Compounds > raxofelast
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raxofelast and benzofurans

raxofelast has been researched along with benzofurans in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (40.00)18.2507
2000's12 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bianco, T; Centore, R; Giannetti, P; Scuri, R1
Avenoso, A; Calandra, S; Campo, GM; Caputi, AP; Ioculano, M; Saitta, A; Scuri, R; Squadrito, F; Zingarelli, B1
Giannetti, P; Paesano, A; Scuri, R1
Calapai, G; Campo, GM; Crisafulli, C; Marciano, MC; Mazzaglia, G; Rizzo, A; Scuri, R; Squadrito, F1
Altavilla, D; Calandra, S; Calapai, G; Campo, GM; Ioculano, M; Pollicino, AM; Rizzo, A; Scuri, R; Squadrito, F; Zingarelli, B1
Altavilla, D; Avenoso, A; Campo, GM; Campo, S; Caputi, AP; Ceccarelli, S; Ferlito, M; Quartarone, C; Saitta, A; Squadrito, F; Squadrito, G1
Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E1
Bello, V; Camastra, C; Ceccarelli, S; Iuliano, L; Pedersen, JZ; Violi, F1
Anggård, EE; Brett, SE; Chowienczyk, PJ; Gopaul, NK; Marchetti, M; Meeking, D; Ritter, JM; Russell-Jones, DL1
Altavilla, D; Campo, GM; Cavallari, V; Colonna, M; Cucinotta, D; Deodato, B; Galeano, M; Russo, G; Saitta, A; Sardella, A; Squadrito, F; Squadrito, G; Torre, V; Urna, G1
Altavilla, D; Buemi, M; Campo, GM; Cavallari, V; Colonna, M; Cucinotta, D; Deodato, B; Galeano, M; Squadrito, F; Sturiale, A; Torre, V1
Altavilla, D; Bono, D; Calò, M; Campo, GM; Famulari, C; Guarini, S; Leone, S; Macrì, A; Marini, H; Mioni, C; Passaniti, M; Santamaria, LB; Seminara, P; Squadrito, F; Venuti, FS1
Cho, HK; Chung, JH; Chung, kH; Hwang, KC; Jang, Y; Kang, SM; Kim, DH; Kwon, HM; Lee, H; Lee, KH; Lim, S1
Altavilla, D; Antonuccio, P; Bitto, A; Esposito, M; Impellizzeri, P; Marini, H; Romeo, C; Squadrito, F; Turiaco, N; Zuccarello, B1
Altavilla, D; Bitto, A; Calapai, G; Calò, M; Caputi, AP; Marini, H; Minutoli, L; Passaniti, M; Seminara, P; Squadrito, F; Squadrito, G1
Adamo, EB; Caccamo, D; Campisi, A; Ientile, R; Li Volti, G; Marini, H; Squadrito, F1
Altavilla, D; Bitto, A; Calò, M; Colonna, M; Galeano, M; Giugliano, G; Leone, S; Lo Cascio, P; Minutoli, L; Mioni, C; Scuderi, N; Seminara, P; Squadrito, F; Squadrito, G; Torre, V; Venuti, FS1
Altavilla, D; Antonuccio, P; Arena, S; Bitto, A; Minutoli, L; Nicòtina, PA; Polito, F; Romeo, C; Squadrito, F; Zuccarello, B1
Altavilla, D; Bitto, A; Minutoli, L; Polito, F; Squadrito, F1
Caccamo, D; Condello, S; Currò, M; Ferlazzo, N; Ientile, R; Parisi, G1

Reviews

1 review(s) available for raxofelast and benzofurans

ArticleYear
Raxofelast, (+/-)5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic acid: a new antioxidant to modulate the inflammatory response during ischemia-reperfusion injury and impaired wound healing.
    Mini reviews in medicinal chemistry, 2007, Volume: 7, Issue:3

    Topics: Animals; Antioxidants; Benzofurans; Biological Availability; Humans; Inflammation; Molecular Structure; Reperfusion Injury; Vitamin E; Wound Healing

2007

Trials

1 trial(s) available for raxofelast and benzofurans

ArticleYear
Oral treatment with an antioxidant (raxofelast) reduces oxidative stress and improves endothelial function in men with type II diabetes.
    Diabetologia, 2000, Volume: 43, Issue:8

    Topics: Acetylcholine; Administration, Oral; Antioxidants; Benzofurans; Biomarkers; Brachial Artery; Diabetes Mellitus, Type 2; Dinoprost; Endothelium, Vascular; Female; Forearm; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Nitric Oxide Donors; Nitroprusside; Oxidative Stress; Reference Values; Vasodilation; Vitamin E

2000

Other Studies

18 other study(ies) available for raxofelast and benzofurans

ArticleYear
Compared kinetics of 2-(2,3-dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 016) and its active metabolite 2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 005) in plasma and bronchial alveolar liquid in mice.
    Drugs under experimental and clinical research, 1992, Volume: 18, Issue:3

    Topics: Administration, Oral; Animals; Antioxidants; Benzofurans; Bronchoalveolar Lavage Fluid; Male; Mice; Time Factors; Vitamin E

1992
IRFI-016, a new radical scavenger, limits ischemic damage following coronary artery occlusion in rats.
    Research communications in chemical pathology and pharmacology, 1992, Volume: 76, Issue:3

    Topics: Animals; Antioxidants; Arterial Occlusive Diseases; Benzofurans; Blood Pressure; Coronary Disease; Electrocardiography; Free Radical Scavengers; Leukocytes; Male; Myocardium; Rats; Rats, Inbred Strains; Vitamin E

1992
2-(2,3-Dihydro-5-acetoxy-4,6,7-tribenzofuranyl)acetic acid (IRFI 016): a new antioxidant mucoactive drug.
    Drugs under experimental and clinical research, 1990, Volume: 16, Issue:12

    Topics: Abscess; Animals; Antioxidants; Benzofurans; Bronchi; Carbon Tetrachloride Poisoning; Carrageenan; Columbidae; Edema; Ethanol; Expectorants; Female; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred Strains; Mucus; Pain; Rabbits; Rats; Rats, Inbred Strains; Stomach; Trachea; Vitamin E

1990
A new antioxidant drug limits brain damage induced by transient cerebral ischaemia.
    Drugs under experimental and clinical research, 1993, Volume: 19, Issue:4

    Topics: Animals; Antioxidants; Benzofurans; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Gerbillinae; Ischemic Attack, Transient; Locomotion; Male; Reperfusion; Vitamin E

1993
Protective effects of IRFI-016, a new antioxidant agent, in myocardial damage, following coronary artery occlusion and reperfusion in the rat.
    Pharmacology, 1994, Volume: 48, Issue:3

    Topics: Animals; Antioxidants; Benzofurans; Blood Pressure; Creatine Kinase; Disease Models, Animal; Electrocardiography; Free Radical Scavengers; Heart; Male; Myocardial Reperfusion Injury; Myocardium; Necrosis; Peroxidase; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vitamin E

1994
Beneficial effect of raxofelast, an hydrophilic vitamin E analogue, in the rat heart after ischemia and reperfusion injury.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:8

    Topics: Alkenes; Animals; Antioxidants; Benzofurans; Glutathione; Hemodynamics; Male; Malondialdehyde; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Peroxidase; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vitamin E

1998
Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E-like antioxidant, in carrageenan-induced pleurisy.
    British journal of pharmacology, 1999, Volume: 126, Issue:2

    Topics: Animals; Antioxidants; Benzofurans; Carrageenan; Cell Respiration; Energy Metabolism; Excipients; Immunohistochemistry; Lung; Macrophages, Alveolar; Malondialdehyde; Peroxidase; Pleurisy; Rats; Tyrosine; Vitamin E

1999
Protection of low density lipoprotein oxidation by the antioxidant agent IRFI005, a new synthetic hydrophilic vitamin E analogue.
    Free radical biology & medicine, 1999, Volume: 26, Issue:7-8

    Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Benzofurans; Copper Sulfate; Electron Spin Resonance Spectroscopy; Humans; Hydrogen Peroxide; Kinetics; Linoleic Acid; Lipid Peroxidation; Lipoproteins, LDL; Middle Aged; Molecular Structure; Structure-Activity Relationship; Vitamin E

1999
Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse.
    Diabetes, 2001, Volume: 50, Issue:3

    Topics: Animals; Benzofurans; Diabetes Mellitus; Endothelial Growth Factors; Female; Lipid Peroxides; Lymphokines; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Skin; Tensile Strength; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vitamin E; Wound Healing; Wounds and Injuries

2001
Raxofelast, a hydrophilic vitamin E-like antioxidant, stimulates wound healing in genetically diabetic mice.
    Surgery, 2001, Volume: 129, Issue:4

    Topics: Animals; Antioxidants; Benzofurans; Diabetes Mellitus, Experimental; Female; Hydroxyproline; Malondialdehyde; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Peroxidase; Skin; Vitamin E; Wound Healing

2001
Lipid peroxidation inhibition reduces NF-kappaB activation and attenuates cerulein-induced pancreatitis.
    Free radical research, 2003, Volume: 37, Issue:4

    Topics: Amylases; Animals; Benzofurans; Blotting, Western; Cell Nucleus; Ceruletide; Cytoplasm; Dimerization; Glutathione; I-kappa B Proteins; Lipase; Lipid Peroxidation; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Pancreas; Pancreatitis; Peroxidase; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha; Vitamin E

2003
Antiproliferative mechanisms of raxofelast (IRFI-016) in H2O2-stimulated rat aortic smooth muscle cells.
    European journal of pharmacology, 2004, Jan-26, Volume: 484, Issue:2-3

    Topics: Animals; Aorta, Thoracic; Benzofurans; Cell Division; Dose-Response Relationship, Drug; Growth Inhibitors; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Vitamin E

2004
Raxofelast, a hydrophilic vitamin E-like antioxidant, reduces testicular ischemia-reperfusion injury.
    Urological research, 2004, Volume: 32, Issue:5

    Topics: Animals; Antioxidants; Benzofurans; Ischemia; Lipid Peroxidation; Male; Rats; Rats, Wistar; Reperfusion Injury; Spermatic Cord Torsion; Testis; Vitamin E

2004
Protective effects of antioxidant raxofelast in alcohol-induced liver disease in mice.
    Pharmacology, 2005, Volume: 74, Issue:1

    Topics: Alanine Transaminase; Animals; Antioxidants; Benzofurans; Female; Glutathione; Intercellular Adhesion Molecule-1; Interleukin-6; Lipid Peroxidation; Liver; Liver Diseases, Alcoholic; Liver Function Tests; Malondialdehyde; Mice; Mice, Inbred C57BL; NF-kappa B; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Toll-Like Receptor 4; Triglycerides; Tumor Necrosis Factor-alpha; Vitamin E

2005
Glutamate promotes NF-kappaB pathway in primary astrocytes: protective effects of IRFI 016, a synthetic vitamin E analogue.
    Experimental neurology, 2005, Volume: 193, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Benzofurans; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Epistasis, Genetic; Free Radical Scavengers; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; NF-kappa B; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Vitamin E

2005
Lipid peroxidation inhibition by raxofelast improves angiogenesis and wound healing in experimental burn wounds.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:1

    Topics: Animals; Benzofurans; Burns; Disease Models, Animal; Glutathione; Immunohistochemistry; Lipid Peroxidation; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Platelet Endothelial Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A; Vitamin E; Wound Healing

2005
Lipid peroxidation activates mitogen-activated protein kinases in testicular ischemia-reperfusion injury.
    The Journal of urology, 2006, Volume: 176, Issue:4 Pt 1

    Topics: Animals; Antioxidants; Benzofurans; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Male; Rats; Reperfusion Injury; RNA, Messenger; Spermatic Cord Torsion; Tumor Necrosis Factor-alpha; Vitamin E

2006
NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells.
    BMC neuroscience, 2008, Jul-07, Volume: 9

    Topics: Acetylcysteine; alpha-Tocopherol; Animals; Apoptosis; bcl-2-Associated X Protein; Benzofurans; Blotting, Western; Caspase 3; Cell Differentiation; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Free Radical Scavengers; Homocysteine; Mitochondria; Neuroblastoma; NF-kappa B; Peptides; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Tumor Suppressor Protein p53; Vitamin E

2008