resiquimod has been researched along with imiquimod in 47 studies
Studies (resiquimod) | Trials (resiquimod) | Recent Studies (post-2010) (resiquimod) | Studies (imiquimod) | Trials (imiquimod) | Recent Studies (post-2010) (imiquimod) |
---|---|---|---|---|---|
465 | 14 | 318 | 3,264 | 284 | 1,963 |
Protein | Taxonomy | resiquimod (IC50) | imiquimod (IC50) |
---|---|---|---|
Histamine H2 receptor | Homo sapiens (human) | 1.506 | |
Alpha-1D adrenergic receptor | Homo sapiens (human) | 2.621 | |
Adenosine receptor A2a | Homo sapiens (human) | 5.32 | |
7,8-dihydro-8-oxoguanine triphosphatase | Homo sapiens (human) | 0.646 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 4 (8.51) | 18.2507 |
2000's | 20 (42.55) | 29.6817 |
2010's | 19 (40.43) | 24.3611 |
2020's | 4 (8.51) | 2.80 |
Authors | Studies |
---|---|
Horscroft, N; Laxton, C; Myangar, N; Parkinson, T; Rodman, J; Thomas, A | 1 |
Aldrich, CC; Chittepu, P; Ferguson, DM; Ohlfest, JR; Shi, C; Xiong, Z | 1 |
Aldrich, CC; Ferguson, DM; Ohlfest, JR; Olin, M; Schiaffo, CE; Shi, C; Xiong, Z | 1 |
Alwan, H; Bista, M; Breed, J; Davies, NL; Eckersley, K; Fillery, S; Foote, KM; Goodwin, L; Jones, DR; Käck, H; Kettle, JG; Lau, A; Nissink, JW; Read, J; Scott, JS; Taylor, B; Walker, G; Wissler, L; Wylot, M | 1 |
Bihi, M; Dembić, Z; Diken, M; Ester, K; Knežević, J; Kralj, M; Lepur, A; Majhen, D; Markotić, A; Oršolić, N; Piantanida, I; Stojković, MR; Teofilović, NK; Tumir, LM; Vrbanec, D; Vugrek, O; Weber, AN | 1 |
Ferguson, DM; Griffith, TS; Kucaba, TA; Larson, P; Olin, M; Xiong, Z | 1 |
Forrest, ML; Hunt, JR; Kleindl, PA; Moulder, KR; Prisinzano, TE | 1 |
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
Carlson, GL; Gibson, SJ; Horton, VL; Imbertson, LM; Myhre, PE; Tomai, MA; Wagner, TL | 1 |
Beaurline, JM; Couture, AM; Gibson, SJ; Imbertson, LM; Miller, RL; Reiter, MJ; Smith, RM; Tomai, MA; Wagner, TL | 1 |
Ahonen, CL; Couture, AM; Gibson, SJ; Miller, RL; Reiter, MJ; Smith, RM; Tomai, MA; Vasilakos, JP; Wagner, TL | 1 |
Buates, S; Matlashewski, G | 1 |
Burns, RP; Ferbel, B; Gaspari, AA; Miller, R; Tomai, M | 1 |
Imbertson, LM; Stanczak, TL; Tomai, MA; Tygrett, LT; Waldschmidt, TJ | 1 |
Dockrell, DH; Kinghorn, GR | 1 |
Akira, S; Hemmi, H; Horiuchi, T; Hoshino, K; Kaisho, T; Sanjo, H; Sato, S; Takeda, K; Takeuchi, O; Tomizawa, H | 1 |
Bernstein, DI; Harrison, CJ; Miller, RL; Tomai, MA | 1 |
Benninghoff, B; Bong, AB; Drewniok, C; Geilen, CC; Gollnick, H; Herz, J; Reifenberger, J; Schön, M; Schön, MP; Slade, HB | 1 |
Hengge, UR; Meykadeh, N | 1 |
Brett, SJ; Daly, MG; Thomsen, LL; Tite, JP; Topley, P | 1 |
Bong, AB; Drewniok, C; Eberle, J; Geilen, CC; Gollnick, H; Schön, M; Schön, MP; Wienrich, BG | 1 |
Cywes, C; Godowski, PJ; Levy, O; Roy, RM; Wessels, MR; Zarember, KA | 1 |
Alkan, SS; Gibson, SJ; Gorden, KB; Gorski, KS; Kedl, RM; Kieper, WC; Qiu, X; Tomai, MA; Vasilakos, JP | 1 |
Amlie-Lefond, C; Connelly, MP; Dunn, KS; Huffnagle, GB; Paz, DA; Whelan, HT; Whelan, NT | 1 |
Akira, S; Amer, A; Barchet, W; Bertin, J; Body-Malapel, M; Colonna, M; Coyle, A; Franchi, L; Grant, EP; Kanneganti, TD; Núñez, G; Ozören, N; Park, JH; Vandenabeele, P; Whitfield, J | 1 |
Liu, YH; Xu, KJ | 1 |
Pillow, J; Skinner, RB; Woodmansee, C | 1 |
Ashkar, AA; Davies, EJ; Gill, N | 1 |
Meng, TC; Miller, RL; Tomai, MA | 1 |
Matlashewski, G; Zhang, WW | 1 |
Da Silva, DM; Fahey, LM; Kast, WM; Raff, AB | 1 |
Martinez-Martin, N; Viejo-Borbolla, A | 1 |
Akira, S; Diebold, SS; Morel, Y; Paturel, C; Rajagopal, D; Uematsu, S | 1 |
Cornella-Taracido, I; De Gregorio, E; Galli-Stampino, L; Harrington, E; Isome, Y; Jain, R; Mbow, ML; Nuti, S; Russo, C; Sammicheli, C; Soldaini, E; Tallarico, J; Tavarini, S; Valiante, NM | 1 |
Baldwin, SL; Ching, LK; Coler, RN; Guderian, JA; Mompoint, F; Orme, IM; Picone, A; Reed, SG | 1 |
Bachmann, M; Bornhäuser, M; Jähnisch, H; Kunze, A; Oehrl, S; Rohayem, J; Schäkel, K; Schmitz, M; Tonn, T; Tunger, A; Wehner, R | 1 |
Tomai, MA; Vasilakos, JP | 1 |
Beringue, V; Blondel, M; Bouaziz, S; Contesse, MA; Desban, N; Galons, H; Massacrier, C; Morel, Y; Nguyen, PH; Oumata, N; Pang, Y; Paturel, C; Sanyal, S; Soubigou, F; Voisset, C | 1 |
Elkon, KB; Sontheimer, C | 1 |
Fujimoto, C; Kamijima, R; Kataoka, S; Nakajima, K; Sano, S; Takaishi, M; Terada, Y; Yokogawa, M | 1 |
Ambrosini, M; Bruijns, SC; de Gruijl, TD; Fehres, CM; Hooijberg, E; Kalay, H; Unger, WW; van Beelen, AJ; van Kooyk, Y | 1 |
Chen, S; Chen, X; Cheng, A; Jia, R; Liu, F; Liu, M; Qi, Y; Wang, M; Zhao, Q; Zhu, D | 1 |
Chai, HH; Cho, YM; Choi, BH; Lim, D; Suk, JE | 1 |
Fan, S; Li, Y; Liu, W; Wang, N; Yang, X; Zheng, X; Zhu, Y | 1 |
Enosi Tuipulotu, D; Lun, JH; Mackenzie, JM; Netzler, NE; White, PA | 1 |
Coimbra, ES; da Silva, AD; Dib, PRB; Fung, J; Granato, JT; Kaushik, D; Macedo, GC; Petrovsky, N; Piplani, S; Salunke, DB | 1 |
Farr, MA; Joshi, TP; Lewis, DJ | 1 |
8 review(s) available for resiquimod and imiquimod
Article | Year |
---|---|
Imiquimod and resiquimod as novel immunomodulators.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Humans; Imidazoles; Imiquimod; Immunologic Factors | 2001 |
Immunomodulation as a treatment strategy for genital herpes: review of the evidence.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Herpes Genitalis; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Imidazoles; Imiquimod; Recurrence | 2002 |
Innate immunity for biodefense: a strategy whose time has come.
Topics: Aminoquinolines; Animals; Humans; Imidazoles; Imiquimod; Immunity, Innate; Oligodeoxyribonucleotides; Toll-Like Receptor 4; Toll-Like Receptor 9 | 2005 |
The role of topical immune response modifiers in skin cancer.
Topics: Adjuvants, Immunologic; Aminoquinolines; Antineoplastic Agents; Cytokines; Humans; Imidazoles; Imiquimod; Models, Biological; Skin Neoplasms; Toll-Like Receptors | 2006 |
The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection.
Topics: Adjuvants, Immunologic; Aminoquinolines; Antiviral Agents; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Imidazoles; Imiquimod; Immunity, Innate; Ligands; Lipopolysaccharides; Mucous Membrane; Poly I-C; Toll-Like Receptors; Vagina | 2008 |
The antiviral activity of Toll-like receptor 7 and 7/8 agonists.
Topics: Aminoquinolines; Animals; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Humans; Imidazoles; Imiquimod; Toll-Like Receptor 7; Toll-Like Receptor 8; Virus Diseases | 2008 |
Toll-like receptor-mediated recognition of herpes simplex virus.
Topics: Aminoquinolines; Animals; Cytokines; Herpes Simplex; Humans; Imidazoles; Imiquimod; Mice; Signal Transduction; Simplexvirus; Toll-Like Receptors | 2010 |
The use of Toll-like receptor 7/8 agonists as vaccine adjuvants.
Topics: Adjuvants, Immunologic; Aminoquinolines; Clinical Trials as Topic; Drug Discovery; Humans; Imidazoles; Imiquimod; Toll-Like Receptor 7; Toll-Like Receptor 8; Vaccines | 2013 |
1 trial(s) available for resiquimod and imiquimod
Article | Year |
---|---|
Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod.
Topics: Administration, Topical; Aminoquinolines; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biopsy; Cell Line, Tumor; fas Receptor; Humans; Imidazoles; Imiquimod; Melanocytes; Melanoma; Membrane Glycoproteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Skin Neoplasms; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2004 |
38 other study(ies) available for resiquimod and imiquimod
Article | Year |
---|---|
Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection.
Topics: Antiviral Agents; Cell Line, Tumor; Cytokines; Hepacivirus; Hepatitis C; Humans; Leukocytes, Mononuclear; Toll-Like Receptor 3; Toll-Like Receptor 7; Toll-Like Receptor 9; Toll-Like Receptors | 2007 |
Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction.
Topics: | 2012 |
Structure-activity relationship analysis of imidazoquinolines with Toll-like receptors 7 and 8 selectivity and enhanced cytokine induction.
Topics: Animals; Bone Marrow Cells; Cytokines; Dendritic Cells; HEK293 Cells; Humans; Imidazoles; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Quinolines; Stereoisomerism; Structure-Activity Relationship; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2014 |
Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; DNA Repair Enzymes; Drug Discovery; Humans; Models, Molecular; Phosphoric Monoester Hydrolases; Rats; RNA, Small Interfering; Structure-Activity Relationship | 2016 |
1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro.
Topics: Cell Line; Down-Regulation; Humans; Immunologic Factors; Intercalating Agents; Interferon-alpha; Interleukin-6; Interleukin-8; Oligodeoxyribonucleotides; Phenanthridines; Signal Transduction; Toll-Like Receptor 3; Toll-Like Receptor 9; Tumor Necrosis Factor-alpha; Urea | 2017 |
Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.
Topics: | 2017 |
Further exploration of the structure-activity relationship of imidazoquinolines; identification of potent C7-substituted imidazoquinolines.
Topics: Binding Sites; Cytokines; Humans; Imidazoles; Leukocytes, Mononuclear; Molecular Docking Simulation; Quinolines; Structure-Activity Relationship; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2020 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Induction of cytokines in cynomolgus monkeys by the immune response modifiers, imiquimod, S-27609 and S-28463.
Topics: Adjuvants, Immunologic; Administration, Oral; Administration, Topical; Aminoquinolines; Animals; Cells, Cultured; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Imiquimod; Interferon Inducers; Leukocytes, Mononuclear; Macaca fascicularis; Male; Models, Chemical; RNA, Messenger; Skin | 1997 |
Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Animals; Antibody Formation; Cells, Cultured; Cytokines; Female; Fibroblasts; Humans; Imiquimod; Interferon-alpha; Keratinocytes; Male; Melanocytes; Mice; Mice, Hairless; Rats; Rats, Nude; RNA, Messenger; Skin | 1998 |
Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cytokines; Humans; Imiquimod; Interferon-alpha; Interferon-gamma; Interleukin-12; Interleukin-5; Male; Mice; Mice, Inbred BALB C; T-Lymphocytes, Helper-Inducer | 1999 |
Treatment of experimental leishmaniasis with the immunomodulators imiquimod and S-28463: efficacy and mode of action.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Bone Marrow Cells; Female; Imiquimod; Leishmania donovani; Leishmaniasis; Macrophages; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-fos; Signal Transduction; Trypanocidal Agents | 1999 |
The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans' cells.
Topics: Adjuvants, Immunologic; Aminoquinolines; Antigen Presentation; Cell Division; Cells, Cultured; Cytokines; Gene Expression; Humans; Imidazoles; Imiquimod; Immunologic Factors; Langerhans Cells; Lymphocyte Culture Test, Mixed; Phenotype; Th1 Cells | 2000 |
The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antibody Specificity; Antigens, CD; B-Lymphocytes; B7-2 Antigen; Cells, Cultured; Guanosine; Humans; Imidazoles; Imiquimod; Immunoglobulin Class Switching; Immunoglobulin E; Immunoglobulin G; Lipopolysaccharides; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Ovalbumin; Spleen | 2000 |
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Topics: Adaptor Proteins, Signal Transducing; Adjuvants, Immunologic; Aminoquinolines; Animals; Antigens, Differentiation; Antiviral Agents; Bone Marrow Cells; Dendritic Cells; Drosophila Proteins; Imidazoles; Imiquimod; Interferon Inducers; Macrophages, Peritoneal; Membrane Glycoproteins; Mice; Mice, Mutant Strains; Myeloid Differentiation Factor 88; Receptors, Cell Surface; Receptors, Immunologic; Spleen; Toll-Like Receptor 7; Toll-Like Receptors | 2002 |
Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod.
Topics: Aminoquinolines; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Caspase 3; Caspases; Cytochrome c Group; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Imiquimod; Immunologic Factors; In Situ Nick-End Labeling; Keratinocytes; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Tumor Cells, Cultured; Up-Regulation | 2003 |
[Topical immunomodulators in dermatology].
Topics: Adjuvants, Immunologic; Administration, Topical; Adult; Aged; Aged, 80 and over; Aminoquinolines; Asthma; Autoimmune Diseases; Bowen's Disease; Child; Cyclopropanes; Dermatitis, Atopic; Dinitrochlorobenzene; Female; Follow-Up Studies; Herpes Simplex; Humans; Imidazoles; Imiquimod; Immunity, Cellular; Immunocompromised Host; Immunoglobulin A; Immunosuppressive Agents; Lichen Sclerosus et Atrophicus; Male; Molluscum Contagiosum; Papillomavirus Infections; Precancerous Conditions; Skin Diseases; Skin Diseases, Viral; Skin Neoplasms; Tacrolimus; Time Factors; Warts | 2003 |
Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Biolistics; CD11 Antigens; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Imidazoles; Imiquimod; Immunization; Immunotherapy; Injections, Subcutaneous; Interferon-gamma; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microspheres; Ovalbumin; Plasmids; Th1 Cells; Vaccines, DNA | 2004 |
Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.
Topics: Adult; Aminoquinolines; Cell Membrane; Female; Fetal Blood; Humans; Imidazoles; Imiquimod; Immune Tolerance; Immunity, Innate; Infant, Newborn; Interferon Inducers; Ligands; Lipopolysaccharide Receptors; Lipopolysaccharides; Lipoproteins; Male; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, Cell Surface; Toll-Like Receptors; Tumor Necrosis Factor-alpha | 2004 |
Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.
Topics: Aminoquinolines; Cell Line; Cell Lineage; Cells, Cultured; Cytokines; Dendritic Cells; Humans; Imidazoles; Imiquimod; Interferon-alpha; Interleukin-12; Leukocytes, Mononuclear; Membrane Glycoproteins; Monocytes; Myeloid Cells; Receptors, Cell Surface; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptors; Transfection; Tumor Necrosis Factor-alpha | 2005 |
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
Topics: Adaptor Proteins, Signal Transducing; Aminoquinolines; Animals; Antiviral Agents; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Cells, Cultured; Cytoskeletal Proteins; Enzyme Activation; Female; Imidazoles; Imiquimod; Inflammation; Interleukin-1; Interleukin-18; Legionella pneumophila; Listeria monocytogenes; Macrophages, Peritoneal; Male; Mice; Mitogen-Activated Protein Kinases; Multiprotein Complexes; Myeloid Differentiation Factor 88; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; RNA, Bacterial; Toll-Like Receptors | 2006 |
[Application of imiquimod and resiquimod in dermatology].
Topics: Adjuvants, Immunologic; Aminoquinolines; Antineoplastic Agents; Condylomata Acuminata; Humans; Imidazoles; Imiquimod; Skin Neoplasms | 2006 |
Immunization with a Toll-like receptor 7 and/or 8 agonist vaccine adjuvant increases protective immunity against Leishmania major in BALB/c mice.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antigens, Protozoan; Female; Foot; Imidazoles; Imiquimod; Injections, Intramuscular; Injections, Subcutaneous; Interferon-gamma; Leishmania major; Leishmaniasis Vaccines; Leishmaniasis, Cutaneous; Lymphocytes; Mice; Mice, Inbred BALB C; Spleen; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2008 |
Reversal of human papillomavirus-specific T cell immune suppression through TLR agonist treatment of Langerhans cells exposed to human papillomavirus type 16.
Topics: Adjuvants, Immunologic; Aminoquinolines; Antineoplastic Agents; Cells, Cultured; Epitopes, T-Lymphocyte; Female; Human papillomavirus 16; Humans; Imidazoles; Imiquimod; Immunity, Cellular; Immunosuppressive Agents; Langerhans Cells; Papillomavirus Infections; Quinolines; T-Lymphocytes; Toll-Like Receptor 7; Toll-Like Receptor 8; Uterine Cervical Neoplasms | 2009 |
Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antineoplastic Agents; Cancer Vaccines; Dendritic Cells; Dose-Response Relationship, Drug; Imidazoles; Imiquimod; Interferon Type I; Melanoma, Experimental; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Quinolines; Receptor, Interferon alpha-beta; RNA; Toll-Like Receptor 7; Tumor Cells, Cultured | 2010 |
Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells.
Topics: Adenine; Aminoquinolines; Antineoplastic Agents; Cells, Cultured; Dendritic Cells; Enzyme Inhibitors; Fluorescent Antibody Technique; Fluorescent Dyes; Genes, MHC Class II; Humans; Imidazoles; Imiquimod; Macrolides; Proton-Translocating ATPases; Quinolines; Toll-Like Receptor 7 | 2011 |
Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Branched DNA Signal Amplification Assay; Chemokine CCL2; Chemokine CXCL1; Chemokines; Cytokines; Female; Gene Expression Profiling; Guinea Pigs; Imidazoles; Imiquimod; Interleukin-12; Interleukin-1beta; Lipopolysaccharides; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Toll-Like Receptor 4; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptors; Transcriptome; Tumor Necrosis Factor-alpha | 2011 |
TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells.
Topics: Aminoquinolines; Antigens, CD; Antineoplastic Agents; B7-2 Antigen; CD83 Antigen; Cell Proliferation; Coculture Techniques; Cytokines; Cytotoxicity, Immunologic; Dendritic Cells; Drug Screening Assays, Antitumor; HLA-DR Antigens; HT29 Cells; Humans; Imidazoles; Imiquimod; Immunoglobulins; Immunomodulation; Inflammation Mediators; K562 Cells; Killer Cells, Natural; Lymphocyte Activation; Membrane Glycoproteins; T-Lymphocytes; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2013 |
The toll-like receptor agonist imiquimod is active against prions.
Topics: Aminoquinolines; Animals; Cell Line; Drug Evaluation, Preclinical; Glutathione Peroxidase; Guanosine; Humans; Imidazoles; Imiquimod; Membrane Glycoproteins; Mice; Peptide Termination Factors; Prion Diseases; Prions; Protein Folding; PrPSc Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2013 |
Editorial: toll-like receptor 7: more than skin deep?
Topics: Aminoquinolines; Animals; Autoimmunity; Imidazoles; Imiquimod; Lupus Erythematosus, Systemic; Toll-Like Receptor 7 | 2014 |
Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Autoantibodies; Autoimmunity; Disease Models, Animal; Imidazoles; Imiquimod; Lupus Erythematosus, Systemic; Mice; Skin; Spleen; Toll-Like Receptor 7 | 2014 |
Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-priming.
Topics: Administration, Topical; Aminoquinolines; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cross-Priming; Cytokines; Dendritic Cells; Humans; Imidazoles; Imiquimod; Injections, Intradermal; Ligands; MART-1 Antigen; Melanoma; Skin; Toll-Like Receptor 7 | 2014 |
Molecular cloning, tissue distribution, and immune function of goose TLR7.
Topics: Amino Acid Sequence; Aminoquinolines; Animals; Aviadenovirus; Avian Proteins; Cells, Cultured; Cloning, Molecular; Cytokines; Geese; Host-Pathogen Interactions; Imidazoles; Imiquimod; Inflammation Mediators; Leukocytes, Mononuclear; Molecular Sequence Data; Phylogeny; Poly I-C; Poultry Diseases; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Spleen; Toll-Like Receptor 7; Transcriptome | 2015 |
Design of anti-BVDV drug based on common chemical features, their interaction, and scaffolds of TLR8 agonists.
Topics: Amino Acid Sequence; Aminoquinolines; Animals; Antiviral Agents; Binding Sites; Cattle; Diarrhea Virus 1, Bovine Viral; Drug Design; Humans; Imidazoles; Imiquimod; Molecular Docking Simulation; Phylogeny; Protein Binding; Protein Domains; Protein Structure, Secondary; Quinolines; Sequence Alignment; Species Specificity; Structural Homology, Protein; Thiazoles; Toll-Like Receptor 8; Viral Nonstructural Proteins | 2016 |
Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation.
Topics: Aminoquinolines; Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Imidazoles; Imiquimod; Immunity, Innate; Immunosuppressive Agents; Inflammasomes; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligodeoxyribonucleotides; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptor 3; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptor 9; Zymosan | 2017 |
TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation.
Topics: Aminoquinolines; Animals; Antiviral Agents; Caliciviridae Infections; Cell Line; Guanosine; Humans; Imidazoles; Imiquimod; Mice; Pteridines; RAW 264.7 Cells; Toll-Like Receptor 7; Virus Replication | 2018 |
Toll-like receptor-7/8 agonist kill Leishmania amazonensis by acting as pro-oxidant and pro-inflammatory agent.
Topics: Animals; Antiprotozoal Agents; Cytokines; Female; Humans; Imidazoles; Imiquimod; Inflammation; Leishmania; Leishmaniasis; Macrophages, Peritoneal; Mice, Inbred BALB C; Nitric Oxide; Reactive Oxygen Species; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2021 |
Resiquimod: a new topical immune-response modifier for the treatment of actinic keratosis.
Topics: Adjuvants, Immunologic; Humans; Imidazoles; Imiquimod; Keratosis, Actinic | 2021 |