yuan, C; Zhao, N; Zheng, Y; Zhu, N | 1 |
| Liu, H; Qin, L; Wang, J; Wang, W; Zhang, L | 1 |
| Ding, X; Hou, J; Huang, Y; Wang, J; Wang, Y; Xuan, Y; Zang, M; Zhang, B; Zhou, Y | 1 |
| Ahn, KS; Alharbi, SA; Chinnathambi, A; Kim, C; Kumar, AP; Manu, KA; Mohan, CD; Rangappa, KS; Rangappa, S; Siveen, KS | 1 |
| Gao, R; Li, X; Song, X; Yu, L; Zhu, J | 1 |
| Chen, G; Deng, Z; Li, L; Liu, Y; Wang, Q; Xu, C; You, S; Zou, J | 1 |
| Qiu, X; Wang, D; Yang, J; Zhou, M | 1 |
| Cai, W; Cao, Y; Chen, S; Jiang, Y; Li, Q; Lin, S; Tong, Y; Tong, Z; Wang, P; Xu, Z; Zahra, BS | 1 |
| Chang, X; Liu, D; Liu, X; Ma, X; Song, X; Sukegawa, M; Wang, DO; Wang, Z; Zu, E | 1 |
| Bastianini, M; Cardellini, F; Collevecchio, C; Epifano, F; Fiorito, S; Genovese, S; Palumbo, L; Spogli, R | 1 |
| Martin, A; Siddiq A, A | 1 |
| He, C; Zhu, L | 1 |
| Ding, Y; Fan, R; He, L; Li, W; Ma, L; Ma, W; Sun, Y; Xu, Q; Zhai, Y; Zhang, B; Zhang, J; Zhang, X; Zhang, Z | 1 |
| Emami, SA; Jafari, F; Javadi, B; Salmasi, Z; Tayarani-Najaran, Z; Tayarani-Najjaran, M | 1 |
| Ahmed, H; Ijaz, MU; Jahan, S; Riaz, M; Saqib, NU; Ullah, F | 1 |
| Chen, Q; Deng, Y; Li, Y; Ma, J; Wang, X; Xi, X; Xia, Y | 1 |
| Gao, K; Guo, H; Luo, Y; Pan, H; Ruan, C; Zhan, X | 1 |
| Banerjee, M; Bernard, A; Burckel, H; Clarke, P; Coliat, P; Detappe, A; Diringer, MC; Grabowska, A; Harvey, P; Laurent, N; Mathieu, C; Mura, C; Noel, G; Pivot, X; Ritchie, A; Vit, C; Zhu, C | 1 |
21 review(s) available for retinol and trans-sodium crocetinate
| Article | Year |
|---|---|
TSC and hemorrhagic shock.
Topics: Animals; Blood Pressure; Carotenoids; Disease Models, Animal; Heart Rate; Humans; Male; Oxygen Consumption; Oxygen Inhalation Therapy; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Vitamin A | 2003 |
Crocetin from saffron: an active component of an ancient spice.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carotenoids; Crocus; Humans; Oxygen; Skin Neoplasms; Vitamin A | 2004 |
Trans-sodium crocetinate for treating hypoxia/ischemia.
Topics: Animals; Carotenoids; Clinical Trials, Phase I as Topic; Diffusion; Drug Evaluation, Preclinical; Erythrocytes; Humans; Hydrogen Bonding; Hypoxia; Ischemia; Male; Models, Animal; Oxygen; Oxygen Consumption; Plasma; Rats; Shock, Hemorrhagic; Swine; Vitamin A; Water | 2008 |
Crocetin: an agent derived from saffron for prevention and therapy for cancer.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carotenoids; Crocus; Humans; Neoplasms; Vitamin A | 2012 |
Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review.
Topics: Carotenoids; Cosmetics; Crocus; Cyclohexenes; Herbal Medicine; History, Medieval; Incunabula as Topic; Plant Extracts; Terpenes; Vitamin A | 2013 |
Anti-inflammatory properties of drugs from saffron crocus.
Topics: Animals; Anti-Inflammatory Agents; Carotenoids; Crocus; Humans; Plant Extracts; Quality Control; Vitamin A | 2012 |
A review of the chemistry and uses of crocins and crocetin, the carotenoid natural dyes in saffron, with particular emphasis on applications as colorants including their use as biological stains.
Topics: Animals; Carotenoids; Coloring Agents; Crocus; Flowers; Humans; Plant Extracts; Vitamin A | 2014 |
Efficacy and Safety of Saffron Supplementation: Current Clinical Findings.
Topics: Affect; Animals; Antioxidants; Cardiovascular System; Carotenoids; Clinical Trials as Topic; Cognition; Crocus; Cyclohexenes; Disease Models, Animal; Humans; Oxidative Stress; Phytotherapy; Plant Preparations; Reproduction; Terpenes; Vision, Ocular; Vitamin A; Zeaxanthins | 2016 |
Patents on Therapeutic and Cosmetic Applications of Bioactives of Crocus Sativus L. and their Production through Synthetic Biology Methods: A Review.
Topics: Animals; Biological Factors; Carotenoids; Cosmeceuticals; Crocus; Cyclohexenes; Databases, Factual; Humans; Metabolic Diseases; Nervous System Diseases; Patents as Topic; Plant Extracts; Synthetic Biology; Terpenes; Vitamin A | 2017 |
Anti-tumor effects of crocetin and related molecular targets.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Carotenoids; Cell Line, Tumor; Chemoprevention; Crocus; Humans; Neoplasms; Nucleic Acid Synthesis Inhibitors; Vitamin A | 2018 |
Mechanism behind the anti-tumour potential of saffron (Crocus sativus L.): The molecular perspective.
Topics: Animals; Antineoplastic Agents; Carotenoids; Crocus; Cyclohexenes; Humans; Terpenes; Vitamin A | 2017 |
Saffron and its derivatives, crocin, crocetin and safranal: a patent review.
Topics: Animals; Carotenoids; Crocus; Cyclohexenes; Drug Design; Humans; Patents as Topic; Plant Extracts; Terpenes; Vitamin A | 2018 |
Pharmacokinetic Properties of Saffron and its Active Components.
Topics: Animals; Carotenoids; Crocus; Humans; Vitamin A | 2018 |
Saffron: An Old Medicinal Plant and a Potential Novel Functional Food.
Topics: Antidepressive Agents; Antineoplastic Agents; Antioxidants; Carotenoids; Color; Crocus; Cyclohexenes; Functional Food; Glucosides; Humans; Phytochemicals; Plants, Medicinal; Spices; Terpenes; Vitamin A | 2017 |
Crocus sativus a natural food coloring and flavoring has potent anti-tumor properties.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carotenoids; Cell Cycle; Crocus; Cyclohexenes; Female; Food Coloring Agents; Glucosides; Humans; Male; Secondary Metabolism; Terpenes; Vitamin A | 2018 |
Phytotherapic use of the Crocus sativus L. (Saffron) and its potential applications: A brief overview.
Topics: Alzheimer Disease; Animals; Atherosclerosis; Carotenoids; Crocus; Cyclohexenes; Depression; Glucosides; Humans; Neoplasms; Phytotherapy; Plant Extracts; Sexual Dysfunction, Physiological; Terpenes; Vitamin A | 2018 |
Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carotenoids; Chemoprevention; Crocus; Humans; Neoplasms; Vitamin A | 2019 |
Saffron (
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carotenoids; Crocus; Eye; Eye Diseases; Humans; Neuroprotective Agents; Phytotherapy; Plant Extracts; Vitamin A | 2019 |
A comprehensive review on biological activities and toxicology of crocetin.
Topics: Animals; Carotenoids; Humans; Vitamin A | 2019 |
Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action.
Topics: Antioxidants; Carotenoids; Crocus; Cyclohexenes; Oxidative Stress; Plant Extracts; Terpenes; Vitamin A | 2022 |
Crocetin and related oxygen diffusion-enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications.
Topics: Animals; Carotenoids; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; COVID-19; Diffusion; Humans; Oxygen Consumption; Oxygen Inhalation Therapy; Vitamin A | 2021 |
5 trial(s) available for retinol and trans-sodium crocetinate
| Article | Year |
|---|---|
Daily oral administration of crocetin attenuates physical fatigue in human subjects.
Topics: Administration, Oral; Adult; Antioxidants; Ascorbic Acid; Bicycling; Carotenoids; Double-Blind Method; Drug Administration Schedule; Exercise; Exercise Test; Fatigue; Female; Humans; Male; Middle Aged; Physical Exertion; Sex Factors; Vitamin A | 2009 |
Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study.
Topics: Adult; Carotenoids; Cross-Over Studies; Double-Blind Method; Fruit; Gardenia; Humans; Male; Middle Aged; Phytotherapy; Pilot Projects; Plant Extracts; Sleep; Sleep Initiation and Maintenance Disorders; Vitamin A | 2010 |
Evaluation of trans sodium crocetinate on safety and exercise performance in patients with peripheral artery disease and intermittent claudication.
Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Carotenoids; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Exercise; Exercise Test; Female; Humans; Injections, Intravenous; Intermittent Claudication; Male; Middle Aged; Peripheral Arterial Disease; Surveys and Questionnaires; Time Factors; Treatment Outcome; Vitamin A; Walking | 2011 |
Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study.
Topics: Adult; Carotenoids; Crocus; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Electroencephalography; Female; Gardenia; Humans; Hypnotics and Sedatives; Male; Middle Aged; Plant Extracts; Sleep; Sleep Initiation and Maintenance Disorders; Vitamin A; Wakefulness | 2018 |
The effect of crocetin supplementation on markers of atherogenic risk in patients with coronary artery disease: a pilot, randomized, double-blind, placebo-controlled clinical trial.
Topics: Atherosclerosis; Biomarkers; Carotenoids; Coronary Disease; Dietary Supplements; Double-Blind Method; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Pilot Projects; Risk Factors; Vitamin A | 2019 |
284 other study(ies) available for retinol and trans-sodium crocetinate
| Article | Year |
|---|---|
The effect of crocetin on skin papillomas and Rous sarcoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carotenoids; Chickens; Mice; Neoplasms, Experimental; Papilloma; Sarcoma, Avian; Skin Neoplasms; Vitamin A | 1976 |
Studies of the mechanism of action of the carotenoid crocetin.
Topics: Animals; Biological Transport; Carotenoids; Cells, Cultured; Kinetics; Muscles; Oxygen; Rats; Spectrum Analysis; Vitamin A | 1979 |
The effect of crocetin on the irradiation of Walker-256: in vitro and in vivo studies.
Topics: Animals; Carcinoma 256, Walker; Carotenoids; Cell Survival; Cells, Cultured; Dose-Response Relationship, Radiation; Male; Radiation-Sensitizing Agents; Rats; Vitamin A | 1979 |
Use of crocetin in experimental spinal cord injury.
Topics: Animals; Carotenoids; Dexamethasone; Dogs; Female; Male; Oxygen; Spinal Cord Injuries; Vitamin A | 1977 |
Effect of increasing the plasma oxygen diffusivity on experimental cryogenic edema.
Topics: Animals; Brain Edema; Carotenoids; Cats; Dexamethasone; Female; Male; Oxygen; Vitamin A | 1976 |
The use of crocetin in experimental atherosclerosis.
Topics: Animals; Aorta; Arteriosclerosis; Carotenoids; Cholesterol; Depression, Chemical; Diet, Atherogenic; Oxygen; Rabbits; Time Factors; Triglycerides; Vitamin A | 1975 |
Effects of crocetin on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Carotenoids; Cytosol; DNA; gamma-Glutamyltransferase; Glutathione; Injections, Intraperitoneal; Liver; Male; Rats; Rats, Inbred Strains; Vitamin A | 1991 |
Modulatory effect of crocetin on aflatoxin B1 cytotoxicity and DNA adduct formation in C3H10T1/2 fibroblast cell.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carotenoids; Cell Survival; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Drug Antagonism; Fibroblasts; Glutathione; Glutathione Peroxidase; Glutathione Transferase; In Vitro Techniques; Male; Mice; Mice, Inbred C3H; Rats; Rats, Inbred Strains; Vitamin A | 1991 |
Suppression of aflatoxin B1-induced hepatotoxic lesions by crocetin (a natural carotenoid).
Topics: Aflatoxin B1; Animals; Carotenoids; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Rats; Rats, Inbred Strains; Vitamin A | 1991 |
The carotenoid crocetin enhances pulmonary oxygenation.
Topics: Animals; Cardiac Output; Carotenoids; Hypoxia; Male; Oxygen; Pulmonary Gas Exchange; Rabbits; Time Factors; Vitamin A | 1988 |
Determination of sulfite radical (SO.3-) reaction rate constants by means of competition kinetics.
Topics: Carotenoids; Fatty Acids, Unsaturated; Free Radicals; Glutathione; Hydrogen-Ion Concentration; Kinetics; Nucleosides; Phenols; Quercetin; Sulfites; Vitamin A | 1987 |
Carotenoid compound crocetin improves cerebral oxygenation in hemorrhaged rats.
Topics: Animals; Blood Pressure; Brain; Carotenoids; Cerebral Hemorrhage; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Vitamin A | 1986 |
[Comparison of natural yellow colors extracted from saffron (Crocus sativus Linne) and gardenia fruit (Gardenia jasminoides Ellis)].
Topics: Carotenoids; Plants, Medicinal; Vitamin A | 1985 |
Effect of crocetin on experimental skin tumors in hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carotenoids; Croton Oil; Female; Mice; Mice, Hairless; Neoplasms, Experimental; Skin Neoplasms; Ultraviolet Rays; Vitamin A | 1982 |
Binding of crocetin to plasma albumin.
Topics: Animals; Biological Transport, Active; Carotenoids; Cattle; Humans; Kinetics; Protein Binding; Serum Albumin; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Vitamin A | 1982 |
Generation and reactivities of various types of oxygen radicals.
Topics: Ascorbic Acid; Carotenoids; Chemical Phenomena; Chemistry; Free Radicals; Kinetics; Oxygen; Photolysis; Vitamin A | 1981 |
Crocetin protects against oxidative damage in rat primary hepatocytes.
Topics: Animals; Antioxidants; Carotenoids; Cells, Cultured; DNA Damage; DNA Repair; Lipid Peroxides; Liver; Male; Paraquat; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides; Vitamin A; Xanthine Oxidase | 1995 |
Protective effects of crocetin on the bladder toxicity induced by cyclophosphamide.
Topics: Animals; Carotenoids; Cyclophosphamide; Glutathione Transferase; Liver; Male; Mice; Mice, Inbred Strains; Random Allocation; Sarcoma 180; Spectrophotometry; Urinary Bladder; Vitamin A | 1993 |
Inhibition of tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by crocetin.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carotenoids; Edema; Enzyme Induction; Female; Hydrogen Peroxide; Hyperplasia; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Peroxidase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A | 1995 |
Crocin (crocetin di-gentiobiose ester) prevents the inhibitory effect of ethanol on long-term potentiation in the dentate gyrus in vivo.
Topics: Animals; Carotenoids; Ethanol; Hippocampus; Long-Term Potentiation; Male; Memory; Plant Extracts; Rats; Rats, Wistar; Vitamin A | 1994 |
Post-harvest degradation of carotenoid glucose esters in saffron.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Carotenoids; Chromatography, High Pressure Liquid; Esters; Glucosides; Hydrolysis; Molecular Sequence Data; Molecular Structure; Spices; Vitamin A | 1994 |
Inhibitory effect of crocetin on intracellular nucleic acid and protein synthesis in malignant cells.
Topics: Carotenoids; Cell Line, Transformed; DNA, Neoplasm; HeLa Cells; Humans; Neoplasm Proteins; Protein Synthesis Inhibitors; RNA, Neoplasm; Tumor Cells, Cultured; Vitamin A | 1994 |
The effect of crocetin on hemorrhagic shock in rats.
Topics: Animals; Carotenoids; Erythrocyte Deformability; Erythrocytes; Kinetics; Magnetic Resonance Spectroscopy; Male; Muscles; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Vitamin A | 1993 |
Inhibition of protein kinase C and proto-oncogene expression by crocetin in NIH/3T3 cells.
Topics: 3T3 Cells; Animals; Anticarcinogenic Agents; Carcinogens; Carotenoids; Enzyme Inhibitors; Gene Expression; Genes, fos; Genes, jun; Mice; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate; Vitamin A | 1996 |
In vitro formation of crocetin glucosyl esters by Crocus sativus callus extract.
Topics: Anticarcinogenic Agents; Antioxidants; Carotenoids; Esters; Glycosides; Vitamin A | 1997 |
Increasing oxygen consumption and survival with fluid resuscitation therapy for hemorrhagic shock in rats.
Topics: Animals; Antioxidants; Carotenoids; Fluid Therapy; Male; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Survival Rate; Time Factors; Vitamin A | 1997 |
Enhanced NOR-1 gene expression by exposure of Chinese hamster cells to high-density 50 Hz magnetic fields.
Topics: Animals; Calcium Channel Blockers; Carotenoids; CHO Cells; Colforsin; Cricetinae; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Magnetics; Naphthalenes; Nerve Tissue Proteins; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Vitamin A | 1998 |
A novel fluid resuscitation therapy for hemorrhagic shock.
Topics: Animals; Carotenoids; Infusions, Intravenous; Injections, Intravenous; Male; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Sodium Chloride; Vitamin A | 1998 |
Characterization of island films as surface-enhanced Raman spectroscopy substrates for detecting low antitumor drug concentrations at single cell level.
Topics: Antineoplastic Agents; Carotenoids; Colloids; Evaluation Studies as Topic; Gold; HL-60 Cells; Humans; Silver; Spectrum Analysis, Raman; Surface Properties; Vitamin A | 1998 |
Simultaneous quantification of five major biologically active ingredients of saffron by high-performance liquid chromatography.
Topics: Carotenoids; Chromatography, High Pressure Liquid; Liliaceae; Spectrophotometry, Ultraviolet; Vitamin A | 1999 |
Intravenous crocetinate prolongs survival in a rat model of lethal hypoxemia.
Topics: Animals; Carotenoids; Dose-Response Relationship, Drug; Hypoxia; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Survival Rate; Time Factors; Vitamin A | 2000 |
Effects of crocetin on pulmonary gas exchange in foxhounds during hypoxic exercise.
Topics: Animals; Antioxidants; Cardiac Output; Carotenoids; Dogs; Hypoxia; Male; Oxygen; Oxygen Consumption; Physical Exertion; Pneumonectomy; Pulmonary Alveoli; Pulmonary Gas Exchange; Ventilation-Perfusion Ratio; Vitamin A | 2000 |
In vitro studies on the selective cytotoxic effect of crocetin and quercetin.
Topics: Animals; Anticarcinogenic Agents; Carotenoids; Chlorocebus aethiops; Cisplatin; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Quercetin; Rhabdomyosarcoma; Tumor Cells, Cultured; Vitamin A | 2000 |
Girard's reagent P derivative of beta-Apo-8'-carotenal: a potent photoprotective agent.
Topics: Anthracenes; Carotenoids; Chromatography, High Pressure Liquid; Humans; K562 Cells; Magnetic Resonance Spectroscopy; Molecular Structure; Oxygen; Perylene; Photochemistry; Photosensitizing Agents; Porphyrins; Protoporphyrins; Singlet Oxygen; Tumor Cells, Cultured; Vitamin A | 2001 |
Trans-sodium crocetinate restores blood pressure, heart rate, and plasma lactate after hemorrhagic shock.
Topics: Animals; Antioxidants; Blood Pressure; Carotenoids; Heart Rate; Hydrogen-Ion Concentration; Lactates; Male; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Vitamin A | 2001 |
Evaluation of the developmental toxicity of crocetin on Xenopus.
Topics: Animals; Carotenoids; Teratogens; Vitamin A; Xenopus | 2002 |
Genotoxicity of gardenia yellow and its components.
Topics: Bacillus subtilis; Carotenoids; Coloring Agents; Disaccharides; DNA Damage; Electrophoresis, Capillary; Food Coloring Agents; Gardenia; Iridoid Glycosides; Iridoids; Mutagenicity Tests; Plant Extracts; Pyrans; Sister Chromatid Exchange; Vitamin A | 2002 |
Trans sodium crocetinate for hemorrhagic shock: effect of time delay in initiating therapy.
Topics: Animals; Blood Pressure; Carotenoids; Heart Rate; Infusions, Intravenous; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Time Factors; Transaminases; Vitamin A | 2002 |
Oxidative remodeling of chromoplast carotenoids: identification of the carotenoid dioxygenase CsCCD and CsZCD genes involved in Crocus secondary metabolite biogenesis.
Topics: Amino Acid Sequence; beta Carotene; Carotenoids; Cloning, Molecular; Crocus; Cyclohexenes; Flowers; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Glucosides; Microscopy, Electron; Molecular Sequence Data; Oxidation-Reduction; Oxygenases; Plant Proteins; Plastids; Sequence Homology, Amino Acid; Terpenes; Vitamin A; Water; Xanthophylls; Zeaxanthins | 2003 |
Sodium crocetinate does not alter gut hypercapnic responses or renal energy stores during transient sub-diaphragmatic ischaemia.
Topics: Animals; Carbon Dioxide; Carotenoids; Disease Models, Animal; Hypercapnia; Intestinal Mucosa; Ischemia; Kidney; Male; Prospective Studies; Rats; Rats, Sprague-Dawley; Vitamin A | 2003 |
[Pharmacokinetics of crocetin in rats].
Topics: Animals; Antineoplastic Agents, Phytogenic; Carotenoids; Chromatography, High Pressure Liquid; Crocus; Female; Male; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Vitamin A | 2002 |
Cellular energetics in hemorrhagic shock: restoring adenosine triphosphate to the cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Antioxidants; Apoptosis; Carotenoids; Disease Models, Animal; Energy Metabolism; Fluid Therapy; Glutamine; Intestine, Small; Liver; Male; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Vitamin A | 2003 |
Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation.
Topics: Animals; Brain; Brain Ischemia; Carotenoids; Male; Oxygen; Oxygen Consumption; Oxygen Inhalation Therapy; Rats; Rats, Sprague-Dawley; Vitamin A | 2003 |
Effects of oral administration of Gardeniae fructus extract and intravenous injection of crocetin on lipopolysaccharide- and prostaglandin E2-induced elevation of aqueous flare in pigmented rabbits.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aqueous Humor; Area Under Curve; Carotenoids; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Injections, Intravenous; Lipopolysaccharides; Male; Rabbits; Time Factors; Uveitis, Anterior; Vitamin A | 2003 |
Effect of crocetin on cardiac hypertrophy induced by overloading pressure in rats.
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Cardiomegaly; Carotenoids; Hydroxyproline; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocardium; Organ Size; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Vitamin A | 2004 |
TSC for hemorrhagic shock: effects on cytokines and blood pressure.
Topics: Animals; Blood Pressure; Carotenoids; Cytokines; Heart Rate; Interleukin-10; Male; Oxygen; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Time Factors; Tumor Necrosis Factor-alpha; Vitamin A | 2004 |
Glucosylation of the saffron apocarotenoid crocetin by a glucosyltransferase isolated from Crocus sativus stigmas.
Topics: Amino Acid Sequence; Carotenoids; Cloning, Molecular; Crocus; Flowers; Gene Expression Regulation, Plant; Glucosyltransferases; Molecular Sequence Data; Molecular Structure; Phylogeny; RNA, Messenger; RNA, Plant; Tissue Distribution; Vitamin A | 2004 |
[Protective effect of crocetin on primary culture of cardiac myocyte treated with noradrenaline in vitro].
Topics: Animals; Animals, Newborn; Apoptosis; Calcium-Transporting ATPases; Carotenoids; Cells, Cultured; Crocus; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Myocytes, Cardiac; Norepinephrine; Plants, Medicinal; Protective Agents; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Succinate Dehydrogenase; Vitamin A | 2004 |
The effect of trans sodium crocetinate (TSC) in a rat oleic acid model of acute lung injury.
Topics: Animals; Antioxidants; Carotenoids; Male; Oleic Acid; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Vitamin A | 2005 |
Neuroprotection by crocetin in a hemi-parkinsonian rat model.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Carotenoids; Catalase; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Homovanillic Acid; Male; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Wistar; Substantia Nigra; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin A | 2005 |
Screening method for the detection of artificial colours in saffron using derivative UV-Vis spectrometry after precipitation of crocetin.
Topics: Antioxidants; Carotenoids; Chemical Precipitation; Condiments; Crocus; Food Coloring Agents; Food Contamination; Hydrogen-Ion Concentration; Hydrolysis; Spectrum Analysis; Spices; Ultraviolet Rays; Vitamin A | 2005 |
Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice.
Topics: Administration, Oral; Animals; Carotenoids; Glucuronides; Hydrolysis; Intestinal Absorption; Male; Mice; Mice, Inbred ICR; Vitamin A | 2005 |
Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits.
Topics: Animals; Atherosclerosis; Base Sequence; Carotenoids; DNA Primers; Hypercholesterolemia; Immunohistochemistry; Male; Rabbits; RNA, Messenger; Vascular Cell Adhesion Molecule-1; Vitamin A | 2005 |
Molecular basis of protective effect by crocetin on survival and liver tissue damage following hemorrhagic shock.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Apoptosis; Carotenoids; Cytochromes c; Cytoplasm; Liver; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Time Factors; Vitamin A | 2005 |
Crocetin prevents dexamethasone-induced insulin resistance in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Carotenoids; Dexamethasone; Disease Models, Animal; Fruit; Gardenia; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Resistance; Male; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Vitamin A | 2005 |
Trans-sodium crocetinate does not affect oxygen uptake in rats during treadmill running.
Topics: Animals; Body Weight; Carotenoids; Male; Oxygen; Physical Exertion; Rats; Rats, Sprague-Dawley; Running; Vitamin A | 2005 |
Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin.
Topics: Animals; Body Weight; Carotenoids; Cholesterol, LDL; Diet; Fruit; Gardenia; Hypercholesterolemia; Hypolipidemic Agents; Lipase; Lipids; Male; Mice; Mice, Inbred ICR; Organ Size; Triglycerides; Vitamin A | 2005 |
Near-infrared spectroscopy in saffron quality control: determination of chemical composition and geographical origin.
Topics: Carotenoids; Chromatography, High Pressure Liquid; Crocus; Glycosides; Greece; Iran; Quality Control; Spain; Spectroscopy, Near-Infrared; Vitamin A | 2005 |
Crocetin attenuates atherosclerosis in hyperlipidemic rabbits through inhibition of LDL oxidation.
Topics: Animals; Antioxidants; Aorta; Atherosclerosis; Carotenoids; Foam Cells; Hyperlipidemias; Lipid Peroxidation; Lipids; Lipoproteins, LDL; Male; Oxidation-Reduction; Rabbits; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin A | 2006 |
Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS.
Topics: Carotenoids; Chromatography, Liquid; Crocus; Cyclohexenes; Esters; Flowers; Fruit; Gardenia; Glucosides; Glycosides; Iridoids; Pyrans; Spectrometry, Mass, Electrospray Ionization; Terpenes; Vitamin A | 2006 |
Crocetin inhibits leukocyte adherence to vascular endothelial cells induced by AGEs.
Topics: Carotenoids; Cell Adhesion; Endothelium, Vascular; Glycation End Products, Advanced; Immunohistochemistry; Intercellular Adhesion Molecule-1; Leukocytes; Malondialdehyde; Membrane Potentials; Mitochondria; Superoxide Dismutase; Superoxides; Vitamin A | 2006 |
ERK1/2 pathway is involved in the inhibitory effect of crocetin on angiotensin II-induced vascular smooth muscle cell proliferation.
Topics: Active Transport, Cell Nucleus; Angiotensin II; Animals; Antioxidants; Blotting, Western; Carotenoids; Cattle; Cell Nucleus; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Phosphorylation; Vitamin A | 2006 |
Effects of crocetin on antioxidant enzymatic activities in cardiac hypertrophy induced by norepinephrine in rats.
Topics: Adrenergic alpha-Agonists; Animals; Antioxidants; Cardiomegaly; Carotenoids; Catalase; Female; Free Radical Scavengers; Glutathione Peroxidase; Lipid Peroxidation; Myocardium; Norepinephrine; Organ Size; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin A | 2006 |
Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biomarkers; Carotenoids; Chemoprevention; Enzymes; Free Radical Scavengers; Lipid Peroxidation; Lung Neoplasms; Male; Mice; Vitamin A | 2006 |
Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats.
Topics: Adipocytes; Adiponectin; Adipose Tissue; Animals; Antioxidants; Blood Pressure; Carotenoids; Cholesterol, LDL; Crocus; Dietary Carbohydrates; Energy Intake; Fructose; Insulin; Insulin Resistance; Leptin; Male; Organ Size; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha; Vitamin A | 2007 |
Crocetin improves endothelium-dependent relaxation of thoracic aorta in hypercholesterolemic rabbit by increasing eNOS activity.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Base Sequence; Carotenoids; Cyclic GMP; DNA Primers; Endothelium, Vascular; Hypercholesterolemia; Male; Muscle Relaxation; Nitric Oxide; Nitric Oxide Synthase Type III; Rabbits; RNA, Messenger; Vitamin A | 2006 |
Crocetin prevents AGEs-induced vascular endothelial cell apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Bisbenzimidazole; Calcium; Carotenoids; Cattle; Coloring Agents; DNA; DNA Fragmentation; Endothelial Cells; Flow Cytometry; Glycation End Products, Advanced; Malondialdehyde; Membrane Potentials; Vitamin A | 2006 |
Generation of saffron volatiles by thermal carotenoid degradation.
Topics: Carotenoids; Crocus; Cyclohexanes; Cyclohexanones; Cyclohexenes; Hot Temperature; Terpenes; Time Factors; Vitamin A; Volatilization | 2006 |
trans-Sodium crocetinate and diffusion enhancement.
Topics: Carotenoids; Chemistry, Physical; Computer Simulation; Diffusion; Dose-Response Relationship, Drug; Humans; Hydrogen; Hydrogen Bonding; Oxygen; Plasma; Spectroscopy, Near-Infrared; Viscosity; Vitamin A | 2006 |
Influence of Crocetin on experimental atherosclerosis in hyperlipidamic-diet quails.
Topics: Animals; Antioxidants; Aorta; Atherosclerosis; Carotenoids; Cholesterol; Cholesterol, Dietary; Cholesterol, LDL; Cholesterol, VLDL; Diet, Atherogenic; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Lipids; Male; Malondialdehyde; Molecular Structure; Nitric Oxide; Quail; Triglycerides; Vitamin A | 2007 |
Involvement of Ca2+ in the inhibition by crocetin of angiotensin II-induced ERK1/2 activation in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Carotenoids; Cattle; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Intracellular Fluid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Time Factors; Verapamil; Vitamin A | 2007 |
Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo.
Topics: Animals; Antioxidants; Brain Infarction; Carotenoids; Caspase 3; Cell Hypoxia; Cell Survival; Crocus; Cyclohexenes; Disease Models, Animal; Glucosides; Glutamate-Cysteine Ligase; Glutathione; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Membrane Lipids; Mice; Molecular Structure; Neurons; Neuroprotective Agents; PC12 Cells; Rats; Structure-Activity Relationship; Terpenes; Time Factors; Vitamin A | 2007 |
Crocetin, dimethylcrocetin, and safranal bind human serum albumin: stability and antioxidative properties.
Topics: Antioxidants; Carotenoids; Cyclohexenes; Drug Stability; Humans; Hydrogen Bonding; Protein Binding; Serum Albumin; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Terpenes; Vitamin A | 2007 |
DNA interaction with saffron's secondary metabolites safranal, crocetin, and dimethylcrocetin.
Topics: Animals; Carotenoids; Cattle; Crocus; Cyclohexenes; DNA; Flowers; Nucleic Acid Conformation; Plant Preparations; Solutions; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Terpenes; Vitamin A; Water | 2007 |
Crocetin attenuates palmitate-induced insulin insensitivity and disordered tumor necrosis factor-alpha and adiponectin expression in rat adipocytes.
Topics: Acetylcysteine; Adipocytes; Adiponectin; Animals; Antimetabolites; Antioxidants; Blotting, Western; Carotenoids; Deoxyglucose; Glucose; Glucose Transporter Type 4; Insulin Resistance; Male; Onium Compounds; Palmitates; Rats; Rats, Wistar; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha; Vitamin A | 2007 |
Interaction of tRNA with Safranal, Crocetin, and Dimethylcrocetin.
Topics: Binding Sites; Carotenoids; Cyclohexenes; Drug Stability; Models, Molecular; RNA, Transfer; Solutions; Terpenes; Vitamin A | 2007 |
Trans-sodium crocetinate and hemorrhagic shock.
Topics: Animals; Blood Pressure; Carotenoids; Free Radical Scavengers; Injections, Intra-Arterial; Injections, Intramuscular; Lung; Male; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Vitamin A | 2007 |
[Studies on chemical constituents in fruit of Gardenia jasminoides].
Topics: Azo Compounds; Carotenoids; Chromatography, Gel; Fruit; Furocoumarins; Gardenia; Plants, Medicinal; Vitamin A | 2007 |
Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG.dC)15, and Oligo (dA.dT)15.
Topics: Animals; Antineoplastic Agents; Binding Sites; Carotenoids; Cattle; Circular Dichroism; Crocus; DNA; Molecular Conformation; Molecular Structure; Oligodeoxyribonucleotides; Poly dA-dT; Spectrometry, Fluorescence; Vitamin A | 2007 |
Direct process integration of extraction and expanded bed adsorption in the recovery of crocetin derivatives from Fructus Gardenia.
Topics: Adsorption; Carotenoids; Chromatography; Gardenia; Molecular Structure; Reproducibility of Results; Vitamin A | 2007 |
Neocrocin A: a novel crocetin glycoside with a unique system for binding sugars isolated from gardenia yellow.
Topics: Anticarcinogenic Agents; Antioxidants; Binding Sites; Carbohydrates; Carotenoids; Gardenia; Glycosides; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Extracts; Stereoisomerism; Vitamin A | 2007 |
Crocetin suppresses angiotensin II-induced vascular smooth-muscle cell proliferation through inhibition of ERK1/2 activation and cell-cycle progression.
Topics: Angiotensin II; Animals; Antioxidants; Carotenoids; Cattle; Cell Cycle; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Structure; Myocytes, Smooth Muscle; NADPH Oxidases; Phosphorylation; Proto-Oncogene Proteins c-fos; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Vitamin A | 2007 |
Pharmacological interventions to decompression sickness in rats: comparison of five agents.
Topics: Air Pressure; Analysis of Variance; Animals; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Carotenoids; Cyclic N-Oxides; Decompression Sickness; Kaplan-Meier Estimate; Lidocaine; Methylprednisolone; Rats; Rats, Sprague-Dawley; Treatment Outcome; Vitamin A | 2008 |
Kinetics of individual crocetin ester degradation in aqueous extracts of saffron (Crocus sativus L.) upon thermal treatment in the dark.
Topics: Carotenoids; Crocus; Darkness; Esters; Food Handling; Hot Temperature; Kinetics; Thermodynamics; Vitamin A | 2008 |
Rapid determination of crocetin esters and picrocrocin from saffron spice (Crocus sativus L.) using UV-visible spectrophotometry for quality control.
Topics: Carotenoids; Chromatography, High Pressure Liquid; Crocus; Cyclohexenes; Esters; Glucosides; Least-Squares Analysis; Quality Control; Spectrophotometry; Spectrophotometry, Ultraviolet; Terpenes; Vitamin A | 2008 |
Inhibitory effects of crocetin on high glucose-induced apoptosis in cultured human umbilical vein endothelial cells and its mechanism.
Topics: Antioxidants; Apoptosis; Carotenoids; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Endothelial Cells; Glucose; Humans; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Time Factors; Umbilical Veins; Vitamin A | 2008 |
Use of trans sodium crocetinate for sensitizing glioblastoma multiforme to radiation: laboratory investigation.
Topics: Animals; Brain Neoplasms; Carotenoids; Female; Glioblastoma; Immunohistochemistry; Magnetic Resonance Imaging; Radiation-Sensitizing Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Vitamin A | 2008 |
Crocetin improves the insulin resistance induced by high-fat diet in rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Carnitine O-Palmitoyltransferase; Carotenoids; Dietary Fats; Disease Models, Animal; Dyslipidemias; Fatty Acids, Nonesterified; Glucose Clamp Technique; Hypolipidemic Agents; Insulin; Insulin Resistance; Lipase; Lipoprotein Lipase; Lipoproteins; Liver; Male; Muscle, Skeletal; Oxidation-Reduction; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Triglycerides; Vitamin A | 2008 |
Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors.
Topics: Carotenoids; Crocus; Cyclohexanones; Cyclohexenes; Flowers; Glucosides; Plant Extracts; Quality Control; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Reference Standards; Sigma-1 Receptor; Terpenes; Vitamin A | 2008 |
Effect of centrifugal ultrafiltration on the composition of aqueous extracts of saffron spice (Crocus sativus L.).
Topics: Carotenoids; Centrifugation; Crocus; Cyclohexenes; Esters; Glucosides; Kaempferols; Plant Extracts; Terpenes; Ultrafiltration; Vitamin A; Water | 2008 |
Bacillus subtilis FZB24 affects flower quantity and quality of saffron (Crocus sativus).
Topics: Bacillus subtilis; Biomass; Carotenoids; Crocus; Cyclohexenes; Flowers; Glucosides; Terpenes; Vitamin A | 2008 |
Reduction of mitochondrial oxidative damage and improved mitochondrial efficiency by administration of crocetin against benzo[a]pyrene induced experimental animals.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenosine Triphosphatases; Animals; Antioxidants; Benzo(a)pyrene; Blotting, Western; Carcinogens; Carotenoids; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Damage; Erythrocyte Membrane; In Vitro Techniques; Lung; Male; Malondialdehyde; Membrane Fluidity; Membrane Potentials; Mice; Mitochondria; Oxidative Stress; Reactive Oxygen Species; Vitamin A | 2008 |
Involvement of Ca2+ in the inhibition by crocetin of platelet activity and thrombosis formation.
Topics: Animals; Anticoagulants; Blood Platelets; Calcium; Carotenoids; Cell Degranulation; Crocus; Cyclic AMP; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Serotonin; Thrombosis; Vitamin A | 2008 |
In vivo protective effect of crocetin on benzo(a)pyrene-induced lung cancer in Swiss albino mice.
Topics: Adenoma; Animals; Antineoplastic Agents, Phytogenic; Benzo(a)pyrene; Carotenoids; Glycoproteins; Hexosamines; Liver; Lung; Lung Neoplasms; Male; Mice; Polyamines; Proliferating Cell Nuclear Antigen; Vitamin A | 2009 |
[Content comparison of diterpenoid pigments in different processed products of Gardenia jasminoides].
Topics: Carotenoids; Chromatography, High Pressure Liquid; Diterpenes; Drugs, Chinese Herbal; Gardenia; Reproducibility of Results; Vitamin A | 2008 |
Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carotenoids; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Progression; ErbB Receptors; Female; Humans; Mice; Mice, Nude; Neoplasm Proteins; Pancreatic Neoplasms; Proliferating Cell Nuclear Antigen; Vitamin A; Xenograft Model Antitumor Assays | 2009 |
Further examination of antiradical properties of Crocus sativus stigmas extract rich in crocins.
Topics: Antioxidants; Carotenoids; Crocus; Flowers; Free Radical Scavengers; Humans; Monocytes; Plant Extracts; Reactive Oxygen Species; Vitamin A | 2009 |
Parabens as agents for improving crocetin esters' shelf-life in aqueous saffron extracts.
Topics: Carotenoids; Crocus; Cyclohexenes; Esters; Food Preservatives; Glucosides; Half-Life; Kinetics; Parabens; Plant Extracts; Preservatives, Pharmaceutical; Terpenes; Vitamin A; Water | 2009 |
Effect of trans sodium crocetinate on brain tumor oxygenation. Laboratory investigation.
Topics: Animals; Brain Neoplasms; Carotenoids; Magnetic Resonance Imaging; Oxygen Consumption; Radiation-Sensitizing Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured; Vitamin A | 2009 |
An overview of structural features of DNA and RNA complexes with saffron compounds: Models and antioxidant activity.
Topics: Antioxidants; Carotenoids; Crocus; Cyclohexenes; DNA; DNA Adducts; Models, Chemical; Nucleic Acid Conformation; RNA, Transfer; Spectroscopy, Fourier Transform Infrared; Terpenes; Vitamin A | 2009 |
Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway.
Topics: Animals; Animals, Newborn; Antioxidants; Cardiomegaly; Carotenoids; Cell Size; Cells, Cultured; Collagen; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; GATA4 Transcription Factor; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vitamin A | 2009 |
Effect of crocetin on blood pressure restoration and synthesis of inflammatory mediators in heart after hemorrhagic shock in anesthetized rats.
Topics: Animals; Antioxidants; Blood Pressure; Carotenoids; Heart; Inflammation Mediators; Interleukin-6; Male; Malondialdehyde; Myocardium; NF-kappa B; Nitric Oxide Synthase Type II; Nitrogen Oxides; Rats; Shock, Hemorrhagic; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vitamin A | 2010 |
Crocetin attenuates norepinephrine-induced cytotoxicity in primary cultured rat cardiac myocytes by antioxidant in vitro.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Calcium; Carotenoids; Glutathione; Lipid Peroxidation; Molecular Structure; Myocytes, Cardiac; Norepinephrine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Vitamin A | 2009 |
Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: a combination therapy study with tissue plasminogen activator.
Topics: Animals; Brain Infarction; Brain Ischemia; Carotenoids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Emergency Medical Services; Fibrinolytic Agents; Intracranial Embolism; Male; Neuroprotective Agents; Rabbits; Time Factors; Tissue Plasminogen Activator; Treatment Outcome; Vitamin A | 2010 |
Protection against focal ischemic injury to the brain by trans-sodium crocetinate. Laboratory investigation.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Carotenoids; Carotid Artery, Common; Cerebral Infarction; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Hemodynamics; Ischemic Attack, Transient; Ligation; Male; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Vitamin A | 2010 |
Trans-sodium crocetinate enhancing survival and glioma response on magnetic resonance imaging to radiation and temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carotenoids; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Diffusion; Disease Models, Animal; Glioblastoma; Hypoxia, Brain; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Neoplasm Transplantation; Oxygen; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Temozolomide; Vitamin A | 2010 |
Crocetin inhibits cell cycle G1/S transition through suppressing cyclin D1 and elevating p27kip1 in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Carotenoids; Cattle; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Vitamin A | 2010 |
Effects of mild temperature conditions during dehydration procedures on saffron quality parameters.
Topics: Carotenoids; Color; Crocus; Cyclohexenes; Desiccation; Esters; Flowers; Food Preservation; Glucosides; Odorants; Spices; Taste; Temperature; Terpenes; Vitamin A | 2010 |
Quantification of crocetin esters in saffron (Crocus sativus L.) using Raman spectroscopy and chemometrics.
Topics: Calibration; Carotenoids; Chromatography, High Pressure Liquid; Color; Crocus; Esters; Least-Squares Analysis; Quality Control; Reproducibility of Results; Spectrum Analysis, Raman; Vitamin A | 2010 |
Inhibitory effect on protein kinase Ctheta by Crocetin attenuates palmitate-induced insulin insensitivity in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Carotenoids; Deoxyglucose; Enzyme Activation; Glucose; I-kappa B Kinase; Inflammation; Insulin; Insulin Receptor Substrate Proteins; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mice; Palmitates; Phosphorylation; Protein Kinase C; Protein Kinase C-theta; Protein Kinase Inhibitors; Serine; Signal Transduction; Vitamin A | 2010 |
Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases.
Topics: Anticarcinogenic Agents; Antioxidants; Breast Neoplasms; Carotenoids; Cell Line, Tumor; Cell Proliferation; Crocus; Down-Regulation; Female; Flowers; Gelatinases; Humans; Matrix Metalloproteinases; Neoplasm Invasiveness; Reverse Transcriptase Polymerase Chain Reaction; Tretinoin; Vitamin A | 2011 |
Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Brain; Carotenoids; Cytokines; Interferon-gamma; Lipopolysaccharides; Male; Mice; Microglia; Neurons; NF-kappa B; Nitric Oxide; Peptide Fragments; Rats; Reactive Oxygen Species; Vitamin A | 2010 |
Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity.
Topics: Administration, Oral; Animals; Carotenoids; Caspase Inhibitors; Caspases; Cell Death; Cell Line; Chromans; Endoplasmic Reticulum; Enzyme Activation; Enzyme Inhibitors; Fluoresceins; Gene Expression Regulation; Humans; Hydrogen Peroxide; Intracellular Space; Light; Male; Membrane Potential, Mitochondrial; Mice; Oxidation-Reduction; Oxidative Stress; Photoreceptor Cells, Vertebrate; Rats; Retinal Degeneration; Retinal Ganglion Cells; Tunicamycin; Vitamin A; Xanthenes | 2011 |
Crocetin from the tubular calyx of Nyctanthes arbor-tristis.
Topics: Animals; Carotenoids; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hemolysis; Oleaceae; Rats; Spectrum Analysis; Vitamin A | 2010 |
Protein kinase C pathway is involved in the inhibition by crocetin of vascular smooth muscle cells proliferation.
Topics: Angiotensin II; Animals; Aorta; Carotenoids; Cattle; Cell Proliferation; Cells, Cultured; Gardenia; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase C; Vitamin A | 2010 |
β-cyclocitral, a grazer defence signal unique to the cyanobacterium Microcystis.
Topics: Aldehydes; Animals; beta-Carotene 15,15'-Monooxygenase; Carotenoids; Daphnia; Diterpenes; Escape Reaction; Feeding Behavior; Microcystis; Odorants; Swimming; Vitamin A | 2010 |
The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration.
Topics: Administration, Oral; Adult; Antioxidants; beta Carotene; Carotenoids; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Gardenia; Humans; Lutein; Lycopene; Male; Medicine, Traditional; Middle Aged; Plant Extracts; Plants, Medicinal; Time Factors; Vitamin A | 2011 |
Metabolic reflow as a therapy for ischemic brain injury.
Topics: Animals; Carotenoids; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; Glucose; Infarction, Middle Cerebral Artery; Male; Oxygen; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Time Factors; Vitamin A | 2011 |
[Partial endothelium-dependent vasorelaxation of crocetin and its mechanism].
Topics: Animals; Aorta, Thoracic; Carotenoids; Endothelium, Vascular; In Vitro Techniques; Male; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents; Vitamin A | 2010 |
Crocetin reduces activation of hepatic apoptotic pathways and improves survival in experimental hemorrhagic shock.
Topics: Animals; Apoptosis; Carotenoids; Caspase 3; Crocus; Cytochromes c; Disease Models, Animal; Liver; Male; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Vitamin A | 2011 |
Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection.
Topics: Acetylcholinesterase; Aging; Animals; Antioxidants; Avoidance Learning; Brain Chemistry; Carotenoids; Caspase 3; Cell Line, Tumor; Cell Survival; Crocus; Enzyme Activation; Humans; Hydrogen Peroxide; Injections, Intraperitoneal; Learning; Male; Memory; Mice; Mice, Inbred BALB C; Oxidants; Plant Extracts; Reactive Oxygen Species; Vitamin A | 2011 |
Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices.
Topics: Animals; Carotenoids; Crocus; Gyrus Cinguli; Male; Microelectrodes; Organ Culture Techniques; Patch-Clamp Techniques; Plant Extracts; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials; Synaptic Transmission; Vitamin A | 2011 |
A new validated SPE-HPLC method for monitoring crocetin in human plasma--application after saffron tea consumption.
Topics: Adult; Beverages; Carotenoids; Chromatography, High Pressure Liquid; Crocus; Drug Monitoring; Female; Humans; Limit of Detection; Male; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Vitamin A | 2011 |
Conjugation to the cell-penetrating peptide TAT potentiates the photodynamic effect of carboxytetramethylrhodamine.
Topics: Amino Acid Sequence; Animals; Carotenoids; Cell Death; Cell Line; Cell Membrane; Cell Membrane Permeability; Cell-Penetrating Peptides; Drug Synergism; Endocytosis; Endosomes; Humans; Light; Molecular Sequence Data; Photochemotherapy; Photolysis; Protein Processing, Post-Translational; Rhodamines; Singlet Oxygen; Vitamin A | 2011 |
Trans sodium crocetinate: functional neuroimaging studies in a hypoxic brain tumor.
Topics: Animals; Brain Neoplasms; Carotenoids; Frontal Lobe; Glioblastoma; Hypoxia; Neoplasm Transplantation; Radionuclide Imaging; Rats; Vitamin A | 2011 |
The role of crocetin in protection following cerebral contusion and in the enhancement of angiogenesis in rats.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Carotenoids; Crocus; Female; Male; Neurons; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Serum Response Factor; Vascular Endothelial Growth Factor Receptor-2; Vitamin A | 2011 |
Suppression of NF-κB pathway by crocetin contributes to attenuation of lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Carotenoids; Chemokine CCL2; Edema; Female; Gene Expression Regulation; I-kappa B Kinase; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; NF-kappa B; Peroxidase; Phosphoproteins; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vitamin A | 2012 |
Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Carotenoids; Fluorescence; Humans; Molecular Sequence Data; Thiazoles; Vitamin A | 2011 |
[Determination of geniposide, crocin and crocetin in different processing products of fructus gardeniae by HPLC-ELSD].
Topics: Carotenoids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fruit; Gardenia; Iridoids; Quality Control; Reproducibility of Results; Technology, Pharmaceutical; Vitamin A | 2011 |
Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and -independent mechanisms.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carotenoids; Cell Line, Tumor; Drug Synergism; Flow Cytometry; Humans; Tumor Suppressor Protein p53; Vincristine; Vitamin A | 2011 |
Crocin promotes non-rapid eye movement sleep in mice.
Topics: Administration, Oral; Animals; Carotenoids; Crocus; Dose-Response Relationship, Drug; Electroencephalography; Injections, Intraperitoneal; Mice; Sleep Stages; Sleep, REM; Time; Vitamin A | 2012 |
Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment.
Topics: Animals; Antioxidants; Carotenoids; Cognition Disorders; Male; Maze Learning; Memory; Nardostachys; Oxidative Stress; Phytotherapy; Rats; Rats, Wistar; Selenium; Vitamin A | 2012 |
Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation.
Topics: Angiogenesis Inhibitors; Carotenoids; Cells, Cultured; Coculture Techniques; Down-Regulation; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Pathologic; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Vascular Endothelial Growth Factor A; Vitamin A | 2012 |
UGT75L6 and UGT94E5 mediate sequential glucosylation of crocetin to crocin in Gardenia jasminoides.
Topics: Alkylation; Carotenoids; Cells, Cultured; Dietary Supplements; Food Coloring Agents; Fruit; Gardenia; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Glucosides; Glucosyltransferases; Isoenzymes; Phylogeny; Plant Proteins; Recombinant Proteins; RNA, Messenger; Seedlings; Substrate Specificity; Uridine Diphosphate Glucose; Vitamin A | 2012 |
Protective effect of crocetin on hemorrhagic shock-induced acute renal failure in rats.
Topics: Acute Kidney Injury; Animals; Antioxidants; Carotenoids; Cytokines; Drug Evaluation, Preclinical; Inflammation Mediators; Kidney; Male; Malondialdehyde; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Shock, Hemorrhagic; Superoxide Dismutase; Vitamin A | 2012 |
Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding Sites; Carotenoids; Cholinesterase Inhibitors; Crocus; Humans; Kinetics; Models, Molecular; Plant Extracts; Structure-Activity Relationship; Vitamin A | 2012 |
Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice.
Topics: Administration, Oral; Animals; Apoptosis; Calpain; Carotenoids; Caspase 3; Cell Count; Cytoprotection; Enzyme Induction; Male; Mice; N-Methylaspartate; Retina; Retinal Ganglion Cells; Vitamin A | 2012 |
Identification of multiple constituents in the traditional Chinese medicine formula Zhi-zi-chi decoction and rat plasma after oral administration by liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry.
Topics: Administration, Oral; Animals; Carotenoids; Drugs, Chinese Herbal; Iridoid Glucosides; Isoflavones; Male; Mass Spectrometry; Monoterpenes; Plasma; Rats; Rats, Wistar; Time Factors; Vitamin A | 2012 |
Increasing the applications of Crocus sativus flowers as natural antioxidants.
Topics: Anthocyanins; Antioxidants; Carotenoids; Chromatography, High Pressure Liquid; Crocus; Flavonoids; Flowers; Freeze Drying; Plant Extracts; Polyphenols; Vitamin A | 2012 |
Crocetin induces cytotoxicity in colon cancer cells via p53-independent mechanisms.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Carotenoids; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Colonic Neoplasms; Comet Assay; DNA Damage; Flow Cytometry; Humans; Mice; Mutation; NIH 3T3 Cells; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin A | 2012 |
Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment.
Topics: Acetylcholinesterase; Aluminum; Animals; Behavior, Animal; Brain; Carotenoids; Cognition; Crocus; Glutathione; Injections, Intraperitoneal; Learning; Lipid Peroxidation; Liver; Malondialdehyde; Memory; Memory Disorders; Mice; Mice, Inbred BALB C; Monoamine Oxidase; Neuroprotective Agents; Oxidative Stress; Plant Extracts; Vitamin A | 2013 |
New minor glycoside components from saffron.
Topics: Carotenoids; Crocus; Cyclohexenes; Esters; Flowers; Glycosides; Molecular Structure; Plant Extracts; Plants, Medicinal; Terpenes; Vitamin A | 2013 |
Comparative reverse screening approach to identify potential anti-neoplastic targets of saffron functional components and binding mode.
Topics: Antineoplastic Agents; Binding Sites; Carotenoids; Catalytic Domain; Crocus; Cyclohexenes; Glucosides; HSP90 Heat-Shock Proteins; Humans; Models, Molecular; Terpenes; User-Computer Interface; Vitamin A | 2012 |
Crocetin administration ameliorates endotoxin-induced disseminated intravascular coagulation in rabbits.
Topics: Animals; Antioxidants; Blood Platelets; Carotenoids; Disseminated Intravascular Coagulation; Endotoxins; Fibrinogen; Fibrinolytic Agents; Male; Platelet Count; Protein C; Rabbits; Thrombin; Vitamin A | 2013 |
Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice.
Topics: Animals; Apoptosis; Carotenoids; DNA; Electroretinography; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Oxidation-Reduction; Protective Agents; Reperfusion Injury; Retinal Diseases; Vitamin A | 2013 |
Anti-inflammatory activities of crocetin derivatives from processed Gardenia jasminoides.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotenoids; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Gardenia; Macrophages; Mice; Plant Extracts; Vitamin A | 2013 |
Changes in total and individual crocetin esters upon in vitro gastrointestinal digestion of saffron aqueous extracts.
Topics: Animals; Antioxidants; Carotenoids; Cell Survival; Comet Assay; Crocus; Digestion; Esterification; Fruit; Gardenia; Gastric Mucosa; Humans; Intestinal Mucosa; Models, Biological; Molecular Structure; Monocytes; Mouth Mucosa; Pancreatic Juice; Plant Extracts; Spices; U937 Cells; Vitamin A | 2013 |
[Content comparison of main chemical compositions in Gardenia jasminoids roasted with ginger juice].
Topics: Carotenoids; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gardenia; Iridoids; Pharmacology; Vitamin A; Zingiber officinale | 2013 |
Crocetin attenuates spatial learning dysfunction and hippocampal injury in a model of vascular dementia.
Topics: Animals; Carotenoids; Dementia, Vascular; Disease Models, Animal; Hippocampus; Male; Maze Learning; Neuroprotective Agents; Rats; Rats, Wistar; Vitamin A | 2013 |
Crocins with high levels of sugar conjugation contribute to the yellow colours of early-spring flowering crocus tepals.
Topics: beta Carotene; Carotenoids; Color; Crocus; Flowers; Gene Expression; Geranylgeranyl-Diphosphate Geranylgeranyltransferase; Glucose; Glucosyltransferases; Phylogeny; Plant Proteins; Rhamnose; Spectrometry, Mass, Electrospray Ionization; Spices; Tandem Mass Spectrometry; Vitamin A | 2013 |
Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice.
Topics: Animals; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Bleomycin; Carotenoids; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Fibrosis; Immunohistochemistry; Lung; Matrix Metalloproteinase 1; Mice; Mice, Inbred C3H; Real-Time Polymerase Chain Reaction; Scleroderma, Systemic; Skin; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Vitamin A | 2013 |
Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Carotenoids; Caspases; Cell Line, Tumor; Cell Proliferation; Crocus; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; L-Lactate Dehydrogenase; Male; Methylnitronitrosoguanidine; Rats; Rats, Wistar; Signal Transduction; Stomach Neoplasms; Vitamin A | 2013 |
Effective isolation protocol for secondary metabolites from saffron: semi-preparative scale preparation of crocin-1 and trans-crocetin.
Topics: Antidepressive Agents; Carotenoids; Crocus; Flowers; Neuroprotective Agents; Phytotherapy; Plant Extracts; Secondary Metabolism; Vitamin A | 2014 |
Crocetin induces apoptosis of BGC-823 human gastric cancer cells.
Topics: Apoptosis; Carotenoids; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Membrane Potential, Mitochondrial; Stomach Neoplasms; Vitamin A | 2014 |
In-chain neutral hydrocarbon loss from crocin apocarotenoid ester glycosides and the crocetin aglycon (Crocus sativus L.) by ESI-MS(n) (n=2, 3).
Topics: Carotenoids; Crocus; Flowers; Glycosylation; Hydrocarbons; Models, Molecular; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Vitamin A | 2013 |
Crocetin, a carotenoid from Gardenia jasminoides Ellis, protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Carotenoids; Crocus; Fruit; Gardenia; Hypertension; Intracranial Thrombosis; Male; Nitric Oxide; Oxidative Stress; Rats, Inbred SHR; Vasodilation; Vitamin A | 2014 |
Proposed cytotoxic mechanisms of the saffron carotenoids crocin and crocetin on cancer cell lines.
Topics: Carotenoids; Cell Line, Tumor; Crocus; Cytotoxins; Female; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; NF-E2-Related Factor 2; Reactive Oxygen Species; Vitamin A | 2014 |
Sulfone-mediated syntheses of crocetin derivatives: regioselectivity of highly functionalized building blocks.
Topics: Carotenoids; Molecular Structure; Nitriles; Sulfones; Vitamin A | 2014 |
Antitumor effects of saffron-derived carotenoids in prostate cancer cell models.
Topics: Animals; Antineoplastic Agents; beta Catenin; Cadherins; Carotenoids; Cell Line; Cell Line, Tumor; Cell Transdifferentiation; Crocus; Epithelial-Mesenchymal Transition; Humans; Male; Mice; Mice, Nude; NIH 3T3 Cells; Plant Extracts; Prostatic Neoplasms; Vitamin A | 2014 |
The protective effects of crocetin on aβ₁₋₄₂-induced toxicity in Ht22 cells.
Topics: Amyloid beta-Peptides; Animals; Carotenoids; Cell Line, Transformed; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; MAP Kinase Signaling System; Matrix Metalloproteinases; Mice; Neuroprotective Agents; Neurotoxins; Peptide Fragments; Phosphorylation; Reactive Oxygen Species; Vitamin A | 2014 |
Trans-sodium crocetinate improves outcomes in rodent models of occlusive and hemorrhagic stroke.
Topics: Animals; Biomechanical Phenomena; Brain; Brain Edema; Brain Ischemia; Carotenoids; Cerebral Hemorrhage; Disease Models, Animal; Gait; Male; Neuroprotective Agents; Pattern Recognition, Automated; Random Allocation; Rats, Sprague-Dawley; Severity of Illness Index; Stroke; Treatment Outcome; Vitamin A | 2014 |
Protective effects of crocetin pretreatment on myocardial injury in an ischemia/reperfusion rat model.
Topics: Animals; Cardiotonic Agents; Carotenoids; Disease Models, Animal; Male; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Wistar; Treatment Outcome; Vitamin A | 2014 |
Evaluation of gardenia yellow using crocetin from alkaline hydrolysis based on ultra high performance liquid chromatography and high-speed countercurrent chromatography.
Topics: Carotenoids; Chromatography, High Pressure Liquid; Countercurrent Distribution; Evaluation Studies as Topic; Gardenia; Hydrolysis; Molecular Structure; Plant Extracts; Sodium Hydroxide; Vitamin A | 2014 |
Trans-sodium crocetinate provides neuroprotection against cerebral ischemia and reperfusion in obese mice.
Topics: Aldehydes; Analysis of Variance; Animals; Brain; Brain Ischemia; Carotenoids; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Matrix Metalloproteinases; Mice; Nervous System Diseases; Neuroprotective Agents; Obesity; Oxidative Stress; Reperfusion; Tyrosine; Vitamin A | 2015 |
Crocetin, a carotenoid derived from saffron (Crocus sativus L.), improves acetylcholine-induced vascular relaxation in hypertension.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Carotenoids; Crocus; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Male; Myography; Nitric Oxide; Nitric Oxide Synthase; Phytotherapy; Plants, Medicinal; Rats, Inbred SHR; Rats, Wistar; Vasodilation; Vasodilator Agents; Vitamin A | 2014 |
Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier.
Topics: Animals; Biological Availability; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Carotenoids; Crocus; Glycosylation; Humans; Intestinal Absorption; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Plant Extracts; Swine; Vitamin A | 2015 |
CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin.
Topics: Animals; Antioxidants; Apoptosis; Carotenoids; Cell Line; Cell Survival; Copper; Glutathione; Glutathione Peroxidase; Hippocampus; Light; Metal Nanoparticles; Mice; Reactive Oxygen Species; Scattering, Radiation; Superoxide Dismutase; Vitamin A | 2015 |
Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells.
Topics: Animals; Carotenoids; Cyclooxygenase 2; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Interleukin-1beta; Methylcholanthrene; Mice; Neoplasm Proteins; Neoplasms, Experimental; Tumor Necrosis Factor-alpha; Uterine Cervical Neoplasms; Vitamin A | 2015 |
[Effects of crocetin on VCAM-1 expression in human umbilical vein endothelial cells and monocyte-endothelial cell adhesion].
Topics: Angiotensin II; Antioxidants; Carotenoids; Cell Adhesion; Human Umbilical Vein Endothelial Cells; Humans; Monocytes; NF-kappa B; Reactive Oxygen Species; Vascular Cell Adhesion Molecule-1; Vitamin A | 2015 |
Perihematomal Cellular Injury Is Reduced by Trans-sodium Crocetinate in a Model of Intracerebral Hemorrhage.
Topics: Animals; Carotenoids; Caudate Nucleus; Cell Count; Cerebral Hemorrhage; Collagenases; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Hematoma; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Putamen; Rabbits; Rats; Rats, Sprague-Dawley; Vitamin A | 2015 |
Protective effect of crocetin against burn-induced intestinal injury.
Topics: Animals; Antioxidants; Burns; Carotenoids; Dose-Response Relationship, Drug; Intestines; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vitamin A | 2015 |
Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells.
Topics: Animals; Apoptosis; Carotenoids; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromatography, High Pressure Liquid; Crocus; Dose-Response Relationship, Drug; Doublecortin-Like Kinases; Female; Hedgehog Proteins; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Nude; Neoplasm Transplantation; Neoplastic Stem Cells; Pancreatic Neoplasms; Phosphorylation; Plant Extracts; Protein Serine-Threonine Kinases; Receptors, G-Protein-Coupled; Shc Signaling Adaptor Proteins; Signal Transduction; Smoothened Receptor; Spheroids, Cellular; Src Homology 2 Domain-Containing, Transforming Protein 2; Vitamin A | 2015 |
The carotenoid cleavage dioxygenase CCD2 catalysing the synthesis of crocetin in spring crocuses and saffron is a plastidial enzyme.
Topics: Carotenoids; Cell Line, Transformed; Cloning, Molecular; Crocus; Dioxygenases; Escherichia coli; Flowers; Gene Expression Regulation, Plant; Nicotiana; Oryza; Phylogeny; Plant Proteins; Plants, Genetically Modified; Plastids; Sequence Homology, Amino Acid; Vitamin A; Zeaxanthins | 2016 |
Effects of Crocetin Esters and Crocetin from Crocus sativus L. on Aortic Contractility in Rat Genetic Hypertension.
Topics: Animals; Aorta; Carotenoids; Crocus; Disease Models, Animal; Esters; Hypertension; Male; Muscle, Smooth, Vascular; Plant Extracts; Rats; Rats, Inbred SHR; Vitamin A | 2015 |
Enhanced Bioaccessibility of Crocetin Sugar Esters from Saffron in Infusions Rich in Natural Phenolic Antioxidants.
Topics: Antioxidants; Carbohydrates; Carotenoids; Chromatography, High Pressure Liquid; Crocus; Esters; Phenols; Plant Extracts; Vitamin A | 2015 |
Attenuation of Oxidative Stress in HEK 293 Cells by the TCM Constituents Schisanhenol, Baicalein, Resveratrol or Crocetin and Two Defined Mixtures.
Topics: Antioxidants; Carotenoids; Cyclooctanes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavanones; HEK293 Cells; Humans; Medicine, Chinese Traditional; Oxidation-Reduction; Oxidative Stress; Polycyclic Compounds; Resveratrol; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stilbenes; tert-Butylhydroperoxide; Vitamin A | 2015 |
Crocetin Activates Foxp3 Through TIPE2 in Asthma-Associated Treg Cells.
Topics: Animals; Asthma; Carotenoids; Flow Cytometry; Forkhead Transcription Factors; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes, Regulatory; Vitamin A | 2015 |
The synergistic effect of antiglycating agents (MB-92) on inhibition of protein glycation, misfolding and diabetic complications in diabetic-atherosclerotic rat.
Topics: Amino Acids; Animals; Atherosclerosis; Carotenoids; Diabetes Complications; Drug Synergism; Glycosylation; Male; Protein Folding; Rats; Rats, Wistar; Vitamin A | 2016 |
A dramatic effect of oxygen on protection of human cells against γ-radiation by lycopene.
Topics: Ascorbic Acid; Carotenoids; Cell Death; Cytoprotection; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Hydroxyl Radical; Lycopene; Oxygen; Spectrum Analysis; Superoxides; Vitamin A; Vitamin E | 2016 |
Intron retention and rhythmic diel pattern regulation of carotenoid cleavage dioxygenase 2 during crocetin biosynthesis in saffron.
Topics: Amino Acid Sequence; Carotenoids; Crocus; Dioxygenases; Gene Expression Regulation, Plant; Introns; Molecular Sequence Data; Phylogeny; Plant Proteins; Promoter Regions, Genetic; Vitamin A; Zeaxanthins | 2016 |
Determination of gardenia yellow colorants in soft drink, pastry, instant noodles with ultrasound-assisted extraction by high performance liquid chromatography-electrospray ionization tandem mass spectrum.
Topics: Beijing; Carbonated Beverages; Carotenoids; Chromatography, High Pressure Liquid; Coloring Agents; Food Analysis; Gardenia; Iridoids; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Vitamin A | 2016 |
Crocetin ester improves myocardial ischemia via Rho/ROCK/NF-κB pathway.
Topics: Animals; Carotenoids; Creatine Kinase; Crocus; Cytokines; Heart; Inflammation Mediators; Myocardial Ischemia; Myocardium; NF-kappa B; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Superoxide Dismutase-1; Vitamin A | 2016 |
Evaluation of anti-cancer activity of PLGA nanoparticles containing crocetin.
Topics: Antineoplastic Agents; Apoptosis; Carotenoids; Drug Carriers; Drug Liberation; Humans; Lactic Acid; MCF-7 Cells; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Vitamin A | 2017 |
Crocetin improves the quality of in vitro-produced bovine embryos: Implications for blastocyst development, cryotolerance, and apoptosis.
Topics: Animals; Apoptosis; Blastocyst; Carotenoids; Cattle; Cryopreservation; Embryo Culture Techniques; Embryonic Development; Vitamin A | 2016 |
Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo.
Topics: Animals; Antioxidants; Autophagy; Carotenoids; Cell Death; Crocus; Endoplasmic Reticulum Stress; Lipid Peroxidation; Male; Mice; Oxidative Stress; Radiation-Protective Agents; Reactive Oxygen Species; Skin; Ultraviolet Rays; Vitamin A | 2016 |
Protective effect of crocetin on bovine spermatozoa against oxidative stress during in vitro fertilization.
Topics: Animals; Antioxidants; Carotenoids; Cattle; Fertilization; Fertilization in Vitro; Male; Oxidative Stress; Semen Analysis; Semen Preservation; Sperm Motility; Spermatozoa; Vitamin A | 2016 |
Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carotenoids; Caspase 2; Caspase 8; Colorectal Neoplasms; Cysteine Endopeptidases; Death Domain Receptor Signaling Adaptor Proteins; fas Receptor; Fas-Associated Death Domain Protein; HCT116 Cells; HT29 Cells; Humans; Mutation; Signal Transduction; Tumor Protein p73; Tumor Suppressor Protein p53; Vitamin A | 2016 |
Comparison study of the effect of alkyl-modified and unmodified PAMAM and PPI dendrimers on solubility and antitumor activity of crocetin.
Topics: Alkylation; Antineoplastic Agents; Apoptosis; Carotenoids; Dendrimers; Drug Carriers; Drug Liberation; Humans; MCF-7 Cells; Polypropylenes; Solubility; Vitamin A | 2017 |
Trans-crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Antioxidants; Carotenoids; Cathepsin B; Cognition Disorders; Crocus; Dose-Response Relationship, Drug; Female; Humans; Lipopolysaccharide Receptors; Male; Monocytes; Peptide Fragments; Proteolysis; Vitamin A | 2017 |
Crocetin Inhibits Lipopolysaccharide-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells.
Topics: Carotenoids; Cell Adhesion; Cell Death; Chemokine CCL2; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Interleukin-8; Lipopolysaccharides; RNA, Messenger; Signal Transduction; Transcription Factor RelA; U937 Cells; Vitamin A | 2016 |
Comparative evaluation of an ISO 3632 method and an HPLC-DAD method for safranal quantity determination in saffron.
Topics: Carotenoids; Chromatography, High Pressure Liquid; Crocus; Cyclohexenes; Esters; Food Analysis; Food Quality; Glucosides; Plant Extracts; Terpenes; Ultraviolet Rays; Vitamin A; Volatile Organic Compounds | 2017 |
Unraveling Massive Crocins Transport and Accumulation through Proteome and Microscopy Tools during the Development of Saffron Stigma.
Topics: Carotenoids; Crocus; Gene Expression Regulation, Plant; Plant Proteins; Plastids; Proteome; Terpenes; Vitamin A | 2017 |
Sensitive analysis and simultaneous assessment of pharmacokinetic properties of crocin and crocetin after oral administration in rats.
Topics: Administration, Oral; Animals; Biological Availability; Carotenoids; Chromatography, Liquid; Female; Injections, Intravenous; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Vitamin A | 2017 |
Effect of crocetin on vascular smooth muscle cells migration induced by advanced glycosylation end products.
Topics: Animals; Carotenoids; Cell Movement; Cell Proliferation; Cells, Cultured; Diabetic Angiopathies; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Interleukin-6; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Receptor for Advanced Glycation End Products; Signal Transduction; Tumor Necrosis Factor-alpha; Vitamin A | 2017 |
Molecular dynamic simulation and DFT study on the Drug-DNA interaction; Crocetin as an anti-cancer and DNA nanostructure model.
Topics: Base Pairing; Carotenoids; DNA, Neoplasm; Drug Interactions; Humans; Hydrogen Bonding; Models, Chemical; Molecular Dynamics Simulation; Nanostructures; Neoplasms; Thermodynamics; Vitamin A | 2018 |
Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy.
Topics: Apoptosis; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Breast Neoplasms; Carotenoids; Cell Proliferation; Cell Survival; Drug Synergism; Female; Fluorouracil; Humans; Intracellular Signaling Peptides and Proteins; MCF-7 Cells; Medicine, Chinese Traditional; Vitamin A; Xenograft Model Antitumor Assays | 2017 |
Heterologous biosynthesis and manipulation of crocetin in Saccharomyces cerevisiae.
Topics: beta Carotene; Bioreactors; Biosynthetic Pathways; Carotenoids; Fermentation; Metabolic Engineering; Saccharomyces cerevisiae; Synthetic Biology; Vitamin A | 2017 |
Crocetin restores diabetic endothelial progenitor cell dysfunction by enhancing NO bioavailability via regulation of PI3K/AKT-eNOS and ROS pathways.
Topics: Animals; Antioxidants; Apoptosis; Carotenoids; Caspase 3; Cell Survival; Diabetes Mellitus, Experimental; Endothelial Progenitor Cells; Flow Cytometry; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Vitamin A | 2017 |
Saffron carotenoids (crocin and crocetin) binding to human serum albumin as investigated by different spectroscopic methods and molecular docking.
Topics: Binding Sites; Carotenoids; Circular Dichroism; Crocus; Fluorescence; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Docking Simulation; Protein Binding; Serum Albumin, Human; Spectrometry, Fluorescence; Thermodynamics; Vitamin A | 2018 |
Synthesis and cardiomyocyte protection activity of crocetin diamide derivatives.
Topics: Animals; Carotenoids; Cell Hypoxia; Cell Line; Diamide; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Molecular Structure; Myocytes, Cardiac; Oxidative Stress; Rats; Vitamin A | 2017 |
Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.
Topics: Carotenoids; Cell Line; Crocus; Enzyme Inhibitors; Flowers; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Molecular Docking Simulation; Molecular Structure; Neoplasms; Vitamin A | 2017 |
Cardiaprotective effect of crocetin by attenuating apoptosis in isoproterenol induced myocardial infarction rat model.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Cardiotonic Agents; Carotenoids; Caspase 3; Cytokines; Disease Models, Animal; Hemodynamics; Inflammation Mediators; Isoproterenol; Male; Myocardial Infarction; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Rats, Wistar; Ventricular Function, Left; Vitamin A | 2017 |
Crocetin Potentiates Neurite Growth in Hippocampal Neurons and Facilitates Functional Recovery in Rats with Spinal Cord Injury.
Topics: Animals; Antioxidants; Behavior, Animal; Carotenoids; Disease Models, Animal; Hippocampus; Inflammation; Motor Activity; Neurites; Neurons; Rats; Recovery of Function; Spinal Cord Injuries; Vitamin A | 2017 |
Crocetin inhibits the proliferation, migration and TGF-β
Topics: Actins; Cadherins; Carotenoids; Cell Line; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Humans; p38 Mitogen-Activated Protein Kinases; Retinal Pigment Epithelium; Transforming Growth Factor beta2; Tumor Suppressor Protein p53; Vitamin A | 2017 |
Evolutionarily distinct carotenoid cleavage dioxygenases are responsible for crocetin production in Buddleja davidii.
Topics: Buddleja; Carotenoids; Computer Simulation; Dioxygenases; Escherichia coli; Evolution, Molecular; Flowers; Gene Expression Regulation, Plant; Phylogeny; Plant Proteins; Recombinant Fusion Proteins; Vitamin A; Zeaxanthins | 2017 |
Effects of saffron and its constituents, crocin-1, crocin-2, and crocetin on α-synuclein fibrils.
Topics: alpha-Synuclein; Carotenoids; Crocus; Plant Extracts; Vitamin A | 2018 |
Crocetin attenuates spared nerve injury-induced neuropathic pain in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carotenoids; Crocus; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Interleukin-1beta; Male; Mice, Inbred Strains; Neuralgia; Oxidative Stress; Peripheral Nerve Injuries; Phytotherapy; Sciatic Nerve; Spinal Cord; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vitamin A | 2017 |
ROS-scavenging and Anti-tyrosinase Properties of Crocetin on B16F10 Murine Melanoma Cells.
Topics: Agaricales; Animals; Anticarcinogenic Agents; Antioxidants; Carotenoids; Cell Line, Tumor; Enzyme Inhibitors; Melanins; Melanoma, Experimental; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Reactive Oxygen Species; Vitamin A | 2018 |
Synthesis, characterization and inhibitory effects of crocetin derivative compounds in cancer and inflammation.
Topics: A549 Cells; Animals; Anticarcinogenic Agents; Apoptosis; Carotenoids; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Gardenia; Humans; Inflammation; MCF-7 Cells; Melanoma, Experimental; Mice; Plant Extracts; RAW 264.7 Cells; Vitamin A | 2018 |
The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers.
Topics: Animals; Carotenoids; Cyclophosphamide; Female; Humans; Mice; Mitochondria; Ovary; Sirtuin 1; Tellurium; Vitamin A | 2017 |
Quality assessment of saffron (Crocus sativus L.) extracts via UHPLC-DAD-MS analysis and detection of adulteration using gardenia fruit extract (Gardenia jasminoides Ellis).
Topics: Carotenoids; Chromatography, High Pressure Liquid; Crocus; Cyclohexenes; Fruit; Gardenia; Glucosides; Isomerism; Mass Spectrometry; Plant Extracts; Quality Control; Terpenes; Vitamin A | 2018 |
Expression and Interaction Analysis among Saffron ALDHs and Crocetin Dialdehyde.
Topics: Aldehyde Dehydrogenase; Aldehydes; Carotenoids; Crocus; Gene Expression Regulation, Plant; Ligands; Molecular Docking Simulation; Phylogeny; Plant Proteins; Protein Binding; RNA, Messenger; Structural Homology, Protein; Thermodynamics; Vitamin A | 2018 |
Protective Effects of Crocetin on Depression-like Behavior Induced by Immobilization in Rat.
Topics: Animals; Antioxidants; Carotenoids; Corticosterone; Depression; Disease Models, Animal; Exploratory Behavior; Glutathione; Glutathione Reductase; Immobilization; Male; Malondialdehyde; Random Allocation; Rats; Rats, Wistar; Swimming; Vitamin A | 2018 |
Candidate Enzymes for Saffron Crocin Biosynthesis Are Localized in Multiple Cellular Compartments.
Topics: Aldehyde Dehydrogenase; Carotenoids; Crocus; Gene Expression Profiling; Gene Expression Regulation, Plant; Glycosylation; Glycosyltransferases; Green Fluorescent Proteins; Immunohistochemistry; Microscopy, Confocal; Nicotiana; Organ Specificity; Plant Proteins; Plants, Genetically Modified; Vitamin A | 2018 |
Trans-crocin 4 is not hydrolyzed to crocetin following i.p. administration in mice, while it shows penetration through the blood brain barrier.
Topics: Animals; Biological Availability; Biological Transport; Blood-Brain Barrier; Brain Chemistry; Carotenoids; Chromatography, High Pressure Liquid; Male; Mice; Vitamin A | 2018 |
A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes.
Topics: Animals; beta Catenin; Breast Neoplasms; Carotenoids; Cell Adhesion; Cell Movement; Crocus; Female; Humans; Mice; Neoplasm Metastasis; Plant Extracts; Tumor Cells, Cultured; Vitamin A; Wnt Signaling Pathway | 2018 |
Monoolein liquid crystalline phases for topical delivery of crocetin.
Topics: Administration, Cutaneous; Carotenoids; Drug Carriers; Drug Delivery Systems; Glycerides; Humans; Liquid Crystals; Particle Size; Skin; Skin Absorption; Surface Properties; Viscosity; Vitamin A | 2018 |
UHPLC Analysis of Saffron (
Topics: Carotenoids; Chromatography, High Pressure Liquid; Coloring Agents; Crocus; Esters; Glucosides; Mass Spectrometry; Neural Networks, Computer; Plant Extracts; Tracheophyta; Vitamin A | 2018 |
Comparison of the effect of crocin and crocetin, two major compounds extracted from saffron, on osteogenic differentiation of mesenchymal stem cells.
Topics: Animals; Carotenoids; Cell Differentiation; Cells, Cultured; Crocus; Male; Mesenchymal Stem Cells; Osteoblasts; Osteogenesis; Plant Extracts; Rats; Rats, Wistar; Vitamin A | 2018 |
[Effect of different initial processing methods on quality of gardenia].
Topics: Carotenoids; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gardenia; Iridoid Glycosides; Iridoids; Phytochemicals; Vitamin A | 2018 |
Nanotechnological Approach to Increase the Antioxidant and Cytotoxic Efficacy of Crocin and Crocetin.
Topics: Antineoplastic Agents; Antioxidants; Biological Availability; Carotenoids; Cell Line, Tumor; Cytotoxins; Drug Delivery Systems; Humans; Nanoparticles; Vitamin A | 2019 |
Rapid isolation and characterization of crocins, picrocrocin, and crocetin from saffron using centrifugal partition chromatography and LC-MS.
Topics: Acetates; Butanols; Carotenoids; Centrifugation; Chromatography, Liquid; Crocus; Cyclohexenes; Ethanol; Glucosides; Heptanes; Mass Spectrometry; Molecular Structure; Solvents; Terpenes; Vitamin A; Water | 2018 |
Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Carotenoids; Crocus; Dihydrotestosterone; Disease Models, Animal; Drugs, Chinese Herbal; Estrous Cycle; Female; Hypothalamo-Hypophyseal System; Hypothalamus, Anterior; Kisspeptins; Neurons; Ovary; Polycystic Ovary Syndrome; Vitamin A | 2018 |
The effects of crocetin supplementation on the blastocyst outcome, transcriptomic and metabolic profile of in vitro produced bovine embryos.
Topics: Animals; Antioxidants; Blastocyst; Carotenoids; Cattle; Embryo Culture Techniques; Embryonic Development; Gene Expression Regulation, Developmental; Transcriptome; Vitamin A | 2019 |
Efficient Synthesis of Crocins from Crocetin by a Microbial Glycosyltransferase from Bacillus subtilis 168.
Topics: Bacillus subtilis; Bacterial Proteins; Carotenoids; Glycosylation; Glycosyltransferases; Vitamin A | 2018 |
[Crocetin promotes autophagy in injured rat hepatocytes induced by lipopolysaccharide and D-galactosamine
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Autophagy; Carotenoids; Cells, Cultured; Galactosamine; Hepatocytes; L-Lactate Dehydrogenase; Lipopolysaccharides; Rats; Vitamin A | 2018 |
Crocetin inhibits PDGF-BB-induced proliferation and migration of retinal pigment epithelial cells.
Topics: Apoptosis; Becaplermin; Carotenoids; Cell Line; Cell Movement; Cell Proliferation; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; Retinal Pigment Epithelium; Vitamin A | 2019 |
Protective efficacy of crocetin and its nanoformulation against cyclosporine A-mediated toxicity in human embryonic kidney cells.
Topics: Antioxidants; Carotenoids; Cyclosporine; Free Radical Scavengers; HEK293 Cells; Heme Oxygenase-1; Humans; Immunosuppressive Agents; Lipids; Membrane Potential, Mitochondrial; Nanoparticles; NF-E2-Related Factor 2; Reactive Oxygen Species; Vitamin A | 2019 |
Safety, pharmacokinetics, and prevention effect of intraocular crocetin in proliferative vitreoretinopathy.
Topics: Animals; Carotenoids; Cell Line; Disease Models, Animal; Electroretinography; Humans; Intravitreal Injections; Rabbits; Retina; Vitamin A; Vitreoretinopathy, Proliferative | 2019 |
Preparation, chemical characterization and determination of crocetin's pharmacokinetics after oral and intravenous administration of saffron (Crocus sativus L.) aqueous extract to C57/BL6J mice.
Topics: Administration, Intravenous; Administration, Oral; Animals; Biological Availability; Carotenoids; Crocus; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Random Allocation; Vitamin A | 2019 |
Comparative anti-arthritic investigation of iridoid glycosides and crocetin derivatives from Gardenia jasminoides Ellis in Freund's complete adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carotenoids; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Freund's Adjuvant; Gardenia; Iridoid Glycosides; Iridoids; Male; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Vitamin A | 2019 |
Oral crocetin administration suppressed refractive shift and axial elongation in a murine model of lens-induced myopia.
Topics: Administration, Oral; Animals; Carotenoids; Disease Models, Animal; Early Growth Response Protein 1; Mice; Mice, Inbred C57BL; Myopia; Refraction, Ocular; Refractive Errors; Vitamin A | 2019 |
Multiple Signal Pathways Involved in Crocetin-Induced Apoptosis in KYSE-150 Cells.
Topics: Anticarcinogenic Agents; Apoptosis; Carotenoids; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Membrane Potential, Mitochondrial; Signal Transduction; Time Factors; Vitamin A | 2019 |
Trans sodium crocetinate alleviates ischemia/reperfusion-induced myocardial oxidative stress and apoptosis via the SIRT3/FOXO3a/SOD2 signaling pathway.
Topics: Animals; Antioxidants; Apoptosis; Carotenoids; Coronary Occlusion; Disease Models, Animal; Forkhead Box Protein O3; Humans; Male; Myocardial Infarction; Myocardium; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; RNA, Small Interfering; Signal Transduction; Sirtuin 3; Vitamin A | 2019 |
Transcriptome analysis reveals novel enzymes for apo-carotenoid biosynthesis in saffron and allows construction of a pathway for crocetin synthesis in yeast.
Topics: Carotenoids; Crocus; Flowers; Gene Expression Profiling; Genes, Plant; Metabolome; Microorganisms, Genetically-Modified; Saccharomyces cerevisiae; Vitamin A | 2019 |
The effects of geographical origin and virus infection on the saffron (Crocus sativus L.) quality.
Topics: Altitude; Carotenoids; Chromatography, High Pressure Liquid; Crocus; Cyclohexenes; Food Analysis; Food Quality; Glucosides; Iran; Kaempferols; Plant Diseases; Plant Extracts; Rain; Secondary Metabolism; Spectrophotometry, Ultraviolet; Spices; Terpenes; Vitamin A | 2019 |
Construction of Escherichia coli cell factories for crocin biosynthesis.
Topics: Biosynthetic Pathways; Carotenoids; Crocus; Dioxygenases; Escherichia coli; Gardenia; Genes, Plant; Glycosyltransferases; Metabolic Engineering; Plant Proteins; Vitamin A | 2019 |
Encapsulation of crocetin into poly (lactic-co-glycolic acid) nanoparticles overcomes drug resistance in human ovarian cisplatin-resistant carcinoma cell line (A2780-RCIS).
Topics: Carotenoids; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Down-Regulation; Drug Compounding; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Ovarian Neoplasms; Polylactic Acid-Polyglycolic Acid Copolymer; Vitamin A | 2019 |
Stability assessment of crocetin and crocetin derivatives in Gardenia yellow pigment and Gardenia fruit pomace in presence of different cooking methods.
Topics: Carotenoids; Chromatography, High Pressure Liquid; Cooking; Fruit; Gardenia; Pigmentation; Plant Extracts; Vitamin A | 2020 |
Oral and ocular administration of crocetin prevents retinal edema in a murine retinal vein occlusion model.
Topics: Administration, Ophthalmic; Administration, Oral; Animals; Carotenoids; Disease Models, Animal; Edema; Inflammation Mediators; Male; Matrix Metalloproteinase 9; Mice; Occludin; Ophthalmic Solutions; Retina; Retinal Vein Occlusion; Tight Junctions; Tumor Necrosis Factor-alpha; Vitamin A | 2019 |
Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer.
Topics: Animals; Carotenoids; Cell Line; Cell Proliferation; Herbal Medicine; Humans; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Triple Negative Breast Neoplasms; Vitamin A | 2020 |
Chemical analysis of saffron by HPLC based crocetin estimation.
Topics: Carotenoids; Chromatography, High Pressure Liquid; Coloring Agents; Crocus; Food Industry; Quality Control; Vitamin A | 2020 |
Estimation of the Minimum Effective Dose of Dietary Supplement Crocetin for Prevention of Myopia Progression in Mice.
Topics: Animals; Carotenoids; Dietary Supplements; Disease Models, Animal; Disease Progression; Eye; Male; Mice; Mice, Inbred C57BL; Myopia; Vitamin A | 2020 |
Crocetin Extracted from Saffron Shows Antitumor Effects in Models of Human Glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Carotenoids; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape; Crocus; Disease-Free Survival; Fatty Acid Synthases; Female; Glioblastoma; Humans; Hyaluronan Receptors; Injections, Subcutaneous; Kaplan-Meier Estimate; Luminescent Measurements; Mesoderm; Mice, Nude; Neurons; Vitamin A | 2020 |
Crocetin alleviates myocardial ischemia/reperfusion injury by regulating inflammation and the unfolded protein response.
Topics: Animals; Cardiotonic Agents; Carotenoids; Cell Line; Inflammation; Male; Myocardial Reperfusion Injury; Myocardium; NF-E2-Related Factor 2; Perfusion; Rats, Sprague-Dawley; Signal Transduction; Unfolded Protein Response; Vitamin A | 2020 |
Synthesis of crocetin derivatives and their potent inhibition in multiple tumor cells proliferation and inflammatory property of macrophage.
Topics: Animals; Anti-Inflammatory Agents; Carotenoids; Cell Line, Tumor; Cell Proliferation; Crocus; Humans; Macrophages; Mice; Rats; Vitamin A | 2020 |
Comprehensive chemotaxonomic analysis of saffron crocus tepal and stamen samples, as raw materials with potential antidepressant activity.
Topics: Antidepressive Agents; Carotenoids; Chromatography, High Pressure Liquid; Crocus; Cyclohexenes; Flavonoids; Flowers; Glucosides; Kaempferols; Monosaccharides; Plant Extracts; Quercetin; Terpenes; Vitamin A | 2020 |
Delivering Crocetin across the Blood-Brain Barrier by Using γ-Cyclodextrin to Treat Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Carotenoids; CHO Cells; Cricetulus; Disease Models, Animal; gamma-Cyclodextrins; Humans; Rats; Rats, Sprague-Dawley; Vitamin A | 2020 |
Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arsenic Trioxide; Carotenoids; Chemical and Drug Induced Liver Injury; Inflammation; Injections, Intraperitoneal; Male; Molecular Structure; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Vitamin A | 2020 |
Effect of crocetin added to IVM medium for prepubertal goat oocytes on blastocyst outcomes after IVF, intracytoplasmic sperm injection and parthenogenetic activation.
Topics: Animals; Blastocyst; Carotenoids; Embryonic Development; Fertilization in Vitro; Goats; In Vitro Oocyte Maturation Techniques; Oocytes; Sperm Injections, Intracytoplasmic; Vitamin A | 2020 |
Crocetin Improves Dengue Virus-Induced Liver Injury.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Carotenoids; Dengue; Dengue Virus; Disease Models, Animal; Gene Expression; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Transaminases; Virus Replication; Vitamin A | 2020 |
Crocetin attenuates the oxidative stress, inflammation and apoptosisin arsenic trioxide-induced nephrotoxic rats: Implication of PI3K/AKT pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Carotenoids; Kidney; Kidney Diseases; Male; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Vitamin A | 2020 |
Comparative assessment of immunomodulatory, proliferative, and antioxidant activities of crocin and crocetin on mesenchymal stem cells.
Topics: Antioxidants; Apoptosis; Carotenoids; Cell Proliferation; Cells, Cultured; Crocus; Humans; Immunomodulation; Mesenchymal Stem Cells; Multiple Sclerosis; Nitric Oxide; Plant Extracts; Vitamin A | 2021 |
Protective Effects of Crocetin against Radiation-Induced Injury in Intestinal Epithelial Cells.
Topics: Animals; Antioxidants; Apoptosis; Carotenoids; Catalase; Cell Survival; Cells, Cultured; Cytokines; Epithelial Cells; Glutathione Peroxidase; Interleukin-1beta; Intestinal Diseases; Intestines; Malondialdehyde; Oxidative Stress; Peroxidase; Protective Agents; Radiation; Rats; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vitamin A | 2020 |
Inhibitory effects of four active components in saffron on human ether-a-go-go-related gene (hERG) K+ currents.
Topics: Arrhythmias, Cardiac; Carotenoids; Crocus; Cyclohexenes; ERG1 Potassium Channel; Glucosides; Humans; Phytochemicals; Terpenes; Vitamin A | 2020 |
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
Topics: Animals; Antioxidants; Apoptosis; Arsenic Poisoning; Arsenic Trioxide; Cardiotonic Agents; Cardiotoxicity; Carotenoids; China; Heart; Inflammation; Male; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Vitamin A | 2020 |
Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota.
Topics: Animals; Antidepressive Agents; Carotenoids; Depression; Gastrointestinal Microbiome; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Restraint, Physical; Stress, Psychological; Vitamin A | 2021 |
Saffron: Chemical Composition and Neuroprotective Activity.
Topics: Adenosine Triphosphate; Animals; Calcium; Carotenoids; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Crocus; Disease Models, Animal; Flowers; HEK293 Cells; Humans; Light; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Plant Extracts; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Retina; Retinal Degeneration; Vitamin A | 2020 |
Crocetin Mitigates Irradiation Injury in an In Vitro Model of the Pubertal Testis: Focus on Biological Effects and Molecular Mechanisms.
Topics: Animals; Autophagy; Carotenoids; Catalase; Cells, Cultured; Down-Regulation; ELAV-Like Protein 1; Fertility; Gene Expression Regulation, Developmental; Immunohistochemistry; In Vitro Techniques; Male; Mice; Microtubule-Associated Proteins; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Proliferating Cell Nuclear Antigen; Puberty; Radiation Injuries; Seminiferous Tubules; Sirtuin 1; Superoxide Dismutase; Testis; Up-Regulation; Vitamin A; X-Rays | 2021 |
Pathogenic Microenvironment from Diabetic-Obese Visceral and Subcutaneous Adipocytes Activating Differentiation of Human Healthy Preadipocytes Increases Intracellular Fat, Effect of the Apocarotenoid Crocetin.
Topics: Adipocytes; Adipogenesis; Adipokines; Adipose Tissue; Animals; Carotenoids; Cell Differentiation; Cell Line; Diabetes Mellitus; Humans; Intra-Abdominal Fat; Male; Obesity; Rats; Subcutaneous Fat; Vitamin A | 2021 |
Gene Expression Profiling and Biofunction Analysis of HepG2 Cells Targeted by Crocetin.
Topics: Carotenoids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Hep G2 Cells; Humans; Liver; Protein Interaction Maps; Vitamin A | 2021 |
Retinoprotective Effects Of Crocin And Crocetin via Anti-Angiogenic Mechanism in High Glucose-Induced Human Retinal Pigment Epithelium Cells.
Topics: Carotenoids; Glucose; Humans; Retinal Pigment Epithelium; Vascular Endothelial Growth Factor A; Vitamin A | 2021 |
Improved quantification method of crocins in saffron extract using HPLC-DAD after qualification by HPLC-DAD-MS.
Topics: Air; Carotenoids; Chromatography, High Pressure Liquid; Crocus; Food Analysis; Food Storage; Light; Mass Spectrometry; Plant Extracts; Vitamin A | 2021 |
Liposomal encapsulation of trans-crocetin enhances oxygenation in patients with COVID-19-related ARDS receiving mechanical ventilation.
Topics: Animals; Carotenoids; COVID-19; Endothelial Cells; Humans; Mice; Respiration, Artificial; Respiratory Distress Syndrome; SARS-CoV-2; Vitamin A | 2021 |
Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Carotenoids; Cell Line; Crocus; Disease Models, Animal; Drosophila melanogaster; Female; Humans; Longevity; Male; Motor Activity; Mutation; Neurons; Neuroprotective Agents; Parkinson Disease; Retinal Degeneration; Vitamin A | 2021 |
Antidepressant mechanism and active compounds of saffron from network pharmacology study.
Topics: Albumins; Antidepressive Agents; Carotenoids; Class Ia Phosphatidylinositol 3-Kinase; Crocus; Cyclohexenes; Flowers; Glucosides; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Network Pharmacology; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Signal Transduction; Terpenes; Vitamin A | 2021 |
Crocetin suppresses gestational diabetes in streptozotocin-induced diabetes mellitus rats via suppression of inflammatory reaction.
Topics: Animals; Carotenoids; Diabetes, Gestational; Female; Placenta; Pregnancy; Rats; Rats, Wistar; Streptozocin; Vitamin A | 2021 |
Crocetin Exerts a Cardio-protective Effect on Mice with Coxsackievirus B3-induced Acute Viral Myocarditis.
Topics: Acute Disease; Animals; Antiviral Agents; Cardiotonic Agents; Carotenoids; Enterovirus B, Human; Forkhead Transcription Factors; Heart; Interleukin-17; Interleukin-1beta; Male; Mice, Inbred BALB C; Myocarditis; Myocardium; Nuclear Receptor Subfamily 1, Group F, Member 3; rho-Associated Kinases; Tumor Necrosis Factor-alpha; Vitamin A | 2021 |
Crocetin suppresses angiogenesis and metastasis through inhibiting sonic hedgehog signaling pathway in gastric cancer.
Topics: Antioxidants; Carotenoids; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Hedgehog Proteins; Humans; Neoplasm Metastasis; Neovascularization, Pathologic; Signal Transduction; Stomach Neoplasms; Vitamin A | 2021 |
Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carotenoids; Caspase 3; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Interleukin-6; Janus Kinase 2; Poly(ADP-ribose) Polymerases; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Proto-Oncogene Proteins c-akt; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Vitamin A | 2021 |
Cardio-protective and Anti-atherosclerosis Effect of Crocetin on Vitamin D3 and HFD-induced Atherosclerosis in Rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Atherosclerosis; Carotenoids; Chemokine CCL2; Cholecalciferol; Cytokines; Diet, High-Fat; Disease Models, Animal; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipid Metabolism; Phytotherapy; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1; Vitamin A | 2021 |
Preparation and Anti-Tobacco Mosaic Virus Activities of Crocetin Diesters.
Topics: Antiviral Agents; Carotenoids; Drug Design; Ribavirin; Structure-Activity Relationship; Tobacco Mosaic Virus; Vitamin A | 2021 |
Crocetin attenuating Urinary tract Infection and adherence of uropathogenic E. coli in NRK-52E cells via an inflammatory pathway.
Topics: Animals; Carotenoids; Rats; Urinary Tract Infections; Uropathogenic Escherichia coli; Vitamin A | 2021 |
Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model.
Topics: Animals; Carotenoids; Cell Survival; Gene Expression Regulation; Hepatocytes; Humans; Mitochondria, Liver; Mitochondrial Diseases; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phytotherapy; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Vitamin A; Zebrafish | 2022 |
Crocetin Alleviates Ovariectomy-Induced Metabolic Dysfunction through Regulating Estrogen Receptor β.
Topics: Adipose Tissue, White; Animals; Carotenoids; Crocus; Estrogen Receptor beta; Female; Mice; Ovariectomy; Vitamin A | 2021 |
An easy way for the hydrolysis, pre-concentration, and chemical stabilization of crocetin from saffron powder.
Topics: Carotenoids; Crocus; Hydrolysis; Powders; Vitamin A | 2022 |
Crocetin exerts hypocholesterolemic effect by inducing LDLR and inhibiting PCSK9 and Sortilin in HepG2 cells.
Topics: Adaptor Proteins, Vesicular Transport; Carotenoids; Hep G2 Cells; Humans; Proprotein Convertase 9; Receptors, LDL; Vitamin A | 2022 |
Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF-κB.
Topics: Acute Disease; Apoptosis; Carotenoids; Ceruletide; Humans; Inflammation; NF-kappa B; Pancreatitis; Sirtuin 1; Vitamin A | 2022 |
A strategy for attenuation of acute radiation-induced lung injury using crocetin from gardenia fruit.
Topics: Acute Lung Injury; Animals; Carotenoids; Fruit; Gardenia; Lung; Mice; Plant Extracts; Quality of Life; Radiation Injuries; Vitamin A | 2022 |
Inhibitory effect of saffron, crocin, crocetin, and safranal against adipocyte differentiation in human adipose-derived stem cells.
Topics: Adipocytes; Carotenoids; Cell Differentiation; Crocus; Cyclohexenes; Humans; Mesenchymal Stem Cells; Obesity; Plant Extracts; PPAR gamma; Terpenes; Vitamin A | 2022 |
The ameliorating effects of crocetin on frozen-thawed quality, and fertility via attenuating oxidative status of bubaline spermatozoa.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Buffaloes; Carotenoids; Cryopreservation; Cryoprotective Agents; Fertility; Male; Oxidative Stress; Reactive Oxygen Species; Semen; Semen Analysis; Semen Preservation; Sperm Motility; Spermatozoa; Vitamin A | 2022 |
The mechanism by which crocetin regulates the lncRNA NEAT1/miR-125b-5p/SOX7 molecular axis to inhibit high glucose-induced diabetic retinopathy.
Topics: Animals; Carotenoids; Cell Proliferation; Diabetes Mellitus; Diabetic Retinopathy; Endothelial Cells; Glucose; Humans; Mice; MicroRNAs; Neovascularization, Pathologic; RNA, Long Noncoding; SOXF Transcription Factors; Vitamin A | 2022 |
Crocetin Protected Human Hepatocyte LO2 Cell From TGF-β-Induced Oxygen Stress and Apoptosis but Promoted Proliferation and Autophagy
Topics: AMP-Activated Protein Kinases; Apoptosis; Autophagy; Carotenoids; Cell Proliferation; Hepatocytes; Humans; Oxygen; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Vitamin A | 2022 |
Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects.
Topics: Animals; Carotenoids; Humans; Mice; Neoplasms; Tumor Hypoxia; Vitamin A | 2023 |