reamberin and 10-carboxymethyl-9-acridanone

Efficiency of reamberin and cycloferon application combination at the patients with the heavy form of acute tonsillitis was investigated. It is set that cycloferon and reamberin application in the complex of treatment of the patients with this pathology is instrumental in normalization of the general state and feel of patients, liquidation of both commontoxic syndrome and local inflammatory displays in pharynx, and also normalization of the studied biochemical and immunological indexes. Application of cycloferon and reamberin provides the decline of "average molecules" and malon dialdehyde level to norm, that testifies about liquidation endogenous "metabolic" intoxication syndrome, and also instrumental in normalization of phagocytes activity of monocytes indexes, that describe normalize operating of the indicated preparation on the macrophage phagocytes system.

Topics: Acridines; Acute Disease; Adult; Antioxidants; Drug Therapy, Combination; Female; Humans; Interferon Inducers; Male; Meglumine; Middle Aged; Severity of Illness Index; Succinates; Tonsillitis; Treatment Outcome; Young Adult

We studied 73 patients with paranoid schizophrenia with resistance to neuroleptics. All patients were divided into two groups - basic (37 patients) and comparison (36 patients). Both groups received traditional treatment. Patients of the basic group were treated with the combination of reamberin and cycloferon. Before treatment, significant alterations in the interferon status (IFS), which were characterized by the decrease of serum interferon (SIFN) activity and blood α- and γ-interferons (IFN) levels, were identified in both group. The positive effect of the drug combination on clinical symptoms and interferon status (the normalization of SIFN activity, increase in blood α- and γ-IFN levels) was found.

Topics: Acridines; Adult; Antipsychotic Agents; Drug Resistance; Drug Therapy, Combination; Humans; Interferon Inducers; Interferon-alpha; Interferon-gamma; Meglumine; Middle Aged; Schizophrenia, Paranoid; Succinates; Young Adult

To assess efficacy of combined immunocorrection in the treatment of patients with chronic viral hepatitis C (CVHC).. Routine clinicobiochemical tests, examination of immunological homeostasis (cellular immunity, the level of circulating immune complexes - CIC and their molecular composition, macrophagal phagocyting system - MPS) were made in two groups of CVHC patients: the study group (n=68) and control group (n=66). The control patients received standard treatment, the study group received also cyclopheron in combination with reamberin. Cyclopheron was given per os in a single daily dose 600 mg 2 days, then 3 times a week in a dose 150 mg for 48 weeks. Reamberin infusions in a single daily dose 400 ml were made for 5 - 7 days.. CVHC in exacerbation phase is characterized by the presence of secondary immunodeficiency running with T-lymphopenia, low count of peripheral blood lymphocytes with CD4+ phenotype and low immunoregulatory index CD4/CD8, depression of functional activity of T-cells as evidenced by lymphocyte blast transformation test with phytohemagglutinin, inhibition of phagocyting activity of monocytes and inhibition of dermal macrophages. This shows subnormal functional activity of MPS. CVHC runs with accumulation of CIC in blood serum primarily due to increased content of most pathogenic mid- and low-molecular .ifactions of immune complexes. Addition ofcyclopheron and reamberin in combined treatment of CVHC patients promotes normalization of immunological homeostasis which clinically occurs in parallel with achievement of persistent and long-term CVHC remission.. The results of the above investigation support pathogenetic validity and prospects of cyclopheron and reamberin inclusion into combined treatment of CVHC.

Topics: Acridines; Adult; Antigen-Antibody Complex; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Immunity, Cellular; Interferon Inducers; Interferon-alpha; Leukocytes, Mononuclear; Lymphocyte Count; Macrophages; Male; Meglumine; Middle Aged; Phagocytosis; Ribavirin; Succinates; T-Lymphocytes; Treatment Outcome; Young Adult

The 160 patients with paranoid schizophrenia (PSH) with neuroleptic therapeutic resistance (TR) was investigated. The 90 (basic group) patients got of modern detoxic and metabolically active preparation reamberin and immunotropic facilities cycloferon combination additionally to psychotropic preparations and 70 patients (comparison group) - only the generally accepted therapy. Positive influence of reamberin and cycloferon combination was set on clinical states at the patients of PSH such as disease remission, and endogenous toxicosis syndrome liquidation. Positive influence of this preparations combination was rationed on immunological indexes, characterizing composition and functional activity of cellular immunity.

Topics: Acridines; Adult; Drug Therapy, Combination; Female; Humans; Interferon Inducers; Male; Meglumine; Middle Aged; Schizophrenia, Paranoid; Succinates; Young Adult

The increase of severe cases of acute tonsillitis (AT) is presently marked. Severe cases of AT disturb immune and metabolic homoeostasis initiating the development of disease. Therapy optimization is required to select the best treatment. In patients with severe cases of AT of mixed viral/bacterial etiology before the treatment it is revealed the increase of general activity of lactatedehydrigenase (LDH) and increase of the level of cathode "anaerobic" factions LDH4+5 and the decline of concentration ATP in the blood. There was a compensatory rise of level of ADP and АМP. The substantial decline of serum interferon (CIF) activity and diminishing maintenance of α-interferon (α-IFN) and γ-interferon (γ-IFN) in the blood of the patients, that testified to oppressing of interferonogenesis. Treatment of severe cases of AT of mixed viral/bacterial etiology of modern detoxic preparation reamberin and immunoactive preparation cycloferon combination positively influences the studied laboratory indexes. The improvement of power metabolism is marked, that was characterized by normalization of level adenine nucleotides (ATP, АDP, АМP) and general activity of LDH and its izoenzimes spectrum. At the same time the increase of CIF level is set, maintenances α-IFN and γ-IFN in the blood, that testified to the improvement of interferonogenesis. The results demonstrate the therapeutic potential of reamberin and cycloferon combination for treatment of patients with AT of mixed viral/bacterial etiology.

Topics: Acridines; Adenine Nucleotides; Adolescent; Adult; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Injections, Intramuscular; Interferons; Isoenzymes; L-Lactate Dehydrogenase; Male; Meglumine; Middle Aged; Succinates; Tonsillitis

The cytokine profile of blood (CPB) at the patients with chronic sepsis (CS) streptococcus or mixed (by a streptococcus and to staphylococcus etiology) was studied. To beginning of the treatment at intensifying of CS at the patients was detected the substantial increase of maintenance of proinflammatory (IL - 1β, IL - 2, IL - 6, TNF -α) cytokines (CК) in the blood serum at the moderate increase of antiinflammatory CK (IL-4). Thus, indexes, characterizing correlation pro- and antiinflammatory CК was rate, that testified to predominating of proinflammatory potencies of blood. Application in the complex treatment of the patients with CS combination of modern detoxic preparation reamberin and immunoactive preparation cycloferon promotes normalizations of CK maintenance in the blood and betweennesss by them. In a clinical plan the use of the reamberin and cycloferon combination provided acceleration of CS intensifying liquidation. Finding allow to consider pathogenetic reasonable and clinically perspective application of this preparations combination in treatment of the patients with CS.

Topics: Acridines; Adolescent; Adult; Chronic Disease; Cytokines; Drug Therapy, Combination; Female; Humans; Male; Meglumine; Middle Aged; Sepsis; Succinates

The clinical efficiency of a reamberin and cycloferon combination for the treatment of hepatic cirrhosis (HC) associated with chronic HCV infection has been studied. Immunological investigation of patients carried out before the treatment revealed a significant increase in the level of proinflammatory cytokines (CK) in serum, whereas the level of anti-inflammatory CK changed rather insignificantly. Use of the reamberin - cycloferon combination provided faster clinical-biochemical remission and, in respect of the pathogenetic state, ensured normalization of the CK profile in the blood. Based on these data, it can be considered as pathogenetically proved and clinically feasible and promising to use the reamberin - cycloferon combinations for a complex treatment of patients with HC associated with chronic HCV-infection.

Topics: Acridines; Antiviral Agents; Cytokines; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon Inducers; Liver; Liver Cirrhosis; Meglumine; Remission Induction; Succinates; Th1-Th2 Balance; Treatment Outcome; Viral Load

The use of reamberin and cycloferon combination for increasing the antibacterial therapy efficacy in patients with chronic sepsis (CS) was studied. It was shown that the combination provided more rapid elimination of the CS exacerbation symptoms, normalization of the hematologic indices, bacteriemia eradication and reduction of the cytokine blood profile--normal serum levels of proinflammatory (IL-1beta, IL-2, IL-6 and TNF-alpha) and antiinflammatory (IL-4) cytokines. The findings allowed to considered the use of the reamberin and cycloferon combination in the treatment of patients with CS pathogenetically reasonable and clinically perspective for increasing the antibacterial therapy efficacy.

Topics: Acridines; Adolescent; Adult; Anti-Bacterial Agents; Bacteremia; Cytokines; Drug Therapy, Combination; Female; Humans; Interferon Inducers; Interleukin-1beta; Interleukin-2; Interleukin-4; Interleukin-6; Male; Meglumine; Middle Aged; Sepsis; Streptococcus pyogenes; Succinates; Tumor Necrosis Factor-alpha

The purpose of the study was to improve efficiency of treatment of the patients with severe community-acquired pneumonia at the expense of optimization of schemes of intensive therapy using immunomodulators, antioxidants and antihypoxants. The study involved 142 patients with severe community-acquired pneumonia who were divided into 4 groups. The properties of the erythrocytes membranes, some indicators of immune system and endotoxicosis were examined. It has been determined, that the use of Cycloferonum increases the functionale state of active link of T-immunity. It has been established that the use of Reamberinum while applying the complex therapy results in accelerating the normalization of endotoxicosis indices, it favourably effects the properties of the erythrocytes membranes. The positive influence of Cycloferonum and Reamberinum has been proved. The inclusion of the preparations Reamberinum and Cycloferonum into the complex of intensive therapy to the patients with severe community-acquired pneumonia reduces the bed-staying at the department of intensive care unit.

Topics: Acridines; Adult; Aged; B-Lymphocytes; Combined Modality Therapy; Community-Acquired Infections; Critical Care; Female; Humans; Interferon Inducers; Lymphocyte Count; Male; Meglumine; Middle Aged; Pneumonia, Bacterial; Republic of Belarus; Succinates; T-Lymphocytes; Young Adult