repinotan hydrochloride has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 6 studies
*8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. [MeSH]
*8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. [MeSH]
| Studies (repinotan hydrochloride) | Trials (repinotan hydrochloride) | Recent Studies (post-2010) (repinotan hydrochloride) | Studies (8-hydroxy-2-(di-n-propylamino)tetralin) | Trials (8-hydroxy-2-(di-n-propylamino)tetralin) | Recent Studies (post-2010) (8-hydroxy-2-(di-n-propylamino)tetralin) |
|---|---|---|---|---|---|
| 35 | 4 | 1 | 3,530 | 7 | 389 |
| Protein | Taxonomy | repinotan hydrochloride (IC50) | 8-hydroxy-2-(di-n-propylamino)tetralin (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.0012 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0032 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| D(2) dopamine receptor | Bos taurus (cattle) | 0.8 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 2.8959 | |
| Lysosomal alpha-glucosidase | Bos taurus (cattle) | 0.0021 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Vry, J; Glaser, T; Greuel, JM; Heine, HG; Mauler, F; Schmidt, B; Schohe-Loop, R; Sommermeyer, H | 1 |
| Blier, P; de Montigny, C; Dong, J | 1 |
| Adell, A; Artigas, F | 1 |
| Artigas, F; Casanovas, JM; Hervás, I | 1 |
| Harkany, T; Horvath, KM; Keijser, J; Luiten, PG; Mulder, J; Nyakas, C; van der Meeberg, EK | 1 |
| Adayev, T; Banerjee, P; Ray, I; Sobocki, T; Sondhi, R | 1 |
6 other study(ies) available for repinotan hydrochloride and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Benzopyrans; Body Temperature; Cyclic AMP; Hippocampus; Humans; Male; Phosphatidylinositols; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Thiazoles | 1998 |
Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Benzopyrans; Hippocampus; Male; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Thiazoles | 1998 |
A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Uptake Inhibitors; Animals; Benzopyrans; Male; Microdialysis; Piperazines; Pyridines; Quinolines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reserpine; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin; Thiazoles | 1998 |
Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Benzopyrans; Male; Neurons; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synapses; Thiazoles | 1999 |
Oral post-lesion administration of 5-HT(1A) receptor agonist repinotan hydrochloride (BAY x 3702) attenuates NMDA-induced delayed neuronal death in rat magnocellular nucleus basalis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Administration, Oral; Animals; Apoptosis; Basal Nucleus of Meynert; Behavior, Animal; Benzopyrans; Choline O-Acetyltransferase; Excitatory Amino Acid Agonists; Male; Memory; N-Methylaspartate; Neurons; Neuroprotective Agents; Parietal Lobe; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles | 2001 |
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apoptosis; Benzopyrans; Calcium; Caspase 3; Caspase Inhibitors; Cell Line; Enzyme Activation; Hydrogen Peroxide; Mice; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Protein Kinase C; Protein Kinase C-alpha; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles | 2003 |