Page last updated: 2024-09-04

resiquimod and imiquimod

resiquimod has been researched along with imiquimod in 47 studies

Compound Research Comparison

Studies (resiquimod)	Trials (resiquimod)	Recent Studies (post-2010) (resiquimod)	Studies (imiquimod)	Trials (imiquimod)	Recent Studies (post-2010) (imiquimod)
465	14	318	3,264	284	1,963

Protein Interaction Comparison

Protein	Taxonomy	imiquimod (IC50)
Histamine H2 receptor	Homo sapiens (human)	1.506
Alpha-1D adrenergic receptor	Homo sapiens (human)	2.621
Adenosine receptor A2a	Homo sapiens (human)	5.32
7,8-dihydro-8-oxoguanine triphosphatase	Homo sapiens (human)	0.646

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (8.51)	18.2507
2000's	20 (42.55)	29.6817
2010's	19 (40.43)	24.3611
2020's	4 (8.51)	2.80

Authors

Authors	Studies
Horscroft, N; Laxton, C; Myangar, N; Parkinson, T; Rodman, J; Thomas, A	1
Aldrich, CC; Chittepu, P; Ferguson, DM; Ohlfest, JR; Shi, C; Xiong, Z	1
Aldrich, CC; Ferguson, DM; Ohlfest, JR; Olin, M; Schiaffo, CE; Shi, C; Xiong, Z	1
Alwan, H; Bista, M; Breed, J; Davies, NL; Eckersley, K; Fillery, S; Foote, KM; Goodwin, L; Jones, DR; Käck, H; Kettle, JG; Lau, A; Nissink, JW; Read, J; Scott, JS; Taylor, B; Walker, G; Wissler, L; Wylot, M	1
Bihi, M; Dembić, Z; Diken, M; Ester, K; Knežević, J; Kralj, M; Lepur, A; Majhen, D; Markotić, A; Oršolić, N; Piantanida, I; Stojković, MR; Teofilović, NK; Tumir, LM; Vrbanec, D; Vugrek, O; Weber, AN	1
Ferguson, DM; Griffith, TS; Kucaba, TA; Larson, P; Olin, M; Xiong, Z	1
Forrest, ML; Hunt, JR; Kleindl, PA; Moulder, KR; Prisinzano, TE	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Carlson, GL; Gibson, SJ; Horton, VL; Imbertson, LM; Myhre, PE; Tomai, MA; Wagner, TL	1
Beaurline, JM; Couture, AM; Gibson, SJ; Imbertson, LM; Miller, RL; Reiter, MJ; Smith, RM; Tomai, MA; Wagner, TL	1
Ahonen, CL; Couture, AM; Gibson, SJ; Miller, RL; Reiter, MJ; Smith, RM; Tomai, MA; Vasilakos, JP; Wagner, TL	1
Buates, S; Matlashewski, G	1
Burns, RP; Ferbel, B; Gaspari, AA; Miller, R; Tomai, M	1
Imbertson, LM; Stanczak, TL; Tomai, MA; Tygrett, LT; Waldschmidt, TJ	1
Dockrell, DH; Kinghorn, GR	1
Akira, S; Hemmi, H; Horiuchi, T; Hoshino, K; Kaisho, T; Sanjo, H; Sato, S; Takeda, K; Takeuchi, O; Tomizawa, H	1
Bernstein, DI; Harrison, CJ; Miller, RL; Tomai, MA	1
Benninghoff, B; Bong, AB; Drewniok, C; Geilen, CC; Gollnick, H; Herz, J; Reifenberger, J; Schön, M; Schön, MP; Slade, HB	1
Hengge, UR; Meykadeh, N	1
Brett, SJ; Daly, MG; Thomsen, LL; Tite, JP; Topley, P	1
Bong, AB; Drewniok, C; Eberle, J; Geilen, CC; Gollnick, H; Schön, M; Schön, MP; Wienrich, BG	1
Cywes, C; Godowski, PJ; Levy, O; Roy, RM; Wessels, MR; Zarember, KA	1
Alkan, SS; Gibson, SJ; Gorden, KB; Gorski, KS; Kedl, RM; Kieper, WC; Qiu, X; Tomai, MA; Vasilakos, JP	1
Amlie-Lefond, C; Connelly, MP; Dunn, KS; Huffnagle, GB; Paz, DA; Whelan, HT; Whelan, NT	1
Akira, S; Amer, A; Barchet, W; Bertin, J; Body-Malapel, M; Colonna, M; Coyle, A; Franchi, L; Grant, EP; Kanneganti, TD; Núñez, G; Ozören, N; Park, JH; Vandenabeele, P; Whitfield, J	1
Liu, YH; Xu, KJ	1
Pillow, J; Skinner, RB; Woodmansee, C	1
Ashkar, AA; Davies, EJ; Gill, N	1
Meng, TC; Miller, RL; Tomai, MA	1
Matlashewski, G; Zhang, WW	1
Da Silva, DM; Fahey, LM; Kast, WM; Raff, AB	1
Martinez-Martin, N; Viejo-Borbolla, A	1
Akira, S; Diebold, SS; Morel, Y; Paturel, C; Rajagopal, D; Uematsu, S	1
Cornella-Taracido, I; De Gregorio, E; Galli-Stampino, L; Harrington, E; Isome, Y; Jain, R; Mbow, ML; Nuti, S; Russo, C; Sammicheli, C; Soldaini, E; Tallarico, J; Tavarini, S; Valiante, NM	1
Baldwin, SL; Ching, LK; Coler, RN; Guderian, JA; Mompoint, F; Orme, IM; Picone, A; Reed, SG	1
Bachmann, M; Bornhäuser, M; Jähnisch, H; Kunze, A; Oehrl, S; Rohayem, J; Schäkel, K; Schmitz, M; Tonn, T; Tunger, A; Wehner, R	1
Tomai, MA; Vasilakos, JP	1
Beringue, V; Blondel, M; Bouaziz, S; Contesse, MA; Desban, N; Galons, H; Massacrier, C; Morel, Y; Nguyen, PH; Oumata, N; Pang, Y; Paturel, C; Sanyal, S; Soubigou, F; Voisset, C	1
Elkon, KB; Sontheimer, C	1
Fujimoto, C; Kamijima, R; Kataoka, S; Nakajima, K; Sano, S; Takaishi, M; Terada, Y; Yokogawa, M	1
Ambrosini, M; Bruijns, SC; de Gruijl, TD; Fehres, CM; Hooijberg, E; Kalay, H; Unger, WW; van Beelen, AJ; van Kooyk, Y	1
Chen, S; Chen, X; Cheng, A; Jia, R; Liu, F; Liu, M; Qi, Y; Wang, M; Zhao, Q; Zhu, D	1
Chai, HH; Cho, YM; Choi, BH; Lim, D; Suk, JE	1
Fan, S; Li, Y; Liu, W; Wang, N; Yang, X; Zheng, X; Zhu, Y	1
Enosi Tuipulotu, D; Lun, JH; Mackenzie, JM; Netzler, NE; White, PA	1
Coimbra, ES; da Silva, AD; Dib, PRB; Fung, J; Granato, JT; Kaushik, D; Macedo, GC; Petrovsky, N; Piplani, S; Salunke, DB	1
Farr, MA; Joshi, TP; Lewis, DJ	1

Reviews

8 review(s) available for resiquimod and imiquimod

Article	Year
Imiquimod and resiquimod as novel immunomodulators. The Journal of antimicrobial chemotherapy, 2001, Volume: 48, Issue:6 Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Humans; Imidazoles; Imiquimod; Immunologic Factors	2001
Immunomodulation as a treatment strategy for genital herpes: review of the evidence. International immunopharmacology, 2002, Volume: 2, Issue:4 Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Herpes Genitalis; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Imidazoles; Imiquimod; Recurrence	2002
Innate immunity for biodefense: a strategy whose time has come. The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:6 Topics: Aminoquinolines; Animals; Humans; Imidazoles; Imiquimod; Immunity, Innate; Oligodeoxyribonucleotides; Toll-Like Receptor 4; Toll-Like Receptor 9	2005
The role of topical immune response modifiers in skin cancer. Drugs, 2006, Volume: 66, Issue:13 Topics: Adjuvants, Immunologic; Aminoquinolines; Antineoplastic Agents; Cytokines; Humans; Imidazoles; Imiquimod; Models, Biological; Skin Neoplasms; Toll-Like Receptors	2006
The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection. American journal of reproductive immunology (New York, N.Y. : 1989), 2008, Volume: 59, Issue:1 Topics: Adjuvants, Immunologic; Aminoquinolines; Antiviral Agents; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Imidazoles; Imiquimod; Immunity, Innate; Ligands; Lipopolysaccharides; Mucous Membrane; Poly I-C; Toll-Like Receptors; Vagina	2008
The antiviral activity of Toll-like receptor 7 and 7/8 agonists. Drug news & perspectives, 2008, Volume: 21, Issue:2 Topics: Aminoquinolines; Animals; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Humans; Imidazoles; Imiquimod; Toll-Like Receptor 7; Toll-Like Receptor 8; Virus Diseases	2008
Toll-like receptor-mediated recognition of herpes simplex virus. Frontiers in bioscience (Scholar edition), 2010, 01-01, Volume: 2, Issue:2 Topics: Aminoquinolines; Animals; Cytokines; Herpes Simplex; Humans; Imidazoles; Imiquimod; Mice; Signal Transduction; Simplexvirus; Toll-Like Receptors	2010
The use of Toll-like receptor 7/8 agonists as vaccine adjuvants. Expert review of vaccines, 2013, Volume: 12, Issue:7 Topics: Adjuvants, Immunologic; Aminoquinolines; Clinical Trials as Topic; Drug Discovery; Humans; Imidazoles; Imiquimod; Toll-Like Receptor 7; Toll-Like Receptor 8; Vaccines	2013

Trials

1 trial(s) available for resiquimod and imiquimod

Article	Year
Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod. The Journal of investigative dermatology, 2004, Volume: 122, Issue:5 Topics: Administration, Topical; Aminoquinolines; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biopsy; Cell Line, Tumor; fas Receptor; Humans; Imidazoles; Imiquimod; Melanocytes; Melanoma; Membrane Glycoproteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Skin Neoplasms; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha	2004

Article

Year

Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod.

The Journal of investigative dermatology, 2004, Volume: 122, Issue:5

Topics: Administration, Topical; Aminoquinolines; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biopsy; Cell Line, Tumor; fas Receptor; Humans; Imidazoles; Imiquimod; Melanocytes; Melanoma; Membrane Glycoproteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Skin Neoplasms; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2004

Other Studies

38 other study(ies) available for resiquimod and imiquimod

Article	Year
Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8 Topics: Antiviral Agents; Cell Line, Tumor; Cytokines; Hepacivirus; Hepatitis C; Humans; Leukocytes, Mononuclear; Toll-Like Receptor 3; Toll-Like Receptor 7; Toll-Like Receptor 9; Toll-Like Receptors	2007
Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction. ACS medicinal chemistry letters, 2012, Jun-14, Volume: 3, Issue:6 Topics:	2012
Structure-activity relationship analysis of imidazoquinolines with Toll-like receptors 7 and 8 selectivity and enhanced cytokine induction. Journal of medicinal chemistry, 2014, Jan-23, Volume: 57, Issue:2 Topics: Animals; Bone Marrow Cells; Cytokines; Dendritic Cells; HEK293 Cells; Humans; Imidazoles; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Quinolines; Stereoisomerism; Structure-Activity Relationship; Toll-Like Receptor 7; Toll-Like Receptor 8	2014
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. Journal of medicinal chemistry, 2016, Mar-24, Volume: 59, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; DNA Repair Enzymes; Drug Discovery; Humans; Models, Molecular; Phosphoric Monoester Hydrolases; Rats; RNA, Small Interfering; Structure-Activity Relationship	2016
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorganic & medicinal chemistry letters, 2017, 04-01, Volume: 27, Issue:7 Topics: Cell Line; Down-Regulation; Humans; Immunologic Factors; Intercalating Agents; Interferon-alpha; Interleukin-6; Interleukin-8; Oligodeoxyribonucleotides; Phenanthridines; Signal Transduction; Toll-Like Receptor 3; Toll-Like Receptor 9; Tumor Necrosis Factor-alpha; Urea	2017
Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8. ACS medicinal chemistry letters, 2017, Nov-09, Volume: 8, Issue:11 Topics:	2017
Further exploration of the structure-activity relationship of imidazoquinolines; identification of potent C7-substituted imidazoquinolines. Bioorganic & medicinal chemistry letters, 2020, 01-15, Volume: 30, Issue:2 Topics: Binding Sites; Cytokines; Humans; Imidazoles; Leukocytes, Mononuclear; Molecular Docking Simulation; Quinolines; Structure-Activity Relationship; Toll-Like Receptor 7; Toll-Like Receptor 8	2020
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Induction of cytokines in cynomolgus monkeys by the immune response modifiers, imiquimod, S-27609 and S-28463. Cytokine, 1997, Volume: 9, Issue:11 Topics: Adjuvants, Immunologic; Administration, Oral; Administration, Topical; Aminoquinolines; Animals; Cells, Cultured; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Imiquimod; Interferon Inducers; Leukocytes, Mononuclear; Macaca fascicularis; Male; Models, Chemical; RNA, Messenger; Skin	1997
Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463. The Journal of investigative dermatology, 1998, Volume: 110, Issue:5 Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Animals; Antibody Formation; Cells, Cultured; Cytokines; Female; Fibroblasts; Humans; Imiquimod; Interferon-alpha; Keratinocytes; Male; Melanocytes; Mice; Mice, Hairless; Rats; Rats, Nude; RNA, Messenger; Skin	1998
Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod. Cellular immunology, 1999, Jan-10, Volume: 191, Issue:1 Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cytokines; Humans; Imiquimod; Interferon-alpha; Interferon-gamma; Interleukin-12; Interleukin-5; Male; Mice; Mice, Inbred BALB C; T-Lymphocytes, Helper-Inducer	1999
Treatment of experimental leishmaniasis with the immunomodulators imiquimod and S-28463: efficacy and mode of action. The Journal of infectious diseases, 1999, Volume: 179, Issue:6 Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Bone Marrow Cells; Female; Imiquimod; Leishmania donovani; Leishmaniasis; Macrophages; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-fos; Signal Transduction; Trypanocidal Agents	1999
The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans' cells. Clinical immunology (Orlando, Fla.), 2000, Volume: 94, Issue:1 Topics: Adjuvants, Immunologic; Aminoquinolines; Antigen Presentation; Cell Division; Cells, Cultured; Cytokines; Gene Expression; Humans; Imidazoles; Imiquimod; Immunologic Factors; Langerhans Cells; Lymphocyte Culture Test, Mixed; Phenotype; Th1 Cells	2000
The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes. Cellular immunology, 2000, Jul-10, Volume: 203, Issue:1 Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antibody Specificity; Antigens, CD; B-Lymphocytes; B7-2 Antigen; Cells, Cultured; Guanosine; Humans; Imidazoles; Imiquimod; Immunoglobulin Class Switching; Immunoglobulin E; Immunoglobulin G; Lipopolysaccharides; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Ovalbumin; Spleen	2000
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nature immunology, 2002, Volume: 3, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Adjuvants, Immunologic; Aminoquinolines; Animals; Antigens, Differentiation; Antiviral Agents; Bone Marrow Cells; Dendritic Cells; Drosophila Proteins; Imidazoles; Imiquimod; Interferon Inducers; Macrophages, Peritoneal; Membrane Glycoproteins; Mice; Mice, Mutant Strains; Myeloid Differentiation Factor 88; Receptors, Cell Surface; Receptors, Immunologic; Spleen; Toll-Like Receptor 7; Toll-Like Receptors	2002
Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod. Journal of the National Cancer Institute, 2003, Aug-06, Volume: 95, Issue:15 Topics: Aminoquinolines; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Caspase 3; Caspases; Cytochrome c Group; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Imiquimod; Immunologic Factors; In Situ Nick-End Labeling; Keratinocytes; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Tumor Cells, Cultured; Up-Regulation	2003
[Topical immunomodulators in dermatology]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2003, Volume: 54, Issue:7 Topics: Adjuvants, Immunologic; Administration, Topical; Adult; Aged; Aged, 80 and over; Aminoquinolines; Asthma; Autoimmune Diseases; Bowen's Disease; Child; Cyclopropanes; Dermatitis, Atopic; Dinitrochlorobenzene; Female; Follow-Up Studies; Herpes Simplex; Humans; Imidazoles; Imiquimod; Immunity, Cellular; Immunocompromised Host; Immunoglobulin A; Immunosuppressive Agents; Lichen Sclerosus et Atrophicus; Male; Molluscum Contagiosum; Papillomavirus Infections; Precancerous Conditions; Skin Diseases; Skin Diseases, Viral; Skin Neoplasms; Tacrolimus; Time Factors; Warts	2003
Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery. Vaccine, 2004, Apr-16, Volume: 22, Issue:13-14 Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Biolistics; CD11 Antigens; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Imidazoles; Imiquimod; Immunization; Immunotherapy; Injections, Subcutaneous; Interferon-gamma; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microspheres; Ovalbumin; Plasmids; Th1 Cells; Vaccines, DNA	2004
Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. Journal of immunology (Baltimore, Md. : 1950), 2004, Oct-01, Volume: 173, Issue:7 Topics: Adult; Aminoquinolines; Cell Membrane; Female; Fetal Blood; Humans; Imidazoles; Imiquimod; Immune Tolerance; Immunity, Innate; Infant, Newborn; Interferon Inducers; Ligands; Lipopolysaccharide Receptors; Lipopolysaccharides; Lipoproteins; Male; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, Cell Surface; Toll-Like Receptors; Tumor Necrosis Factor-alpha	2004
Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. Journal of immunology (Baltimore, Md. : 1950), 2005, Feb-01, Volume: 174, Issue:3 Topics: Aminoquinolines; Cell Line; Cell Lineage; Cells, Cultured; Cytokines; Dendritic Cells; Humans; Imidazoles; Imiquimod; Interferon-alpha; Interleukin-12; Leukocytes, Mononuclear; Membrane Glycoproteins; Monocytes; Myeloid Cells; Receptors, Cell Surface; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptors; Transfection; Tumor Necrosis Factor-alpha	2005
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature, 2006, Mar-09, Volume: 440, Issue:7081 Topics: Adaptor Proteins, Signal Transducing; Aminoquinolines; Animals; Antiviral Agents; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Cells, Cultured; Cytoskeletal Proteins; Enzyme Activation; Female; Imidazoles; Imiquimod; Inflammation; Interleukin-1; Interleukin-18; Legionella pneumophila; Listeria monocytogenes; Macrophages, Peritoneal; Male; Mice; Mitogen-Activated Protein Kinases; Multiprotein Complexes; Myeloid Differentiation Factor 88; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; RNA, Bacterial; Toll-Like Receptors	2006
[Application of imiquimod and resiquimod in dermatology]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2006, Volume: 28, Issue:3 Topics: Adjuvants, Immunologic; Aminoquinolines; Antineoplastic Agents; Condylomata Acuminata; Humans; Imidazoles; Imiquimod; Skin Neoplasms	2006
Immunization with a Toll-like receptor 7 and/or 8 agonist vaccine adjuvant increases protective immunity against Leishmania major in BALB/c mice. Infection and immunity, 2008, Volume: 76, Issue:8 Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antigens, Protozoan; Female; Foot; Imidazoles; Imiquimod; Injections, Intramuscular; Injections, Subcutaneous; Interferon-gamma; Leishmania major; Leishmaniasis Vaccines; Leishmaniasis, Cutaneous; Lymphocytes; Mice; Mice, Inbred BALB C; Spleen; Toll-Like Receptor 7; Toll-Like Receptor 8	2008
Reversal of human papillomavirus-specific T cell immune suppression through TLR agonist treatment of Langerhans cells exposed to human papillomavirus type 16. Journal of immunology (Baltimore, Md. : 1950), 2009, Mar-01, Volume: 182, Issue:5 Topics: Adjuvants, Immunologic; Aminoquinolines; Antineoplastic Agents; Cells, Cultured; Epitopes, T-Lymphocyte; Female; Human papillomavirus 16; Humans; Imidazoles; Imiquimod; Immunity, Cellular; Immunosuppressive Agents; Langerhans Cells; Papillomavirus Infections; Quinolines; T-Lymphocytes; Toll-Like Receptor 7; Toll-Like Receptor 8; Uterine Cervical Neoplasms	2009
Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists. Blood, 2010, Mar-11, Volume: 115, Issue:10 Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antineoplastic Agents; Cancer Vaccines; Dendritic Cells; Dose-Response Relationship, Drug; Imidazoles; Imiquimod; Interferon Type I; Melanoma, Experimental; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Quinolines; Receptor, Interferon alpha-beta; RNA; Toll-Like Receptor 7; Tumor Cells, Cultured	2010
Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells. Blood, 2011, May-26, Volume: 117, Issue:21 Topics: Adenine; Aminoquinolines; Antineoplastic Agents; Cells, Cultured; Dendritic Cells; Enzyme Inhibitors; Fluorescent Antibody Technique; Fluorescent Dyes; Genes, MHC Class II; Humans; Imidazoles; Imiquimod; Macrolides; Proton-Translocating ATPases; Quinolines; Toll-Like Receptor 7	2011
Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay. Journal of immunological methods, 2011, Oct-28, Volume: 373, Issue:1-2 Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Branched DNA Signal Amplification Assay; Chemokine CCL2; Chemokine CXCL1; Chemokines; Cytokines; Female; Gene Expression Profiling; Guinea Pigs; Imidazoles; Imiquimod; Interleukin-12; Interleukin-1beta; Lipopolysaccharides; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Toll-Like Receptor 4; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptors; Transcriptome; Tumor Necrosis Factor-alpha	2011
TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells. Cancer letters, 2013, Jul-10, Volume: 335, Issue:1 Topics: Aminoquinolines; Antigens, CD; Antineoplastic Agents; B7-2 Antigen; CD83 Antigen; Cell Proliferation; Coculture Techniques; Cytokines; Cytotoxicity, Immunologic; Dendritic Cells; Drug Screening Assays, Antitumor; HLA-DR Antigens; HT29 Cells; Humans; Imidazoles; Imiquimod; Immunoglobulins; Immunomodulation; Inflammation Mediators; K562 Cells; Killer Cells, Natural; Lymphocyte Activation; Membrane Glycoproteins; T-Lymphocytes; Toll-Like Receptor 7; Toll-Like Receptor 8	2013
The toll-like receptor agonist imiquimod is active against prions. PloS one, 2013, Volume: 8, Issue:8 Topics: Aminoquinolines; Animals; Cell Line; Drug Evaluation, Preclinical; Glutathione Peroxidase; Guanosine; Humans; Imidazoles; Imiquimod; Membrane Glycoproteins; Mice; Peptide Termination Factors; Prion Diseases; Prions; Protein Folding; PrPSc Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship; Toll-Like Receptor 7; Toll-Like Receptor 8	2013
Editorial: toll-like receptor 7: more than skin deep? Arthritis & rheumatology (Hoboken, N.J.), 2014, Volume: 66, Issue:3 Topics: Aminoquinolines; Animals; Autoimmunity; Imidazoles; Imiquimod; Lupus Erythematosus, Systemic; Toll-Like Receptor 7	2014
Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus. Arthritis & rheumatology (Hoboken, N.J.), 2014, Volume: 66, Issue:3 Topics: Administration, Cutaneous; Aminoquinolines; Animals; Autoantibodies; Autoimmunity; Disease Models, Animal; Imidazoles; Imiquimod; Lupus Erythematosus, Systemic; Mice; Skin; Spleen; Toll-Like Receptor 7	2014
Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-priming. European journal of immunology, 2014, Volume: 44, Issue:8 Topics: Administration, Topical; Aminoquinolines; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cross-Priming; Cytokines; Dendritic Cells; Humans; Imidazoles; Imiquimod; Injections, Intradermal; Ligands; MART-1 Antigen; Melanoma; Skin; Toll-Like Receptor 7	2014
Molecular cloning, tissue distribution, and immune function of goose TLR7. Immunology letters, 2015, Volume: 163, Issue:2 Topics: Amino Acid Sequence; Aminoquinolines; Animals; Aviadenovirus; Avian Proteins; Cells, Cultured; Cloning, Molecular; Cytokines; Geese; Host-Pathogen Interactions; Imidazoles; Imiquimod; Inflammation Mediators; Leukocytes, Mononuclear; Molecular Sequence Data; Phylogeny; Poly I-C; Poultry Diseases; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Spleen; Toll-Like Receptor 7; Transcriptome	2015
Design of anti-BVDV drug based on common chemical features, their interaction, and scaffolds of TLR8 agonists. International journal of biological macromolecules, 2016, Volume: 92 Topics: Amino Acid Sequence; Aminoquinolines; Animals; Antiviral Agents; Binding Sites; Cattle; Diarrhea Virus 1, Bovine Viral; Drug Design; Humans; Imidazoles; Imiquimod; Molecular Docking Simulation; Phylogeny; Protein Binding; Protein Domains; Protein Structure, Secondary; Quinolines; Sequence Alignment; Species Specificity; Structural Homology, Protein; Thiazoles; Toll-Like Receptor 8; Viral Nonstructural Proteins	2016
Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation. Mediators of inflammation, 2017, Volume: 2017 Topics: Aminoquinolines; Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Imidazoles; Imiquimod; Immunity, Innate; Immunosuppressive Agents; Inflammasomes; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligodeoxyribonucleotides; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptor 3; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptor 9; Zymosan	2017
TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:5 Topics: Aminoquinolines; Animals; Antiviral Agents; Caliciviridae Infections; Cell Line; Guanosine; Humans; Imidazoles; Imiquimod; Mice; Pteridines; RAW 264.7 Cells; Toll-Like Receptor 7; Virus Replication	2018
Toll-like receptor-7/8 agonist kill Leishmania amazonensis by acting as pro-oxidant and pro-inflammatory agent. The Journal of pharmacy and pharmacology, 2021, Aug-12, Volume: 73, Issue:9 Topics: Animals; Antiprotozoal Agents; Cytokines; Female; Humans; Imidazoles; Imiquimod; Inflammation; Leishmania; Leishmaniasis; Macrophages, Peritoneal; Mice, Inbred BALB C; Nitric Oxide; Reactive Oxygen Species; Toll-Like Receptor 7; Toll-Like Receptor 8	2021
Resiquimod: a new topical immune-response modifier for the treatment of actinic keratosis. Expert opinion on emerging drugs, 2021, Volume: 26, Issue:4 Topics: Adjuvants, Immunologic; Humans; Imidazoles; Imiquimod; Keratosis, Actinic	2021