rb 101 has been researched along with morphine in 17 studies
| Studies (rb 101) | Trials (rb 101) | Recent Studies (post-2010) (rb 101) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 57 | 0 | 2 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | rb 101 (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (64.71) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S | 1 |
| Coric, P; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O | 1 |
| Abbadie, C; Besson, JM; Fournié-Zaluski, MC; Honoré, P; Roques, BP | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Carp, HM; Fournié-Zaluski, MC; Jayaram, A; Noreuil, T; Singh, P | 1 |
| Borrelli, E; Maldonado, R; Roques, BP; Saiardi, A; Samad, TA; Valverde, O | 1 |
| Beslot, F; Daugé, V; Fournié-Zaluski, MC; Noble, F; Roques, BP; Valverde, O | 1 |
| Benavides, J; Fournié-Zaluski, MC; Nieto, MM; Noble, F; Roques, BP; Walker, J; Wilson, J | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Noble, F; Roques, BP | 1 |
| Cordonnier, L; Noble, F; Roques, BP; Sanchez, M | 1 |
| Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A | 1 |
| Hurlé, MA; Lantero, A; Pílar-Cuellar, F; Roques, BP; Santillán, R; Tramullas, M; Valdizán, E | 1 |
17 other study(ies) available for rb 101 and morphine
| Article | Year |
|---|---|
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time | 1992 |
Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101.
Topics: Animals; Behavior, Animal; Body Weight; Disulfides; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss | 1995 |
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1994 |
Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation.
Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disulfides; Drug Interactions; Drug Tolerance; Hot Temperature; Immunohistochemistry; Injections, Intravenous; Male; Morphine; Neurons; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
Topics: Animals; Conditioning, Operant; Disulfides; Drug Interactions; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance-Related Disorders | 1993 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
Similar involvement of several brain areas in the antinociception of endogenous and exogenous opioids.
Topics: Analgesia; Analgesics, Opioid; Animals; Brain; Disulfides; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Opioid Peptides; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1996 |
RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Depression, Chemical; Disulfides; Enkephalins; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Phenylalanine; Pregnancy; Pregnancy, Animal; Prodrugs; Respiration | 1997 |
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors.
Topics: Animals; Behavior, Addictive; Blotting, Northern; Disulfides; Enzyme Inhibitors; Locomotion; Mice; Morphine; Phenylalanine; Receptors, Dopamine D2; Reward; Substance-Related Disorders | 1997 |
Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect.
Topics: Analgesics; Animals; Binding, Competitive; Conditioning, Psychological; Diprenorphine; Disulfides; Dronabinol; Drug Interactions; Enkephalin, Methionine; Extracellular Space; Male; Mice; Morphine; Motor Activity; Narcotic Antagonists; Narcotics; Neurons; Nociceptors; Nucleus Accumbens; Phenylalanine; Psychotropic Drugs; Reward; Substance Withdrawal Syndrome; Tritium | 2001 |
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disulfides; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Morphine; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time | 2001 |
RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.
Topics: Analgesics; Animals; Disulfides; Drug Tolerance; Enkephalins; Enzyme Inhibitors; Male; Morphine; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Blockade of morphine-induced behavioral sensitization by a combination of amisulpride and RB101, comparison with classical opioid maintenance treatments.
Topics: Amisulpride; Animals; Behavior, Animal; Buprenorphine; Disulfides; Male; Methadone; Mice; Morphine; Motor Activity; Opioid-Related Disorders; Phenylalanine; Sulpiride | 2007 |
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming | 2008 |
TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
Topics: Adenylyl Cyclase Inhibitors; Analgesia; Analgesics, Opioid; Animals; Disulfides; Hyperalgesia; Infusions, Subcutaneous; Membrane Proteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Neuralgia; Peripheral Nerve Injuries; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Signal Transduction; Spinal Cord; Transforming Growth Factor beta | 2014 |