Page last updated: 2024-09-03

rb 38 a and naloxone

rb 38 a has been researched along with naloxone in 7 studies

Compound Research Comparison

Studies
(rb 38 a)
Trials
(rb 38 a)
Recent Studies (post-2010)
(rb 38 a)
Studies
(naloxone)
Trials
(naloxone)
Recent Studies (post-2010) (naloxone)
100020,1341,2573,321

Protein Interaction Comparison

ProteinTaxonomyrb 38 a (IC50)naloxone (IC50)
Cytochrome P450 2D6Homo sapiens (human)2
Delta-type opioid receptorMus musculus (house mouse)0.043
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0219
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0019
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0019
Mu-type opioid receptorHomo sapiens (human)0.0397
Delta-type opioid receptorHomo sapiens (human)0.1896
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.05
Kappa-type opioid receptorHomo sapiens (human)0.0795
Mu-type opioid receptorMus musculus (house mouse)0.0154
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0089
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0055

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's6 (85.71)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fournié-Zaluski, MC; Maldonado, R; Roques, BP1
Fournié-Zaluski, MC; Noble, F; Peyroux, J; Roques, BP; Schmidt, C1
Feger, J; Maldonado, R; Roques, BP; Waksman, G1
Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP1
Callebert, J; Daugé, V; Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Villette, JM1
Gibert-Rahola, J; Maldonado, R; Mico, JA; Roques, BP; Tejedor-Real, P1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O1

Other Studies

7 other study(ies) available for rb 38 a and naloxone

ArticleYear
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:4

    Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan

1992
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.
    European journal of pharmacology, 1991, Jan-10, Volume: 192, Issue:2

    Topics: Analgesics; Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalins; Hydroxamic Acids; Male; Mice; Morphine; Naloxone; Phenylalanine; Rats; Rats, Inbred Strains

1991
Naloxone-induced withdrawal syndrome after administration of selective opioid agonists or after activation of the endogenous enkephalinergic system.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Animals; Behavior, Animal; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Weight Loss

1990
Differences in physical dependence induced by selective mu or delta opioid agonists and by endogenous enkephalins protected by peptidase inhibitors.
    Brain research, 1990, Jun-18, Volume: 520, Issue:1-2

    Topics: Animals; Cerebral Ventricles; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Injections, Intraventricular; Male; Naloxone; Neprilysin; Oligopeptides; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values; Substance Withdrawal Syndrome; Substance-Related Disorders

1990
Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome.
    European journal of pharmacology, 1989, Jun-20, Volume: 165, Issue:2-3

    Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Hydroxamic Acids; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Neprilysin; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan

1989
Implication of endogenous opioid system in the learned helplessness model of depression.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Depression; Electroshock; Endorphins; Enkephalins; Helplessness, Learned; Hydroxamic Acids; Imipramine; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neprilysin; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar

1995
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
    Pain, 1994, Volume: 58, Issue:1

    Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley

1994