Page last updated: 2024-09-03

reboxetine and paroxetine

reboxetine has been researched along with paroxetine in 21 studies

Compound Research Comparison

Studies
(reboxetine)
Trials
(reboxetine)
Recent Studies (post-2010)
(reboxetine)
Studies
(paroxetine)
Trials
(paroxetine)
Recent Studies (post-2010) (paroxetine)
6261931844,2571,0311,031

Protein Interaction Comparison

ProteinTaxonomyreboxetine (IC50)paroxetine (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)3.9
MyeloperoxidaseHomo sapiens (human)0.02
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.086
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.532
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.244
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.123
Quinolone resistance protein NorAStaphylococcus aureus7
Cytochrome P450 2D6Homo sapiens (human)0.5003
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.145
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.179
Beta-adrenergic receptor kinase 1Bos taurus (cattle)1.08
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.093
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.623
Beta-adrenergic receptor kinase 1Homo sapiens (human)1.24
Substance-P receptorHomo sapiens (human)0.9
Sodium-dependent serotonin transporterHomo sapiens (human)0.0007
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0003
P2X purinoceptor 4Rattus norvegicus (Norway rat)2.45
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)3.9
Sodium-dependent dopamine transporter Homo sapiens (human)0.672
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)3.9
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)3.9
P2X purinoceptor 4Homo sapiens (human)2.8067
Sigma non-opioid intracellular receptor 1Homo sapiens (human)5.366
TransporterRattus norvegicus (Norway rat)0.535

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.76)18.2507
2000's13 (61.90)29.6817
2010's5 (23.81)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Avenoso, A; FacciolĂ , G; Scordo, MG; Spina, E1
Carpentier, C; Costentin, J; Leroux-Nicollet, I; Naudon, L; Vilpoux, C1
Ferguson, JM; Schwartz, GE; Wesnes, KA1
Arnone, D; Hansen, L; Kerr, JS1
Frazer, A; Gould, GG; Morilak, DA; Pardon, MC1
Bellodi, L; Bertani, A; Caldirola, D; Di Pasquale, D; Migliarese, G; Perna, G1
Cryan, JF; Dalvi, A; Friedland, JC; Hirsch, BR; Jin, SH; Lucki, I; O'Leary, OF; Ouyang, M; Page, ME; Thomas, SA1
Bellodi, L; Bertani, A; Caldirola, D; Cucchi, M; Di Pasquale, D; Migliarese, G; Perna, G1
Carey, GJ; Gold, LH; Nielsen, DM1
Baldwin, D; Bridgman, K; Buis, C1
Balogh, A; Eberhardt, AM; Härtter, S; Hiemke, C; Kirsch, M; Kuhn, UD; Maurer, I; Merkel, U; Volz, HP; Wenda, B1
Bajbouj, M; Danker-Hopfe, H; Gallinat, J; Hellen, F; Lang, UE; Lisanby, SH; Neu, P; Vesper, J1
Bayindirli, D; Caykoylu, A; Deniz, O; Ekinci, O; Kuloglu, M; Vural, G1
Aburakawa, Y; Aizawa, H; Hasebe, N; Kwak, S; Sawada, J; Yamashita, T1
Barbato, A; Bortolotti, A; D'Avanzo, B; Fortino, I; Franchi, C; Merlino, L; Nobili, A; Parabiaghi, A; Tettamanti, M1
Barbui, C; Churchill, R; Cipriani, A; Furukawa, TA; Imperadore, G; Purgato, M; Signoretti, A; Trespidi, C; Watanabe, N1
Buoli, M; Cahn, W; Serati, M1
Jiao, Y; Liang, Y; Lin, J; Qu, H; Sun, Y; Xu, J; Zhao, C1
Hatano, M; Ikuta, T; Iwata, N; Kishi, T; Matsuda, Y; Okuya, M; Sakuma, K1
Barbui, C; Bighelli, I; Caldwell, DM; Cipriani, A; Davies, SJ; Dawson, S; Dias, S; Furukawa, TA; Guaiana, G; Imai, H; Koesters, M; Meader, N; Pompoli, A; Robertson, L; Tajika, A1

Reviews

4 review(s) available for reboxetine and paroxetine

ArticleYear
Citalopram versus other anti-depressive agents for depression.
    The Cochrane database of systematic reviews, 2012, Jul-11, Issue:7

    Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Citalopram; Cyclohexanols; Depression; Humans; Morpholines; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Venlafaxine Hydrochloride

2012
Alternative pharmacological strategies for adult ADHD treatment: a systematic review.
    Expert review of neurotherapeutics, 2016, Volume: 16, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Central Nervous System Stimulants; Desipramine; Dopamine Agents; Droxidopa; Drug Combinations; Duloxetine Hydrochloride; Guanfacine; Histamine Agents; Humans; Lisdexamfetamine Dimesylate; Lithium Compounds; Lobeline; Mecamylamine; Memantine; Modafinil; Morpholines; Nicotinic Agonists; Nicotinic Antagonists; Nomifensine; Paroxetine; Pyridines; Pyridoxine; Pyrrolidonecarboxylic Acid; Quinazolinones; Reboxetine; Venlafaxine Hydrochloride; Wakefulness-Promoting Agents

2016
Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis.
    Molecular psychiatry, 2023, Volume: 28, Issue:1

    Topics: Adult; Amitriptyline; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Desvenlafaxine Succinate; Duloxetine Hydrochloride; Female; Fluoxetine; Fluvoxamine; Humans; Mirtazapine; Network Meta-Analysis; Paroxetine; Randomized Controlled Trials as Topic; Reboxetine; Sertraline; Venlafaxine Hydrochloride; Vortioxetine

2023
Pharmacological treatments in panic disorder in adults: a network meta-analysis.
    The Cochrane database of systematic reviews, 2023, 11-28, Volume: 11

    Topics: Adult; Alprazolam; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipramine; Clonazepam; Desipramine; Diazepam; Fluoxetine; Humans; Network Meta-Analysis; Panic Disorder; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Venlafaxine Hydrochloride

2023

Trials

7 trial(s) available for reboxetine and paroxetine

ArticleYear
No effect of the new antidepressant reboxetine on CYP2D6 activity in healthy volunteers.
    Therapeutic drug monitoring, 1999, Volume: 21, Issue:5

    Topics: Adult; Antidepressive Agents; Cross-Over Studies; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Drug Interactions; Enzyme Inhibitors; Female; Humans; Isoenzymes; Male; Morpholines; Paroxetine; Phenotype; Reboxetine; Time Factors

1999
Reboxetine versus paroxetine versus placebo: effects on cognitive functioning in depressed patients.
    International clinical psychopharmacology, 2003, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Cognition Disorders; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Morpholines; Paroxetine; Placebos; Reboxetine; Selective Serotonin Reuptake Inhibitors; Treatment Outcome

2003
Modulation of hyperreactivity to 35% CO2 after one week of treatment with paroxetine and reboxetine: a double-blind, randomized study.
    Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Analysis of Variance; Bronchial Hyperreactivity; Carbon Dioxide; Chi-Square Distribution; Double-Blind Method; Female; Humans; Male; Morpholines; Panic Disorder; Paroxetine; Reboxetine; Statistics, Nonparametric

2004
Comparison of the treatment with paroxetine and reboxetine in panic disorder: a randomized, single-blind study.
    Pharmacopsychiatry, 2004, Volume: 37, Issue:5

    Topics: Adrenergic Uptake Inhibitors; Adult; Female; Humans; Male; Morpholines; Panic Disorder; Paroxetine; Psychometrics; Reboxetine; Selective Serotonin Reuptake Inhibitors; Single-Blind Method

2004
Resolution of sexual dysfunction during double-blind treatment of major depression with reboxetine or paroxetine.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Male; Middle Aged; Morpholines; Paroxetine; Psychiatric Status Rating Scales; Reboxetine; Sexual Behavior; Sexual Dysfunctions, Psychological

2006
Reboxetine and cytochrome P450--comparison with paroxetine treatment in humans.
    International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:1

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Enzyme Inhibitors; Genotype; Humans; Male; Mixed Function Oxygenases; Morpholines; Mutation; Paroxetine; Phenotype; Reboxetine; Reference Values; Selective Serotonin Reuptake Inhibitors

2007
Motor cortex excitability after vagus nerve stimulation in major depression.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:2

    Topics: Adult; Benzodiazepines; Citalopram; Clomipramine; Clozapine; Depressive Disorder; Doxepin; Drug Therapy, Combination; Electric Stimulation; Female; Humans; Lamotrigine; Lithium Carbonate; Male; Mianserin; Middle Aged; Mirtazapine; Morpholines; Motor Cortex; Neural Conduction; Neural Inhibition; Olanzapine; Paroxetine; Psychiatric Status Rating Scales; Reboxetine; Tranylcypromine; Triazines; Vagus Nerve; Valproic Acid

2007

Other Studies

10 other study(ies) available for reboxetine and paroxetine

ArticleYear
Differential effects of chronic antidepressant treatments on micro- and delta-opioid receptors in rat brain.
    European journal of pharmacology, 2002, May-17, Volume: 443, Issue:1-3

    Topics: Animals; Antidepressive Agents; Autoradiography; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Injections, Intraperitoneal; Male; Moclobemide; Morpholines; Paroxetine; Rats; Rats, Sprague-Dawley; Reboxetine; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors

2002
Acute dystonic reaction in an elderly patient with mood disorder after titration of paroxetine: possible mechanisms and implications for clinical care.
    Journal of psychopharmacology (Oxford, England), 2002, Volume: 16, Issue:4

    Topics: Aged; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dystonic Disorders; Electroconvulsive Therapy; Humans; Male; Morpholines; Olanzapine; Paroxetine; Pirenzepine; Reboxetine

2002
Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:9

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Autoradiography; Binding Sites; Brain; Brain Mapping; Carrier Proteins; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Interactions; Idazoxan; In Situ Hybridization; Male; Membrane Glycoproteins; Membrane Transport Proteins; Morpholines; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Reboxetine; Receptors, Adrenergic; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Symporters; Time Factors; Tissue Distribution; Tyrosine 3-Monooxygenase

2003
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, May-25, Volume: 101, Issue:21

    Topics: Animals; Antidepressive Agents; Citalopram; Depression; Desipramine; Dopamine beta-Hydroxylase; Droxidopa; Fluoxetine; Gene Deletion; Mice; Morpholines; Norepinephrine; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Tail

2004
Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice.
    European journal of pharmacology, 2004, Sep-19, Volume: 499, Issue:1-2

    Topics: Animals; Antidepressive Agents; Clorgyline; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Hindlimb Suspension; Male; Mice; Morpholines; Motor Activity; Paroxetine; Pyrazoles; Pyrimidines; Pyrroles; Reboxetine; Receptors, Corticotropin-Releasing Hormone; Selegiline; Swimming; Tranylcypromine; Triazines

2004
[Depressed, lacking motivation, unconcentrated. Signs of central deficiency of noradrenaline].
    MMW Fortschritte der Medizin, 2004, Jul-08, Volume: 146, Issue:27-28

    Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Attention; Brain; Depressive Disorder; Humans; Morpholines; Motivation; Norepinephrine; Paroxetine; Randomized Controlled Trials as Topic; Reboxetine; Selective Serotonin Reuptake Inhibitors

2004
Successful management of depression with reboxetine in a patient who developed Parkinsonism related to paroxetine use.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Humans; Male; Middle Aged; Morpholines; Parkinson Disease, Secondary; Paroxetine; Psychiatric Status Rating Scales; Reboxetine; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Treatment Outcome

2010
Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line.
    Neuroscience research, 2009, Volume: 64, Issue:3

    Topics: Adenosine Deaminase; Amitriptyline; Amyotrophic Lateral Sclerosis; Antidepressive Agents; Arginine; Cyclopropanes; Desipramine; Fluoxetine; Fluvoxamine; Glutamine; HeLa Cells; Humans; Imipramine; Milnacipran; Morpholines; Paroxetine; Reboxetine; Receptors, AMPA; RNA Editing; RNA-Binding Proteins; RNA, Messenger

2009
The declining use of reboxetine in years 2000 to 2006: a pharmacoepidemiological comparative study.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:2

    Topics: Antidepressive Agents; Depression; Fluoxetine; Humans; Morpholines; Paroxetine; Pharmacoepidemiology; Practice Patterns, Physicians'; Publication Bias; Reboxetine; Selective Serotonin Reuptake Inhibitors

2012
Comparative efficacy and acceptability of antidepressant treatment in poststroke depression: a multiple-treatments meta-analysis.
    BMJ open, 2017, Aug-03, Volume: 7, Issue:8

    Topics: Aged; Antidepressive Agents; Antidepressive Agents, Second-Generation; Citalopram; Depression; Depressive Disorder; Doxepin; Duloxetine Hydrochloride; Female; Fluoxetine; Humans; Male; Morpholines; Paroxetine; Patient Acceptance of Health Care; Reboxetine; Selective Serotonin Reuptake Inhibitors; Stroke; Treatment Outcome

2017