Page last updated: 2024-09-03

reboxetine and amitriptyline

reboxetine has been researched along with amitriptyline in 10 studies

Compound Research Comparison

Studies
(reboxetine)
Trials
(reboxetine)
Recent Studies (post-2010)
(reboxetine)
Studies
(amitriptyline)
Trials
(amitriptyline)
Recent Studies (post-2010) (amitriptyline)
6261931846,9351,3811,060

Protein Interaction Comparison

ProteinTaxonomyreboxetine (IC50)amitriptyline (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.006
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.023
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.081
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.0053
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.3
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.044
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.008
Alpha-2A adrenergic receptorHomo sapiens (human)0.1755
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.011
D(2) dopamine receptorHomo sapiens (human)1.009
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.044
Alpha-2B adrenergic receptorHomo sapiens (human)0.004
Alpha-2C adrenergic receptorHomo sapiens (human)0.0295
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.02
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.026
D(1A) dopamine receptorHomo sapiens (human)0.355
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.0324
Histamine H2 receptorHomo sapiens (human)0.73
Alpha-1D adrenergic receptorHomo sapiens (human)0.105
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.015
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.006
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)1.02
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 6Rattus norvegicus (Norway rat)0.044
Sodium-dependent serotonin transporterHomo sapiens (human)0.2756
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 5ARattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 5BRattus norvegicus (Norway rat)0.044
Histamine H1 receptorHomo sapiens (human)0.0048
D(3) dopamine receptorHomo sapiens (human)0.182
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.07
Histamine H2 receptorCavia porcellus (domestic guinea pig)0.66
5-hydroxytryptamine receptor 6Homo sapiens (human)0.14
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)7.2446
Sodium channel protein type 5 subunit alphaHomo sapiens (human)1.6
Sodium channel protein type 9 subunit alphaHomo sapiens (human)4
5-hydroxytryptamine receptor 4 Rattus norvegicus (Norway rat)0.044
Sodium channel protein type 2 subunit alphaHomo sapiens (human)3.1
Sigma non-opioid intracellular receptor 1Homo sapiens (human)1.031
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)0.044

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's6 (60.00)29.6817
2010's1 (10.00)24.3611
2020's2 (20.00)2.80

Authors

AuthorsStudies
Hindmarch, I; Kerr, JS; Powell, J1
Bradshaw, CM; Langley, RW; Phillips, MA; Szabadi, E1
Bitsios, P; Bradshaw, CM; Phillips, MA; Szabadi, E1
Hinkka, S; Kuusela, T; Penttilä, J; Scheinin, H; Syvälahti, E1
Agelink, MW; Brockmeyer, NH; Passenberg, P; Sayar, K; Ullrich, H1
Amann, B; Hegerl, U; Juckel, G; Mergl, R; Mulert, C; Padberg, F; Pogarell, O; Sterr, A1
Aburakawa, Y; Aizawa, H; Hasebe, N; Kwak, S; Sawada, J; Yamashita, T1
Fisar, Z; Hroudová, J; Raboch, J1
Koziorowski, M; Mytych, J; Sołek, P; Tabęcka-Łonczyńska, A1
Hatano, M; Ikuta, T; Iwata, N; Kishi, T; Matsuda, Y; Okuya, M; Sakuma, K1

Reviews

1 review(s) available for reboxetine and amitriptyline

ArticleYear
Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis.
    Molecular psychiatry, 2023, Volume: 28, Issue:1

    Topics: Adult; Amitriptyline; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Desvenlafaxine Succinate; Duloxetine Hydrochloride; Female; Fluoxetine; Fluvoxamine; Humans; Mirtazapine; Network Meta-Analysis; Paroxetine; Randomized Controlled Trials as Topic; Reboxetine; Sertraline; Venlafaxine Hydrochloride; Vortioxetine

2023

Trials

4 trial(s) available for reboxetine and amitriptyline

ArticleYear
The effects of reboxetine and amitriptyline, with and without alcohol on cognitive function and psychomotor performance.
    British journal of clinical pharmacology, 1996, Volume: 42, Issue:2

    Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Central Nervous System Depressants; Cognition; Drug Interactions; Ethanol; Humans; Male; Morpholines; Psychomotor Performance; Reboxetine

1996
The effects of some antidepressant drugs on prepulse inhibition of the acoustic startle (eyeblink) response and the N1/P2 auditory evoked response in man.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:1

    Topics: Administration, Oral; Adolescent; Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Antidepressive Agents; Arousal; Attention; Blinking; Cross-Over Studies; Double-Blind Method; Electroencephalography; Electromyography; Evoked Potentials, Auditory; Fluvoxamine; Humans; Male; Morpholines; Neural Inhibition; Reaction Time; Reboxetine; Reflex, Startle

2000
Comparison of the antidepressants reboxetine, fluvoxamine and amitriptyline upon spontaneous pupillary fluctuations in healthy human volunteers.
    Psychopharmacology, 2000, Volume: 149, Issue:1

    Topics: Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents; Anxiety; Cross-Over Studies; Double-Blind Method; Fluvoxamine; Happiness; Humans; Male; Morpholines; Psychiatric Status Rating Scales; Pupil; Reboxetine; Wakefulness

2000
The effects of amitriptyline, citalopram and reboxetine on autonomic nervous system. A randomised placebo-controlled study on healthy volunteers.
    Psychopharmacology, 2001, Volume: 154, Issue:4

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Analysis of Variance; Autonomic Nervous System; Blood Pressure; Catecholamines; Citalopram; Cross-Over Studies; Double-Blind Method; Heart Rate; Humans; Linear Models; Male; Morpholines; Reboxetine; Salivation; Selective Serotonin Reuptake Inhibitors; Statistics, Nonparametric

2001

Other Studies

5 other study(ies) available for reboxetine and amitriptyline

ArticleYear
Superior safety of reboxetine over amitryptiline in the elderly.
    European journal of medical research, 2002, Sep-30, Volume: 7, Issue:9

    Topics: Aged; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Female; Humans; Morpholines; Reboxetine; Suicide, Attempted

2002
Electroencephalographic abnormalities associated with antidepressant treatment: a comparison of mirtazapine, venlafaxine, citalopram, reboxetine, and amitriptyline.
    The Journal of clinical psychiatry, 2006, Volume: 67, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents; Cerebral Cortex; Citalopram; Cyclohexanols; Electroencephalography; Epilepsy; Female; Humans; Male; Mental Disorders; Mianserin; Middle Aged; Mirtazapine; Morpholines; Reboxetine; Venlafaxine Hydrochloride

2006
Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line.
    Neuroscience research, 2009, Volume: 64, Issue:3

    Topics: Adenosine Deaminase; Amitriptyline; Amyotrophic Lateral Sclerosis; Antidepressive Agents; Arginine; Cyclopropanes; Desipramine; Fluoxetine; Fluvoxamine; Glutamine; HeLa Cells; Humans; Imipramine; Milnacipran; Morpholines; Paroxetine; Reboxetine; Receptors, AMPA; RNA Editing; RNA-Binding Proteins; RNA, Messenger

2009
Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.
    Neuro endocrinology letters, 2010, Volume: 31, Issue:5

    Topics: Affect; Amitriptyline; Animals; Antidepressive Agents; Antimanic Agents; Benzodiazepines; Cerebral Cortex; Citalopram; Clorgyline; Cocaine; Cyclohexanols; Desipramine; Fluoxetine; Imipramine; In Vitro Techniques; Iproniazid; Lithium; Mianserin; Mirtazapine; Mitochondria; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; Olanzapine; Pargyline; Reboxetine; Swine; Thiazepines; Valproic Acid; Venlafaxine Hydrochloride

2010
Molecular Consequences of Depression Treatment: A Potential In Vitro Mechanism for Antidepressants-Induced Reprotoxic Side Effects.
    International journal of molecular sciences, 2021, Nov-01, Volume: 22, Issue:21

    Topics: Amitriptyline; Animals; Antidepressive Agents; Antipsychotic Agents; Cell Line; Escitalopram; Fluoxetine; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation; Imipramine; Male; Mice; Micronuclei, Chromosome-Defective; Mirtazapine; Models, Biological; Olanzapine; Organ Specificity; Reboxetine; Reproduction; Signal Transduction; Spermatogenesis; Telomeric Repeat Binding Protein 1; Telomeric Repeat Binding Protein 2; Time Factors; Venlafaxine Hydrochloride

2021