rehmannic-acid and 1-1-diphenyl-2-picrylhydrazyl

Lantadenes are pentacyclic triterpenoids present in the leaves of the plant Lantana camara. In the present study, in vitro antioxidant activity and free radical scavenging capacity of lantadene A was evaluated using established in vitro models such as ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH•), hydroxyl radical (OH•), nitric oxide radical (NO•), superoxide anion scavenging activities and ferrous ion chelating assay. Interestingly, lantadene A showed considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner when compared with the standard antioxidant in nitric oxide scavenging, superoxide anion radical scavenging and ferrous ion chelating assay. These findings show that the lantadene A possesses antioxidant activity with different mechanism of actions towards the different free radicals tested. Since lantadene A is a very popular drug in modern medicine, it is a promising candidate for use as an antioxidant and hepatoprotective agent.

Topics: Animals; Antioxidants; Biphenyl Compounds; Cell Line; Chlorocebus aethiops; Free Radical Scavengers; Hydroxyl Radical; Lantana; Nitric Oxide; Oleanolic Acid; Oxidation-Reduction; Picrates; Plant Leaves; Superoxides; Triterpenes; Vero Cells