razaxaban has been researched along with isoxazoles in 9 studies
Studies (razaxaban) | Trials (razaxaban) | Recent Studies (post-2010) (razaxaban) | Studies (isoxazoles) | Trials (isoxazoles) | Recent Studies (post-2010) (isoxazoles) |
---|---|---|---|---|---|
20 | 0 | 2 | 8,633 | 900 | 3,337 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (55.56) | 29.6817 |
2010's | 4 (44.44) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Alexander, RS; Bai, S; Clark, CG; Ellis, CD; Han, Q; He, MY; Knabb, RM; Lam, PY; Li, R; Luettgen, JM; Pinto, DJ; Quan, ML; Sun, JH; Teleha, CA; Wexler, RR; Wong, PC | 1 |
Badawy, SI; Gray, DB; Hussain, MA; Schuster, AE; Sun, D; Zhao, F | 1 |
Crain, EJ; Knabb, RM; Lam, PY; Quan, ML; Watson, CA; Wexler, RR; Wong, PC | 1 |
Bonacorsi, SJ; Chen, SY; He, K; Knabb, RM; Lam, PY; Lecureux, L; Patrone, LM; Quan, M; Raghavan, N; Skiles, GL; Zhang, D; Zhang, H | 1 |
Badawy, SI; Friedman, EM; Hilden, LR; Pommier, CJ | 1 |
Alexander, RS; Amparo, E; Kish, K; Knabb, RM; Luettgen, JM; Morin, P; Pinto, DJ; Quan, ML; Rossi, KA; Sheriff, S; Smallwood, A; Wexler, RR; Woerner, FJ | 1 |
Barrett, YC; Frost, C; Shenker, A; Wang, Z | 1 |
Davis, B; Farndale, RW; Jarvis, GE; Koch, A; Pugh, N; Sakariassen, KS | 1 |
Badawy, SI; LaMarche, K; Narang, AS; Subramanian, G; Varia, SA | 1 |
9 other study(ies) available for razaxaban and isoxazoles
Article | Year |
---|---|
Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.
Topics: Administration, Oral; Animals; Biological Availability; Blood Proteins; Caco-2 Cells; Crystallography, X-Ray; Dogs; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; Imidazoles; Isoxazoles; Models, Molecular; Permeability; Protein Binding; Pyrazoles; Rabbits; Structure-Activity Relationship; Thrombosis | 2005 |
Formulation of solid dosage forms to overcome gastric pH interaction of the factor Xa inhibitor, BMS-561389.
Topics: Animals; Biological Availability; Chemistry, Pharmaceutical; Dogs; Drug Interactions; Excipients; Factor Xa Inhibitors; Famotidine; Gastric Acid; Gastrointestinal Agents; Gastrointestinal Tract; Histamine H2 Antagonists; Hydrogen-Ion Concentration; Intestinal Absorption; Isoxazoles; Pentagastrin; Povidone; Pyrazoles; Solubility; Tablets | 2006 |
Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Factor Xa; Fibrinolytic Agents; Hemorrhage; Hemostasis; Isoxazoles; Male; Platelet Aggregation; Pyrazoles; Rabbits; Thrombosis; Ticlopidine | 2007 |
Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs.
Topics: Animals; Anticoagulants; Benzamidines; Bile; Biotransformation; Cells, Cultured; Dogs; Feces; Hepatocytes; Isoxazoles; Liver; Male; Oxidation-Reduction; Pyrazoles; Rats; Rats, Sprague-Dawley | 2008 |
NIR chemical imaging to guide/support BMS-561389 tablet formulation development.
Topics: Antithrombin III; Chemistry, Pharmaceutical; Excipients; Isoxazoles; Particle Size; Pyrazoles; Spectroscopy, Near-Infrared; Tablets; Tartrates; Technology, Pharmaceutical | 2008 |
Phenyltriazolinones as potent factor Xa inhibitors.
Topics: Anticoagulants; Crystallography, X-Ray; Drug Design; Factor Xa Inhibitors; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Pyrazoles; Pyridones; Sulfones | 2010 |
Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay.
Topics: Anticoagulants; Blood Coagulation; Blood Coagulation Tests; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Drug Monitoring; Factor Xa Inhibitors; Humans; International Normalized Ratio; Isoxazoles; Morpholines; Predictive Value of Tests; Prothrombin Time; Pyrazoles; Pyridones; Reproducibility of Results; Rivaroxaban; Thiophenes; Venous Thromboembolism | 2010 |
The impact of factor Xa inhibition on axial dependent arterial thrombus formation triggered by a tissue factor rich surface.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Factor Xa; Factor Xa Inhibitors; Humans; Isoxazoles; Male; Middle Aged; Perfusion; Pyrazoles; Surface Properties; Thromboplastin; Thrombosis; Young Adult | 2012 |
Mechanistic basis for the effects of process parameters on quality attributes in high shear wet granulation.
Topics: Alanine; Drug Compounding; Isoxazoles; Particle Size; Porosity; Powders; Pyrazoles; Quality Control; Solubility; Tablets; Technology, Pharmaceutical; Triazines; Water | 2012 |