rb 38 a has been researched along with thiorphan in 3 studies
*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]
*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]
| Studies (rb 38 a) | Trials (rb 38 a) | Recent Studies (post-2010) (rb 38 a) | Studies (thiorphan) | Trials (thiorphan) | Recent Studies (post-2010) (thiorphan) |
|---|---|---|---|---|---|
| 10 | 0 | 0 | 665 | 50 | 82 |
| Protein | Taxonomy | rb 38 a (IC50) | thiorphan (IC50) |
|---|---|---|---|
| Thermolysin | Bacillus thermoproteolyticus | 9.5 | |
| Neprilysin | Rattus norvegicus (Norway rat) | 0.0058 | |
| Neprilysin | Oryctolagus cuniculus (rabbit) | 0.0085 | |
| Neprilysin | Homo sapiens (human) | 0.0024 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.2281 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.42 | |
| Neprilysin | Sus scrofa (pig) | 0.0062 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Delay-Goyet, P; Meucci, E; Roques, BP; Zajac, JM | 1 |
| Callebert, J; Daugé, V; Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Villette, JM | 1 |
3 other study(ies) available for rb 38 a and thiorphan
| Article | Year |
|---|---|
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1992 |
Binding in vivo of selective mu and delta opioid receptor agonists: opioid receptor occupancy by endogenous enkephalins.
Topics: Animals; Brain; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; In Vitro Techniques; Injections; Kinetics; Male; Mice; Morphine; Oligopeptides; Phenylalanine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan | 1989 |
Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Hydroxamic Acids; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Neprilysin; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1989 |