rb 101 has been researched along with enkephalin, leucine in 32 studies
| Studies (rb 101) | Trials (rb 101) | Recent Studies (post-2010) (rb 101) | Studies (enkephalin, leucine) | Trials (enkephalin, leucine) | Recent Studies (post-2010) (enkephalin, leucine) |
|---|---|---|---|---|---|
| 57 | 0 | 2 | 11,524 | 80 | 754 |
| Protein | Taxonomy | rb 101 (IC50) | enkephalin, leucine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.0142 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0417 | |
| Mu-type opioid receptor | Homo sapiens (human) | 9.5 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0308 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.246 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (59.38) | 18.2507 |
| 2000's | 12 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Baamonde, A; Fournie-Zaluski, MC; Roques, BP; Ruiz-Gayo, M; Turcaud, S | 1 |
| Baamonde, A; Daugé, V; Fournié-Zaluski, MC; Fulga, IG; Roques, BP; Ruiz-Gayo, M; Turcaud, S | 1 |
| Durieux, C; Fournié-Zaluski, MC; Roques, BP; Ruiz-Gayo, M | 1 |
| Fournie-Zaluski, MC; Noble, F; Roques, BP; Soleilhac, JM; Soroca-Lucas, E; Turcaud, S | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Corringer, PJ; Dauge, V; Roques, BP | 1 |
| Blommaert, AG; Ducos, B; Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP | 2 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O | 1 |
| Noble, F; Roques, BP; Smadja, C | 1 |
| Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Derrien, M; Noble, F; Roques, BP | 1 |
| Fournie-Zaluski, MC; Maldonado, R; Roques, BP; Smadja, C; Turcaud, S | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F | 1 |
| Carp, HM; Fournié-Zaluski, MC; Jayaram, A; Noreuil, T; Singh, P | 1 |
| Coric, P; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F; Smadja, C | 1 |
| Liupina, IuV; Maldonado, R; Medvedeva, OF; Sudakov, SK; Tiurina, IV | 1 |
| Gilbert-Rahola, J; Maldonado, R; Micó, JA; Roques, BP; Smadja, C; Tejedor-Real, P | 1 |
| Boudinot, E; Denavit-Saubié, M; Fournié-Zaluski, M; Foutz, AS; Morin-Surun, M; Roques, BP | 1 |
| Benavides, J; Fournié-Zaluski, MC; Nieto, MM; Noble, F; Roques, BP; Walker, J; Wilson, J | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Noble, F; Roques, BP | 1 |
| Besson, JM; Buritova, J; Catheline, G; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
| Cordonnier, L; Noble, F; Roques, BP; Sanchez, M | 1 |
| Guen, SL; Kieffer, BL; Nieto, MM; Noble, F; Roques, BP | 1 |
| Canestrelli, C; Crété, D; Jardinaud, F; Ledent, C; Noble, F; Roques, BP | 1 |
| Bilkei-Gorzo, A; Michel, K; Noble, F; Roques, BP; Zimmer, A | 1 |
| Jutkiewicz, EM | 1 |
| Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A | 1 |
| Cabañero, D; Célérier, E; García-Nogales, P; Maldonado, R; Mata, M; Puig, MM; Roques, BP | 1 |
| Bansal, N; Fonseca, A; Gillis, J; Gulati, A; Horine, SV; Kuppalli, S; Mendelson, A; Southerland, WA | 1 |
2 review(s) available for rb 101 and enkephalin, leucine
| Article | Year |
|---|---|
RB101-mediated protection of endogenous opioids: potential therapeutic utility?
Topics: Aminopeptidases; Animals; Cholecystokinin; Disulfides; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Mice; Phenylalanine; Prodrugs; Rats | 2007 |
Dual Enkephalinase Inhibitors and Their Role in Chronic Pain Management.
Topics: CD13 Antigens; Chronic Pain; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Humans; Neprilysin; Phenylalanine; Propionates; Propylamines | 2021 |
30 other study(ies) available for rb 101 and enkephalin, leucine
| Article | Year |
|---|---|
In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding.
Topics: Analgesics; Animals; Brain; Cell Membrane; Diprenorphine; Disulfides; Enkephalins; Hot Temperature; Kinetics; Male; Mice; Mice, Inbred Strains; Neprilysin; Pain; Phenylalanine; Receptors, Opioid; Stress, Psychological; Tritium | 1992 |
Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Disulfides; Dopamine; Enkephalins; Male; Mice; Motor Activity; Phenylalanine; Prodrugs; Receptors, Dopamine D1; Receptors, Opioid, delta; Swimming | 1992 |
Stimulation of delta-opioid receptors reduces the in vivo binding of the cholecystokinin (CCK)-B-selective agonist [3H]pBC 264: evidence for a physiological regulation of CCKergic systems by endogenous enkephalins.
Topics: Analgesics; Analgesics, Opioid; Animals; Cholecystokinin; Dipeptides; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Narcotic Antagonists; Peptide Fragments; Phenylalanine; Prodrugs; Receptors, Cholecystokinin; Receptors, Opioid | 1992 |
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.
Topics: Aminopeptidases; Analgesia; Analgesics; Animals; Cell Membrane; Chromatography, High Pressure Liquid; Disulfides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Neprilysin; Phenylalanine; Prodrugs; Rats; Rats, Inbred Strains | 1992 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101.
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalins; Enzyme Inhibitors; Male; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Narcotic Antagonists; Peptide Fragments; Phenylalanine; Receptors, Cholecystokinin | 1995 |
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Body Temperature; Diprenorphine; Disulfides; Drug Combinations; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Mice; Morphine; Motor Activity; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Weight Loss | 1995 |
Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation.
Topics: Abdominal Muscles; Aminopeptidases; Analgesics; Animals; CD13 Antigens; Disulfides; Enkephalins; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Phenylalanine | 1994 |
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1994 |
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide | 1994 |
Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.
Topics: Adamantane; Analgesics; Animals; Benzodiazepinones; Dipeptides; Disulfides; Drug Synergism; Enkephalins; Indoles; Male; Meglumine; Nociceptors; Pain Measurement; Phenylalanine; Phenylurea Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Regression Analysis; Tail | 1994 |
Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain.
Topics: Amino Acid Sequence; Analgesics; Animals; Cholecystokinin; Disulfides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Oligopeptides; Pain; Pain Measurement; Peptide Fragments; Phenylalanine; Sincalide; Spinal Cord | 1993 |
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
Topics: Animals; Conditioning, Operant; Disulfides; Drug Interactions; Enkephalins; Enzyme Inhibitors; Male; Mice; Morphine; Naloxone; Phenylalanine; Prodrugs; Substance-Related Disorders | 1993 |
Opposite role of CCKA and CCKB receptors in the modulation of endogenous enkephalin antidepressant-like effects.
Topics: Analgesics; Animals; Antidepressive Agents; Benzodiazepinones; Cholecystokinin; Disulfides; Enkephalins; Male; Mice; Mice, Inbred Strains; Motor Activity; Peptide Fragments; Phenylalanine; Phenylurea Compounds; Receptors, Cholecystokinin | 1995 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Depression, Chemical; Disulfides; Enkephalins; Female; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Phenylalanine; Pregnancy; Pregnancy, Animal; Prodrugs; Respiration | 1997 |
CCK-B receptors in the limbic system modulate the antidepressant-like effects induced by endogenous enkephalins.
Topics: Amygdala; Animals; Caudate Nucleus; Disulfides; Enkephalins; Enzyme Inhibitors; Hormone Antagonists; Indoles; Injections, Intraventricular; Limbic System; Male; Meglumine; Mice; Motor Activity; Neprilysin; Nucleus Accumbens; Phenylalanine; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1997 |
[Characteristics of effects of mu-, delta-, and kappa-opioid agonists and enkephalinase inhibitor RB101 in rats of two inbred strains].
Topics: Analgesics; Animals; Depression, Chemical; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Male; Motor Activity; Neprilysin; Oligopeptides; Pain Measurement; Peptides; Phenylalanine; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model.
Topics: Analgesics; Animals; Behavior, Animal; Disulfides; Drug Interactions; Enkephalins; Helplessness, Learned; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta | 1998 |
Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration.
Topics: Analgesics; Animals; Cats; Dipeptides; Disulfides; Enkephalins; Enzyme Inhibitors; Mice; Naloxone; Narcotic Antagonists; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiration | 2001 |
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disulfides; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Morphine; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time | 2001 |
RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.
Topics: Analgesics; Animals; Disulfides; Drug Tolerance; Enkephalins; Enzyme Inhibitors; Male; Morphine; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Further evidence for the interaction of mu- and delta-opioid receptors in the antinociceptive effects of the dual inhibitor of enkephalin catabolism, RB101(S). A spinal c-Fos protein study in the rat under carrageenin inflammation.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Edema; Enkephalins; Gene Expression Regulation; Inflammation; Male; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 2003 |
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Inflammation; Male; Naloxone; Narcotic Antagonists; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2003 |
Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.
Topics: Amisulpride; Animals; Behavior, Animal; Disulfides; Dopamine Antagonists; Enkephalins; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Sulpiride; Swimming | 2005 |
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Emotions; Enkephalins; Enzyme Inhibitors; Exploratory Behavior; Freezing Reaction, Cataleptic; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Swimming; Time Factors | 2005 |
CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited.
Topics: Analysis of Variance; Animals; Anxiety; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Female; Immobility Response, Tonic; Male; Mice; Mice, Knockout; Motor Activity; Pain Threshold; Phenylalanine; Receptor, Cannabinoid, CB1 | 2005 |
Preproenkephalin knockout mice show no depression-related phenotype.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Hindlimb Suspension; Immobility Response, Tonic; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Motor Activity; Nialamide; Phenotype; Phenylalanine; Protein Precursors; Swimming; Vocalization, Animal | 2007 |
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming | 2008 |
The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins.
Topics: Analgesics; Animals; Disease Models, Animal; Disulfides; Down-Regulation; Enkephalins; Ganglia, Spinal; Male; Methyl Ethers; Mice; Pain Measurement; Pain Threshold; Pain, Postoperative; Phenylalanine; Piperidines; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Remifentanil; RNA, Messenger; Sevoflurane; Spinal Cord; Time Factors | 2009 |