Page last updated: 2024-09-03

reboxetine and dextromethorphan

reboxetine has been researched along with dextromethorphan in 2 studies

Compound Research Comparison

Studies (reboxetine)	Trials (reboxetine)	Recent Studies (post-2010) (reboxetine)	Studies (dextromethorphan)	Trials (dextromethorphan)	Recent Studies (post-2010) (dextromethorphan)
626	193	184	2,020	342	593

Protein Interaction Comparison

Protein	Taxonomy	dextromethorphan (IC50)
Sodium channel protein type 1 subunit alpha	Rattus norvegicus (Norway rat)	1.3
Sodium channel protein type 2 subunit alpha	Rattus norvegicus (Norway rat)	1.3
Sodium channel protein type 3 subunit alpha	Rattus norvegicus (Norway rat)	1.3
Cytochrome P450 2D26	Rattus norvegicus (Norway rat)	5.6
Cytochrome P450 2D6	Homo sapiens (human)	2.1768
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.0027
Sigma non-opioid intracellular receptor 1	Cavia porcellus (domestic guinea pig)	0.1236

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Avenoso, A; Facciolà, G; Scordo, MG; Spina, E	1
Balogh, A; Eberhardt, AM; Härtter, S; Hiemke, C; Kirsch, M; Kuhn, UD; Maurer, I; Merkel, U; Volz, HP; Wenda, B	1

Trials

2 trial(s) available for reboxetine and dextromethorphan

Article	Year
No effect of the new antidepressant reboxetine on CYP2D6 activity in healthy volunteers. Therapeutic drug monitoring, 1999, Volume: 21, Issue:5 Topics: Adult; Antidepressive Agents; Cross-Over Studies; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Drug Interactions; Enzyme Inhibitors; Female; Humans; Isoenzymes; Male; Morpholines; Paroxetine; Phenotype; Reboxetine; Time Factors	1999
Reboxetine and cytochrome P450--comparison with paroxetine treatment in humans. International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:1 Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Enzyme Inhibitors; Genotype; Humans; Male; Mixed Function Oxygenases; Morpholines; Mutation; Paroxetine; Phenotype; Reboxetine; Reference Values; Selective Serotonin Reuptake Inhibitors	2007

Article

Year

No effect of the new antidepressant reboxetine on CYP2D6 activity in healthy volunteers.

Therapeutic drug monitoring, 1999, Volume: 21, Issue:5

Topics: Adult; Antidepressive Agents; Cross-Over Studies; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Drug Interactions; Enzyme Inhibitors; Female; Humans; Isoenzymes; Male; Morpholines; Paroxetine; Phenotype; Reboxetine; Time Factors

1999

Reboxetine and cytochrome P450--comparison with paroxetine treatment in humans.

International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:1

Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Enzyme Inhibitors; Genotype; Humans; Male; Mixed Function Oxygenases; Morpholines; Mutation; Paroxetine; Phenotype; Reboxetine; Reference Values; Selective Serotonin Reuptake Inhibitors

2007