Compounds > razoxane
Page last updated: 2024-08-23

razoxane and merbarone

razoxane has been researched along with merbarone in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (55.56)18.2507
2000's4 (44.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allan, WP; Fattman, CL; Hasinoff, BB; Yalowich, JC1
Anderson, H; Roberge, M1
Allan, WP; Creighton, AM; Fattman, CL; Hasinoff, BB; Kuschak, TI; Thampatty, P; Yalowich, JC1
Beck, WT; Mo, YY1
Falck, J; Jensen, LH; Jensen, PB; Nitiss, JL; Roerth, M; Rose, A; Sehested, M; Wessel, I1
Boland, MP; Fitzgerald, KA; O'Neill, LA1
Berger, NA; Chatterjee, S; Gosky, D; Hirota, H1
Eastmond, DA; Wang, L1
Snyder, RD1

Other Studies

9 other study(ies) available for razoxane and merbarone

ArticleYear
Collateral sensitivity to the bisdioxopiperazine dexrazoxane (ICRF-187) in etoposide (VP-16)-resistant human leukemia K562 cells.
    Biochemical pharmacology, 1996, Aug-23, Volume: 52, Issue:4

    Topics: Alkenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Humans; Leukemia; Polyenes; Pyrones; Razoxane; Thiobarbiturates

1996
Topoisomerase II inhibitors affect entry into mitosis and chromosome condensation in BHK cells.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1996, Volume: 7, Issue:1

    Topics: Aclarubicin; Alkenes; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Cycle Proteins; Cell Line; Chromosomes; Cricetinae; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; G2 Phase; Guanine Nucleotide Exchange Factors; Kidney; Mitosis; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Polyenes; Pyrones; Razoxane; Temperature; Thiobarbiturates; Topoisomerase II Inhibitors

1996
Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II.
    Biochemical pharmacology, 1997, Jun-15, Volume: 53, Issue:12

    Topics: Aclarubicin; Animals; CHO Cells; Cricetinae; DNA Topoisomerases, Type II; Drug Resistance; Ethylenediamines; Etoposide; Glycine; Mutation; Razoxane; Thiobarbiturates; Topoisomerase II Inhibitors; Verapamil

1997
DNA damage signals induction of fas ligand in tumor cells.
    Molecular pharmacology, 1999, Volume: 55, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; CHO Cells; Cricetinae; DNA; DNA Damage; Doxorubicin; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Jurkat Cells; Membrane Glycoproteins; Nucleic Acid Synthesis Inhibitors; Promoter Regions, Genetic; Razoxane; Recombinant Fusion Proteins; Signal Transduction; Teniposide; Thiobarbiturates; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Up-Regulation

1999
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
    Cancer research, 1999, Jul-15, Volume: 59, Issue:14

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; Amsacrine; Animals; Antineoplastic Agents; Binding Sites; Carcinoma, Small Cell; Catalysis; CHO Cells; Consensus Sequence; Cricetinae; Cricetulus; DNA Damage; DNA Mutational Analysis; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Humans; Lung Neoplasms; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Isoforms; Razoxane; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Thiobarbiturates; Topoisomerase II Inhibitors; Tumor Stem Cell Assay

1999
Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells.
    The Journal of biological chemistry, 2000, Aug-18, Volume: 275, Issue:33

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Line; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Activation; HL-60 Cells; Humans; Isoenzymes; Mitoxantrone; NF-kappa B; Protein Isoforms; Razoxane; Thiobarbiturates; Transcription, Genetic; Tumor Necrosis Factor-alpha

2000
Interference with topoisomerase IIalpha potentiates melphalan cytotoxicity.
    International journal of oncology, 2002, Volume: 20, Issue:2

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Blotting, Western; Cell Survival; CHO Cells; Chromosomes; Cricetinae; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Humans; Melphalan; Mutation; Razoxane; Sister Chromatid Exchange; Thiobarbiturates; Time Factors; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2002
Catalytic inhibitors of topoisomerase II are DNA-damaging agents: induction of chromosomal damage by merbarone and ICRF-187.
    Environmental and molecular mutagenesis, 2002, Volume: 39, Issue:4

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Kinetochores; Mice; Micronucleus Tests; Razoxane; Thiobarbiturates; Topoisomerase II Inhibitors

2002
Evidence from studies with intact mammalian cells that merbarone and bis(dioxopiperazine)s are topoisomerase II poisons.
    Drug and chemical toxicology, 2003, Volume: 26, Issue:1

    Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Damage; Micronucleus Tests; Molecular Structure; Mutagens; Razoxane; Structure-Activity Relationship; Thiobarbiturates; Topoisomerase II Inhibitors

2003