Page last updated: 2024-09-03

reboxetine and clonidine

reboxetine has been researched along with clonidine in 13 studies

Compound Research Comparison

Studies (reboxetine)	Trials (reboxetine)	Recent Studies (post-2010) (reboxetine)	Studies (clonidine)	Trials (clonidine)	Recent Studies (post-2010) (clonidine)
626	193	184	13,692	2,044	1,394

Protein Interaction Comparison

Protein	Taxonomy	clonidine (IC50)
Alpha-2A adrenergic receptor	Homo sapiens (human)	0.101
Alpha-2B adrenergic receptor	Homo sapiens (human)	0.0353
Alpha-2C adrenergic receptor	Homo sapiens (human)	0.0115
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	5.365
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	0.0173
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	0.0173
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	0.0173
Alpha-1D adrenergic receptor	Homo sapiens (human)	1.21
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	5.365
Alpha-2A adrenergic receptor	Bos taurus (cattle)	0.002
Nischarin	Rattus norvegicus (Norway rat)	0.3662

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (15.38)	18.2507
2000's	6 (46.15)	29.6817
2010's	5 (38.46)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Connor, TJ; Dredge, K; Harkin, A; Kelly, JP; Leonard, BE; McNamara, M; Redmond, A	1
Bernini, M; Bianchetti, A; Invernizzi, RW; Parini, S; Sacchetti, G; Samanin, R	1
Annoni, K; Caccia, S; Fracasso, C; Invernizzi, RW; Parini, S; Sacchetti, G; Samanin, R	1
Harkin, A; Kelly, JP; Leonard, BE; Morris, K; O'Donnell, JM	1
Blier, P; Szabo, ST	1
Lucki, I; Page, ME	1
Battaglia, A; Invernizzi, RW; Parini, S; Renoldi, G	1
Frishtick, R; Pick, CG; Rubovitch, V; Schreiber, S; Volis, I; Weizman, R	1
Born, J; Dahmen, JC; Gais, S; Rasch, B; Sara, S	1
Drugan, RC; Warner, TA	1
Hysek, CM; Liechti, ME	1
Bruzos-Cidón, C; Gutiérrez-Lanza, R; Miguelez, C; Rodríguez, JJ; Torrecilla, M; Ugedo, L	1
Gelbard-Sagiv, H; Hendler, T; Magidov, E; Nir, Y; Sharon, H	1

Reviews

1 review(s) available for reboxetine and clonidine

Article	Year
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex. Psychopharmacology, 2012, Volume: 224, Issue:3 Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affect; Autonomic Agents; Body Temperature Regulation; Carbazoles; Carvedilol; Clonidine; Cross-Over Studies; Dopamine Uptake Inhibitors; Doxazosin; Duloxetine Hydrochloride; Female; Hemodynamics; Humans; Light; Male; Miosis; Morpholines; Mydriasis; Mydriatics; N-Methyl-3,4-methylenedioxyamphetamine; Propanolamines; Randomized Controlled Trials as Topic; Reaction Time; Reboxetine; Recovery of Function; Reflex, Pupillary; Selective Serotonin Reuptake Inhibitors; Thiophenes; Time Factors; Young Adult	2012

Article

Year

Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.

Psychopharmacology, 2012, Volume: 224, Issue:3

Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affect; Autonomic Agents; Body Temperature Regulation; Carbazoles; Carvedilol; Clonidine; Cross-Over Studies; Dopamine Uptake Inhibitors; Doxazosin; Duloxetine Hydrochloride; Female; Hemodynamics; Humans; Light; Male; Miosis; Morpholines; Mydriasis; Mydriatics; N-Methyl-3,4-methylenedioxyamphetamine; Propanolamines; Randomized Controlled Trials as Topic; Reaction Time; Reboxetine; Recovery of Function; Reflex, Pupillary; Selective Serotonin Reuptake Inhibitors; Thiophenes; Time Factors; Young Adult

2012

Trials

1 trial(s) available for reboxetine and clonidine

Article	Year
The memory function of noradrenergic activity in non-REM sleep. Journal of cognitive neuroscience, 2011, Volume: 23, Issue:9 Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Association Learning; Clonidine; Cross-Over Studies; Humans; Male; Memory; Morpholines; Norepinephrine; Odorants; Polysomnography; Reboxetine; Recognition, Psychology; Ribonucleoproteins, Small Nuclear; Saccharomyces cerevisiae Proteins; Sleep Deprivation; Sleep Stages; Time Factors; Verbal Learning; Wakefulness; Young Adult	2011

Article

Year

The memory function of noradrenergic activity in non-REM sleep.

Journal of cognitive neuroscience, 2011, Volume: 23, Issue:9

Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Association Learning; Clonidine; Cross-Over Studies; Humans; Male; Memory; Morpholines; Norepinephrine; Odorants; Polysomnography; Reboxetine; Recognition, Psychology; Ribonucleoproteins, Small Nuclear; Saccharomyces cerevisiae Proteins; Sleep Deprivation; Sleep Stages; Time Factors; Verbal Learning; Wakefulness; Young Adult

2011

Other Studies

11 other study(ies) available for reboxetine and clonidine

Article	Year
Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression. European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Analgesics; Animals; Antidepressive Agents; Body Temperature; Clonidine; Depression; Disease Models, Animal; Drug Therapy, Combination; Exploratory Behavior; Hydroxyindoleacetic Acid; Male; Morpholines; Motor Activity; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Reboxetine; Serotonin Receptor Agonists; Sertraline; Swimming	1999
Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain. British journal of pharmacology, 1999, Volume: 128, Issue:6 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Biogenic Monoamines; Brain; Clonidine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Space; Frontal Lobe; Hippocampus; Idazoxan; Male; Microdialysis; Morpholines; Norepinephrine; Rats; Rats, Sprague-Dawley; Reboxetine; Serotonin; Sodium Chloride; Time Factors	1999
Chronic treatment with reboxetine by osmotic pumps facilitates its effect on extracellular noradrenaline and may desensitize alpha(2)-adrenoceptors in the prefrontal cortex. British journal of pharmacology, 2001, Volume: 132, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Clonidine; Dopamine; Extracellular Space; Injections, Intraperitoneal; Male; Microdialysis; Morpholines; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reboxetine; Receptors, Adrenergic, alpha-2; Time Factors	2001
Modulation of MK-801-induced behaviour by noradrenergic agents in mice. Psychopharmacology, 2001, Mar-01, Volume: 154, Issue:2 Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Ataxia; Benzylamines; Clonidine; Desipramine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Frontal Lobe; Male; Mesencephalon; Mice; Morpholines; Motor Activity; Norepinephrine; Prazosin; Reboxetine; Stereotyped Behavior	2001
Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons. The European journal of neuroscience, 2001, Volume: 13, Issue:11 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Clonidine; Depression; Dose-Response Relationship, Drug; Indophenol; Locus Coeruleus; Male; Morpholines; Norepinephrine; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reboxetine; Serotonin; Serotonin Receptor Agonists	2001
Effects of acute and chronic reboxetine treatment on stress-induced monoamine efflux in the rat frontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 27, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Biogenic Monoamines; Clonidine; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Space; Male; Microdialysis; Morpholines; Neural Pathways; Norepinephrine; Pain Threshold; Physical Stimulation; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reboxetine; Receptors, Adrenergic, alpha-2; Serotonin; Stress, Physiological; Synaptic Transmission	2002
Chronic reboxetine desensitizes terminal but not somatodendritic alpha2-adrenoceptors controlling noradrenaline release in the rat dorsal hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:6 Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Clonidine; Dendrites; Extracellular Space; Hippocampus; Infusion Pumps, Implantable; Injections, Intraperitoneal; Locus Coeruleus; Male; Microinjections; Morpholines; Norepinephrine; Rats; Reboxetine; Receptors, Adrenergic, alpha-2	2005
The antinociceptive properties of reboxetine in acute pain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:10 Topics: Adrenergic Antagonists; Analgesics; Animals; Antidepressive Agents; Clonidine; Disease Models, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Reboxetine; Receptors, Opioid, mu	2009
Morris water maze performance deficit produced by intermittent swim stress is partially mediated by norepinephrine. Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Clonidine; Desipramine; Hippocampus; Learning; Male; Maze Learning; Memory Disorders; Morpholines; Norepinephrine; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reboxetine; Swimming	2012
Altered neuronal activity and differential sensitivity to acute antidepressants of locus coeruleus and dorsal raphe nucleus in Wistar Kyoto rats: a comparative study with Sprague Dawley and Wistar rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:7 Topics: Action Potentials; Animals; Antidepressive Agents; Clonidine; Dorsal Raphe Nucleus; Locus Coeruleus; Male; Morpholines; Neurons; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Rats, Wistar; Reboxetine; Species Specificity	2014
Noradrenaline Modulates Visual Perception and Late Visually Evoked Activity. Current biology : CB, 2018, 07-23, Volume: 28, Issue:14 Topics: Adult; Clonidine; Cross-Over Studies; Double-Blind Method; Down-Regulation; Electroencephalography; Evoked Potentials, Visual; Humans; Magnetic Resonance Imaging; Male; Norepinephrine; Reboxetine; Sympatholytics; Sympathomimetics; Up-Regulation; Visual Perception; Young Adult	2018