rcc 36 has been researched along with temiverine in 11 studies
| Studies (rcc 36) | Trials (rcc 36) | Recent Studies (post-2010) (rcc 36) | Studies (temiverine) | Trials (temiverine) | Recent Studies (post-2010) (temiverine) |
|---|---|---|---|---|---|
| 11 | 0 | 0 | 34 | 1 | 2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hirota, T; Morino, A; Nakamura, A; Sugihara, K | 2 |
| Fukui, H; Hamada, K; Kimura, K; Kimura, Y; Ogasawara, T; Ukai, Y; Yamazaki, C; Yoshikuni, Y | 1 |
| Fukui, H; Hamada, K; Kimura, K; Kimura, Y; Ogasawara, T; Ukai, Y; Yoshikuni, Y | 1 |
| Hayashi, S; Kimura, K; Natsukawa, T; Suma, C; Ukai, Y; Yoshikuni, Y | 1 |
| Hayashi, S; Kimura, K; Natsukawa, T; Ukai, Y; Yoshikuni, Y | 1 |
| Furukawa, S; Ishibashi, S; Iwakura, K; Kikumori, M; Kouyama, H; Nishimori, T; Sumi, N; Taniguchi, Y | 1 |
| Iwakura, K; Kitayama, E; Sumi, N; Tamura, H; Watanabe, M; Yamashita, Y | 1 |
| Hamada, K; Kimura, K; Kimura, Y; Sasaki, Y; Seto, T; Ukai, Y; Yamazaki, C; Yoshikuni, Y | 1 |
| Hayashi, S; Kimura, K; Matsuzaki, T; Natsukawa, T; Ukai, Y; Yoshikuni, Y | 1 |
| Kikukawa, H; Nishi, K; Ueda, S; Wada, Y; Yoshida, M | 1 |
11 other study(ies) available for rcc 36 and temiverine
| Article | Year |
|---|---|
Pharmacokinetics of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate. 3rd communication: plasma concentrations of the unchanged drug and its deethylated metabolite in rats, dogs and monkey
Topics: Administration, Oral; Animals; Antihypertensive Agents; Biotransformation; Blood Proteins; Calcium Channel Blockers; Dealkylation; Dogs; Hydroxylation; In Vitro Techniques; Injections, Intravenous; Macaca fascicularis; Male; Microsomes, Liver; Phenylacetates; Protein Binding; Rats; Rats, Sprague-Dawley | 1997 |
Pharmacokinetics of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate. 4th communication: metabolism in rats and dogs.
Topics: Animals; Antihypertensive Agents; Bile; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dealkylation; Dogs; Hydroxylation; Male; Mass Spectrometry; Phenylacetates; Rats; Rats, Sprague-Dawley | 1997 |
Effect of the anticholinergic drug with calcium antagonistic activity, (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate, on lower urinary tract function in decerebrated dogs.
Topics: Animals; Calcium Channel Blockers; Cholinergic Antagonists; Decerebrate State; Dogs; Electromyography; Phenylacetates; Urinary Bladder; Urinary Tract; Urination; Urodynamics | 1997 |
Effect of the anticholinergic drug with calcium antagonistic activity, (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate, on lower urinary tract function in rhesus monkeys.
Topics: Animals; Calcium Channel Blockers; Cholinergic Antagonists; Cystoscopy; Injections, Intravenous; Macaca mulatta; Male; Phenylacetates; Urinary Bladder; Urinary Tract; Urination; Urodynamics | 1997 |
Cardiac electrophysiological actions of NS-21 and its active metabolite, RCC-36, compared with terodiline.
Topics: Animals; Butylamines; Calcium; Calcium Channel Blockers; Cholinergic Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart; Myocardial Contraction; Myocardium; Parasympatholytics; Patch-Clamp Techniques; Phenylacetates; Potassium | 1997 |
Inhibitory effects of NS-21, a novel drug for urinary incontinence, and its active metabolite, RCC-36, on L-type calcium currents in isolated guinea pig detrusor smooth muscle cells.
Topics: Animals; Butylamines; Calcium; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle, Smooth; Parasympatholytics; Patch-Clamp Techniques; Phenylacetates; Urinary Bladder; Urinary Incontinence | 1997 |
[Oral single-dose and 13-week repeat-dose toxicity studies of RCC-36, the active metabolite of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate(NS-21), a novel drug for urinary frequency a
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Male; Phenylacetates; Rats; Rats, Sprague-Dawley; Urinary Incontinence; Urination Disorders | 1997 |
[Mutagenicity studies of RCC-36, the active metabolite of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence].
Topics: Animals; Cells, Cultured; Cricetinae; Erythrocytes; Escherichia coli; Male; Mice; Molecular Structure; Mutagenicity Tests; Mutagens; Phenylacetates; Salmonella typhimurium; Urinary Incontinence; Urination Disorders | 1997 |
Effect of NS-21, an anticholinergic drug with calcium antagonistic activity, on lower urinary tract function in a rat model of urinary frequency.
Topics: Animals; Atropine; Benzilates; Calcium Channel Blockers; Denervation; Disease Models, Animal; Flavoxate; Hypogastric Plexus; Male; Mandelic Acids; Parasympatholytics; Phenylacetates; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urinary Incontinence | 1997 |
Comparison of the effects of NS-21 and terodiline on the QTc interval in dogs.
Topics: Animals; Butylamines; Calcium Channel Blockers; Cholinergic Antagonists; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Guinea Pigs; In Vitro Techniques; Phenylacetates | 1998 |
Pharmacologic actions of temiverine (p-INN) and its active metabolite, RCC-36, on isolated human urinary bladder muscle.
Topics: Acetylcholine; Aged; Atropine; Calcium Channel Blockers; Calcium Chloride; Cholinergic Antagonists; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Mandelic Acids; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Phenylacetates; Potassium Chloride; Urinary Bladder | 1998 |