Compounds > ranolazine
Page last updated: 2024-08-24

ranolazine and gs-458967

ranolazine has been researched along with gs-458967 in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (77.78)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Avila, B; Belardinelli, L; Dhalla, AK; Elzein, E; Hirakawa, R; Jiang, RH; Kobayashi, T; Koltun, DO; Li, X; Mollova, N; Parkhill, EQ; Perry, TD; Rajamani, S; Smith-Maxwell, C; Stafford, B; Tang, J; Wang, WQ; Wu, L; Zablocki, JA1
Avila, B; Belardinelli, L; Dhalla, AK; Elzein, E; Jiang, RH; Kalla, R; Kobayashi, T; Koltun, DO; Li, X; Mollova, N; Notte, GT; Parkhill, EQ; Perry, TD; Rajamani, S; Smith-Maxwell, C; Stafford, B; Tang, J; Wang, WQ; Zablocki, JA1
Belardinelli, L; Crumb, W; Dhalla, AK; El-Bizri, N; Hirakawa, R; Hu, L; Karpinski, S; Koltun, D; Li, CH; Li, XJ; Liu, G; Rajamani, S; Shryock, JC; Smith-Maxwell, C; Wang, WQ; Wu, L; Yao, L; Zablocki, J1
Anderson, LL; Bush, WS; Frankel, WN; George, AL; Hawkins, NA; Kearney, JA; Nath, RD; Petersohn, AA; Rajamani, S; Thompson, CH; Vanoye, CG1
George, AL; Potet, F; Vanoye, CG1
Azam, MA; Kusha, M; Labos, C; Lai, PF; Massé, S; Nair, GK; Nanthakumar, K; Tan, NS; Zamiri, N1
Belardinelli, L; Cerbai, E; Coppini, R; Ferrantini, C; Gentile, F; Matucci, R; Mazzoni, L; Mugelli, A; Olivotto, I; Palandri, C; Pioner, JM; Poggesi, C; Rossi, A; Tesi, C; Tosi, B1
Burridge, PW; Egecioglu, DE; George, AL; Potet, F1
Abi-Gerges, N; Cotta, T; Espinoza, A; Geft, V; Ghetti, A; Hernandez, E; Indersmitten, T; Macias, A; Mai, C; Miller, PE; Miron, Y; Nguyen, W; Page, G; Rasoul, L; Stafford, A; Sweat, K; Ton, AT; Truong, K; Wong, T1

Other Studies

9 other study(ies) available for ranolazine and gs-458967

ArticleYear
Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine.
    Bioorganic & medicinal chemistry letters, 2016, 07-01, Volume: 26, Issue:13

    Topics: Animals; Azoles; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Ether-A-Go-Go Potassium Channels; Haplorhini; Heart; Humans; Molecular Structure; NAV1.5 Voltage-Gated Sodium Channel; Pyridines; Rabbits; Ranolazine; Rats; Sodium Channel Blockers; Structure-Activity Relationship

2016
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.
    Bioorganic & medicinal chemistry letters, 2016, 07-01, Volume: 26, Issue:13

    Topics: Animals; Caco-2 Cells; Dose-Response Relationship, Drug; Drug Discovery; Ether-A-Go-Go Potassium Channels; Heart; Humans; Macaca fascicularis; Microsomes, Liver; Molecular Structure; NAV1.5 Voltage-Gated Sodium Channel; Pyridines; Rabbits; Ranolazine; Rats; Sodium Channel Blockers; Structure-Activity Relationship; Triazoles

2016
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1

    Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Cnidarian Venoms; Female; Flecainide; Heart Conduction System; Long QT Syndrome; Mutation; Myocardial Ischemia; Myocytes, Cardiac; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Pyridines; Quaternary Ammonium Compounds; Rabbits; Ranolazine; Sodium Channel Blockers; Triazoles

2013
Antiepileptic activity of preferential inhibitors of persistent sodium current.
    Epilepsia, 2014, Volume: 55, Issue:8

    Topics: Acetanilides; Animals; Anticonvulsants; Cells, Cultured; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Piperazines; Pyridines; Ranolazine; Seizures; Sodium Channel Blockers; Triazoles

2014
Use-Dependent Block of Human Cardiac Sodium Channels by GS967.
    Molecular pharmacology, 2016, Volume: 90, Issue:1

    Topics: Anesthetics; Humans; Ion Channel Gating; Lidocaine; Myocardium; Pyridines; Ranolazine; Sodium Channel Blockers; Sodium Channels; Triazoles

2016
Effects of Late Sodium Current Blockade on Ventricular Refibrillation in a Rabbit Model.
    Circulation. Arrhythmia and electrophysiology, 2017, Volume: 10, Issue:3

    Topics: Animals; Calcium; Calcium Channels; Disease Models, Animal; Electric Countershock; Heart Arrest; Logistic Models; Pyridines; Rabbits; Random Allocation; Ranolazine; Reference Values; Sodium Channel Blockers; Sodium Channels; Statistics, Nonparametric; Triazoles; Ventricular Fibrillation

2017
Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.
    British journal of pharmacology, 2018, Volume: 175, Issue:13

    Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Hypertrophic; Cohort Studies; Dose-Response Relationship, Drug; Exercise; Female; Humans; Male; Middle Aged; Myocardium; Pyridines; Ranolazine; Sodium; Sodium Channel Blockers; Triazoles

2018
GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Molecular pharmacology, 2020, Volume: 98, Issue:5

    Topics: Action Potentials; Anti-Arrhythmia Agents; Cells, Cultured; Humans; Induced Pluripotent Stem Cells; Ion Channel Gating; Lidocaine; Myocytes, Cardiac; Oxazepines; Pyridines; Ranolazine; Sodium Channel Blockers; Sodium Channels; Triazoles

2020
Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart.
    Scientific reports, 2021, 06-08, Volume: 11, Issue:1

    Topics: Adult; Atrial Fibrillation; Calcium; Cnidarian Venoms; ERG1 Potassium Channel; Heart Atria; Humans; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Piperidines; Pyridines; Ranolazine; Sodium; Triazoles

2021